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CrAssphages are a type of bacteriophage, a virus that infects bacteria and reproduces within them. They are thought to infect one of the most prevalent bacteria in the human gut microbiome, Bacteroides (Dutilh et al., 2014). CrAssphages are suspected to be in 73-77% of humans (Siranosian et al., 2020), however

CrAssphages are a type of bacteriophage, a virus that infects bacteria and reproduces within them. They are thought to infect one of the most prevalent bacteria in the human gut microbiome, Bacteroides (Dutilh et al., 2014). CrAssphages are suspected to be in 73-77% of humans (Siranosian et al., 2020), however little is known about the effects they might have on the gut microbiome or the host organism’s digestion, metabolism, nutrition, or host immune function and disease states (Shreiner et al., 2015). CrAssphages were recently identified in gelada fecal samples from infants and adults. This study analyzed variables surrounding crAssphage presence in fecal samples collected throughout infant development and from adults and analyzed the presence of six crAssphages that were genetically similar to the proto-crAssphage originally discovered in humans (Dutilh et al., 2014). It was determined that recent rainfall has a significant effect on crAssphage presence. Additionally, recent rainfall and gelada sex have significant effects on the likelihood of infection by multiple crAssphages at once. The six crAssphages analyzed all peaked in presence between 10-20 months of age, while Bacteroides presence decreases at ~10 months (Baniel et al., 2022). It remains unsure if Bacteroides are the true host of crAssphages, or if there are other possible hosts.
ContributorsMoya, Isabella (Author) / Snyder-Mackler, Noah (Thesis director) / Schneider-Crease, India (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor)
Created2023-12
Description
This project explores the impact of prolonged intermittent fasting on cognitive function and physiological behavior through the GetSmart study—a nationwide 8-week Randomized Control Trial. The presentation covers intermittent fasting basics, its historical context, and its positive correlation with cognitive performance. Key points include the physiological mechanisms influenced by intermittent fasting,

This project explores the impact of prolonged intermittent fasting on cognitive function and physiological behavior through the GetSmart study—a nationwide 8-week Randomized Control Trial. The presentation covers intermittent fasting basics, its historical context, and its positive correlation with cognitive performance. Key points include the physiological mechanisms influenced by intermittent fasting, such as circadian, cellular, and metabolic processes. The study focuses on midlife adults with obesity and memory decline, comparing Prolonged Nightly Fasting (PNF) against a Health Education Control (HEC) group. The presentation details eligibility criteria, screening, and data collection methods, including T-MoCA assessments and REDCap. It also depicts a flow diagram that illustrates the study process, and the researcher-participant connection emphasizes the importance of circadian rhythms for health. The conclusion of the presentation highlights the positive impacts of intermittent fasting on cognitive function.
ContributorsChelberg, Paige (Author) / Kantor, Jayda (Co-author) / James, Dara (Thesis director) / Kechter, Afton (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2023-12
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Description

Theories about the human origin in evolution and religion are fundamentally countering beliefs that are still debated to this day. This study continues to explore this relationship in the college population at a public university with the intention of targeting a diverse religious population. This research hopes to answer the

Theories about the human origin in evolution and religion are fundamentally countering beliefs that are still debated to this day. This study continues to explore this relationship in the college population at a public university with the intention of targeting a diverse religious population. This research hopes to answer the question: does having greater literacy in evolution lead to a noninterventionist perspective on evolution? The prediction is that evidence of increased evolution comprehension will influence students to have a more agnostic, or noninterventionist, view on evolution. An evolution class was given a survey that had two parts broken into demographic and evolution sections with one question that asks about compatibility between evolution and religion. This was given twice in a single semester to track the growth of evolution knowledge and any other differences. There were 265 students in the initial survey, but only 223 responses in the post-survey. The compatibility question had 8 statements that range from creationist to atheistic perspectives and was divided into two sides: interventionist (divine involvement) and noninterventionist (deity may be present but does not intervene). More than 70% of the class had a noninterventionist perspective on evolution despite the Christian categories being the second largest group students identified with after agnostic. The agnostic statement was the top choice followed by the atheistic answer on the noninterventionist side. Lastly, there was some growth of evolution knowledge for each religious category in the evolution section but is not significant for interpretation. Based on the collected data, it is not sufficient to answer the question and requires more data collection via a longitudinal study.

ContributorsLam, Monica (Author) / Kappes, Janelle (Thesis director) / Sterner, Beckett (Committee member) / Barrett, The Honors College (Contributor) / Watts College of Public Service & Community Solut (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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Description

Simplifying science means more than just making science understandable for people of lower chronological age, it also encompasses making science more accessible to people with a lower educational age. Through their “Embryo Tales,” Ask a Biologist discusses topics such as fetal alcohol syndrome, ectopic pregnancies, polio, etc. and the science

Simplifying science means more than just making science understandable for people of lower chronological age, it also encompasses making science more accessible to people with a lower educational age. Through their “Embryo Tales,” Ask a Biologist discusses topics such as fetal alcohol syndrome, ectopic pregnancies, polio, etc. and the science behind them in an easy-to-understand manner. The Ask a Biologist materials are directed at a younger audience in terms of educational age compared to most textbooks and other sources, which allows them to communicate information to people who otherwise may not comprehend the science at hand. As Ask a Biologist states, their main goal is to “increase communication between scientists and the public” (Ask a biologist). They increase the cognition of the public by using a readability level checker to keep each sentence easy to understand, implementing well thought-out analogies throughout the article, incorporating helpful pictures, and including an engaging, related story at the beginning of each article. This thesis explains studies both for and agains those techniques aiming to make science-related topics more understandable. The thesis encompasses some of my own Embryo Tales with an analysis of them, highlights my role in shaping Embryo Tales into what they are today, and also details how I will apply what I learned to my career as a future physician.

ContributorsHunt, Logan (Author) / Maienschein, Jane (Thesis director) / Schnebly, Risa (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Department of Psychology (Contributor)
Created2023-05
Description
Can Body Height and BMI predict cancer trends in humans? Using a dataset of 220,181 individuals, with 31,822 individuals having malignancy records, we found that body height (p < 2e-16) and Body Mass Index (BMI) (p < 5.6e-05) are significant predictors of developing cancer. After stratifying by sex, we determined

Can Body Height and BMI predict cancer trends in humans? Using a dataset of 220,181 individuals, with 31,822 individuals having malignancy records, we found that body height (p < 2e-16) and Body Mass Index (BMI) (p < 5.6e-05) are significant predictors of developing cancer. After stratifying by sex, we determined that men and women face an elevated risk of developing cancer with increases in body height, but a very slight increase in cancer risk with increases in BMI.
ContributorsMartins, Brian (Author) / Maley, Carlo (Thesis director) / Richker, Harley (Committee member) / Marquez Alcaraz, Gissel (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of Life Sciences (Contributor)
Created2023-12
Description
Climate change is a well-known global threat to societal systems; however, its effects on the health of individuals are often less evident. Physicians who aim to properly treat patients holistically must be educated on the various forms of illness and disease projected to be exacerbated by climate change. Without this

Climate change is a well-known global threat to societal systems; however, its effects on the health of individuals are often less evident. Physicians who aim to properly treat patients holistically must be educated on the various forms of illness and disease projected to be exacerbated by climate change. Without this necessary climate education, physicians run the risk of being unable to fulfill the most sacred charge of the Hippocratic oath: Do No Harm. To ensure that physicians moving forward are prepared to face this new global health threat, the prevalence of climate change in current medical school curricula must be examined. Content analysis of publicly available medical school curricula in the Southwest U.S. was done using ChatGPT to track the frequency of climate health search terms. Medical school curricula analyzed included mandatory degree programs as well as optional dual degree programs or pathways for medical student education. Researchers found that medical schools within the Southwest region of the United States are not sufficiently preparing students to mitigate the regional effects of climate change on the health of patients. Mandatory medical degree curriculum does not sufficiently educate on climate health issues, nor is it present in Utah, New Mexico, or Colorado. Optional degrees and pathways are available to medical students to enroll in and may be sufficient to educate a medical student, but are not enticing enough to sufficiently educate all medical students. Some medical schools have recently conducted revisals of their mandatory curriculum and still show a lack of education available about climate health issues. The lack of educational resources for future providers could lead to detrimental health outcomes for patients, and medical schools in development should take the lead in educating their students about climate health issues.
ContributorsJamieson, Ann (Author) / Gutierrez, Sean (Co-author) / Vanos, Jennifer (Thesis director) / Lobo, Jose (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2023-12
Description
Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized primarily by physical impairments such as tremors, poor balance, and bradykinesia; however, some individuals with PD will additionally experience numerous nonmotor symptoms such as dementia, depression, and sleep disturbances amongst various other life-altering ailments. Two of the key pathological hallmarks of

Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized primarily by physical impairments such as tremors, poor balance, and bradykinesia; however, some individuals with PD will additionally experience numerous nonmotor symptoms such as dementia, depression, and sleep disturbances amongst various other life-altering ailments. Two of the key pathological hallmarks of PD include the death of melanated dopaminergic neurons in the nigrostriatal pathway and the accumulation of Lewy bodies, which are primarily composed of aggregates of the protein α-synuclein (α-syn). Interestingly, members of the chitinase protein family, namely chitinase-3-like protein-1 (L1), have heightened concentrations in a number of neurodegenerative diseases other than PD. To investigate the specific role L1 plays in PD etiology, we evaluated if astrocytic L1 expression was elevated in postmortem brain tissue of PD patients as well as in an α-syn overexpression rat model, and further tested if manipulating astrocytic-specific L1 expression correlated with neuroinflammation and nigral neuronal degeneration in the model. Preliminary histological analysis has shown increased levels of L1 expression in the α-syn model before neuronal loss occurs, and in human tissue, L1 was found to be significantly increased in the postmortem tissue of individuals with PD versus non-diseased controls. Investigations in identifying an astrocytic-specific virus capsid and manipulating L1 expression in the α-syn model are ongoing. This preliminary data thus far supports that increased astrocytic expression of L1 is associated with PD pathology.
ContributorsPettigrew, Tiffany (Author) / Manfredsson, Fredric (Thesis director) / Sandoval, Ivette (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2023-12
Description
Burnout due to work and school-related stress negatively impacts college student’s confidence, motivation, and mindset. Burnout can manifest as lower quality of a student’s education, performance, relationships, and overall well-being. Using the Maslach Burnout Inventory™ - General Survey for Students: MBI-GS (S), researchers assessed the effectiveness of a five-part worksho

Burnout due to work and school-related stress negatively impacts college student’s confidence, motivation, and mindset. Burnout can manifest as lower quality of a student’s education, performance, relationships, and overall well-being. Using the Maslach Burnout Inventory™ - General Survey for Students: MBI-GS (S), researchers assessed the effectiveness of a five-part workshop series titled “A Series on Self-Reflection, Self-Understanding, and Strengthening the Mind,” focused on improving burnout symptoms in students attending ASU’s Barrett, the Honors College, against a control group of non-workshop participating honors students. Data was collected through MBI-GS (S) evaluation surveys after each workshop attendance, via the daily honors newsletter, and through subject interviews. The researchers conducted a qualitative study consistent with case studies and focus groups. Descriptive statistics of survey responses were quantified in Excel, representing varying burnout levels in honors students throughout the Spring 2023 school semester. Overall, the surveys from the workshop attendees and Honors Digest students yielded insignificant differences in burnout levels. The eight interviewee case studies emphasize the complex influences of culture and environment on burnout. While burnout levels between Honors Digest students and workshop attendees were insignificantly different, each interviewee student presented changed perspectives on their studies and themselves.
ContributorsBeyfuss, Natalie (Author) / Kappes, Janelle (Thesis director) / Schuster, Roseanne (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution & Social Change (Contributor) / Edson College of Nursing and Health Innovation (Contributor) / School of Life Sciences (Contributor)
Created2023-12
Description
Current methods for quantifying microplastics via LC-MS/MS analysis have been adapted from environmental monitoring protocols and are often inadequate for sampling within complex matrices. This study explores the application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the detection of microplastics. The initial phase of this research utilized pork kidney

Current methods for quantifying microplastics via LC-MS/MS analysis have been adapted from environmental monitoring protocols and are often inadequate for sampling within complex matrices. This study explores the application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the detection of microplastics. The initial phase of this research utilized pork kidney samples to establish a baseline for background and efficacy of sample processing. These findings underscore the complexity of developing a sensitive and specific analytical technique for microplastics in tissues. The observed discrepancies in contamination and replicability between samples emphasize the need for continual method optimization.
ContributorsBabbrah, Ayesha (Author) / Halden, Rolf (Thesis director) / Newell, Melanie (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2023-12
Description
Alzheimer's disease (AD) is characterized by the progressive loss of cognitive function and memory, and is the most common cause of dementia. Alzheimer's disease targets the brain and is associated with the accumulation of abnormal protein aggregates that disrupt neural network communication and lead to various facets of cognitive decline.

Alzheimer's disease (AD) is characterized by the progressive loss of cognitive function and memory, and is the most common cause of dementia. Alzheimer's disease targets the brain and is associated with the accumulation of abnormal protein aggregates that disrupt neural network communication and lead to various facets of cognitive decline. Current problems in AD research originates from the inability to identify individuals that are at risk. With the limitations of patients already displaying signs of neurodegeneration, strategies for prevention are not effective. Through developing a comprehensive cognitive test that tests a range of mental abilities, data can be collected, and a longitudinal study can be proposed to track cognitive decline in a multifaceted approach over a period of time. Previous literature indicates that functional decline is present years before the manifestation of symptoms in Alzheimer’s disease. Identifying pre-diagnostic cognitive and functional changes could lead to an improved and wider selection for preventive treatment trials. By designing a comprehensive cognitive experiment, an initial data set was obtained, and trends related to time and answer response were analyzed. The scope, applications and limitations within this experimental design is discussed, and future directions are proposed.
ContributorsDale, Anna (Author) / Hartwell, Leland (Thesis director) / Huseby, Carol (Committee member) / Barrett, The Honors College (Contributor) / School of Music, Dance and Theatre (Contributor) / School of Life Sciences (Contributor)
Created2023-12