Matching Items (182)
Description本文对中国制药企业并购溢价影响因素进行了研究，提出了对制药企业并购非常重要的两个新的影响因素：可生产药品批文和在研新药批文。本文以2011年1月—2019年12月间我国制药行业上市公司并购事件为样本，对在研新药和可生产药品批文的价值从四个维度度量：是否有在研新药和可生产药品批文；在研新药数量及可生产药品批文数量；根据创新药和仿制药两个类别进行细分；标的企业所拥有的在研新药和可生产药品批文的市场价值。论文发现药品批文对企业并购溢价的影响不是很显著。进一步的，本文探究了药品批文对主并企业的对被并购公司的估值的影响。实证结果表明，我国制药企业在并购估值时确实会考虑到在研新药和可生产药品批文的价值。本文还发现对于可生产药品来说，相对创新药，被并购公司持有的仿制药批文影响更显著。而对于在研新药来说，主并企业更看重在研的创新药，在研仿制药对并购估值的影响不大。最后，本文选取了两个代表性案例进一步分析和探讨药品批文对企业并购的影响。
ContributorsYe, Tao (Author) / Shen, Wei (Thesis advisor) / Chang, Chun (Thesis advisor) / Jiang, Zhan (Committee member) / Gu, Bin (Committee member) / Arizona State University (Publisher)
Created2022
Description汽车行业属于国家支柱型产业，创造了高额的产值，增加了就业岗位。随着汽车生产行业竞争日趋激烈的趋势影响，汽车经销商在未来会出现明显的分化，并且逐步向头部集中。基于这样的行业背景，本项研究开展汽车经销商整体经营和盈利能力等方面的详细深入分析，即系统整合汽车经销商业务运营层面和财务层面数据，结合统计研究方法，对经销商盈利能力进行系统且详实归因分析，从而试别驱动盈利能力的关键业务要素。其研究成果能够完善对行业发展规律和经营模式系统性理解，从而进一步指导该领域的相关业务实践，提高经销商整体经营业绩。本课题通过四个阶段来开展经销商整体经营与盈利归因的相关研究。首先，本课题梳理了中国汽车消费行业发展的历史，同时阐述样本期内（2018-2020年）国内宏观经济和汽车消费市场的特征进行，并介绍X品牌汽车经销商的地理分布、资质和业绩评级体系、自身经营特征以及汽车生产商对经销商扶持政策等方面。在第二阶段，本课题聚焦研究假设、模型与方法，通过对X品牌汽车经销商的业务结构和运营管理开展分析，并逐步识别影响经销商盈利的关键指标变量，并提出研究假设和相关模型（即时间序列模型和面板回归模型）。在第三阶段，本课题首先开展经销商相关信息整体性统计分析，获得关键业务指标在样本期内动态特征，并结合时间序列回归模型探讨各项业务指标对经销商整体盈利能力的影响程度。在第四阶段，本课题采用（个体）固定效应的面板回归模型来研究不同组别（控制）条件下经销商盈利能力的影响因素以及其盈利能力对这些因素的敏感程度，从而更深入和全面地揭示影响经销商盈利能力的潜在因素。
基于上述四阶段的研究结果，本研究进一步就提升经销商盈利能力展开讨论，并提出相应对策。本课题相关结论仅从X品牌汽车经销商经营和财务数据进行定性和定量分析获得，但衷心希望本研究的成果能够对汽车经销商改善经营业务方面能起到实践上的借鉴和指导意义。
ContributorsPan, Guangxiong (Author) / Shen, Wei (Thesis advisor) / Wu, Fei (Thesis advisor) / Zhu, Qigui (Committee member) / Arizona State University (Publisher)
Created2022
Description
Interdigitated back contact (IBC) solar cells have achieved the highest single junction silicon wafer-based solar cell power conversion efficiencies reported to date. This thesis is about the fabrication of a high-efficiency silicon heterojunction IBC solar cell for potential use as the bottom cell for a 3-terminal lattice-matched dilute-nitride Ga (In)NP(As)/Si monolithic tandem solar cell. An effective fabrication process has been developed and the process challenges related to open circuit voltage (Voc), series resistance (Rs), and fill factor (FF) are experimentally analyzed. While wet etching, the sample lost the initial passivation, and by changing the etchant solution and passivation process, the voltage at maximum power recovered to an initial value of over 710 mV before metallization. The factors reducing the series resistance loss in IBC cells were also studied. One of these factors was the Indium Tin Oxide (ITO) sputtering parameters, which impact the conductivity of the ITO layer and transport across the a-Si:H/ITO interface. For the standard recipe, the chamber pressure was 3.5 mTorr with no oxygen partial pressure, and the thickness of the ITO layer in contact with the a-Si:H layers, was optimized to 150 nm. The patterning method for the metal contacts and final annealing also change the contact resistance of the base and emitter stack layers. The final annealing step is necessary to recover the sputtering damage; however, the higher the annealing time the higher the final IBC series resistance. The best efficiency achieved was 19.3% (Jsc = 37 mA/cm2, Voc = 691 mV, FF = 71.7%) on 200 µm thick 1-15 Ω-cm n-type CZ C-Si with a designated area of 4 cm2.
ContributorsMoeini Rizi, Mansoure (Author) / Goodnick, Stephen (Thesis advisor) / Honsberg, Christina (Committee member) / Goryll, Michael (Committee member) / Smith, David (Committee member) / Bowden, Stuart (Committee member) / Arizona State University (Publisher)
Created2022
Description
Portable health diagnostic systems seek to perform medical grade diagnostics in non-ideal environments. This work details a robust fault tolerant portable health diagnostic design implemented in hardware, firmware and software for the detectionof HPV in low-income countries. The device under device under test (DUT) is a fluorescence based lateral flow assay (LFA) point-of-care (POC) device. This work’s contributions are: firmware and software development, calibration routine implementation, device performance characterization and a proposed method of in-software fault detection. Firmware was refactored from the original implementation of the POC fluorescence reader to expose an application programming interface (API) via USB. Companion software available for desktop environments (Windows, Mac and Linux) was created to interface with this firmware API and conduct macro level routines to request and receive fluorescence data while presenting a user-friendly interface to clinical technicians. Lastly, an environmental chamber was constructed to conduct sequential diagnostic reads in order to observe sensor drift and other deviations that might present themselves in real-world usage. The results from these evaluations show a standard deviation of less than 1% in fluorescence readings in nominal temperature environments (approx. 25C) suggesting that this system will have a favorable signal-to-noise (SNR) ratio in such a setting. In non-ideal over heated environments (≥38C), the evaluation results showed performance degradation with standard deviations as large as 15%.
ContributorsLue Sang, Christopher David (Author) / Blain Christen, Jennifer M (Thesis advisor) / Ozev, Sule (Committee member) / Goryll, Michael (Committee member) / Raupp, Gregory (Committee member) / Arizona State University (Publisher)
Created2022
Description
Dynamical decoupling (DD) is a promising approach to mitigate the detrimental effects that interactions with the environment have on a quantum system. In DD, the finite-dimensional system is rotated about specified axes using strong and fast controls that eliminate system-environment interactions and protect the system fromdecoherence. In this thesis, the framework of DD is theoretically studied, and later it discusses how this framework can be implemented on an infinite-dimensional system that amplifies system components rather than suppressing them through quadrature squeezing operations. It begins by studying the impact of system-environment interactions on a quantum system, and then it analyzes how DD suppresses these interactions. The conditions for protecting a finite-dimensional system through DD are reviewed, and a numerical analysis of the DD conditions for simple systems is conducted. Using bang-bang controls, a framework for decoupling decoherence-inducing components from a general finite-dimensional system is studied. Later, following an overview of schemes that amplify the strength of a quantum signal through reversible
squeezing, a theoretical study of Hamiltonian Amplification (HA) for quantum harmonic oscillators is presented. By implementing the DD framework with squeezing operations, HA achieves speed-up in the dynamics of quantum harmonic oscillators, which translates into the strengthening of interactions between harmonic oscillators. Finally, the application of HA in amplifying the third-order nonlinearity in a Kerr medium is proposed to obtain a speed-up in the implementation of controlled phase gates for optical quantum computations. Numerically simulated results show that large amplification in nonlinearity is feasible with sufficient squeezing resources, completing the set of universal quantum gates in optical quantum computing.
ContributorsTiwari, Ankit (Author) / Arenz, Christian (Thesis advisor) / Sinha, Kanu (Committee member) / Goryll, Michael (Committee member) / Arizona State University (Publisher)
Created2023
Description
The strong demand for the advancing of Moore’s law on device size scaling down has accelerated the miniaturization of passive devices. Among these important electronic components, inductors are facing challenges because the inductance value, which is strongly dependent on the coil number for the air core inductor case, will be sacrificed when the size is shrinking. Adding magnetic core is one of the solutions due to its enhancement of inductance density but it will also add complexity to the fabrication process, and the core loss induced by the eddy current at high frequency is another drawback. In this report, the output of this research will be presented, which has three parts. In the first part, the CoZrTaB thin films are sputtered on different substrates and characterized comprehensively. The laminated CoZrTaB thin films have been also investigated, showing low coercivity and anisotropy field on both Si and polyimide substrates. Also, the different process conditions that could affect the magnetic properties are investigated.
In the second part, Ansys Maxwell software is used to optimize the lamination profile and the magnetic core inductor structure. The measured M-H loop is imported to improve the simulation accuracy.
In the third part, a novel method to fabricate the magnetic core inductors on flexible substrates is proposed. The sandwich magnetic core inductor is fabricated and assembled with flipchip bonder. The measurement result shows that this single-turn magnetic core inductor can achieve up to 24% inductance enhancement and quality factor of 7.42. The super low DC resistance (< 60 mΩ) proves that it is a good candidate to act as the passive component in the power delivery module and the use of polyimide-based substrate extends its compatibility to more packaging form factors.
ContributorsWu, Yanze (Author) / Yu, Hongbin (Thesis advisor) / Chickamenahalli, Shamala (Committee member) / Rizzo, Nicholas (Committee member) / Goryll, Michael (Committee member) / Arizona State University (Publisher)
Created2022
Description
In-field characterization of photovoltaics is crucial to understanding performance and degradation mechanisms, subsequently improving overall reliability and lifespans. Current outdoor characterization is often limited by logistical difficulties, variable weather, and requirements to measure during peak production hours. It becomes a challenge to find a characterization technique that is affordable with a low impact on system performance while still providing useful device parameters. For added complexity, this characterization technique must have the ability to scale for implementation in large powerplant applications. This dissertation addresses some of the challenges of outdoor characterization by expanding the knowledge of a well-known indoor technique referred to as Suns-VOC. Suns-VOC provides a pseudo current-voltage curve that is free of any effects from series resistance. Device parameters can be extracted from this pseudo I-V curve, allowing for subsequent degradation analysis. This work introduces how to use Suns-VOC outdoors while normalizing results based on the different effects of environmental conditions. This technique is validated on single-cells, modules, and small arrays with accuracies capable of measuring yearly degradation. An adaptation to Suns-VOC, referred to as Suns-Voltage-Resistor (Suns-VR), is also introduced to complement the results from Suns-VOC. This work can potentially be used to provide a diagnostic tool for outdoor characterization in various applications, including residential, commercial, and industrial PV systems.
ContributorsKillam, Alexander Cameron (Author) / Bowden, Stuart G (Thesis advisor) / Goryll, Michael (Committee member) / Augusto, Andre (Committee member) / Rand, James (Committee member) / Arizona State University (Publisher)
Created2022
Description
The development of biosensing platforms not only has an immediate lifesaving effect but also has a significant socio-economic impact. In this dissertation, three very important biomarkers with immense importance were chosen for further investigation, reducing the technological gap and improving their sensing platform.Firstly, gold nanoparticles (AuNP) aggregation and sedimentation-based assays were developed for the sensitive, specific, and rapid detection of Ebola virus secreted glycoprotein (sGP)and severe acute respiratory syndrome coronavirus 2 (SARS-COV2) receptor-binding domain (RBD) antigens. An extensive study was done to develop a complete assay workflow from critical nanobody generation to optimization of AuNP size for rapid detection. A rapid portable electronic reader costing (<$5, <100 cm3), and digital data output was developed. Together with the developed workflow, this portable electronic reader showed a high sensitivity (limit of detection of ~10 pg/mL, or 0.13 pM for sGP and ~40 pg/mL, or ~1.3 pM for RBD in diluted human serum), a high specificity, a large dynamic range (~7 logs), and accelerated readout within minutes. Secondly, A general framework was established for small molecule detection using plasmonic metal nanoparticles through wide-ranging investigation and optimization of assay parameters with demonstrated detection of Cannabidiol (CBD). An unfiltered assay suitable for personalized dosage monitoring was developed and demonstrated. A portable electronic reader demonstrated optoelectronic detection of CBD with a limit of detection (LOD) of <100 pM in urine and saliva, a large dynamic range (5 logs), and a high specificity that differentiates closely related Tetrahydrocannabinol (THC). Finally, with careful biomolecular design and expansion of the portable reader to a dual-wavelength detector the classification of antibodies based on their affinity to SARS-COV2 RBD and their ability to neutralize the RBD from binding to the human Angiotensin-Converting Enzyme 2 (ACE2) was demonstrated with the capability to detect antibody concentration as low as 1 pM and observed neutralization starting as low as 10 pM with different viral load and variant. This portable, low-cost, and versatile readout system holds great promise for rapid, digital, and portable data collection in the field of biosensing.
ContributorsIkbal, Md Ashif (Author) / Wang, Chao (Thesis advisor) / Goryll, Michael (Committee member) / Zhao, Yuji (Committee member) / Wang, Shaopeng (Committee member) / Arizona State University (Publisher)
Created2022
Description
Metallization of solar cells is a critical process step in the manufacturing of silicon photovoltaics (PV) as it plays a large role in device performance and production cost. Improvements in device performance linked to metallization and reduction in material usage and processing costs will continue to drive next-generation silicon PV technology. Chapter 1 introduces the context for the contributions of this thesis by providing background information on silicon PV cell technology, solar cell device physics and characterization, and metallization performance for common silicon cell structures. Chapter 2 presents a thermal model that links sub-bandgap reflectance, an important metric at the rear metal interface, to outdoor module operating temperature. Chapter 3 implements this model experimentally with aluminum back-surface field (Al-BSF), passivated emitter and rear contact (PERC), and passivated emitter rear totally diffused (PERT) mini-modules, where the PERT cells were modified to include an optimized sub-bandgap reflector stack. The dedicated optical layer was a porous low-refractive index silica nanoparticle film and was deposited between the dielectric passivation and full area metallization. This created an appreciable boost in sub-bandgap reflectance over the PERC and Al-BSF cells, which directly lead to cooler operating temperature of the fielded module. Chapter 4 investigates low-temperature Ag metallization approaches to SiO2/polysilicon passivating contacts (TOPCon architecture). The low-temperature Ag sintering process does not damage TOPCon passivation for structures with 40-nm-thick poly-Si but shows higher contact resistivity than sputtered references. This disparity is investigated and the impact of Ag diffusion processes, microstructure changes, ambient gases, and interfacial chemical reactions are evaluated. Chapter 5 investigates sputtered Al metallization to silicon heterojunction contacts of both polarities. This In-free and Ag-free metallization process can achieve low contact resistivity and no passivation loss when annealed between 150-180 °C. The passivation degradation at higher temperatures was studied with high-resolution microscopy and elemental mapping, where the interdiffusion processes were identified. Lastly, Chapter 6 summarizes the contribution of this work.
ContributorsBryan, Jonathan Linden (Author) / Holman, Zachary C (Thesis advisor) / Bertoni, Mariana I (Committee member) / Bowden, Stuart G (Committee member) / Goryll, Michael (Committee member) / Arizona State University (Publisher)
Created2022
Description新世纪以来中国电影的产业化改革与探索愈发呈现良好的态势，国产院线电影也在实践中努力赢得观众和票房市场。其中类型喜剧电影，最符合商业电影规律、最顺应影视市场需求、最能获得票房收益而备受影视创投机构、制作公司青睐。本论文研究对象聚焦类型喜剧电影，通过“欢声笑语里的财富”现象，探究类型喜剧电影内部本体构成要素与外部客观促成要素的关联；以通过分析自变量与因变量因素对中国电影票房之类型喜剧影响因素进行实证研究，为影视创投和影视制作总结并提供可靠建议。
本论文整体结构包括：第一部分为导论，包括研究背景、目的意义，相关文献综述与文献评述和论文创新性。第二部分聚焦类型喜剧本身，从电影学范畴的电影本体出发，探究“笑”的心理、社会与文化内涵，并分析将“笑”对经济领域的延伸。第三部分以影视投资、票房为依托，从现象和数据中探寻影响类型喜剧电影的因素，为展开中国电影票房之类型喜剧影响因素实证研究做好理论的铺垫。第四与第五部分则基于上述理论进行实证检验，选用2013-2020年电影样本，采用多元线性回归模型研究喜剧类型对票房的吸引力，以及不同种类型喜剧对电影票房的提振效果作用差异。研究发现喜剧电影对电影票房有显著的提振作用；以及研究电影的外部影响因素（续集效应）对电影票房的作用。发现续集电影有更好的票房表现，续集效应的票房提升作用在喜剧电影中表现的更加明显。
本论文研究成果最终将回归到“欢声笑语里的财富”本身；即“类型复合喜剧”对促进电影与金融产业的互动关联、实现更加可持续化发展，以及进而推动经济及文化业的发展。
ContributorsLiu, Yongqian (Author) / Shen, Wei (Thesis advisor) / Zhu, Ning (Thesis advisor) / Dong, Xiaodan (Committee member) / Arizona State University (Publisher)
Created2022