Matching Items (674)
Description
Hepatitis C virus (HCV) is a globally prevalent infection which is a main contributor to the global burden of liver disease. Due to its ability to establish a chronic infection, and the lack of usefulness of traditional neutralizing antibody vaccine design in producing a protective immune response, a preventative vaccine has been notoriously difficult to produce. To overcome this, a vaccine using non-structural protein 3 (NS3) as a target to elicit a T cell specific immune response is thought to be a possible strategy for eliciting a protective immune response against hepatitis C infection. In this paper, a recombinant strain of measles virus (MV) that expresses HCV NS3 protein was analyzed. The replication fitness of this recombinant virus also indicates that this construct replicates at a higher rate than parental measles strain. It is also demonstrated through western blot analysis of protein expression and immunofluorescence that this recombinant virus expresses both the inserted HCV NS3 protein, as well as native measles proteins.
ContributorsWoell, Dana Marie (Author) / Reyes del Valle, Jorge (Thesis director) / Nickerson, Cheryl (Committee member) / Julik, Emily (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
Due to persistent undernutrition in India and the increased demands placed on a woman’s body during childbearing and lactation, the Indian government has implemented a program to provide supplemental nutrition packets to women in rural India. This study examines the factors influencing uptake of nutritional packets by lactating mothers in southern, rural Rajasthan. Women were recruited from 65 villages in Rajasthan, India (n=149, minimum of 2 per village) to evaluate the relationship of nutrition packet uptake and two factors--education levels and distance to the health center.
Level of education had little impact on whether or not women received the nutrition packet. Of those women with no education, 63.1% received the packet. Of those with any education, 63.9% got the packet.
In contrast, distance was strongly correlated with whether or not women received the packet. For example, of the women living within 200 meters of the health center, 93.2% received a nutrition packet. Of the women living between 250 meters and one kilometer of the health center, 68.4% received a nutrition packet. Of the women living over one kilometer from the health center, only 25% received a nutrition packet. The relationship between uptake of packets and women’s perception of distance to the health center was also explored. Out of 50 women who did not receive the packet, all of the women who said there was no health center in their village did live more than one kilometer from a health center. Of the women who lived between 250 meters and one kilometer from the health center, 40% felt it was too far. Of the women who lived more than a kilometer from the health center, 66.7% felt it was too far and 29.6% said there was no health center in their village. Again, it does not appear that ‘too far’ is just a default reason for women, but that actual distance, more so than education, is a major contributing factor in their ability to take the nutrition packet. These findings suggest that improving access to supplemental nutrition packets at the village level may increase uptake by the women.
Level of education had little impact on whether or not women received the nutrition packet. Of those women with no education, 63.1% received the packet. Of those with any education, 63.9% got the packet.
In contrast, distance was strongly correlated with whether or not women received the packet. For example, of the women living within 200 meters of the health center, 93.2% received a nutrition packet. Of the women living between 250 meters and one kilometer of the health center, 68.4% received a nutrition packet. Of the women living over one kilometer from the health center, only 25% received a nutrition packet. The relationship between uptake of packets and women’s perception of distance to the health center was also explored. Out of 50 women who did not receive the packet, all of the women who said there was no health center in their village did live more than one kilometer from a health center. Of the women who lived between 250 meters and one kilometer from the health center, 40% felt it was too far. Of the women who lived more than a kilometer from the health center, 66.7% felt it was too far and 29.6% said there was no health center in their village. Again, it does not appear that ‘too far’ is just a default reason for women, but that actual distance, more so than education, is a major contributing factor in their ability to take the nutrition packet. These findings suggest that improving access to supplemental nutrition packets at the village level may increase uptake by the women.
ContributorsJeffers, Eva Marie (Author) / Hruschka, Daniel (Thesis director) / Maupin, Jonathan (Committee member) / Cook, Jeffrey (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
Students not only deserve to be actively involved and engaged in learning content knowledge, but it can in fact help them learn better. Arguably too few classrooms actually utilize teaching methods that support this kind of environment. There is perhaps fear that methods like integrated curriculum may detract from student knowledge. The purpose of this intervention study was to determine how the integration of dance and social studies with an anthropological framework effects student learning of content knowledge in social studies, as well as student attitude toward the topic. Research questions that were addressed in this study are the following: (a) How does the integration of dance and social studies with an anthropological framework affect students' chapter test scores when compared to typical instruction?; (b) How does the integration of dance and social studies with an anthropological framework affect students' attitude toward social studies when compared to typical instruction?. Participants were two 6th grade classes at the same elementary school. As a supplement to a unit on Ancient Egypt, the experimental group received four intervention lessons, taught by the investigator, incorporating creative dance to encourage student exploration and increased understanding of content. An anthropological framework was also implemented to foster respectful investigation of culture. Results show that at posttest the intervention group had significantly higher content knowledge, as measured by a chapter test, compared to the control group. This suggests that this program did in fact help students to reach a better understanding of content. Though surveys showed no difference in attitude between groups or over the course of the study, qualitative student responses from the experimental group suggest extremely positive feelings towards concepts covered in the intervention lessons.
ContributorsSmith, Karli Elizabeth (Author) / Kulinna, Pamela (Thesis director) / Vissicaro, Pegge (Committee member) / Barrett, The Honors College (Contributor) / School of Film, Dance and Theatre (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
For my creative project, I originally decided to produce an original instrumental EP (Extended Play), its aim to bridge the gap between classical Choral/Orchestral literature and more modern Hip-Hop/Rhythm & Blues through the implementation of sample-based sounds and melodies. As the semester went on, however, I realized that my original focus was really putting a strain on my creativity. A broadening in scope was exactly what I needed to spark the creativity within me. I had to create what suited me at the time, or what was a reflection of my current environment. This change began to push me beyond what I believed I was capable of; the tracks for the EP seemed to follow effortlessly. For the first production on my EP, I sampled from an a cappella file that I found on a royalty-free music database. The file had a raw cut, sans instrumentation and effects, of a teenage girl singing an original Soul/Rhythm & Blues tune of hers named "Don't Go." Atop the vocal, I added an original drum kit and sub-bass waveform, sound-designed by me, and an airy synthesizer line. My second original production, titled "Dreams," is a production that exudes everything that I stand for and am inspired by with regards to music. This work is the kind of production that got me into producing music in the first place. It demonstrates simplicity and elegance in every sense. A Rhythm & Blues record (Monnie Riperton's Edge of a Dream), a simple, yet hard-hitting drum groove with drum sounds sampled from live drums, and bass-line were the only ingredients necessary to produce "Dreams." The video logs, an addition to the original productions, were put in place to track my progress throughout the semester. The observer gets to learn alongside me, from the inception and into the execution of the project, the facets of sampling, building a drum groove, and creating an arrangement. By including access to my workflow as part of this project, I wish to provide a dynamic, evolving tool for producers in the future.
ContributorsShargal, Tamir Mike (Author) / Tobias, Evan (Thesis director) / Evans, Bartlett (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
Among wild rodent populations, vertical transmission is believed to constitute the primary route of infection for Lymphocytic Choriomeningitis Virus (LCMV), a non-lytic arenavirus with both acute and chronic forms. When carrier mice infected at birth with the acute Armstrong strain reproduce, they generate congenital carrier offspring containing a quasispecies of LCMV that includes Armstrong as well as its chronic Clone-13 variant. This study examined the genetic trends in the vertical transmission of LCMV from mothers infected perinatally with Clone-13. Viral isolates obtained from the serum of congenital carrier offspring were partially sequenced to reveal residue 260 in the glycoprotein-encoding region of their S segment, the site of a major amino acid change differentiating the chronic and acute strains. It was found that the phenylalanine-to-leucine mutation associated with Clone-13 was present in 100% of the isolates, strongly indicating that the offspring of Clone-13 carriers contain exclusively the chronic variant. This research has broad implications for the epidemiology of the virus, and, given the predominance of Armstrong in the wild, suggests that there must be a biological cost associated with Clone-13 infection in non-carriers.
ContributorsFrear, Cody Christian (Author) / Blattman, Joseph (Thesis director) / Hogue, Brenda (Committee member) / Holechek, Susan (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
Maternal health and mental health have recently become globally recognized as critical areas of focus. The continued research into the relationship between maternal health and mental health—in particular, how they are affected by public policy and infrastructure—is vital to the improvement of general health outcomes. An investigation of literature, current health landscape and indicators, gray literature, and the current policy landscape in an exemplar country (Australia), Bangladesh and Nepal was done. Bangladesh and Nepal were chosen due to the recent amounts of change seen in each country’s maternal health status. Both Bangladesh and Nepal are severely lacking in official mental health services, facilities, and personnel. The analysis revealed flaws and disparities in each country’s current policy landscape. Despite these disparities it should be recognized that policies and programs are being implemented – just in a very piecemeal manner, and not entirely by each country’s respective government. Integration of maternal health services and mental health services is recommended to improve functionality of already existing services. The addition of minimal but necessary components to health systems is recommended.
ContributorsCiampaglio, Kaitlyn Rae (Author) / Gaughan, Monica (Thesis director) / Hagaman, Ashley (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Sustainability (Contributor)
Created2015-05
Description
Breast cancer affects hundreds of thousands of women a year in the United States, and kills tens of thousands. African-American women experience a lower incidence of breast cancer, yet they die at twice the rate of Caucasian women. This disparity demonstrates the ineffectiveness of mammography at decreasing mortality in women at higher risk of late stage diagnosis. In this paper I argue that the continued support of the predominating idea that the benefits of mammograms strictly outweigh their negative effects may be a factor in the continued racial disparity in breast cancer mortality between African-American and Caucasian women. In addition, I will argue that mammograms are less effective for African American women because they are predisposed to later stage diagnosis and the accompanying poorer mortality prognosis due to higher-risk environments caused by varied socio-political status. My claims are supported by studies of incidence rates, survivorship versus mortality rates, screening usage rates, late stage and early stage diagnosis rate, tumor type, and the effects of socioeconomic status on stage of diagnosis. In particular, mortality rates have not decreased parallel with increased mammogram usage, especially in African-American women. Although early stage diagnosis has drastically increased, late stage-diagnosis remains unchanged and higher in African-American women. Tumor types vary by race, and African American women tend to have tumors that are highly prolific and more likely to be metastatic. Socioeconomic factors are more of a marker for breast cancer disparities than race, however race and socio-political structures that embody racism are often intersected.
ContributorsHuper-Holmes, Chloe Lynn (Author) / Lynch, John (Thesis director) / Brian, Jennifer (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
Patients who are infected with the human immunodeficiency virus (HIV) and who remain adherent to their highly active antiretroviral treatment (HAART) regimen are likely to achieve good virologic control over significant periods of time. Children who start with a low CD4 percentage (below 15%) are associated with adverse clinical outcomes and the risk of never increasing their CD4 counts to normal functioning levels. While adherent adult HIV patients have been studied frequently, this was a retrospective chart study that aimed to describe the immune reconstitution pattern for up to 16 years in virologically controlled pediatric patients who had been or who are currently being treated at the Bill Holt Clinic at Phoenix Children's Hospital. In the preliminary study, 35 patients met criteria for inclusion and three years later for this extension study 7 more were added while 17 of the initial patients were followed further because they have remained in care and virologically controlled. All 28 patients who achieved 5 years of viral suppression were >25% CD4. All 8 patients who achieved 12 years of viral suppression were >31% CD4. All patients who achieved 16 years of viral suppression were >41% CD4. After 12 years, the 8 patients who maintained viral suppression all had absolute CD4 counts of over 600 cells and additionally each had CD4/CD8 ratios greater than 1. Overall, the data shows immune system normalization for up to 16 years, although CD4/CD8 ratios improved but never completely normalized. Some limitations include a small sample size and missing data points due to laboratory testing errors or the lack of technology in different countries to test for CD8 cells. These findings suggest that children who remain adherent to HAART can experience ongoing immune healing for up to 16 years. This may provide additional incentive to providers and caretakers to encourage adherence and maximize long-term immune competence in HIV positive children.
ContributorsRichards, Anne Elizabeth (Author) / Wachter, Rebekka (Thesis director) / Blattman, Joseph (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
Waste generation in the U.S. has reached new heights, but the exploitation of Native American lands for waste disposal is nothing new. Many of the negative effects of massive waste production and toxic pollution, such as poor health outcomes and decreased property values, disproportionately burden impoverished, minority communities inside and outside the United States (Brulle and Pellow, 2006). Native American communities have long been exploited for their natural resources and land-use, but in recent decades Indian country has also become a common place to store nuclear, hazardous and municipal wastes. This project is a case study of a local Indian reservation, the Salt River Pima-Maricopa Indian Community, and examined the socio-historical context of the landfill operations in terms of five principles of environmental justice. Each principle was defined and key moments from the SRPMIC's landfill history were discussed to demonstrate ways that the situation has improved, stayed the same or worsened with regard to the rights outlined in each principle. It was concluded that there needs to be an acknowledgement by involved municipalities and industries of the historical context that make the SRPMIC and other nearby Native American communities "ideal" contractors for waste management. Additionally, while the SRPMIC could currently benefit from looking into the principles of environmental justice as a guide to manage past and operating landfills, the Community will have a specific opportunity to revisit these issues under closer scrutiny during the closure of the Salt River Landfill in 2032 in order to ensure more environmentally just outcomes. Finally, it was concluded that scholarship at the intersection of environmental justice and Native American communities should continue because looking closer at the ways that local Native American communities are facing and resisting environmental injustice can serve to develop future models for other communities facing similar challenges to achieving environmental justice.
ContributorsScott, Nicole Danielle (Author) / Kinzig, Ann (Thesis director) / Harlan, Sharon (Committee member) / Maienschein, Jane (Committee member) / Barrett, The Honors College (Contributor) / School of Community Resources and Development (Contributor) / School of Social Transformation (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
With an increasing global interest in Chinese economics and society, more and more native English speakers have started to learn Chinese as a second language (L2). While English and Chinese share a similar word order at the syntactic level, they differ significantly in ways to keep track of reference at the discourse level. There are generally three ways to keep track of reference: repeating the full noun phrase (NP), replacing the full NP with a lexical pronoun, or omitting the NP using zero anaphora. Chinese, a topic-prominent language, allows a wide use of zero anaphora to maintain reference; whereas English, a subject-prominent language, allows only a limited use of zero anaphora. Due to this difference, Chinese as a second language learners whose native language is English (CSL learners), must learn to implement the use of zero anaphora more frequently in their Chinese discourse. The purpose of this study is to investigate how CSL learners keep track of reference using zero anaphora. It is hypothesized that CSL learners at intermediate proficiency level would display a transfer effect from English to Chinese in their Chinese discourse. Specifically, they would produce fewer zero anaphora than native Chinese speakers, and they would also tend to consider discourse with many uses of zero anaphora for reference tracking as less appropriate. To test the hypothesis, a story-retelling task and multiple-choice questions task were adopted. The results of both tasks supported the hypothesis. Meanwhile, it is also evident that the CSL learners have acquired some usage of zero anaphora in their Chinese discourse as the usage of zero anaphora was more frequent when speaking Chinese than English.
ContributorsTang, Tianyu (Co-author) / Abdulla, Farzana (Co-author) / Chien, Jasmine (Co-author) / Zhang, Xia (Thesis director) / Bahtchevanova, Mariana (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / School of Human Evolution and Social Change (Contributor) / Department of Supply Chain Management (Contributor)
Created2015-05