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- Creators: School of Sustainability
- Resource Type: Text
- Status: Published
Description
microRNAs (miRNAs) are short ~22nt non-coding RNAs that regulate gene output at the post-transcriptional level. Via targeting of degenerate elements primarily in 3'untranslated regions (3'UTR) of mRNAs, miRNAs can target thousands of varying genes and suppress their protein translation. The precise mechanistic function and bio- logical role of miRNAs is not fully understood and yet it is a major contributor to a pleth- ora of diseases, including neurological disorders, muscular disorders, and cancer. Cer- tain model organisms are valuable in understanding the function of miRNA and there- fore fully understanding the biological significance of miRNA targeting. Here I report a mechanistic analysis of miRNA targeting in C. elegans, and a bioinformatic approach to aid in further investigation of miRNA targeted sequences. A few of the biologically significant mechanisms discussed in this thesis include alternative polyadenylation, RNA binding proteins, components of the miRNA recognition machinery, miRNA secondary structures, and their polymorphisms. This thesis also discusses a novel bioinformatic approach to studying miRNA biology, including computational miRNA target prediction software, and sequence complementarity. This thesis allows a better understanding of miRNA biology and presents an ideal strategy for approaching future research in miRNA targeting.
ContributorsWeigele, Dustin Keith (Author) / Mangone, Marco (Thesis director) / Katchman, Benjamin (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Life Sciences (Contributor)
Created2014-12
Description
This paper explores women and bicycling, with the focus of looking at how to get more women onto the bicycle in Tempe, Arizona. The main areas of interest for this study are improvements to bicycling infrastructure and an increase in the safety and the perception of safety of women cyclists in the Tempe area. In order to explore this topic, an online survey of 75 Arizona State students was conducted. From the results women were primarily concerned with their safety due to the condition of the overall infrastructure and the lack of bicycle related improvements. Research such as this that examines women and cycling is significant due to the current underrepresentation of women in the cycling community and has the potential to improve safety and increase bicycle ridership.
ContributorsStarr, Nicole (Author) / Kelley, Jason (Thesis director) / Golub, Aaron (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor) / School of Sustainability (Contributor)
Created2014-12
Description
Colorectal cancer (CRC) is one of the most highly diagnosed cancers in the United States and accounts for 9.5% of all new cancer cases worldwide. With a 50% five-year prognosis, it is the second highest cancerous cause of death in the U.S. CRC tumors express antigens that are capable of inducing an immune response. The identification of autoantibodies (AAb) against tumor-associated antigens (TAA) may facilitate personalized tumor treatment in the form of targeted immunotherapy. The objective of this study was to observe the AAb expression raised against a 2000 human gene survey in late-stage colorectal cancer using the Nucleic Acid Programmable Protein Arrays (NAPPA). AAbs from serum samples were collected from 80 patients who died within 24 months of their last blood draw and 80 age and gender matched healthy control were profiled using NAPPA. TAA p53, a well-established protein that is one of the most highly mutated across a variety of cancers, was one of the top candidates based on statistical analysis, which, along with its family proteins p63 and p73 (which showed inverse AAb response profiles) warranted further testing via RAPID ELISA. Statistical analysis from these results revealed an inverse differential relationship between p53 and p63, in which p53 seropositivity was higher in patients than in controls, while the opposite was unexpectedly the case for p63. This study involving the AAb immunoprofiling of advanced stage CRC patients is one of the first to shed light on the high-throughput feasibility of immunoproteomic experiments using protein arrays as well as the identification of immunotherapy targets in a more rapid move towards specialized treatment of advanced CRC.
ContributorsSzeto, Emily (Author) / LaBaer, Joshua (Thesis director) / Qiu, Ji (Committee member) / Demirkan, Gokhan (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor)
Created2014-12
Description
While public transit systems are perceived to produce lower GHG emission intensities per passenger miles traveled (PMT) and per vehicle miles traveled (VMT), there is a limited understanding of emissions per PMT/VMT across cities, or of how emissions may change across modes (light, metro, commuter, and bus) and time (e.g., with changing electricity mixes in the future). In order to better understand the GHG emissions intensity of public transit systems, a comparative emissions assessment was developed utilizing the National Transit Database (NTD) which reports energy use from 1997 to 2012 of rail and bus systems across the US. By determining the GHG emission intensities (per VMT or per PMT) for each mode of transit across multiple years, the modes of transit can be better compared between one another. This comparison can help inform future goals to reduce GHG emissions as well as target reductions from the mode of transit that has the highest emissions. The proposed analysis of the NTD and comparison of modal emission intensities will be used to develop future forecasting that can guide public transit systems towards a sustainable future.
ContributorsCano, Alex (Author) / Chester, Mikhail (Thesis director) / Seager, Thomas (Committee member) / Civil, Environmental and Sustainable Engineering Programs (Contributor) / Barrett, The Honors College (Contributor) / School of Sustainability (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2014-12
Description
The price charged between related parties for the transfer of goods, services, or intangibles, is known as a transfer price. A taxpayer is required to set its transfer price at arm's-length, similar to what would be charged to an unrelated party, to prevent a taxpayer from greatly reducing its global tax by shifting profits from its U.S. entity to an entity located in a jurisdiction with a lower tax rate. Section 482 of the Internal Revenue Code and its associated regulations advises taxpayers on the various methods to calculate its transfer price. These include: the Comparable Uncontrolled Transaction (CUT) method, the Comparable Profits Method (CPM), and the Profit Split Method. Section 482 also grants the Internal Revenue Service (IRS) the authority to allocate a corporation's transfer price if it is not at arm's-length. With millions and sometimes billions of dollars at stake, it is important for the IRS to resolve the incredibly complex issue of transfer pricing without placing an unnecessary burden on U.S. corporations.
ContributorsWilliams, Gary Spencer (Author) / Goldman, Donald (Thesis director) / Levendowski, Glenda (Committee member) / Barrett, The Honors College (Contributor) / WPC Graduate Programs (Contributor) / School of Sustainability (Contributor) / School of Accountancy (Contributor)
Created2014-12
Description
As feminist understandings of the role that gender plays in the field of international development have evolved over time, there have been countless criticisms of organizations in the field due to their slowness in accounting for and responding to these academic contributions. Largely, these criticisms are lobbied against oversimplifications of the use of the term gender, often as interchangeable with the term girls/women, effectively excluding boys/men. In attempt to determine the extent to which boys and men have been excluded from the discourse of gender equality focused international development programs, this thesis conducts a rhetorical analysis of Plan International’s ‘Because I am a Girl’ Campaign. As an international nongovernmental organization that has made some attempt to include boys and men in its work, it serves as an important site for investigating why development organizations have not fully embraced the work done in masculinities studies and in feminist/gender studies on development. The analysis concludes that the intended audience is critical in shaping the way that an organization represents its gender-related programming.
ContributorsMcHugh, Megan Leigh (Author) / Gillis, Georganne (Thesis director) / Switzer, Heather (Committee member) / Barrett, The Honors College (Contributor) / School of Social Transformation (Contributor) / School of Sustainability (Contributor) / School of Politics and Global Studies (Contributor)
Created2014-05
Description
FLARE is a concept developed to aid efficiency and effectiveness of Search and Rescue. It is a wearable technology device that encompasses GPS capabilities, backup offline locating capabilities, 2-way text communication via satellite, and other various features suited for outdoors. It is intended for both Search and Rescue as well as recreational outdoor enthusiasts, with same hardware, but different software.
ContributorsKawski, Anna Simone (Author) / McDermott, Lauren (Thesis director) / Dhadphale, Tejas (Committee member) / Barrett, The Honors College (Contributor) / School of Sustainability (Contributor) / The Design School (Contributor)
Created2014-05
Description
This project explores a variety of ways of framing the problem of obesity, beginning with a multidisciplinary assessment of genetic, environmental, cultural, nutritional, and socioeconomic factors involved in the structure and the consequences of each frame. How obesity is framed as a problem has a profound impact on the kinds of solutions that may be deemed scientifically appropriate. But frames are not entirely evidence-based, inasmuch as political and moral values infuse debates about the nature of obesity. Drawing on interdisciplinary resources from bioethics and the philosophy of science, I strive to offer strategic insight in to how to navigate the complexity of these issues.
ContributorsYanamandra, Meghana (Author) / Robert, Jason (Thesis director) / Wharton, Christopher (Committee member) / Drago, Mary (Committee member) / Barrett, The Honors College (Contributor) / School of Sustainability (Contributor) / School of Life Sciences (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2014-05
Description
Now dry and broken, the Salt River once supplied a great legacy of Riparian vegetation through the Sonoran desert. This verdant landscape flourished from perennial flows of a river fed by high mountain snowmelt. However, multiple dams within those mountain canyons and channelization for the purpose of flood protection have nearly dried up the Salt. Through the process of design I examined the potential to repair, restore, and redevelop the river, choosing a site within the reach of the Salt River that currently includes an artificial retention area called Tempe Town Lake. Since 1999 a two mile portion of the river channel has contained the reservoir for the purpose of recreation and development within the city of Tempe. As I investigated the viability of restoring an urban desert river to a more natural riparian condition, I developed a master plan that merges ecological river restoration with sustainable urban development. Research into the vegetative communities historically occurring along the river's edge guided me to create a project based in ecological principles. Expanding the concrete channel to a wider river presence followed examples set by case studies and the historic character of the Salt River. A new braided low flow channel, allowed to meander with the natural currents of the river, is terraced upwards in a gentle slope that maintains current 500-year flow plains. The vegetation communities I propose to establish along the new terraced elevations are adapted from Charles H. Lowe's profile of a foothill canyon and archival research specific to this portion of the Salt River. As a way to support the reintroduction of Arizona's lost riparian plant communities, the master plan incorporates the use of greywater and A/C condensate collection from proposed developments along the river's edge. These new water systems would be substantial enough to sustain riparian vegetation creation and in addition, provide for ground water recharge. Additional developments continue the City of Tempe's goal to expand development along the river and adjacent to the downtown core. Providing for increased recreational opportunity in a river setting improves the quality of life in Tempe and sets the community apart from surrounding desert cities. By applying ecological and sustainable design and planning principles, the Salt River Diaries master plan repairs the river's flow, restores the riparian vegetation, and redevelops the edge between the city and river.
ContributorsBruckner, Coby Ryan (Author) / Fish Ewan, Rebecca (Thesis director) / Cook, Edward (Committee member) / Sykes, Astrid (Committee member) / Barrett, The Honors College (Contributor) / School of Sustainability (Contributor) / The Design School (Contributor)
Created2014-05
Description
This paper explores the relationship between wildfire management and the consideration of ecological and environmental concerns in Arizona. To get a proper perspective on the current state of wildfire management in Arizona, information on two wildfire management programs, the Four Forests Restoration Initiative and FireScape, was researched and analyzed, as well as contemporary fire policy, a history of wildfire in Arizona, and two recent fires in Sedona, AZ. The two fires in Sedona, the Brins Fire of 2006 and the Slide Fire of 2014, act as a focal point for this ecological management transition, as even within an 8-year period, we can see the different ways the two fires were managed and the transition to a greater ecological importance in management strategies. These all came together to give a full spectrum for the factors that have led to more ecologically-prominent wildfire management strategies in Arizona.
ContributorsGeorge-Sills, Dylan (Author) / Pyne, Stephen (Thesis director) / Hirt, Paul (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Sustainability (Contributor)
Created2015-05