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A variety of studies have shown that the tendency toward nicotine dependence has a genetic component. The work described in this thesis addresses three separate questions: i) are there unidentified SNPs in the nicotinic receptors or other genes that contribute to the risk for nicotine dependence; ii) is there evidence of ongoing selection at nicotinic receptor loci; and, iii) since nicotine dependence is unlikely to be the phenotype undergoing selection, is a positive effect on memory or cognition the selected phenotype. I first undertook a genome –wide association scan of imputed data using samples from the Collaborative Study of the Genetics of Nicotine Dependence (COGEND). A novel association was found between nicotine dependence and SNPs at 13q31. The genes at this newly associated locus on chromosome 13 encode a group of micro-RNAs and a member of the glypican gene family. These are among the first findings to implicate a non-candidate gene in risk for nicotine dependence. I applied several complimentary methods to sequence data from the 1000 Genomes Project to test for evidence of selection at the nicotinic receptor loci. I found strong evidence for selection for alleles in the nicotinic receptor cluster on chromosome 8 that confer risk of nicotine dependence. I then used the dataset from the Collaborative Studies on the Genetics of Alcoholism (COGA) and looked for an association between neuropsychological phenotypes and SNPs conferring risk of nicotine dependence. One SNP passed multiple test correction for association with WAIS digit symbol score. This SNP is not itself associated with nicotine dependence but is in reasonable (r 2 = 0.75) LD with SNPs that are associated with nicotine dependence. These data suggest at best, a weak correlation between nicotine dependence and any of the tested cognitive phenotypes. Given the reproducible finding of an inverse relationship between SNPs associated with risk for nicotine dependence and cocaine dependence, I hypothesize that the apparently detrimental phenotype of nicotine dependence may confer decreased risk for cocaine dependence. As cocaine use impairs the positive rewards associated with social interactions, reducing the risk of cocaine addiction may be beneficial to both the individual and the group.
ContributorsSadler, Brooke (Author) / Hurtado, Ana Magdalena (Thesis advisor) / Goate, Alison (Thesis advisor) / Hill, Kim (Committee member) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2014
Description
Recent studies have investigated reproductive coercion, a form of intimate partner violence (IPV) defined as when one partner attempts to control another through pregnancy; however, research has focused only on female victim-survivors. Accordingly, the purpose of this three-paper dissertation was to explore the context of male- and female-perpetrated reproductive coercion via interview data from perpetrators of this abuse. The objective of the first paper was to gain a more complicated understanding of male-perpetrated reproductive coercion, with attention to why the phenomenon only sometimes co-occurs with other forms of IPV. A multiple case study analysis framework was used to interpret interview data from men who self-identified as having perpetrating reproductive coercion (n=5). Several men attempted to impregnate non-consenting partners because they perceived value in fatherhood, or the label of "family man." Many justified their behavior by positioning themselves as the rightful "head of household" and minimized their actions by noting their partners' love for their children. The purpose of the second paper, a close narrative analysis of one male participant's interview (n=1), was to gain deeper understanding of how enactment of a certain type of masculinity influences articulations of power within an intimate relationship. Four interview excerpts were organized into stanzas, which were analyzed for narrative disjuncture as well as minimizations and justifications of coercive behavior, with the finding that desire for biological offspring and enactment of power and control may both be tied to a need to perform masculine identity. Finally, the aim of the third paper was to develop an understanding of the contexts in which women perpetrate reproductive coercion. A modified grounded theory approach was used to interpret interview data from women who self-identified as having perpetrated reproductive coercion (n=8), and an initial explanatory model was developed to illustrate a pathway leading to this behavior. Pregnancy appeared to be a means to end (meeting a critical unmet need) more than an end in itself. Preliminary findings suggest that differences exist between female- and male-perpetrated reproductive coercion. Generalizable research that investigates the function of gender in the perpetration of reproductive coercion can inform the development of targeted, gender-appropriate interventions.
ContributorsThaller, Jonel (Author) / Messing, Jill T (Thesis advisor) / Jackson, Kelly F (Committee member) / Durfee, Alesha (Committee member) / Arizona State University (Publisher)
Created2014
Description
The health situation of indigenous peoples is comparable to that of the world's poorest populations, but with the additional burdens of social and cultural marginalization, geographic and cultural barriers to accessing health services, and, in some areas, appropriation of land and natural resources. Cultural transmission (the transfer of beliefs, ideas, and behaviors from one culture to another) from outsider health institutions should presumably aid in closing this health gap by transferring knowledge, practices, and infrastructure to prevent and treat disease. This study examines the biosocial construction of the disease ecology of tuberculosis (TB) in indigenous communities of the Paraguayan Chaco with varying degrees of cultural transmission from outside institutions (government, religious, and NGOs), to determine the influence of cultural transmission on local disease ecologies. Using a biocultural epidemiological framework for the analysis of human infectious disease ecology, this study employed an interdisciplinary, mixed methods approach to examine the interactions of host, pathogen, and the environment in the Paraguayan Chaco. Three case studies examining aspects of TB disease ecology in indigenous communities are presented: (1) The effective cultural transmission of biomedical knowledge to isolated communities, (2) Public health infrastructure, hygiene, and the prevalence of intestinal parasites: co-morbidities that promote the progression to active TB disease, and (3) Community-level risk factors for TB and indigenous TB burden. Findings from the case studies suggest that greater influence from outside institutions was not associated with greater adoption of biomedical knowledge of TB. The prevalence of helminthiasis was unexpectedly low, but infection with giardia was common, even in a community with cleaner water sources. Communities with a health post were more likely to report active adult TB, while communities with more education were less likely to report active pediatric TB, suggesting that healthcare access is the major determinant of TB detection. More research is needed on the role of non-indigenous community residents and other measures of acculturation or integration in TB outcomes, especially at the household level. Indigenous TB burden in the Chaco is disproportionately high, and better understanding of the mechanisms that produce higher incidence and prevalence of the disease is needed.
ContributorsVansteelandt, Amanda (Author) / Hurtado, Ana Magdalena (Thesis advisor) / Stone, Anne (Thesis advisor) / Hruschka, Daniel (Committee member) / Rojas de Arias, Antonieta (Committee member) / Arizona State University (Publisher)
Created2014
Description
In spite of numerous legal interventions and a fairly strong legal capacity compared to other neighboring countries, Zimbabwean law enforcement and judiciary have failed to overcome Intimate Partner Violence (IPV). This research examines the role of customary law in the continued prevalence of IPV among Zimbabwean women, particularly, the subtle ways in which customary law legitimates the ideals of patriarchal domination in the communal and legal handling of IPV cases. The study utilized qualitative methodology in the form of structured interviews as well as pre-interview questionnaires. Eighteen women who identified as IPV survivors or victims were recruited using snowball sampling method whereby each person interviewed was asked to suggest additional people who were either present victims or survivors of IPV. Five lawyers from Chinhoyi, ten lawyers from Harare, ten police officers from Chinhoyi and ten police officers from Harare were identified using judgement or purposive sampling where subjects are chosen due to availability. The research established that IPV is a way in which abusers exercise their assumed patriarchal rights over women. Likewise, police officers are also influenced by attitudes and mentalities acquired from customary law in the way they handle IPV cases which resultantly leads to secondary victimization of IPV victims. The research concluded that much work still needs to be done by the judiciary, law enforcement and the community to combat the prevalence of IPV in Zimbabwe.
ContributorsMarekera, Shantel (Author) / Durfee, Alesha (Thesis advisor) / Adelman, Madelaine (Committee member) / Kittilson, Miki (Committee member) / Arizona State University (Publisher)
Created2019
Description
Sexual assault at colleges and universities in the United States is a significant health and human rights issue that impacts somewhere between one-in-four and one-in-five students. Despite the alarmingly high burden, overall rates of disclosing to crisis, health, and victim services, and reporting to schools and law enforcement remain low. In order to buffer students from associated short- and long-term harm, and help them reestablish safety and pursue justice, empirically-supported, innovative, and trauma-informed secondary prevention strategies are needed. To address this pressing issue, the current study used a trauma-informed, feminist community research approach to develop and design a prototype of an internet-based decision aid specifically tailored to assist students at Arizona State University who experience sexual assault with making informed choices about reporting and seeking care, advocacy, and support on and off campus. Results from preliminary alpha testing of the tool showed that: 1. It is feasible to adapt decision aids for use with the target population, and 2. While aspects of the tool can be improved during the next phases of redrafting and redesign, members of the target population find it to be acceptable, comprehensible, and usable.
ContributorsVillegas-Gold, Michelle (Author) / Hurtado, Ana Magdalena (Thesis advisor) / Gaughan, Monica (Thesis advisor) / Durfee, Alesha (Committee member) / Arizona State University (Publisher)
Created2018
Description
This study explores the topic of the birth control use of college women, and the factors that influence their decision of whether or not to use contraception consistently. A literature review was performed on Academic Search Premier, SocIndex, Women's Studies International, Pubmed, CINAHL, and ICRW. Interviews were conducted with 7 participants recruited through convenience sampling. The results suggest that low perception of risk, lack of access, and alcohol use are all major influences on women's decisions regarding birth control. A review of current policy was also completed, and potential policy changes are suggested in order to improve college women's consistent contraceptive use.
ContributorsMorehouse, Brittany Anne (Author) / Weitz, Rose (Thesis director) / Durfee, Alesha (Committee member) / School of Politics and Global Studies (Contributor) / School of Social Transformation (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Social media is an increasingly pertinent facet of popular culture. Research has found that a rape culture, a culture that tolerates and condones sexual assault, is evident in many forms of pop culture. This study looks at the way sexual assault is discussed in social media through an examination of Internet memes, trends and images that go viral online. The study found that there is evidence to belief a rape culture exists online. It offers solutions for decreasing incidences of gender-based attacks online.
ContributorsOrtiz, Analise Tomai (Author) / Durfee, Alesha (Thesis director) / McGibbney-Vlahoulis, Michelle (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor)
Created2014-12
Description
Unfortunately, rape has always been a part of war, but recently, media attention has focused on how rape has become a weapon of war on a massive scale. Though wartime rape and sexual assault has come to the forefront of our attention, the theories explaining wartime rape are still not adequate enough to explicate its presence in both the Rwandan and Bosnian Wars. These conflicts were chosen for two reasons. Firstly, they are two of the major conflicts in which rape ahs played a significant part. Secondly, these conflicts played an important role in the transistion in international law from focusing on murders and death to rape and sexual violence. For example, the Jean-Paul Akayesu trial was the first time in which rape was considered a crime against humanity. However, if the ultimate goal is to prevent wartime rape, it is not enough to simply prosecute those who commit it; rather, we must understand the reasons that it occurs. All of the existing theories are partially valid, but none presents a truly holistic explanation for wartime rape. In this paper, I will seek to composite a holistic approach, with the hope that such an approach will prevent the institution of policies that may be either ineffective or counter-productive for the safety of women.
ContributorsBarchilon, Michael (Author) / Durfee, Alesha (Thesis director) / Peskin, Victor (Committee member) / Borg, Stephan (Committee member) / Barrett, The Honors College (Contributor)
Created2009-05
Description
The purpose of this study is to discover the exposure and network patterns during the 2013-2015 Ebola Virus Disease epidemic. The author accomplished this by taking an opportunistic sample of news and academic articles, some of which may also capture cases untreated and therefore unrecorded by hospitals and treatment units. Most of the 315 cases came from the Washington Post, New York Times, and World Health Organization, and they consistently captured between 1-2% of WHO case numbers. The results show that of cases with known exposures, 53.6% became infected through contact with sick family members. Hospital and funeral transmission accounted for the second and third most frequent exposure scenarios at 24.6% and 12.9% respectively. The exposures over time imply that hospital and funeral transmission prevention efforts have been successful, but family transmission has remained common throughout the outbreak. Prevention initiatives should focus on families earlier in epidemics to help control EVD's spread.
ContributorsCleaton, Julie Marie (Author) / Chowell, Gerardo (Thesis director) / Hurtado, Ana Magdalena (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
This study aims to determine if there are differences in body mass index (BMI) across ethnic groups in the United States. Modern medicine is increasingly going the way of personalized medicine, and existing literature has begun to suggest that cultural differences may have an effect on physical health. Initially, this study was to explore anorexia nervosa prevalence, but the data is simply not there; this led to a shift in focus to exploring health differences in terms of BMI. The data analyzed is from the National Health and Nutritional Examination Survey (NHANES) collected by the Centers of Disease Control and Prevention (CDC) from 1999-2013. The subjects used were aged 13-25, and the ethnicities compared were African American, Caucasian American, Mexican American, Other Hispanic American, Asian American, and Other (including multiracial). Statistical tests were run through the software program SAS and included ANOVA tests, t-tests, and z-tests. It was found that there are differences across ethnicities, and that there are far more differences among females than among males. Asian American males and Mexican American males appear to be the groups that caused males to have significant differences. Asian Americans were also found to have the lowest average BMI by far. On the other hand, African Americans and Mexican Americans appeared to have the highest average BMIs. Although these findings and others detailed in the paper are intriguing, the BMI data is not strictly normal, and is still not normalized even by transforming the variable into a log of BMI. The data is still right skewed, and must be attacked in the future with different transformations and non-parametric tests to increase the accuracy and strength of these findings.
ContributorsJohnson, Courtney Elizabeth (Author) / Hurtado, Ana Magdalena (Thesis director) / Samara, Marko (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05