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- Creators: School of Politics and Global Studies
Description
One of the largest problems facing modern medicine is drug resistance. Many classes of drugs can be rendered ineffective if their target is able to acquire beneficial mutations. While this is an excellent showcase of the power of evolution, it necessitates the development of increasingly stronger drugs to combat resistant pathogens. Not only is this strategy costly and time consuming, it is also unsustainable. To contend with this problem, many multi-drug treatment strategies are being explored. Previous studies have shown that resistance to some drug combinations is not possible, for example, resistance to a common antifungal drug, fluconazole, seems impossible in the presence of radicicol. We believe that in order to understand the viability of multi-drug strategies in combating drug resistance, we must understand the full spectrum of resistance mutations that an organism can develop, not just the most common ones. It is possible that rare mutations exist that are resistant to both drugs. Knowing the frequency of such mutations is important for making predictions about how problematic they will be when multi-drug strategies are used to treat human disease. This experiment aims to expand on previous research on the evolution of drug resistance in S. cerevisiae by using molecular barcodes to track ~100,000 evolving lineages simultaneously. The barcoded cells were evolved with serial transfers for seven weeks (200 generations) in three concentrations of the antifungal Fluconazole, three concentrations of the Hsp90 inhibitor Radicicol, and in four combinations of Fluconazole and Radicicol. Sequencing data was used to track barcode frequencies over the course of the evolution, allowing us to observe resistant lineages as they rise and quantify differences in resistance evolution across the different conditions. We were able to successfully observe over 100,000 replicates simultaneously, revealing many adaptive lineages in all conditions. Our results also show clear differences across drug concentrations and combinations, with the highest drug concentrations exhibiting distinct behaviors.
ContributorsApodaca, Samuel (Author) / Geiler-Samerotte, Kerry (Thesis director) / Schmidlin, Kara (Committee member) / Huijben, Silvie (Committee member) / School of Life Sciences (Contributor) / School of Molecular Sciences (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
As Arizona enters its fifteenth year of drought and Lake Mead hits historic lows, water management and policy planning will become increasingly important to ensure future water security in the Southwestern region of the United States. This thesis compares water demand trends and policies at the municipal level in Phoenix and Tucson, Arizona over the time period from 1980-2010. By analyzing gallons per capita per day (GPCD) trends for each city in the context of population growth, drought, and major state and local policies over the twenty year period, reasons for declines in per capita water demand were explored. Despite differences in their available water sources and political cultures, both the City of Phoenix and the City of Tucson have successfully reduced their per capita water consumption levels between 1980 and 2010. However, this study suggests that each city's measured success at reducing GPCD has been more a result of external events (supply augmentation, drought, and differing development trends) rather than conservation and demand reduction regulations adopted under the auspices of the Groundwater Management Act.
ContributorsSnyder, Rachel Claire (Author) / Larson, Kelli (Thesis director) / Hirt, Paul (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Sustainability (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05
Description
The purpose of this study is to first investigate the role of political socialization on young men and women and what motivates them to become politically active and make the ultimate decision to run for elected office. These effects include parental attitudes, exposure to political shows and news sources, participation in voluntary organizations, and overall community involvement. After understanding these direct and indirect effects of political socialization, I can attempt to explain the causes for the gender gap in political ambition \u2014 meaning that significantly more men are running for elected office compared to women.
ContributorsOsgood, Shannon Marie (Author) / Woodall, Gina (Thesis director) / Herrera, Richard (Committee member) / Barrett, The Honors College (Contributor) / College of Public Service and Community Solutions (Contributor) / School of Public Affairs (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05
Description
Conflict in Israel is ongoing and permeates through international borders by stimulating discussion worldwide. Whether or not diplomatic relations have been successful, counterterrorism policies have developed and been adopted by other countries like the United States. The targeting and elimination of militant terrorist figures is one of the policies that have stirred much controversy. The effectiveness of it, however, continues to be in question. This research paper aims to take a rounded approach to analyze the efficacy of targeted killings for national security. I employ a three-dimensional method by measuring the influence of targeted killings on violence, public opinion, and economy. Statistical analysis is conducted through Paired-Sample T-tests with data derived from the period of the al-Aqsa Intifada. There is suggestive evidence that targeted killings have a significant negative effect on Palestinian violence.
ContributorsUpart, Yonit (Author) / Manekin, Devorah (Thesis director) / Wright, Thorin (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / Department of Marketing (Contributor)
Created2015-05
Description
As the poverty level increases in Arizona, so does the opportunity gap between high- income and low-income students. We believe that all youth regardless of their zip code, the color of their skin, or their family background should see themselves as leaders and scholars in the community. Access to higher education, quite simply should be attainable for all students. The New American University charter that ASU has adopted is inspiring and groundbreaking. We believe this charter underscores the significance of equal access to education. The REACH program embraces the urgency of educational inequity, by enhancing the potential success of high school teenagers, who attend the Boys & Girls Club \u2014 Ladmo Branch in Tempe, Arizona. REACH empowers youth to develop stronger leadership skills, while becoming more involved in their community. We provide an opportunity for these teens to engage in leadership discussions, receive college mentoring/tutoring, and connect with the community and resources that Arizona State University (ASU) has to offer. It is our hope that every REACH teen is inspired to apply for college. REACH strives to provide any support the teens require to be successful throughout the college testing and admission process. REACH works with multiple communities at Arizona State University including the Pat Tillman Scholars, Devils' Advocates, Honors Devils, Changemaker Central, Barrett, The Honors College and W. P. Carey School of Business to organize and lead a group of teens through a remarkable curriculum that will shape the way they view cultural diversity, educational achievement, and leadership. The weekly meetings consist of discussions, creative team-building, critical thinking exercises, and cultural awareness experiences. Demonstrating to the teens, administrators, volunteers, mentors, and tutors the rich culture that Tempe has to offer and the skills and experience that they have to offer their community as well. In this thesis will we present our work developing and implementing the REACH program at the Ladmo Branch of the Tempe Boys and Girls Club from the Spring of 2013 through the Spring of 2015. We will describe the structure of REACH, our weekly leadership curriculum, our assessment and evaluation method, and the supplemental programs that we instituted (i.e., tutoring and mentoring). We will reflect on our successes and the challenges that we faced over the span of three years. We will conclude our thesis with a critical analysis of the program as a whole in order to provide advice for others who want to create and engage in a sustainable, student lead, community action organization.
ContributorsBurba, Monica (Co-author) / Smith, Jenna (Co-author) / Mokwa, Michael (Thesis director) / Eaton, John (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Sustainability (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of International Letters and Cultures (Contributor)
Created2015-05
Description
Corruption is a growing issue in China that has only worsened in recent years due to the competition for power between the two foremost factions within the Chinese Communist Party (CCP), the Tuanpai and Princelings. Based on a series of case studies of high-ranking Chinese officials, I analyze patterns of corruption employed by members of the two factions that enable them to gain power and authority within the CCP. This analysis argues that due to the high levels of intense corruption within China and the CCP, change in the form of small and gradual reform is the only way to battle this corruption without further threatening the legitimacy of the government. Small changes such as allowing the competition between factions to remain as a form of checks and balances for the government or allowing more freedom with social media will gain some trust back for the Chinese government. If drastic changes are made and all corrupt officials in the government are indicted, that may in turn destabilize the country by ruining all faith in the government and removing so many individuals who contribute to day-to-day governance. This analysis suggests that possible solutions must start small and gradually increase to maintain the stability and legitimacy of China and the CCP while also beginning to fight the corruption culture.
ContributorsLloyd, Jennifer Alexandra (Author) / Shair-Rosenfield, Sarah (Thesis director) / Bustikova-Siroky, Lenka (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Politics and Global Studies (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2015-05
Description
I travelled and worked in international fisheries policy for 7 months in preparation for this thesis. During this time I completed one internship in Rome, Italy with the Food and Agriculture Organization of the United Nations (UNFAO) and another internship on the island of Pohnpei with the Secretariat of the Western and Central Pacific Fisheries Commission (WCPFC). From these experiences, I selected the subject of this thesis. My thesis analyzes the management system for South Pacific albacore tuna, the source stock for brands like "Chicken of the Sea" and "Starkist". South Pacific albacore tuna pass through international waters and the waters of several Pacific Island countries and territories, necessitating States to cooperate and coordinate to sustain the future viability of the stock. A case study for transboundary natural resource management, I discuss the institutional complexity that arises from managing such a resource. I use common-pool resource (CPR) theory to describe this complexity, which frames natural resource management as a collective-action problem among resource users. I first conceptualize the management system as having multiple institutional scales and multiple levels of organization. Then, employing Ostrom's 8 design principles for successful CPR management, I conduct a multi-institution analysis of the international, regional, and subregional institutions that participate in the management system. Finally, I also conduct a cross-institution analysis by examining the interactions between these institutions. I find that significant space for theoretical development exists in CPR theory for understanding complex management systems for transboundary natural resources. Furthermore, I find that interactions between institutions create linkages that could be retooled to improve the performance of the South Pacific albacore tuna management system.
ContributorsAbolhassani, Angela Maryam (Author) / Abbott, Kenneth (Thesis director) / Schoon, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Life Sciences (Contributor) / Department of English (Contributor)
Created2015-05
Description
Through oral history and interviewing Veterans, I explored what military service looks like, and how diverse different service member's experiences are. I conducted comprehensive interviews with four Veterans: three Marines and an Army Medic. Each interview covered basic questions centered on enlistment, service/deployment, and the transition back into civilian life. After the interviews, I wrote interview summaries to provide a written account of the Veteran's experience. I also created a video compilation of the four veterans and their responses to certain questions. The objective of my project was to make the Veterans' experiences accessible to people without a military background.
ContributorsWestlund, Chloe Grace (Author) / Von Hagen, Mark (Thesis director) / Dallett, Nancy (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2015-05
Description
This paper develops a theoretical price competition model, based on the model established in Brekke et al. (2010), in order to analyze the effects of exogenous reference price regulations on pharmaceutical firms' pricing strategies and competitive decisions. Our model establishes demand schedules that represent consumer demand for generic, brand-name, and on-patent drugs under free competition and governmental regulation. Drug equilibrium prices are determined by having firms play a Bertrand game. Equilibrium prices under reference price regulation indicate that the reference price set by regulators affects the price decisions of firms. Our model concludes that a higher reference price will increase the price of both the on-patent pioneer drug as well as the brand-name drug, while the generic drug price equilibrium is not affected by the reference price.
ContributorsSpurlin, Jordan (Co-author) / Fiacco, Leah (Co-author) / Datta, Manjira (Thesis director) / Leiva Bertran, Fernando (Committee member) / Barrett, The Honors College (Contributor) / Department of Economics (Contributor) / Department of Finance (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05
Description
There are many fans who invest a lot of time, money, and effort into fantasy football. Finding a balance between maintaining loyalty to a favorite team while trying to win a fantasy league has become an issue. There are those fans who take precautions to assure loyalty while playing and then there are those who put their loyalties aside and treat fantasy football as its own entity outside of their fandom. In this project I am studying how playing fantasy football affects an individual's team loyalty.
ContributorsAssi, Stephanie Faye (Author) / Ingram-Waters, Mary (Thesis director) / Soares, Rebecca (Committee member) / Dwyer, Brendan P. (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05