From Anglo-American Martial and Social Culture to a Distinct American Martial and Social Culture is a historical thesis which documents the origins and perspectives of English settlers in North America from 1607 until American independence recognized in the 1783 Treaty of Paris. Over the course of these 176 years, the mindset of those living on the American frontier was analyzed through the martial and social culture that developed. Some examples of Anglo-American adaptations to living on the American frontier were legislative assemblies and a continent-spanning local militia. Questions ranging from why the English settlers chose to live in the Americas to how they overcame sectional differences to form the United States of America were questions that this thesis attempted to answer. The conclusion from analyzing primary and secondary sources shows the initial development of an Anglo-American culture which over the course of more than a century diverges into a unique American identity, distinct from British subjects and agents of empire. Whereas British citizens in the Americas started out as staunch defenders and agents of the global British Empire, this thesis documents the transformation of British citizens in North America from a British cultural identity to a distinct American cultural identity.

X-ray phase contrast imaging (XPCI) is a novel imaging method that utilizes phase information of X-rays in order to produce images. XPCI allows for highly resolved features that traditional X-ray imaging modalities cannot discern. The objective of this experiment was to model initial simulations predicting the output signal of the future compact x-ray free electron laser (CXFEL) XPCI source. The signal was reported in tonal values (“counts”), where MATLAB and MATLAB App Designer were the computing environments used to develop the simulations. The experimental setup’s components included a yttrium aluminum garnet (YAG) scintillating screen, mirror, and Mako G-507C camera with a Sony IMX264 sensor. The main function of the setup was to aim the X-rays at the YAG screen, then measure its scintillation through the photons emitted that hit the camera sensor. The resulting quantity used to assess the signal strength was tonal values (“counts”) per pixel on the sensor. Data for X-ray transmission through water, air, and polyimide was sourced from The Center for X-ray Optics’s simulations website, after which the data was interpolated and referenced in MATLAB. Matrices were an integral part of the saturation calculations; field-of-view (FOV), magnification and photon energies were also necessary. All the calculations were compiled into a graphical user interface (GUI) using App Designer. The code used to build this GUI can be used as a template for later, more complex GUIs and is a great starting point for future work in XPCI research at CXFEL.

X-ray phase contrast imaging (XPCI) is a novel imaging method that utilizes phase information of X-rays in order to produce images. XPCI allows for highly resolved features that traditional X-ray imaging modalities cannot discern. The objective of this experiment was to model initial simulations predicting the output signal of the future compact x-ray free electron laser (CXFEL) XPCI source. The signal was reported in tonal values (“counts”), where MATLAB and MATLAB App Designer were the computing environments used to develop the simulations. The experimental setup’s components included a yttrium aluminum garnet (YAG) scintillating screen, mirror, and Mako G-507C camera with a Sony IMX264 sensor. The main function of the setup was to aim the X-rays at the YAG screen, then measure its scintillation through the photons emitted that hit the camera sensor. The resulting quantity used to assess the signal strength was tonal values (“counts”) per pixel on the sensor. Data for X-ray transmission through water, air, and polyimide was sourced from The Center for X-ray Optics’s simulations website, after which the data was interpolated and referenced in MATLAB. Matrices were an integral part of the saturation calculations; field-of-view (FOV), magnification and photon energies were also necessary. All the calculations were compiled into a graphical user interface (GUI) using App Designer. The code used to build this GUI can be used as a template for later, more complex GUIs and is a great starting point for future work in XPCI research at CXFEL.

Patients need to know current and available options for prosthetic devices. Devices are categorized depending on the region of amputation and their purpose. Retrospection on the history of prosthetic devices leading into modern ones allows for an interpretation of successes and necessary improvements moving forward. One promising avenue for prostheses is the development of neuroprostheses that much more closely resemble some of the functionality taken for granted in natural limbs. Proprioception, more commonly known as the ‘sixth sense’, would be a very desirable characteristic of these devices and is the subject of current research efforts. In the meantime, it is necessary to help patients evaluate what products are out there that identify more strongly with their individualized preferences.

Considered by colonists as an extension of France, Algeria was subjected to more than 125 years of French control. The Algerian people were thus heavily influenced by the French language and were required to abandon their native language in many aspects of their life such as government and education. This thesis aims to highlight the linguistic power relations established by the French in Colonial Algeria. Language usage and policies leading up to the Algerian War for Independence are critical to understanding the successor government. Analyzing three sections of language in Colonial Algeria- radio, language of instruction, and literature- I find that the language of instruction in education is the most influential in determining and formulating identities and power relations. Ultimately, this thesis concludes that language, power, and identity overlap and influence each other in several ways, producing a complex post-colonial society

Regenerative medicine utilizes living cells as therapeutics to replace or repair damaged or diseased tissue, but the manufacturing processes to produce cell-based tissue products require customized biounit operations that do not currently exist as conventional biochemical and biopharma manufacturing processes. Living cells are constantly changing and reacting to their environment, which in the case of cells isolated from their hosts, are utilized as living bioreactor components that, by themselves, are manipulated to biomanufacturer selected tissue products. Therefore, specialized technology is required to assure that cellular products produce the phenotypical tissue characteristics that the final product is designated to have, while also maintaining sterility of the culture. Because of this, FDA guidelines encourage the use of Process Analytical Technology (PAT – see Ref ) to be integrated into manufacturing systems of biologics to ensure quality and safety. To address the need for evaluation of sensor technologies for potential use in PAT, a literature review of both existing sensing technologies and biomarkers was conducted. After a thorough assessment of the sensor technologies that were most applicable to biomanufacturing, spectrophotometry was selected to monitor the metabolic components glucose and lactate of living cells in culture in real time. Initially, spectrophotometric measurements were taken of mock solutions of glucose and lactate solutions at concentrations relevant to human cell culture and physiology. With that data, a mathematical model was developed to predict a solution’s glucose and lactate concentration. This model was then integrated into a Matlab program that was used to continuously monitor and estimate solutions of glucose and lactate concentrations in real time. After testing the accuracy of this program in different solutions, it was determined that calibration curves and models must be made for each media type and estimates of glucose and lactate were found accurate only at higher concentrations. This program was successfully utilized to monitor in real time glucose and lactate production and consumption trends of Mesenchymal Stem Cells (MSCs) in culture, demonstrating proof-of-concept of the proposed bioprocess monitoring schema.

My honors thesis focuses on the technological aspects and the legal impacts of prosthetics and advanced prosthetics. There is a lot of case law dealing with early prosthetics when it comes to worker’s compensation, airport security, prisons and sports. However, there has been little case law that has dealt with advanced prosthetics. As prosthetic limbs become more technologically advanced and intertwined with one’s identity, it is crucial that laws are made to draw a new line between person and property. The innovation of prosthetic limbs has just begun and will surely face setbacks along the way, but the benefits will be worth it once the law catches up with the rapidly advancing technology.