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This study looked at the accuracy in sexual orientation judgment in college-age students from Arizona State University’s West Campus while viewing female actors. One actor was straight and the other bisexual. Participants viewed a 3-minute-long video with audio and visual of a mock forensic interview between Taylor Addams (played by

This study looked at the accuracy in sexual orientation judgment in college-age students from Arizona State University’s West Campus while viewing female actors. One actor was straight and the other bisexual. Participants viewed a 3-minute-long video with audio and visual of a mock forensic interview between Taylor Addams (played by one of the actors) and Officer Carter (played by Kiersten Carter), and were not told this was a test of their gaydar. It was found that though each group was biased toward straight responses, the straight actor group scored significantly higher on the straightness measure than the bisexual actor group. There was also no significant difference between the two groups in their confidence in their answers.

ContributorsCarter, Kiersten M (Author) / Holloway, Steven (Thesis director) / Walker, Michael (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Critical flicker fusion thresholds (CFFTs) describe when quick amplitude modulations of a light source become undetectable as the frequency of the modulation increases and are thought to underlie a number of visual processing skills, including reading. Here, we compare the impact of two vision-training approaches, one involving contrast sensitivity training

Critical flicker fusion thresholds (CFFTs) describe when quick amplitude modulations of a light source become undetectable as the frequency of the modulation increases and are thought to underlie a number of visual processing skills, including reading. Here, we compare the impact of two vision-training approaches, one involving contrast sensitivity training and the other directional dot-motion training, compared to an active control group trained on Sudoku. The three training paradigms were compared on their effectiveness for altering CFFT. Directional dot-motion and contrast sensitivity training resulted in significant improvement in CFFT, while the Sudoku group did not yield significant improvement. This finding indicates that dot-motion and contrast sensitivity training similarly transfer to effect changes in CFFT. The results, combined with prior research linking CFFT to high-order cognitive processes such as reading ability, and studies showing positive impact of both dot-motion and contrast sensitivity training in reading, provide a possible mechanistic link of how these different training approaches impact reading abilities.

ContributorsZhou, Tianyou (Author) / Nanez, Jose (Author) / Zimmerman, Daniel (Author) / Holloway, Steven (Author) / Seitz, Aaron (Author) / New College of Interdisciplinary Arts and Sciences (Contributor)
Created2016-10-26
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Although autism spectrum disorder (ASD) is a serious lifelong condition, its underlying neural mechanism remains unclear. Recently, neuroimaging-based classifiers for ASD and typically developed (TD) individuals were developed to identify the abnormality of functional connections (FCs). Due to over-fitting and interferential effects of varying measurement conditions and demographic distributions, no

Although autism spectrum disorder (ASD) is a serious lifelong condition, its underlying neural mechanism remains unclear. Recently, neuroimaging-based classifiers for ASD and typically developed (TD) individuals were developed to identify the abnormality of functional connections (FCs). Due to over-fitting and interferential effects of varying measurement conditions and demographic distributions, no classifiers have been strictly validated for independent cohorts. Here we overcome these difficulties by developing a novel machine-learning algorithm that identifies a small number of FCs that separates ASD versus TD. The classifier achieves high accuracy for a Japanese discovery cohort and demonstrates a remarkable degree of generalization for two independent validation cohorts in the USA and Japan. The developed ASD classifier does not distinguish individuals with major depressive disorder and attention-deficit hyperactivity disorder from their controls but moderately distinguishes patients with schizophrenia from their controls. The results leave open the viable possibility of exploring neuroimaging-based dimensions quantifying the multiple-disorder spectrum.

ContributorsYahata, Noriaki (Author) / Morimoto, Jun (Author) / Hashimoto, Ryuichiro (Author) / Lisi, Giuseppe (Author) / Shibata, Kazuhisa (Author) / Kawakubo, Yuki (Author) / Kuwabara, Hitoshi (Author) / Kuroda, Miho (Author) / Yamada, Takashi (Author) / Megumi, Fukuda (Author) / Imamizu, Hiroshi (Author) / Nanez, Jose (Author) / Takahashi, Hidehiko (Author) / Okamoto, Yasumasa (Author) / Kasai, Kiyoto (Author) / Kato, Nobumasa (Author) / Sasaki, Yuka (Author) / Watanabe, Takeo (Author) / Kawato, Mitsuo (Author) / New College of Interdisciplinary Arts and Sciences (Contributor)
Created2016-04-14
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Fetal androgen exposure and childhood experiences are believed to contribute to the development and organization of the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes, which are responsible for the regulation and release of stress and sex hormones, respectively. Evidence suggests the HPA and HPG axes can couple in response to childhood

Fetal androgen exposure and childhood experiences are believed to contribute to the development and organization of the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes, which are responsible for the regulation and release of stress and sex hormones, respectively. Evidence suggests the HPA and HPG axes can couple in response to childhood adversity, and that hormonal dysregulation contributes to psychopathological disorders such as anxiety and depression. Recent research also suggests self-compassion interventions could reduce PTSD symptoms, and that the experience of childhood trauma is related to increased empathy. Still, little is known regarding the impact of fetal androgen exposure on PTSD susceptibility and the relationships between self-compassion, compassion for others, and empathy. The current study aims to determine whether fetal androgen exposure mitigates PTSD susceptibility, and to clarify the relationships between empathy, compassion for others, self-compassion, and PTSD symptoms. A sample of 208 adults completed an online survey designed to measure fetal androgen exposure, childhood maltreatment, self-compassion, compassion for others, empathy, and PTSD symptoms. Findings show a significant difference in PTSD symptoms between individuals in high and low fetal androgen exposure groups, and significant correlations were discovered between empathy and compassion for others, empathy and self-compassion, but not compassion for others and self-compassion. Future studies could explore the extent to which fetal androgen exposure influences PTSD symptom susceptibility and the clinical implications therein.

ContributorsMoore, Robin Ann (Author) / Holloway, Steven (Thesis director) / Lewis, Stephen (Committee member) / Nanez, Jose (Committee member) / School of Public Affairs (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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This research project investigated known and novel differential genetic variants and their associated molecular pathways involved in Type II diabetes mellitus for the purpose of improving diagnosis and treatment methods. The goal of this investigation was to 1) identify the genetic variants and SNPs in Type II diabetes to develo

This research project investigated known and novel differential genetic variants and their associated molecular pathways involved in Type II diabetes mellitus for the purpose of improving diagnosis and treatment methods. The goal of this investigation was to 1) identify the genetic variants and SNPs in Type II diabetes to develop a gene regulatory pathway, and 2) utilize this pathway to determine suitable drug therapeutics for prevention and treatment. Using a Gene Set Enrichment Analysis (GSEA), a set of 1000 gene identifiers from a Mayo Clinic database was analyzed to determine the most significant genetic variants related to insulin signaling pathways involved in Type II Diabetes. The following genes were identified: NRAS, KRAS, PIK3CA, PDE3B, TSC1, AKT3, SOS1, NEU1, PRKAA2, AMPK, and ACC. In an extensive literature review and cross-analysis with Kegg and Reactome pathway databases, novel SNPs located on these gene variants were identified and used to determine suitable drug therapeutics for treatment. Overall, understanding how genetic mutations affect target gene function related to Type II Diabetes disease pathology is crucial to the development of effective diagnosis and treatment. This project provides new insight into the molecular basis of the Type II Diabetes, serving to help untangle the regulatory complexity of the disease and aid in the advancement of diagnosis and treatment. Keywords: Type II Diabetes mellitus, Gene Set Enrichment Analysis, genetic variants, KEGG Insulin Pathway, gene-regulatory pathway
ContributorsBucklin, Lindsay (Co-author) / Davis, Vanessa (Co-author) / Holechek, Susan (Thesis director) / Wang, Junwen (Committee member) / Nyarige, Verah (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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The development of stab-resistant Kevlar armor has been an ongoing field of research
since the late 1990s, with the ultimate goal of improving the multi-threat capabilities of
traditional soft-body armor while significantly improving its protective efficiency - the amount
of layers of armor material required to defeat threats. To create a novel, superior

The development of stab-resistant Kevlar armor has been an ongoing field of research
since the late 1990s, with the ultimate goal of improving the multi-threat capabilities of
traditional soft-body armor while significantly improving its protective efficiency - the amount
of layers of armor material required to defeat threats. To create a novel, superior materials
system to reinforce Kevlar armor for the Norica Capstone project, this thesis set out to
synthesize, recover, and characterize zinc oxide nanowire colloids.

The materials synthesized were successfully utilized in the wider Capstone effort to
dramatically enhance the protective abilities of Kevlar, while the data obtained on the 14
hydrothermal synthesis attempts and numerous challenges at recovery provided critical
information on the synthesis parameters involved in the reliable, scalable mass production of the
nanomaterial additive. Additionally, recovery was unconventionally facilitated in the absence of
a vacuum filtration apparatus with nanoscale filters by intentionally inducing electrostatic
agglomeration of the nanowires during standard gravity filtration. The subsequent application of
these nanowires constituted a pioneering use in the production of nanowire-reinforced
STF-based Kevlar coatings, and support the future development and, ultimately, the
commercialization of lighter and more-protective soft armor systems.
ContributorsDurso, Michael Nathan (Author) / Tongay, Sefaattin (Thesis director) / Zhuang, Houlong (Committee member) / Materials Science and Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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This study evaluated the differences in male and female representation in six different United States law magazines issued from 2005-2017. The initial prediction was that women would appear less often than men in these journals. Four periodicals came from Republican-dominated states, including the Arizona Attorney, Duke Law (NC), S.J.

This study evaluated the differences in male and female representation in six different United States law magazines issued from 2005-2017. The initial prediction was that women would appear less often than men in these journals. Four periodicals came from Republican-dominated states, including the Arizona Attorney, Duke Law (NC), S.J. Quinney’s Res Gestae (UT), and the Notre Dame Lawyer (IN) (no issues published in 2014 through 2016). Two of these magazines were from Democratic regions: Berkeley’s Boalt Hall Transcript (now known as Transcript) (CA) and Richmond Law (VA). Photographic depictions of people within the magazines were recorded, only if text directly referenced the individual(s) as being a lawyer (i.e., attorney, public defender, counselor, associate, and lawyer). The number of male and female depictions in each journal were totaled, and means were compared. The data showed that women were underrepresented in all six of the journals, with effect sizes varying from medium to large. It was also found that although the unequal representation was evident in both red and blue states, the inequity gap was much larger in the red states. Overall, this data supports the notion that depictions of women are underrepresented in law magazines in a profession where they make up half of law school graduates as well as students preparing to enter the legal workforce. However, the gender percentages of those who pass the Bar exam would need to be examined to know more. This lack of parity in gender representations is likely due to society’s stereotypical views of women’s and men’s roles in the context of male-dominated professions, but it also seems to be exacerbated, in part, by a state’s political affiliation. This potential equality issue may have gone unnoticed if it weren’t for research that looks into gender differences, such as this study, which should be taken further by others to gather more data on possible discrimination and produce necessary solutions.
ContributorsReissen, Emily Brook (Author) / Holloway, Steven (Thesis director) / Van Etten, Kathryn (Committee member) / School of Social and Behavioral Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Lutein and zeaxanthin are two important carotenoid vitamins related to ocular health and human visual processing. These vitamins can be ingested through supplementation and in regular diet. They concentrate in the central retina where they form a filter of macular pigment and protect the eye from high energy blue and

Lutein and zeaxanthin are two important carotenoid vitamins related to ocular health and human visual processing. These vitamins can be ingested through supplementation and in regular diet. They concentrate in the central retina where they form a filter of macular pigment and protect the eye from high energy blue and yellow light. We examined participants who had a natural diet of high vs low lutein and zeaxanthin intake on tests of contrast sensitivity and glare disability. We also examined participant performance while wearing blue light blocking glasses in order to determine whether these glasses serve a similar protective function as macular pigment in benefiting participants on contrast sensitivity and glare disability tasks. Most of our data did not show statistically significant differences between the high and low lutein and zeaxanthin groups. An unexpected result that the blue blocker glasses hindered the ability of low lutein participants on their glare disability test was observed. We hypothesize that this is due to light scatter produced by the by glasses resulting in an impoverish retinal image reaching the primary visual cortex. Further research is required to examine this new finding.
ContributorsHormann, Breanna Susanne (Author) / Holloway, Steven (Thesis director) / Náñez Sr., José E (Committee member) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
This research project investigated known and novel differential genetic variants and their associated molecular pathways involved in Type II diabetes mellitus for the purpose of improving diagnosis and treatment methods. The goal of this investigation was to 1) identify the genetic variants and SNPs in Type II diabetes to develo

This research project investigated known and novel differential genetic variants and their associated molecular pathways involved in Type II diabetes mellitus for the purpose of improving diagnosis and treatment methods. The goal of this investigation was to 1) identify the genetic variants and SNPs in Type II diabetes to develop a gene regulatory pathway, and 2) utilize this pathway to determine suitable drug therapeutics for prevention and treatment. Using a Gene Set Enrichment Analysis (GSEA), a set of 1000 gene identifiers from a Mayo Clinic database was analyzed to determine the most significant genetic variants related to insulin signaling pathways involved in Type II Diabetes. The following genes were identified: NRAS, KRAS, PIK3CA, PDE3B, TSC1, AKT3, SOS1, NEU1, PRKAA2, AMPK, and ACC. In an extensive literature review and cross-analysis with Kegg and Reactome pathway databases, novel SNPs located on these gene variants were identified and used to determine suitable drug therapeutics for treatment. Overall, understanding how genetic mutations affect target gene function related to Type II Diabetes disease pathology is crucial to the development of effective diagnosis and treatment. This project provides new insight into the molecular basis of the Type II Diabetes, serving to help untangle the regulatory complexity of the disease and aid in the advancement of diagnosis and treatment.
ContributorsDavis, Vanessa Brooke (Co-author) / Bucklin, Lindsay (Co-author) / Holechek, Susan (Thesis director) / Wang, Junwen (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Androgen has been shown to affect functioning of the central nervous system by modulating neural circuitry during in-utero development subsequently affecting parts of the brain implicated in the evaluation of socially relevant stimuli. This can suggest an examination of underlying neurobiological mechanisms that may influence androgen in the brain and

Androgen has been shown to affect functioning of the central nervous system by modulating neural circuitry during in-utero development subsequently affecting parts of the brain implicated in the evaluation of socially relevant stimuli. This can suggest an examination of underlying neurobiological mechanisms that may influence androgen in the brain and likewise human cognition and behavior. Since the index and ring finger ratio is associated with androgen related outcomes, this study sought to identify a relationship between a participant's implicit race association test score and left-handed ring (4D) and index (2D) finger ratio. Specifically, we found that higher androgen exposure in our female subjects equated to a stronger bias for European American faces over African American faces.
ContributorsSaari, Sydney (Author) / Holloway, Steven (Thesis director) / Kim, Linda (Committee member) / Nanez, Jose (Committee member) / Barrett, The Honors College (Contributor)
Created2018-05