There is a growing body of scientific evidence that the health of the microbiome (the trillions of microbes that inhabit the human host) plays an important role in maintaining the health of the host and that disruptions in the microbiome may play a role in certain disease processes. An increasing number of research studies have provided evidence that the composition of the gut (enteric) microbiome (GM) in at least a subset of individuals with autism spectrum disorder (ASD) deviates from what is usually observed in typically developing individuals. There are several lines of research that suggest that specific changes in the GM could be causative or highly associated with driving core and associated ASD symptoms, pathology, and comorbidities which include gastrointestinal symptoms, although it is also a possibility that these changes, in whole or in part, could be a consequence of underlying pathophysiological features associated with ASD. However, if the GM truly plays a causative role in ASD, then the manipulation of the GM could potentially be leveraged as a therapeutic approach to improve ASD symptoms and/or comorbidities, including gastrointestinal symptoms.
One approach to investigating this possibility in greater detail includes a highly controlled clinical trial in which the GM is systematically manipulated to determine its significance in individuals with ASD. To outline the important issues that would be required to design such a study, a group of clinicians, research scientists, and parents of children with ASD participated in an interdisciplinary daylong workshop as an extension of the 1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism (www.microbiome-autism.com). The group considered several aspects of designing clinical studies, including clinical trial design, treatments that could potentially be used in a clinical trial, appropriate ASD participants for the clinical trial, behavioral and cognitive assessments, important biomarkers, safety concerns, and ethical considerations. Overall, the group not only felt that this was a promising area of research for the ASD population and a promising avenue for potential treatment but also felt that further basic and translational research was needed to clarify the clinical utility of such treatments and to elucidate possible mechanisms responsible for a clinical response, so that new treatments and approaches may be discovered and/or fostered in the future.
The purpose of this project stands: An idea that sparks a passion, idea, or question in the audience that ties directly into our current political discussion, while remaining integral to the academic world, serving as one of the most concentrated locations of permission to think openly and ask difficult questions. A Plot Discovered in particular achieves this by asking what it means to have power and to not, to be a man in another man’s world, to be a woman in any man’s world, to be neither really man or woman but somewhere in between, the consequences of dictatorship and revolution, why the human condition loves to get high, as well as the devotion and blindness of love on three different levels: friendship, romance, and family. These themes serve the script as it was written in all three of the applied timelines (it’s original 1600s, the adapted 1970s, and our current) leading to the biggest question of them all, do we as humans really evolve or is it a mere illusion painted by our ability to enhance the environment around us?
The desire to adapt A Plot Discovered came during a conversation with my peers during a semester spent studying classical drama at Oxford University. As we debated the themes of the play, a guitarist played post Vietnam War era music in the street below echoing up the cobblestone street and entering our dining hall window. The result was an artistic revelation that would drive my passion into this project for the next two years. Rewriting, designing, casting, directing, and reflecting upon A Plot Discovered has proved not only the most difficult but also the most rewarding event within my undergraduate studies.
View A Plot Discovered miniature documentary here: https://vimeo.com/325355612