Matching Items (275)
Description
The knowledge of medical genetics is currently used with prenatal testing, and the advancements in the field of behavioral genetics may someday allow for its use with prenatal testing as well. The use of prenatal procedures for medical phenotypes has its own implications and should these techniques be used for behavioral phenotypes, such implications can also apply. The complexity of behavior in terms of the factors that may affect it, along with the way it is conceptualized and perceived, adds further implications for prenatal testing of it. In this thesis, I discuss the qualitative, quantitative, and historical facets of prenatal testing for medical and behavioral phenotypes and the undercurrent of eugenics. I do so by presenting an example of the medical phenotype (cystic fibrosis) as a case for envisioning the implications of medical phenotypes before delving into examples of behavioral phenotypes (aggression, impulsivity, extraversion, and neuroticism) in order to explore the implications shared with those for medical phenotypes as well as those unique to it. These implications then set the foundation for a discussion of eugenics, and the considerations for how behavioral genetics with prenatal testing may give way to a modern form of it.
ContributorsMinai, Mandana (Author) / Maienschein, Jane (Thesis director) / Robert, Jason (Committee member) / Magnus, David (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor)
Created2014-05
Description
Mr. Green has stage 4 prostate cancer which has spread to the bones and liver and has become resistant to radiation and standard chemotherapy treatment. After 3 rounds of chemotherapy, his primary oncologist recommends that he participate in a clinical trial. He went to Dr. Red at the Saguaro Clinic after reading on the internet about a new Phase 1 clinical trial that the clinic is hosting, which is designed to target a specific receptor called AB-111 that may be present in malignant prostate, cervical, ovarian, and breast cells. After signing consent and completing the blood screens in the morning at the clinic, Mr. Green is told his liver enzymes are too high and the ranges specified in the protocol prohibit him from enrolling. Mr. Green is noticeably affected and distressed at this news, and Dr. Red recommends end-of-life care. Behind the scenes, this event is noted on official medical documents and trial study rosters as a "screen fail." This narrative, while fictional, is realistic because similar events occur in cancer clinical trial sites on a regular basis. I look at the inner "world" and mental journey of possible clinical trial candidates as they seek out information about clinical trials and gain understanding of their function \u2014 specifically in the context of Phase 1 cancer clinical trials. To whom is the language of the term "screen failure" useful? How does excluding individuals from clinical trials protect their health and does the integrity of the trial data supersede the person's curative goals? What is the message that cancer patients (potential research subjects) receive regarding clinical trials from sources outside their oncologists?
ContributorsMcKane, Alexandra (Author) / Maienschein, Jane (Thesis director) / Ellison, Karin (Committee member) / Foy, Joseph (Committee member) / Barrett, The Honors College (Contributor)
Created2013-12
Visualizing the Embryo: Establishing Procedures for Digital image Production with the Embryo Project
Description
The Embryo Project (EP) Encyclopedia is an online database that has consolidated hundreds of development-related research articles, with subcategories addressing the context of such research. These articles are written by undergraduate students, graduate students, and professionals in the fields of biology, history, and other fields, and are intended for a diverse audience of readers from both biology and non-biology related backgrounds. As the EP addresses a public audience, it is imperative to utilize all possible means to share the information that each article covers. Until 2013, the EP Encyclopedia did not present images in articles as no formal protocol for image development existed. I have created an image style guide that outlines the basic steps of creating and submitting an image that can complement an EP article and can enhance a reader's understanding of the discussed concept. In creating this style guide, I investigated similar protocols used by other scientific journals and medical professionals. I also used different programs and based my style guide off of the procedures I used in Adobe Illustrator CS6.
ContributorsHamidi, Neekta (Author) / Maienschein, Jane (Thesis director) / Crowe, Nathan (Committee member) / O'Neil, Erica (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2013-05
Description
As green buildings become more popular, the challenge of structural engineer is to move beyond simply green to develop sustainable, and high-performing buildings that are more than just environmentally friendly. For decades, Portland cement-based products have been known as the most commonly used construction materials in the world, and as a result, cement production is a significant source of global carbon dioxide (CO2) emissions, and environmental impacts at all stages of the process. In recent years, the increasing cost of energy and resource supplies, and concerns related to greenhouse gas emissions and environmental impacts have ignited more interests in utilizing waste and by-product materials as the primary ingredient to replace ordinary Portland cement in concrete systems. The environmental benefits of cement replacement are enormous, including the diversion of non-recycled waste from landfills for useful applications, the reduction in non-renewable energy consumption for cement production, and the corresponding emission of greenhouse gases. In the vast available body of literature, concretes consisting activated fly ash or slag as the binder have been shown to have high compressive strengths, and resistance to fire and chemical attack. This research focuses to utilize fly ash, by-product of coal fired power plant along with different alkaline solutions to form a final product with comparable properties to or superior than those of ordinary Portland cement concrete. Fly ash mortars using different concentration of sodium hydroxide and waterglass were dry and moist cured at different temperatures prior subjecting to uniaxial compressive loading condition. Since moist curing continuously supplies water for the hydration process of activated fly ash mortars while preventing thermal shrinkage and cracking, the samples were more durable and demonstrated a noticeably higher compressive strength. The influence of the concentration of the activating agent (4, or 8 M sodium hydroxide solution), and activator-to-binder ratio of 0.40 on the compressive strengths of concretes containing Class F fly ash as the sole binder is analyzed. Furthermore, liquid sodium silicate (waterglass) with silica modulus of 1.0 and 2.0 along with activator-to-binder ratio of 0.04 and 0.07 was also studied to understand its performance in contributing to the strength development of the activated fly ash concrete. Statistical analysis of the compressive strength results show that the available alkali concentration has a larger influence on the compressive strengths of activated concretes made using fly ash than the influence of curing parameters (elevated temperatures, condition, and duration).
ContributorsBanh, Kingsten Chi (Author) / Neithalath, Narayanan (Thesis director) / Rajan, Subramaniam (Committee member) / Mobasher, Barzin (Committee member) / Civil, Environmental and Sustainable Engineering Programs (Contributor) / Barrett, The Honors College (Contributor)
Created2013-05
Description
Civil litigation and medical malpractice both seem to be plagued by similar misperceptions. The general public, lawyers, physicians and our elected officials are all in considerable error regarding the reality behind civil litigation. The perception is that there are an increasing number of claims filed, and that in those cases that are filed the plaintiff is likely to win and be awarded a large sum of money. Regarding medical malpractice, in particular, is the belief that such litigation increases the over-all costs of healthcare by a significant dollar amount through the costs of litigation as well as the increasing instances of defensive medicine. Physicians further state that it is the absurd awards all too common in medical malpractice cases that are to blame for the out of control increases seen in medical malpractice premiums. These increases in premiums are said to have forced a large number of physicians out of practice that will hurt the general public's access to health care. These perceptions are at least reinforced by the media coverage that reports on the rare multimillion-dollar cases and from reports by insurance companies and physicians, in their attempt to lower their business costs by decreasing medical malpractice insurance premiums. By understanding the prevalence of such misperceptions, the truth behind the claims, and how such misinformation reaches the public and has spread to all levels of society, empirical data must be presented to the public in order to overcome the misperceptions.
ContributorsKohl, Mitchell Anthony (Author) / Robert, Jason (Thesis director) / Maienschein, Jane (Committee member) / Mossman, Kenneth (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
Most individuals entering college are taking responsibility for their own health for the first time. Students are used to having a parent or guardian nearby to diagnose and provide remedies for common health issues. Entering college, whether in a different city or just down the road, means they must assume those responsibilities themselves. Navigating that transition can be difficult for college students. A large majority of students turn to internet health resources, such as WebMD, for health information. However, studies show that despite overall internet savvy, college students are not very skilled at finding legitimate health information online. Therefore, a health resource designed specifically for college students would be a valuable resource for many students at ASU. Working with local Phoenix physician Doug Lakin, I and a team of other Barrett students revised Dr. Lakin's healthcare guide, Thrive 101: Health & Wellness for College Students. I was responsible for the guide's second chapter, which provides information on specific illnesses and injuries. I conducted a literature review to discover the best practices for communicating medical information. I found that using short sentences, simple words, bullet point lists, numbered lists, and subheadings improved the effectiveness of a health resource. I also found that health information seekers want resources to be tailored specifically for them. They want personalized resources. Personalization means including health information that the intended reader wants, excluding the health information the reader does not want, as well as featuring personal anecdotes from individuals like the reader dealing with health problems like the reader's. I applied what I discovered to Thrive 101. I reorganized the chapter I was assigned, incorporating subheadings and clear organization of the information. I also eliminated information I judged irrelevant to college students and brainstormed what information was missing that college students would benefit from. At this time, the revision team has not gotten to the point where we are researching and writing new information, but we do have lists of items we want to include. The information already in the guide I reformatted into bulleted and numbered lists where possible. As with the new information, we have not begun to revise the guide on a prose level, shortening the sentences and simplifying the vocabulary, but we intend to work into the summer to finish our revisions.
ContributorsAbboud, Carolina (Author) / Maienschein, Jane (Thesis director) / O'Neil, Erica (Committee member) / Lakin, Douglas (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Planned Parenthood, one of the United States' largest providers of reproductive health services, has campaigned for decades to secure women's reproductive rights in the political sphere. However, few scholars have written on the social and political history that preceded the general religious and Republican hostility toward the organization in the twenty-first century. Through Planned Parenthood's growth in the mid-twentieth century, both political parties and many religious organizations pushed for family planning and access to contraception as solutions to population growth and poverty. Arizona was used as a case study to examine the broader context of the shift in the ideas of political parties and religious organizations surrounding the reproductive rights movement from the start of the twentieth century until the 1980s. The historical trajectory of the shifting religious and political support for Planned Parenthood Arizona was demonstrated using both a literature review and archival research. Throughout the early 1900s, Republicans advocated for limited governmental intrusion into citizens' lives, which extended to women's reproduction, where contraception was seen as a private decision between a woman and her doctor. That changed in the late twentieth century when religious concerns exacerbated the political discussion following the legalization of abortion in 1973 and the appointment of Ronald Regan in 1981, one of the first outspoken pro-life presidents. Planned Parenthood faced increasing criticism from religious organizations and the Republican Party. The social and political history surrounding Planned Parenthood Arizona illustrates the interplay between politics and the reproductive rights movement throughout the twentieth century. The contextualization of major historical events during the development of Planned Parenthood Arizona gives insight into the current political and religious beliefs regarding the reproductive rights movement.
ContributorsNunez-Eddy, Claudia Margarita (Author) / Maienschein, Jane (Thesis director) / O'Neil, Erica (Committee member) / Abboud, Alexis (Committee member) / School of Life Sciences (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Studies in neocortical neurogenesis have experienced an explosive growth since the early 2000s, measured by the increasing number of publications each year. I examine here the influence of Arnold Kriegstein in the field using Topic Modeling, a set of algorithms that can be applied to a collection of texts to elucidate the central themes of said collection. Using a Java-based software called MALLET, I obtained data for his corpus, and compared it to the texts of other researchers in the field. This latter collection, which I dub "General Corpus", was separated by year from 2000 to 2014. I found that Kriegstein's most frequently discussed topic concerned highly unique terms such as GABA, glutamate, and receptor, which did not appear in any of the primary topics of the General Corpus. This was in contrast to my initial hypothesis that Kriegstein's importance stemmed from his examination of different phenomena that constitute the broader aspect of neocortical neurogenesis. I predicted that the terms in Kriegstein's primary topic would appear many times throughout the topics of the General Corpus, but it was not so, aside from the common ones such as neurons, cortical, and development. Taken in tandem with NIH Reporter data, these results suggest that Kriegstein obtains a large amount of research funding because his studies concern unique topics when compared to others in the field. The implications of these findings are especially relevant in a world where funding is becoming increasingly difficult to come by.
ContributorsChhetri, Chandra Divyash (Author) / Laubichler, Manfred (Thesis director) / Maienschein, Jane (Committee member) / Aiello, Kenneth (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
In the digital humanities, there is a constant need to turn images and PDF files into plain text to apply analyses such as topic modelling, named entity recognition, and other techniques. However, although there exist different solutions to extract text embedded in PDF files or run OCR on images, they typically require additional training (for example, scholars have to learn how to use the command line) or are difficult to automate without programming skills. The Giles Ecosystem is a distributed system based on Apache Kafka that allows users to upload documents for text and image extraction. The system components are implemented using Java and the Spring Framework and are available under an Open Source license on GitHub (https://github.com/diging/).
ContributorsLessios-Damerow, Julia (Contributor) / Peirson, Erick (Contributor) / Laubichler, Manfred (Contributor) / ASU-SFI Center for Biosocial Complex Systems (Contributor)
Created2017-09-28
Description
In a recent opinion piece, Denis Duboule has claimed that the increasing shift towards systems biology is driving evolutionary and developmental biology apart, and that a true reunification of these two disciplines within the framework of evolutionary developmental biology (EvoDevo) may easily take another 100 years. He identifies methodological, epistemological, and social differences as causes for this supposed separation. Our article provides a contrasting view. We argue that Duboule’s prediction is based on a one-sided understanding of systems biology as a science that is only interested in functional, not evolutionary, aspects of biological processes. Instead, we propose a research program for an evolutionary systems biology, which is based on local exploration of the configuration space in evolving developmental systems. We call this approach—which is based on reverse engineering, simulation, and mathematical analysis—the natural history of configuration space. We discuss a number of illustrative examples that demonstrate the past success of local exploration, as opposed to global mapping, in different biological contexts. We argue that this pragmatic mode of inquiry can be extended and applied to the mathematical analysis of the developmental repertoire and evolutionary potential of evolving developmental mechanisms and that evolutionary systems biology so conceived provides a pragmatic epistemological framework for the EvoDevo synthesis.
ContributorsJaeger, Johannes (Author) / Laubichler, Manfred (Author) / Callebaut, Werner (Author) / College of Liberal Arts and Sciences (Contributor)
Created2015-02-17