Matching Items (434)
Description
Analysis into the political career of Texas state senator George Ruby provides invaluable insight to the African American experience during Reconstruction in Texas as a whole. Juxtaposing the needs vocalized by African American communities and the actions taken by Ruby, the Freedmen’s Bureau, and other Texas politicians, helps identify how racial politics dictated the lives of Texas African Americans. Ruby’s rise to power can also be utilized as a historical blueprint for how leaders in marginalized communities can become impactful and obtain power within a racially-biased societal structure. Ruby’s rise and fall in Texas politics is tragic as he finds himself forced to separate from his loyal African American support base—deciding to cater to the needs of elite white Texans to help ensure political favor on both sides of the political and racial spectrum. However, Ruby’s legacy remains one of great success as he managed to break the mold forced upon so many African Americans during Reconstruction and enact lasting change in the marginalized Texas African American communities.
ContributorsCourson, Shawn Thomas (Author) / Schermerhorn, J. (Thesis director) / Delmont, Matthew (Committee member) / School of Politics and Global Studies (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The human hairless gene (HR) encodes a 130 kDa transcription factor that is primarily expressed in the brain and skin. In the promoter and 5'-untranslated regions (5'-UTR) of HR, there are three putative consensus p53 responsive elements (p53RE). p53 is a tumor suppressor protein that regulates cell proliferation, apoptosis, and other cell functions. The p53 protein, a known tumor suppressor, acts as a transcription factor and binds to DNA p53REs to activate or repress transcription of the target gene. In general, the p53 binding sequence is 5'-RRRCWWGYYY-3' where W is A or T, and R and Y are purines or pyrimidines, respectively. However, even if the p53 binding sequence does not match the consensus sequence, p53 protein might still be able to bind to the response element. The intent of this investigation was to identify and characterize the p53REs in the promoter and 5'-UTR of HR. If the three p53REs (p53RE1, p53RE2, and p53RE3) are functional, then p53 can bind there and might regulate HR gene expression. The first aim for this thesis was to clone the putative p53REs into a luciferase reporter and to characterize the transcription of these p53REs in glioblastoma (U87 MG) and human embryonic kidney (HEK293) cell lines. Through the transactivation assay, it was discovered that p53REs 2 and 3 were functional in HEK293, but none of the response elements were functional in U87 MG. Since p53 displayed a different regulatory capacity of HR expression in HEK293 and U87 MG cells, the second aim was to verify whether the p53REs are mutated in GBM U87 MG cells by genomic DNA sequencing.
ContributorsMaatough, Anas (Author) / Neisewander, Janet (Thesis director) / Hsieh, Jui-Cheng (Committee member) / Goldstein, Elliott (Committee member) / School of Life Sciences (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
DescriptionCreated a healthy and affordable snack option for ASU students that would contribute to everyday student activities.
ContributorsRicks, Wyatte (Author) / Cuesta, Carlos (Co-author) / Cuesta, Miguel (Co-author) / Bastuba, Ryan (Co-author) / Szczesniak, Jonathan (Co-author) / Brannan, Colin (Co-author) / Byrne, Jared (Thesis director) / Giles, Bret (Committee member) / Griffin, Joy (Committee member) / Barrett, The Honors College (Contributor) / Engineering Programs (Contributor)
Created2024-05
Description
This thesis paper outlines Nova-six company, an honors thesis project conducted through the Founder’s Lab program at Arizona State University. Nova-six is a multimedia company centered around the space industry. Nova-six’s mission is to ignite Generation Z’s passion for space by reimagining it through the lens of contemporary culture. To this end, Nova-six has developed its brand to be a space-themed streetwear, pop art, and entertainment venture. Through its innovative approach, Nova-six aims to transform the space industry's narrative, making it a central part of today's cultural conversations and inspiring a new generation to explore the final frontier.
ContributorsKovalcik, Richard (Author) / Guttilla, Joshua (Co-author) / Everett, Ryan (Co-author) / Renolds, TJ (Co-author) / Gomez, Dominic (Co-author) / Byrne, Jared (Thesis director) / Giles, Charles (Committee member) / Barrett, The Honors College (Contributor) / Engineering Programs (Contributor)
Created2024-05