Matching Items (29)
Description
Past research has shown that students have difficulty developing a robust conception of function. However, little prior research has been performed dealing with student knowledge of function composition, a potentially powerful mathematical concept. This dissertation reports the results of an investigation into student understanding and use of function composition, set against the backdrop of a precalculus class that emphasized quantification and covariational reasoning. The data were collected using task-based, semi-structured clinical interviews with individual students outside the classroom. Findings from this study revealed that factors such as the student's quantitative reasoning, covariational reasoning, problem solving behaviors, and view of function influence how a student understands and uses function composition. The results of the study characterize some of the subtle ways in which these factors impact students' ability to understand and use function composition to solve problems. Findings also revealed that other factors such as a students' persistence, disposition towards "meaning making" for the purpose of conceptualizing quantitative relationships, familiarity with the context of a problem, procedural fluency, and student knowledge of rules of "order of operations" impact a students' progress in advancing her/his solution approach.
ContributorsBowling, Stacey (Author) / Carlson, Marilyn P (Thesis advisor) / Thompson, Patrick W (Committee member) / Moore, Kevin C (Committee member) / Milner, Fabio (Committee member) / Van de Sande, Carla (Committee member) / Arizona State University (Publisher)
Created2014
Description
The phycologist, M. R. Droop, studied vitamin B12 limitation in the flagellate Monochrysis lutheri and concluded that its specific growth rate depended on the concentration of the vitamin within the cell; i.e. the cell quota of the vitamin B12. The Droop model provides a mathematical expression to link growth rate to the intracellular concentration of a limiting nutrient. Although the Droop model has been an important modeling tool in ecology, it has only recently been applied to study cancer biology. Cancer cells live in an ecological setting, interacting and competing with normal and other cancerous cells for nutrients and space, and evolving and adapting to their environment. Here, the Droop equation is used to model three cancers.
First, prostate cancer is modeled, where androgen is considered the limiting nutrient since most tumors depend on androgen for proliferation and survival. The model's accuracy for predicting the biomarker for patients on intermittent androgen deprivation therapy is tested by comparing the simulation results to clinical data as well as to an existing simpler model. The results suggest that a simpler model may be more beneficial for a predictive use, although further research is needed in this field prior to implementing mathematical models as a predictive method in a clinical setting.
Next, two chronic myeloid leukemia models are compared that consider Imatinib treatment, a drug that inhibits the constitutively active tyrosine kinase BCR-ABL. Both models describe the competition of leukemic and normal cells, however the first model also describes intracellular dynamics by considering BCR-ABL as the limiting nutrient. Using clinical data, the differences in estimated parameters between the models and the capacity for each model to predict drug resistance are analyzed.
Last, a simple model is presented that considers ovarian tumor growth and tumor induced angiogenesis, subject to on and off anti-angiogenesis treatment. In this environment, the cell quota represents the intracellular concentration of necessary nutrients provided through blood supply. Mathematical analysis of the model is presented and model simulation results are compared to pre-clinical data. This simple model is able to fit both on- and off-treatment data using the same biologically relevant parameters.
First, prostate cancer is modeled, where androgen is considered the limiting nutrient since most tumors depend on androgen for proliferation and survival. The model's accuracy for predicting the biomarker for patients on intermittent androgen deprivation therapy is tested by comparing the simulation results to clinical data as well as to an existing simpler model. The results suggest that a simpler model may be more beneficial for a predictive use, although further research is needed in this field prior to implementing mathematical models as a predictive method in a clinical setting.
Next, two chronic myeloid leukemia models are compared that consider Imatinib treatment, a drug that inhibits the constitutively active tyrosine kinase BCR-ABL. Both models describe the competition of leukemic and normal cells, however the first model also describes intracellular dynamics by considering BCR-ABL as the limiting nutrient. Using clinical data, the differences in estimated parameters between the models and the capacity for each model to predict drug resistance are analyzed.
Last, a simple model is presented that considers ovarian tumor growth and tumor induced angiogenesis, subject to on and off anti-angiogenesis treatment. In this environment, the cell quota represents the intracellular concentration of necessary nutrients provided through blood supply. Mathematical analysis of the model is presented and model simulation results are compared to pre-clinical data. This simple model is able to fit both on- and off-treatment data using the same biologically relevant parameters.
ContributorsEverett, Rebecca Anne (Author) / Kuang, Yang (Thesis advisor) / Nagy, John (Committee member) / Milner, Fabio (Committee member) / Crook, Sharon (Committee member) / Jackiewicz, Zdzislaw (Committee member) / Arizona State University (Publisher)
Created2015
Description
Since Duffin and Schaeffer's introduction of frames in 1952, the concept of a frame has received much attention in the mathematical community and has inspired several generalizations. The focus of this thesis is on the concept of an operator-valued frame (OVF) and a more general concept called herein an operator-valued frame associated with a measure space (MS-OVF), which is sometimes called a continuous g-frame. The first of two main topics explored in this thesis is the relationship between MS-OVFs and objects prominent in quantum information theory called positive operator-valued measures (POVMs). It has been observed that every MS-OVF gives rise to a POVM with invertible total variation in a natural way. The first main result of this thesis is a characterization of which POVMs arise in this way, a result obtained by extending certain existing Radon-Nikodym theorems for POVMs. The second main topic investigated in this thesis is the role of the theory of unitary representations of a Lie group G in the construction of OVFs for the L^2-space of a relatively compact subset of G. For G=R, Duffin and Schaeffer have given general conditions that ensure a sequence of (one-dimensional) representations of G, restricted to (-1/2,1/2), forms a frame for L^{2}(-1/2,1/2), and similar conditions exist for G=R^n. The second main result of this thesis expresses conditions related to Duffin and Schaeffer's for two more particular Lie groups: the Euclidean motion group on R^2 and the (2n+1)-dimensional Heisenberg group. This proceeds in two steps. First, for a Lie group admitting a uniform lattice and an appropriate relatively compact subset E of G, the Selberg Trace Formula is used to obtain a Parseval OVF for L^{2}(E) that is expressed in terms of irreducible representations of G. Second, for the two particular Lie groups an appropriate set E is found, and it is shown that for each of these groups, with suitably parametrized unitary duals, the Parseval OVF remains an OVF when perturbations are made to the parameters of the included representations.
ContributorsRobinson, Benjamin (Author) / Cochran, Douglas (Thesis advisor) / Moran, William (Thesis advisor) / Boggess, Albert (Committee member) / Milner, Fabio (Committee member) / Spielberg, John (Committee member) / Arizona State University (Publisher)
Created2014
Description
Persistence theory provides a mathematically rigorous answer to the question of population survival by establishing an initial-condition- independent positive lower bound for the long-term value of the population size. This study focuses on the persistence of discrete semiflows in infinite-dimensional state spaces that model the year-to-year dynamics of structured populations. The map which encapsulates the population development from one year to the next is approximated at the origin (the extinction state) by a linear or homogeneous map. The (cone) spectral radius of this approximating map is the threshold between extinction and persistence. General persistence results are applied to three particular models: a size-structured plant population model, a diffusion model (with both Neumann and Dirichlet boundary conditions) for a dispersing population of males and females that only mate and reproduce once during a very short season, and a rank-structured model for a population of males and females.
ContributorsJin, Wen (Author) / Thieme, Horst (Thesis advisor) / Milner, Fabio (Committee member) / Quigg, John (Committee member) / Smith, Hal (Committee member) / Spielberg, John (Committee member) / Arizona State University (Publisher)
Created2014
Description
Nonlinear dispersive equations model nonlinear waves in a wide range of physical and mathematics contexts. They reinforce or dissipate effects of linear dispersion and nonlinear interactions, and thus, may be of a focusing or defocusing nature. The nonlinear Schrödinger equation or NLS is an example of such equations. It appears as a model in hydrodynamics, nonlinear optics, quantum condensates, heat pulses in solids and various other nonlinear instability phenomena. In mathematics, one of the interests is to look at the wave interaction: waves propagation with different speeds and/or different directions produces either small perturbations comparable with linear behavior, or creates solitary waves, or even leads to singular solutions. This dissertation studies the global behavior of finite energy solutions to the $d$-dimensional focusing NLS equation, $i partial _t u+Delta u+ |u|^{p-1}u=0, $ with initial data $u_0in H^1,; x in Rn$; the nonlinearity power $p$ and the dimension $d$ are chosen so that the scaling index $s=frac{d}{2}-frac{2}{p-1}$ is between 0 and 1, thus, the NLS is mass-supercritical $(s>0)$ and energy-subcritical $(s<1).$ For solutions with $ME[u_0]<1$ ($ME[u_0]$ stands for an invariant and conserved quantity in terms of the mass and energy of $u_0$), a sharp threshold for scattering and blowup is given. Namely, if the renormalized gradient $g_u$ of a solution $u$ to NLS is initially less than 1, i.e., $g_u(0)<1,$ then the solution exists globally in time and scatters in $H^1$ (approaches some linear Schr"odinger evolution as $ttopminfty$); if the renormalized gradient $g_u(0)>1,$ then the solution exhibits a blowup behavior, that is, either a finite time blowup occurs, or there is a divergence of $H^1$ norm in infinite time. This work generalizes the results for the 3d cubic NLS obtained in a series of papers by Holmer-Roudenko and Duyckaerts-Holmer-Roudenko with the key ingredients, the concentration compactness and localized variance, developed in the context of the energy-critical NLS and Nonlinear Wave equations by Kenig and Merle. One of the difficulties is fractional powers of nonlinearities which are overcome by considering Besov-Strichartz estimates and various fractional differentiation rules.
ContributorsGuevara, Cristi Darley (Author) / Roudenko, Svetlana (Thesis advisor) / Castillo_Chavez, Carlos (Committee member) / Jones, Donald (Committee member) / Mahalov, Alex (Committee member) / Suslov, Sergei (Committee member) / Arizona State University (Publisher)
Created2011
Description
This dissertation describes an investigation of four students' ways of thinking about functions of two variables and rate of change of those two-variable functions. Most secondary, introductory algebra, pre-calculus, and first and second semester calculus courses do not require students to think about functions of more than one variable. Yet vector calculus, calculus on manifolds, linear algebra, and differential equations all rest upon the idea of functions of two (or more) variables. This dissertation contributes to understanding productive ways of thinking that can support students in thinking about functions of two or more variables as they describe complex systems with multiple variables interacting. This dissertation focuses on modeling the way of thinking of four students who participated in a specific instructional sequence designed to explore the limits of their ways of thinking and in turn, develop a robust model that could explain, describe, and predict students' actions relative to specific tasks. The data was collected using a teaching experiment methodology, and the tasks within the teaching experiment leveraged quantitative reasoning and covariation as foundations of students developing a coherent understanding of two-variable functions and their rates of change. The findings of this study indicated that I could characterize students' ways of thinking about two-variable functions by focusing on their use of novice and/or expert shape thinking, and the students' ways of thinking about rate of change by focusing on their quantitative reasoning. The findings suggested that quantitative and covariational reasoning were foundational to a student's ability to generalize their understanding of a single-variable function to two or more variables, and their conception of rate of change to rate of change at a point in space. These results created a need to better understand how experts in the field, such as mathematicians and mathematics educators, thinking about multivariable functions and their rates of change.
ContributorsWeber, Eric David (Author) / Thompson, Patrick (Thesis advisor) / Middleton, James (Committee member) / Carlson, Marilyn (Committee member) / Saldanha, Luis (Committee member) / Milner, Fabio (Committee member) / Van de Sande, Carla (Committee member) / Arizona State University (Publisher)
Created2012
Description
The theory of geometric quantum mechanics describes a quantum system as a Hamiltonian dynamical system, with a projective Hilbert space regarded as the phase space. This thesis extends the theory by including some aspects of the symplectic topology of the quantum phase space. It is shown that the quantum mechanical uncertainty principle is a special case of an inequality from J-holomorphic map theory, that is, J-holomorphic curves minimize the difference between the quantum covariance matrix determinant and a symplectic area. An immediate consequence is that a minimal determinant is a topological invariant, within a fixed homology class of the curve. Various choices of quantum operators are studied with reference to the implications of the J-holomorphic condition. The mean curvature vector field and Maslov class are calculated for a lagrangian torus of an integrable quantum system. The mean curvature one-form is simply related to the canonical connection which determines the geometric phases and polarization linear response. Adiabatic deformations of a quantum system are analyzed in terms of vector bundle classifying maps and related to the mean curvature flow of quantum states. The dielectric response function for a periodic solid is calculated to be the curvature of a connection on a vector bundle.
ContributorsSanborn, Barbara (Author) / Suslov, Sergei K (Thesis advisor) / Suslov, Sergei (Committee member) / Spielberg, John (Committee member) / Quigg, John (Committee member) / Menéndez, Jose (Committee member) / Jones, Donald (Committee member) / Arizona State University (Publisher)
Created2011
Description
Factory production is stochastic in nature with time varying input and output processes that are non-stationary stochastic processes. Hence, the principle quantities of interest are random variables. Typical modeling of such behavior involves numerical simulation and statistical analysis. A deterministic closure model leading to a second order model for the product density and product speed has previously been proposed. The resulting partial differential equations (PDE) are compared to discrete event simulations (DES) that simulate factory production as a time dependent M/M/1 queuing system. Three fundamental scenarios for the time dependent influx are studied: An instant step up/down of the mean arrival rate; an exponential step up/down of the mean arrival rate; and periodic variation of the mean arrival rate. It is shown that the second order model, in general, yields significant improvement over current first order models. Specifically, the agreement between the DES and the PDE for the step up and for periodic forcing that is not too rapid is very good. Adding diffusion to the PDE further improves the agreement. The analysis also points to fundamental open issues regarding the deterministic modeling of low signal-to-noise ratio for some stochastic processes and the possibility of resonance in deterministic models that is not present in the original stochastic process.
ContributorsWienke, Matthew (Author) / Armbruster, Dieter (Thesis advisor) / Jones, Donald (Committee member) / Platte, Rodrigo (Committee member) / Gardner, Carl (Committee member) / Ringhofer, Christian (Committee member) / Arizona State University (Publisher)
Created2015
Description
Presented is a study on the chemotaxis reaction process and its relation with flow topology. The effect of coherent structures in turbulent flows is characterized by studying nutrient uptake and the advantage that is received from motile bacteria over other non-motile bacteria. Variability is found to be dependent on the initial location of scalar impurity and can be tied to Lagrangian coherent structures through recent advances in the identification of finite-time transport barriers. Advantage is relatively small for initial nutrient found within high stretching regions of the flow, and nutrient within elliptic structures provide the greatest advantage for motile species. How the flow field and the relevant flow topology lead to such a relation is analyzed.
ContributorsJones, Kimberly (Author) / Tang, Wenbo (Thesis advisor) / Kang, Yun (Committee member) / Jones, Donald (Committee member) / Arizona State University (Publisher)
Created2015
Description
There have been a number of studies that have examined students’ difficulties in understanding the idea of logarithm and the effectiveness of non-traditional interventions. However, there have been few studies that have examined the understandings students develop and need to develop when completing conceptually oriented logarithmic lessons. In this document, I present the three papers of my dissertation study. The first paper examines two students’ development of concepts foundational to the idea of logarithm. This paper discusses two essential understandings that were revealed to be problematic and essential for students’ development of productive meanings for exponents, logarithms and logarithmic properties. The findings of this study informed my later work to support students in understanding logarithms, their properties and logarithmic functions. The second paper examines two students’ development of the idea of logarithm. This paper describes the reasoning abilities two students exhibited as they engaged with tasks designed to foster their construction of more productive meanings for the idea of logarithm. The findings of this study provide novel insights for supporting students in understanding the idea of logarithm meaningfully. Finally, the third paper begins with an examination of the historical development of the idea of logarithm. I then leveraged the insights of this literature review and the first two papers to perform a conceptual analysis of what is involved in learning and understanding the idea of logarithm. The literature review and conceptual analysis contributes novel and useful information for curriculum developers, instructors, and other researchers studying student learning of this idea.
ContributorsKuper Flores, Emily Ginamarie (Author) / Carlson, Marilyn (Thesis advisor) / Thompson, Patrick (Committee member) / Milner, Fabio (Committee member) / Zazkis, Dov (Committee member) / Czocher, Jennifer (Committee member) / Arizona State University (Publisher)
Created2018