Ethical Considerations: The thesis presents the three main threads of thought regarding terraforming – that we should because it is there and man – superior to all other forms of life – wants challenges; that we should not since we are not superior to other forms of life and have no right; and the middle position – that we should be able to terraform Mars only if we clean up our act on Earth first. This is the point of view taken by the author of the thesis.
5 Ways Mars Can Kill You: the essay portion of the thesis is an overview of the research regarding the main obstacles to terraforming Mars and potential solutions.
Storyboard: Depicts the ethical efforts one must achieve before traveling to Mars as well as the process of terraforming – all images in chronological order.
Graphics: A series of Illustrator/Photoshop graphics moves the reader through the problems we have here on Earth that must be solved before terraforming, the process of getting to Mars and the activities involved in making her inhabitable for man.
WIKI: The WIKI showcases thesis material in a more interactive manner. JavaScript animations run throughout the WIKI and the user is able to create posts within the website – which acts as a forum.
Background: Recurrent glioblastoma (GBM) is resistant to available treatments and continued growth of the tumor is inevitable; this process is facilitated by the expression of genes regulated by the Signal Transducer and Activator of Transcription (STAT) family of transcription factors, namely STAT5, active in the invasive rim of GBM tumors. Currently, there are no targeted therapies for recurrent GBM that increase the overall patient survival rate. This study aims to analyze the differential expression of genes regulated by STAT5 between primary and recurrent GBM.<br/>Methods: Analysis of whole exome and RNA sequencing were performed on matched bulk primary and multiple recurrent tumor samples from GBM patients who received the current standard care to determine significant changes in gene expression of STAT3/5 targets. <br/>Results: Statistical analysis reveals a decrease in Synaptotagmin 2 (SYT2) and Pleckstrin Homology Domain Containing A3 (PLEKHA3) at recurrence, previously identified as potential STAT5 targets. <br/>Conclusions: To get a better understanding of the roles of STAT5 in GBM recurrence, their downstream effects need to be better understood. The transcriptomic program initiated by STAT5 activation is distinct from that of STAT3 activation. The roles of STAT5 target genes in GBM are poorly characterized, so further research should focus on understanding the effects of altered expression of these genes as they relate to STAT3/5 in GBM recurrence.
Interstellar travel has been one of planet Earth’s grandest achievements in modern history. To send people and entire laboratories beyond Earth’s atmosphere is an unfathomably complex and challenging accomplishment; the logistics and engineering alone took decades to execute, and even now, it remains problematic. The risks involved with space travel are immense: rocket failures such as that in Columbia, hull breaches, or simple miscalculations that may result in numerous deaths and severe casualties. For much of its history, space travel has emphasized practicality, economics, and engineering, leaving little room to design an environment supporting those in orbit. While engineering, finances, and feasibility reign as the highest priorities in space habitation, there is an often overlooked necessity to design environments that better address station inhabitants' mental and behavioral needs.