Matching Items (3)
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Description
Skeletal muscle injury may occur from repetitive short bursts of biomechanical strain that impair muscle function. Alternatively, variations of biomechanical strain such as those held for long-duration are used by clinicians to repair muscle and restore its function. Fibroblasts embedded within the unifying connective tissue of skeletal muscle experience these

Skeletal muscle injury may occur from repetitive short bursts of biomechanical strain that impair muscle function. Alternatively, variations of biomechanical strain such as those held for long-duration are used by clinicians to repair muscle and restore its function. Fibroblasts embedded within the unifying connective tissue of skeletal muscle experience these multiple and diverse mechanical stimuli and respond by secreting cytokines. Cytokines direct all stages of muscle regeneration including myoblasts differentiation, fusion to form myotubes, and myotube functionality. To examine how fibroblasts respond to variations in mechanical strain that may affect juxtapose muscle, a myofascial junction was bioengineered that examined the interaction between the two cell types. Fibroblasts were experimentally shown to increase myoblast differentiation, and fibroblast biomechanical strain mediated the extent to which differentiation occurred. Intereleukin-6 is a strain-regulated cytokine secreted by fibroblasts was determined to be necessary for fibroblast-mediated myoblast differentiation. Myotubes differentiated in the presence of strained fibroblasts express greater number of acetylcholine receptors, greater acetylcholine receptor sizes, and modified to be more or less sensitive to acetylcholine-induced contraction. This study provides direct evidence that strained and non-strained fibroblasts can serve as a vehicle to modify myoblast differentiation and myotube functionality. Further understanding the mechanisms regulating these processes may lead to clinical interventions that include strain-activated cellular therapies and bioengineered cell engraftment for mediating the regeneration and function of muscle in vivo.
ContributorsHicks, Michael (Author) / Standley, Paul R (Thesis advisor) / Rawls, Jeffrey (Committee member) / Lake, Douglas (Committee member) / Hinrichs, Richard (Committee member) / Arizona State University (Publisher)
Created2014
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Description
This study investigates the success of a method used to encourage active engagement strategies among community and research faculty in a College of Medicine, and examines the effects of these strategies on medical student engagement and exam scores. Ten faculty used suggestions from the Active Engagement Strategies Website (AESW), which

This study investigates the success of a method used to encourage active engagement strategies among community and research faculty in a College of Medicine, and examines the effects of these strategies on medical student engagement and exam scores. Ten faculty used suggestions from the Active Engagement Strategies Website (AESW), which explained four strategies that could easily be incorporated into medical education lectures; pause procedure, audience response system, think-pair-share, and muddiest point. Findings from observations conducted during sessions where an active engagement strategy was implemented and when strategies were not implemented, faculty and student surveys, and exam question analysis indicate faculty members found active engagement strategies easy to incorporate, student engagement and exam score means increased when an active engagement strategy was implemented, and students reported perceptions of attaining a higher level of learning, especially when the pause procedure was implemented. Discussion and implications address low cost and easy ways to provide faculty development in medical education that potentially improves the quality of instruction and enhances student outcomes.
ContributorsYanez, Lisa C (Author) / Puckett, Kathleen (Thesis advisor) / Crawford, Steven R (Committee member) / Standley, Paul R (Committee member) / Arizona State University (Publisher)
Created2017
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Description

The behavior of animals is an intrinsically fascinating topic for students from a wide array of backgrounds. We describe a learning experience using animal behavior that we created for middle school students as part of a graduate-student outreach program, Graduate Partners in Science Education, at Arizona State University in collaboration

The behavior of animals is an intrinsically fascinating topic for students from a wide array of backgrounds. We describe a learning experience using animal behavior that we created for middle school students as part of a graduate-student outreach program, Graduate Partners in Science Education, at Arizona State University in collaboration with a K-8 public school. This activity capitalizes on the interest that animal behavior can generate to introduce and reinforce student understanding of the scientific method. Specifically, our activity highlights the general utility of the scientific method and uses this method to examine ant social behavior, with emphasis on generating and testing hypotheses. Furthermore, this activity introduces the idea of animal societies and encourages students to apply the concepts they learn to other species, including humans. By collecting ants locally, from schoolyards or nearby habitats, this experience situates learning in the context of students' own communities. We also provide optional assessment materials that teachers can use to assess learning objectives and standard mastery.

ContributorsLigon, Russell (Author) / Hicks, Michael (Author) / Dolezal, Adam G. (Author) / Butler, Michael W. (Author) / Morehouse, Nathan I. (Author) / Ganesh, Tirupalavanam (Author) / College of Liberal Arts and Sciences (Contributor)
Created2014-10-01