The goal of this project was to design and create a genetic construct that would allow for <br/>tumor growth to be induced in the center of the wing imaginal disc of Drosophila larvae, the <br/>R85E08 domain, using a heat shock. The resulting transgene would be combined with other <br/>transgenes in a single fly that would allow for simultaneous expression of the oncogene and, in <br/>the surrounding cells, other genes of interest. This system would help establish Drosophila as a <br/>more versatile and reliable model organism for cancer research. Furthermore, pilot studies were <br/>performed, using elements of the final proposed system, to determine if tumor growth is possible <br/>in the center of the disc, which oncogene produces the best results, and if oncogene expression <br/>induced later in development causes tumor growth. Three different candidate genes were <br/>investigated: RasV12, PvrACT, and Avli.
The Body Integrity Identity Disorder Screenplay, tentatively entitled Detach, is a full-‐length feature film script. Based on a fascinating mental disorder (generally referred to as the acronym BIID) where an individual does not associate a limb with the rest of their body, the script follows a sufferer and a reporter attempting to write a story on his struggle.
As my creative sensibilities and skills have developed over the span of my undergraduate career, the most ambitious undertaking imaginable for myself at this moment is the completion of a feature script. This project was a significant test of my storytelling skills and ability to format an unusual tale into a conceivable film.
I am proud of the end result and believe that the final version of my screenplay is an accurate representation of my taste as a filmmaker. I hope to actualize this project one day and help facilitate a transformation of the script into a feature film.