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- Creators: School of Molecular Sciences
- Resource Type: Text
Description
This study investigates how the patient-provider relationship between lesbian, gay, and bisexual women and their healthcare providers influences their access to, utilization of, and experiences within healthcare environments. Nineteen participants, ages 18 to 34, were recruited using convenience and snowball sampling. Interviews were conducted inquiring about their health history and their experiences within the healthcare system in the context of their sexual orientation. The data collected from these interviews was used to create an analysis of the healthcare experiences of those who identify as queer. Although the original intention of the project was to chronicle the experiences of LGB women specifically, there were four non-binary gender respondents who contributed interviews. In an effort to not privilege any orientation over another, the respondents were collectively referred to as queer, given the inclusive and an encompassing nature of the term. The general conclusion of this study is that respondents most often experienced heterosexism rather than outright homophobia when accessing healthcare. If heterosexism was present within the healthcare setting, it made respondents feel uncomfortable with their providers and less likely to inform them of their sexuality even if it was medically relevant to their health outcomes. Gender, race, and,socioeconomic differences also had an effect on the patient-provider relationship. Non-binary respondents acknowledged the need for inclusion of more gender options outside of male or female on the reporting forms often seen in medical offices. By doing so, medical professionals are acknowledging their awareness and knowledge of people outside of the binary gender system, thus improving the experience of these patients. While race and socioeconomic status were less relevant to the context of this study, it was found that these factors have an affect on the patient-provider relationship. There are many suggestions for providers to improve the experiences of queer patients within the healthcare setting. This includes nonverbal indications of acknowledgement and acceptance, such as signs in the office that indicate it to be a queer friendly space. This will help in eliminating the fear and miscommunication that can often happen when a queer patient sees a practitioner for the first time. In addition, better education on medically relevant topics to queer patients, is necessary in order to eliminate disparities in health outcomes. This is particularly evident in trans health, where specialized education is necessary in order to decrease poor health outcomes in trans patients. Future directions of this study necessitate a closer look on how race and socioeconomic status have an effect on a queer patient's relationship with their provider.
ContributorsRajan, Sindhu (Co-author) / Bradley, Arianna (Co-author) / Larson, Michelle (Co-author) / Alvarado, Aimee (Co-author) / Ingram-Waters, Mary (Thesis director) / Arnold, Michelle (Committee member) / School of Molecular Sciences (Contributor) / School of Social Transformation (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / College of Public Service and Community Solutions (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Methods of second language (L2) teaching should involve exposure to authentic forms to facilitate the development of proficiency and fluency. Exposure to authentic forms is important because prior research has shown that natural language discourse uses mostly prefabricated linguistic units (prefabs-formulaic language) that aid in developing linguistic competence and fluency; this occurs because learners' cognitive load is decreased when they are able to retrieve prefabricated wholes from their L2 repertoire as they produce L2 discourse (Erman & Warren, 2000). An effective method of acquiring prefabricated constructions as single units of meaning or structure is repetition of exposure to whole collocations (words that occur together in fixed phrases), since attention will shift from the individual constituents of the phrase to the unit as a whole as the meaning-bearing stored form (Bybee et al., 2006). Authentic materials (materials produced by native speakers for native speakers) contain a substantial number of prefabricated meaning units that are characteristic of native-speaker produced natural language. Compared to traditional L2 classroom approaches, authentic materials are more likely to engage learners due to the range of options available for learner interest; there is a psychological benefit for students who can be certain that their progress with authentic materials is tantamount to progress outside the classroom setting (Berardo, 2006; Ugalde, 2008). The efficacy of exposure to authentic forms can also be explained by virtue of the fact that it promotes incidental acquisition, which is the primary manner by which language is learned (Ellis & Wulff, 2015); it does so through facilitating implicit pattern recognition of exemplar structures. The research concludes with a discussion of why pedagogical approaches should seek to incorporate formulaic language for learners to achieve fluency.
ContributorsGuerithault, Nicolas Owen (Author) / Lafford, Barbara (Thesis director) / Martinez, Jacqueline (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Isotopic analyses of archaeological and modern materials are commonly used to reconstruct diet, climate, and habitat. This study analyzes 15 camelid samples from three sites (two archaeological, one modern) in South America to determine their carbon and nitrogen isotopic values to further explore the relationship between stable isotopes and environments. Camelid individuals in the modern site of Cuenca, Ecuador had a diet of almost entirely C3 vegetation, while those in Chen Chen, Peru had slightly higher values, still consistent with C3 plants. Those in the higher altitude site of Pumapunku, Bolivia had higher δ13C values than expected, indicating they may have been foddered with a mixed diet. These isotopic data indicate that vegetation, and therefore herbivore diets, are influenced by altitude. Additionally, it was found that a positive linear relationship exists between δ15N values and aridity of a site. Results indicate that aspects of the environment such as aridity are reflected in isotopic signatures. These results contribute to the increasing amount of data on isotopic variation in South American camelids, both modern and archaeological.
ContributorsSpencer, Katherine Clare (Author) / Knudson, Kelly (Thesis director) / Reed, Kaye (Committee member) / School of Human Evolution and Social Change (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This project was generated out of a desire to understand and explore a novel twist on a well-traversed route to happiness. I set out looking for a new perspective on fulfillment and found sustainable, everyday joy through gratitude. In doing so, I created a space where a group of people could practice and share gratitude as a community. Gratitude is familiar to most as a feeling, but putting intention behind gratitude turns it into an action, and even a virtue. In fact, Roman philosopher Cicero says, "Gratitude is not only the greatest of virtues, but the parent of all others." I created a Facebook community called Marvel at The Ordinary (MATO) applying principles rooted in the Theory of Change to express this greatest virtue. I found both success and earnest support from others in this novel approach to current gratitude practices. Defined by Dr. Robert Emmons, an expert in the science of gratitude, practicing gratitude is a two-step process: "(1.) affirming goodness in one's life, and (2.) recognizing that the sources of this goodness lie at least partially outside of the self." There is substantial research touting the worth of gratitude journaling, in fact, few things have been more repeatedly and empirically vetted than the connection between gratitude and overall happiness and well-being. Yet there is one facet ubiquitously overlooked in current gratitude research: what happens when gratitude journaling is shared with others? With anecdotal evidence, short-form interview analysis, thematic analysis of journaling lexicon, and a case study on the growth and engagement of Marvel at The Ordinary as a social movement, there is reason to believe that a social media-based community centered around gratitude may support and even enhance the practice of gratitude, which is typically practiced in isolation. It was also found that communities of this sort are highly sought after, based on the engagement within and growth of the Facebook group from 50 to 600+ members in a period of 2 months. MATO set out with the aspirations of creating a community which encourages others to gratitude journal, raising awareness about gratitude journaling, and building a community which fosters empathy, optimism, and awareness in an everyday sense. In each of these goals, overwhelming success was found.
ContributorsMccawley, Kevin William (Author) / Mokwa, Michael (Thesis director) / Huerta, Mark (Committee member) / Micevic, Vid (Committee member) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Recent evidence suggests that youth from affluent and upper-middle-class, white collar families are at high risk for maladaptive behaviors, such as aggression, rule breaking, and substance use. A major hypothesized underlying factor is lax parental discipline that involves low repercussions for errant behaviors such as substance use—also known as perceived parents’ “containment” of such behaviors. In this study, the focus is on multiple dimensions of perceived containment among parents and school authorities, in relation to both externalizing problems and drug use behaviors. These associations are examined in four different schools: two boarding schools and two day schools. Results show much stronger links with maladjustment for perceived containment by parents as opposed to perceived containment by school. The largest significant effects within the containment indices were found to be between parent containment of drug use and the levels of substance use behaviors reported by students. These effects were found across gender and all schools, indicating robust links. Overall, the most robust index studied was the perceived parental monitoring variables; monitoring effects were stronger than effects from any containment variables. Students who perceived the highest levels of parental monitoring exhibited the least amount of externalizing behaviors across all schools and genders. A possible explanation includes students perceiving that their parents monitor their behavior due to caring on the behalf of the parent, which then leads to fewer externalizing outcomes. These results suggest that the most effective means of decreasing substance use levels seem to lie within the parents of the students and not the schools.
ContributorsHudson, Johnny (Author) / Luthar, Suniya (Thesis director) / Glenberg, Arthur (Committee member) / Cavanaugh Toft, Carolyn (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Cancer is a disease that occurs in many and perhaps all multicellular organisms. Current research is looking at how different life history characteristics among species could influence cancer rates. Because somatic maintenance is an important component of a species' life history, we hypothesize the same ecological forces shaping the life history of a species should also determine its cancer susceptibility. By looking at varying life histories, potential evolutionary trends could be used to explain differing cancer rates. Life history theory could be an important framework for understanding cancer vulnerabilities with different trade-offs between life history traits and cancer defenses. Birds have diverse life history strategies that could explain differences in cancer suppression. Peto's paradox is the observation that cancer rates do not typically increase with body size and longevity despite an increased number of cell divisions over the animal's lifetime that ought to be carcinogenic. Here we show how Peto’s paradox is negatively correlated for cancer within the clade, Aves. That is, larger, long-lived birds get more cancer than smaller, short-lived birds (p=0.0001; r2= 0.024). Sexual dimorphism in both plumage color and size differ among Aves species. We hypothesized that this could lead to a difference in cancer rates due to the amount of time and energy sexual dimorphism takes away from somatic maintenance. We tested for an association between a variety of life history traits and cancer, including reproductive potential, growth rate, incubation, mating systems, and sexual dimorphism in both color and size. We found male birds get less cancer than female birds (9.8% vs. 11.1%, p=0.0058).
ContributorsDolan, Jordyn Nicole (Author) / Maley, Carlo (Thesis director) / Harris, Valerie (Committee member) / Boddy, Amy (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The primary objective of this project is to further the knowledge about SCL26 family of anion transporters. The goals of the experiment were to find the lowest sulfate concentration where the yeast without Sulp1 and Sulp2 is able to grow, but it grows very slowly, and to find a higher sulfate concentration where the yeast grows quickly, with or without the sulfate transporters. The lowest sulfate concentration where the yeast without the sulfate transporters is able to grow was determined to be 2-4 mM, however, this range can likely be refined by more quantitative analytical methods. At a sulfate concentration of 20 mM sulfate or higher, the yeast is able to grow quickly without high-affinity sulfate transporters. The next step in the project is to re-introduce the Sulp1 and Sulp2 genes into the yeast, so that growth in low and high sulfate conditions can be compared with and without the Sulp1 and Sulp2 proteins. The long-term goals of the project are to bring experience with yeast to Dr. Nannenga’s structural discovery lab, to determine if yeast sulfate transporters respond in the same way to drug candidates as human sulfate transporters, and to determine the structure of the proteins using cryo-electron microscopy.
ContributorsCall, Nicolas I (Author) / Nannenga, Brent (Thesis director) / Wang, Xuan (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The aims of this project are: (i) to identify structural and molecular changes in the brains of 3xTg-AD mice and (ii) to determine whether decreasing S6K1 protects the brain from these changes. To achieve our goals, we decided to remove one copy of the S6K1 gene in 3xTg-AD mice by breeding them with S6K1 knockout mice (S6K1+/-). In previous studies, we have seen that reducing S6K1 levels in 3xTg-AD mice improved spatial memory and synaptic plasticity which was associated with reduced A and tau pathology. Here, we used a multiparametric MRI to assess volumetric and blood flow changes in the brain of 20-month-old 3xTg-AD mice. We found that 3xTg-AD/S6K1+/- mice had higher blood flow and cortical volume compared to 3xTg-AD mice. However, we saw no significant differences between 3xTg-AD mice and NonTg mice. We further found A levels and plaque numbers were significantly lower in 3xTg-AD/S6K1+/- mice compared to 3xTg-AD mice. This reduction in plaques could account for the improvement in blood flow in 3xTg-AD/S6K1+/- mice. To try to understand the reason behind the increase in cortical volume in the 3xTg-AD/S6K1+/- when compared to the 3xTg-AD, we measured markers of synaptic density, PSD95, and synaptophysin. We found that PSD95 levels were not different between the four groups. However, synaptophysin levels were significantly lower in 3xTg-AD mice compared to NonTg levels and returned to baseline levels in 3xTg-AD mice lacking one copy of the S6K1 gene. This difference in synaptophysin could explain, at least in part, the difference in volume between the four groups analyzed. Overall, this represents the first evidence showing that reducing mTOR signaling improves blood flow and cortical volume in a mouse model of AD.
ContributorsShukla, Prakriti (Author) / Oddo, Salvatore (Thesis director) / Caccamo, Antonella (Committee member) / Jankowsky, Joanna (Committee member) / School of Molecular Sciences (Contributor) / School of Public Affairs (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Currently, many patients suffer from post-circumcision complications caused by poor patient selection and/or poor technique of the practicing physician. In addition, the majority of medical practitioners are incapable of/unwilling to conduct specific circumcision procedures on their patients. In the end, this either results in unsatisfied patient families, who unwillingly have their children circumcised using methods contrary to their belief, or results in individuals who are not certified practitioners of medicine conducting the procedures, greatly increasing the risk of the patients experiencing preventable complications. In order to locally address the aforementioned problems, this thesis committee, consisting of Dr. Frank Infurna, Dr. Justin Ryan, and Dr. Zachary Zuniga, and I, developed a training module that standardized the instruction that interns, residents, attendings, fellows, hospitalists, and other interested physicians will receive regarding neonatal circumcision at Phoenix Children's Hospital. To begin, the pre-operative, intra-operative, and post-operative procedures related to the Gomco clamp neonatal circumcision procedure were heavily researched using literature sourced from library databases and consultation of specialists, such as Dr. Zuniga. Given that the training was developed to instruct individuals within the medical field, the material was then truncated to promote succinctness and specificity towards the targeted population. In order to convey the specific techniques that are clinically preferred to be used in the procedure, one of Dr. Zuniga's Gomco clamp neonatal circumcision procedures was recorded and converted into GIFs, with each GIF depicting a specific technique of the procedure. The aforementioned materials were then arranged into a slide deck in order to mitigate the need for future training facilitators to tamper with the material in the process of creating visuals to be used during the training. Given the sensitivity of the material included in the slide deck, it will only be available for use on Phoenix Children's Hospital premises. To incorporate instruction regarding both the traditional (Gomco clamp) and religiously-preferred circumcision techniques into the training module, appointments, consisting of discussions regarding the procedural, cultural, and social facets that must be taken into consideration when conducting a circumcision procedure on a patient from a Muslim family, were set-up with pediatric physicians, currently practicing in Abu Dhabi, United Arab Emirates, who have specialized knowledge of conducting circumcisions in the Middle East. Since Brit Milah, the Jewish circumcision ceremony, is, unlike in Islam, required to be conducted by a Mohel in either a synagogue or house, it was not covered as holistically as "Khtan", Islamic circumcision, which is less heavily regulated. Thus far, the training module has been piloted twice, once with a group of medical students and physicians and once with medical education program directors and instructors. The critique from both sessions has been used to prepare the material for use in neonatal circumcision training sessions that will be introduced in clerkship and residency curriculum. In the future, the results of this implementation can be used to prepare the module for submission to the American Academy of Pediatrics to be made a prerequisite for physicians to undergo before conducting neonatal circumcisions.
ContributorsMeraban, Amir Reza (Author) / Infurna, Frank (Thesis director) / Ryan, Justin (Committee member) / Zuniga, Zachary (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
I investigated if race/ethnicity was associated with self- and peer-reported victimization and aggression in a sample of 5th through 8th graders (N = 383, 51% males) from two schools in which Hispanic/Latino students were the ethnic-racial majority. Self-reported victimization did not differ between races. In contrast, White students often had higher peer-reported victimization relative to Hispanic and Multi-racial students. Few significant associations were found for aggression. There was some, albeit inconsistent, support for the idea that power imbalance based on race/ethnicity is shifted by numbers. In the future, researchers should conduct studies aimed verifying this notion and that are tailored toward answering questions of mechanism.
ContributorsMitiku, Helen (Author) / Wilkens, Natalie (Thesis director) / Lindstrom Johnson, Sarah (Committee member) / White, Rebecca (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05