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Member of: Barrett, The Honors College Thesis/Creative Project Collection

Health & Wealthness Podcast

Description

Health and Wealthness is a podcast where your hosts, Emily Weigel and Hanaa Khan discuss pressing and trending topics about health and wealth that everyone should know about. Our first four episodes focus on the opioid crisis. Both the science and healthcare sides. We then go on to talk about…

ContributorsKhan, Hanaa S (Co-author) / Weigel, Emily (Co-author) / Olive, Foster (Thesis director) / Bonfiglio, Thomas (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)

Created2021-05

PLUR Responsibly: An evaluation of attitudes regarding drug presence and harm reduction efforts at EDM events by attendees

Description

The electronic dance music (EDM) rave community prides itself in fostering an all- accepting subculture for people to unite in style, song, and dance. Based on the principles of Peace, Love, Unity, and Respect (PLUR), rave events have unique and colorful themes, bass levels you can feel in your heart, bright and invigorating laser light shows, and in many cases, a heavy presence of both legal and illegal drug use. Because of the association with illegal substances, open discussions regarding drug presence, use, and harm reduction have been stigmatized and limited in the rave community. This study aims to evaluate the current level of knowledge and attitudes regarding drug presence and harm reduction among “ravers.” All participants were required to be of 18 years of age or older and have attended at least 1 EDM event in the past 5 years. The study involved two stages: (1) collecting qualitative data through in person, phone call, or Zoom interviews (n=14), and (2) collecting quantitative data through closed-ended, anonymous surveys via QuestionPro (n=64). The results indicate that a significant portion of participants in both stages express a desire for easily accessible harm reduction information and increased measures prior to and at EDM events. Starting an open dialogue about drug use and harm reduction efforts within this subculture could help create a safer environment and reduce the negative consequences of drug use.

ContributorsOrillo, Rebecca Marie (Author) / Hruschka, Daniel (Thesis director) / Olive, Foster (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)

Created2023-05

5-HT1B receptor agonist CP 94,253 reduces cocaine intake in female rats post-abstinence and after resuming self-administration

Description

Approximately five million Americans suffer from cocaine use disorder with no FDA approved pharmaceutical to help their path to recovery (Yerby, 2019). Serotonin is heavily implicated in cocaine use and in the reward system, and is therefore a suggested target for pharmaceuticals aiming to aid in psychostimulant addiction (Sarlin, 2019; Clark and Neumaier, 2001). CP 94,253, a 5-HT1BR agonist, has been shown to increase cocaine intake during maintenance of daily cocaine self-administration, though it has also been shown to decrease intake after a period of forced abstinence (Parsons et al., 1998; Pentowski et al., 2009). While a decrease in cocaine intake post-abstinence is promising post-abstinence, it remains to be seen whether this is a viable option if patients relapse. Most experiments are conducted with male rats, though an increasing amount of data has come to light on the differing effects of drugs on male and female rats (Mennenga and Bimonte-Nelson, 2014). Previous studies conducted through our lab have shown no difference in cocaine self-administration behavior across the estrous cycle phases with CP 94,253. It remains to be seen however, whether CP 94,253 would function dissimilarly in female rats than in male rats. This experiment studied the effects of CP 94,253 on post-abstinence and post-resumption cocaine self-administration in free-cycling female rats across two doses of cocaine. It was shown that CP 94,253 reduces cocaine intake both post-abstinence and post-resumption, suggesting that this pharmacotherapy would work in cases of relapse, and that there are no sex differences in its effects. While more studies should be conducted with locomotion and stress tests, thus far this experiment provides further evidence for the validity of CP 94,253 to be a promising pharmacotherapeutic option for future investigation.

ContributorsDoyle, Sophia Marie (Author) / Neisewander, Janet (Thesis director) / Olive, Foster (Committee member) / Scott, Samantha (Committee member) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)

Created2020-05