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- Creators: Poulenc, Francis, 1899-1963
Description
Signal processing techniques have been used extensively in many engineering problems and in recent years its application has extended to non-traditional research fields such as biological systems. Many of these applications require extraction of a signal or parameter of interest from degraded measurements. One such application is mass spectrometry immunoassay (MSIA) which has been one of the primary methods of biomarker discovery techniques. MSIA analyzes protein molecules as potential biomarkers using time of flight mass spectrometry (TOF-MS). Peak detection in TOF-MS is important for biomarker analysis and many other MS related application. Though many peak detection algorithms exist, most of them are based on heuristics models. One of the ways of detecting signal peaks is by deploying stochastic models of the signal and noise observations. Likelihood ratio test (LRT) detector, based on the Neyman-Pearson (NP) lemma, is an uniformly most powerful test to decision making in the form of a hypothesis test. The primary goal of this dissertation is to develop signal and noise models for the electrospray ionization (ESI) TOF-MS data. A new method is proposed for developing the signal model by employing first principles calculations based on device physics and molecular properties. The noise model is developed by analyzing MS data from careful experiments in the ESI mass spectrometer. A non-flat baseline in MS data is common. The reasons behind the formation of this baseline has not been fully comprehended. A new signal model explaining the presence of baseline is proposed, though detailed experiments are needed to further substantiate the model assumptions. Signal detection schemes based on these signal and noise models are proposed. A maximum likelihood (ML) method is introduced for estimating the signal peak amplitudes. The performance of the detection methods and ML estimation are evaluated with Monte Carlo simulation which shows promising results. An application of these methods is proposed for fractional abundance calculation for biomarker analysis, which is mathematically robust and fundamentally different than the current algorithms. Biomarker panels for type 2 diabetes and cardiovascular disease are analyzed using existing MS analysis algorithms. Finally, a support vector machine based multi-classification algorithm is developed for evaluating the biomarkers' effectiveness in discriminating type 2 diabetes and cardiovascular diseases and is shown to perform better than a linear discriminant analysis based classifier.
ContributorsBuddi, Sai (Author) / Taylor, Thomas (Thesis advisor) / Cochran, Douglas (Thesis advisor) / Nelson, Randall (Committee member) / Duman, Tolga (Committee member) / Arizona State University (Publisher)
Created2012
Description
Data centers connect a larger number of servers requiring IO and switches with low power and delay. Virtualization of IO and network is crucial for these servers, which run virtual processes for computing, storage, and apps. We propose using the PCI Express (PCIe) protocol and a new PCIe switch fabric for IO and switch virtualization. The switch fabric has little data buffering, allowing up to 512 physical 10 Gb/s PCIe2.0 lanes to be connected via a switch fabric. The switch is scalable with adapters running multiple adaptation protocols, such as Ethernet over PCIe, PCIe over Internet, or FibreChannel over Ethernet. Such adaptation protocols allow integration of IO often required for disjoint datacenter applications such as storage and networking. The novel switch fabric based on space-time carrier sensing facilitates high bandwidth, low power, and low delay multi-protocol switching. To achieve Terabit switching, both time (high transmission speed) and space (multi-stage interconnection network) technologies are required. In this paper, we present the design of an up to 256 lanes Clos-network of multistage crossbar switch fabric for PCIe system. The switch core consists of 48 16x16 crossbar sub-switches. We also propose a new output contention resolution algorithm utilizing an out-of-band protocol of Request-To-Send (RTS), Clear-To-Send (CTS) before sending PCIe packets through the switch fabric. Preliminary power and delay estimates are provided.
ContributorsLuo, Haojun (Author) / Hui, Joseph (Thesis advisor) / Song, Hongjiang (Committee member) / Reisslein, Martin (Committee member) / Zhang, Yanchao (Committee member) / Arizona State University (Publisher)
Created2013
Description
Scarcity of potable water is one of the major problems faced in the world today. Majority of this problem can be solved if technology is developed to obtain potable water from brackish or saline water. The present desalination methods face challenges such as high costs in terms of energy consumption and infrastructure, physical size of the system, requirement of membrane and high pressure systems and hence have been facing various issues in implementation of the same.
This research provides a new low pressure, low energy, portable method to desalinate water without the need for separation membranes, heat or chemical reactions. This method is energy efficient, cost effective, compact, environment friendly and suitable for portable desalination units. This technology, named as Polyphase Alternating current Bi-Ionic Propulsion System (PACBIPS) makes use of polyphase alternating current source to create a gradient in salt concentration. The gradient in salt concentration is achieved due to the creation of a traveling wave which attracts anions on its positive peak (crests) and cations on its negative peak (troughs) and travels along a central pipe thereby flushing the ions down.
Another method of PACBIPS is based on Helmholtz capacitor which involves the formation of an electric double layer between the electrode and electrolyte consisting of equal and opposite ions which can be approximated as a capacitor. Charging and discharging this capacitor helps adsorb the ions onto a carbon electrode which has high surface area and electrical conductivity. This desalinates seawater and provides pure water. Mathematical modeling, analysis and implementation of the two methods have
been presented in this work. The effects of zeta potential, electric field screening, electric mobility on desalination have been discussed.
This research provides a new low pressure, low energy, portable method to desalinate water without the need for separation membranes, heat or chemical reactions. This method is energy efficient, cost effective, compact, environment friendly and suitable for portable desalination units. This technology, named as Polyphase Alternating current Bi-Ionic Propulsion System (PACBIPS) makes use of polyphase alternating current source to create a gradient in salt concentration. The gradient in salt concentration is achieved due to the creation of a traveling wave which attracts anions on its positive peak (crests) and cations on its negative peak (troughs) and travels along a central pipe thereby flushing the ions down.
Another method of PACBIPS is based on Helmholtz capacitor which involves the formation of an electric double layer between the electrode and electrolyte consisting of equal and opposite ions which can be approximated as a capacitor. Charging and discharging this capacitor helps adsorb the ions onto a carbon electrode which has high surface area and electrical conductivity. This desalinates seawater and provides pure water. Mathematical modeling, analysis and implementation of the two methods have
been presented in this work. The effects of zeta potential, electric field screening, electric mobility on desalination have been discussed.
ContributorsKrishna Kashyap, Suhas (Author) / Hui, Joseph (Thesis advisor) / Ayyanar, Raja (Committee member) / Rodriguez, Armando A (Committee member) / Arizona State University (Publisher)
Created2014
Description
In this thesis, a Built-in Self Test (BiST) based testing solution is proposed to measure linear and non-linear impairments in the RF Transmitter path using analytical approach. Design issues and challenges with the impairments modeling and extraction in transmitter path are discussed. Transmitter is modeled for I/Q gain & phase mismatch, system non-linearity and DC offset using Matlab. BiST architecture includes a peak detector which includes a self mode mixer and 200 MHz filter. Self Mode mixing operation with filtering removes the high frequency signal contents and allows performing analysis on baseband frequency signals. Transmitter impairments were calculated using spectral analysis of output from the BiST circuitry using an analytical method. Matlab was used to simulate the system with known test impairments and impairment values from simulations were calculated based on system modeling in Mathematica. Simulated data is in good correlation with input test data along with very fast test time and high accuracy. The key contribution of the work is that, system impairments are extracted from transmitter response at baseband frequency using envelope detector hence eliminating the need of expensive high frequency ATE (Automated Test Equipments).
ContributorsGoyal, Nitin (Author) / Ozev, Sule (Thesis advisor) / Duman, Tolga (Committee member) / Bakkaloglu, Bertan (Committee member) / Arizona State University (Publisher)
Created2011
Description
A unique feature, yet a challenge, in cognitive radio (CR) networks is the user hierarchy: secondary users (SU) wishing for data transmission must defer in the presence of active primary users (PUs), whose priority to channel access is strictly higher.Under a common thread of characterizing and improving Quality of Service (QoS) for the SUs, this dissertation is progressively organized under two main thrusts: the first thrust focuses on SU's throughput by exploiting the underlying properties of the PU spectrum to perform effective scheduling algorithms; and the second thrust aims at another important QoS performance of the SUs, namely delay, subject to the impact of PUs' activities, and proposes enhancement and control mechanisms. More specifically, in the first thrust, opportunistic spectrum scheduling for SU is first considered by jointly exploiting the memory in PU's occupancy and channel fading. In particular, the underexplored scenario where PU occupancy presents a {long} temporal memory is taken into consideration. By casting the problem as a partially observable Markov decision process, a set of {multi-tier} tradeoffs are quantified and illustrated. Next, a spectrum shaping framework is proposed by leveraging network coding as a {spectrum shaper} on the PU's traffic. Such shaping effect brings in predictability of the primary spectrum, which is utilized by the SUs to carry out adaptive channel sensing by prioritizing channel access order, and hence significantly improve their throughput. On the other hand, such predictability can make wireless channels more susceptible to jamming attacks. As a result, caution must be taken in designing wireless systems to balance the throughput and the jamming-resistant capability. The second thrust turns attention to an equally important performance metric, i.e., delay performance. Specifically, queueing delay analysis is conducted for SUs employing random access over the PU channels. Fluid approximation is taken and Poisson driven stochastic differential equations are applied to characterize the moments of the SUs' steady-state queueing delay. Then, dynamic packet generation control mechanisms are developed to meet the given delay requirements for SUs.
ContributorsWang, Shanshan (Author) / Zhang, Junshan (Thesis advisor) / Xue, Guoliang (Committee member) / Hui, Joseph (Committee member) / Duman, Tolga (Committee member) / Arizona State University (Publisher)
Created2012
Description
This thesis aims to investigate the capacity and bit error rate (BER) performance of multi-user diversity systems with random number of users and considers its application to cognitive radio systems. Ergodic capacity, normalized capacity, outage capacity, and average bit error rate metrics are studied. It has been found that the randomization of the number of users will reduce the ergodic capacity. A stochastic ordering framework is adopted to order user distributions, for example, Laplace transform ordering. The ergodic capacity under different user distributions will follow their corresponding Laplace transform order. The scaling law of ergodic capacity with mean number of users under Poisson and negative binomial user distributions are studied for large mean number of users and these two random distributions are ordered in Laplace transform ordering sense. The ergodic capacity per user is defined and is shown to increase when the total number of users is randomized, which is the opposite to the case of unnormalized ergodic capacity metric. Outage probability under slow fading is also considered and shown to decrease when the total number of users is randomized. The bit error rate (BER) in a general multi-user diversity system has a completely monotonic derivative, which implies that, according to the Jensen's inequality, the randomization of the total number of users will decrease the average BER performance. The special case of Poisson number of users and Rayleigh fading is studied. Combining with the knowledge of regular variation, the average BER is shown to achieve tightness in the Jensen's inequality. This is followed by the extension to the negative binomial number of users, for which the BER is derived and shown to be decreasing in the number of users. A single primary user cognitive radio system with multi-user diversity at the secondary users is proposed. Comparing to the general multi-user diversity system, there exists an interference constraint between secondary and primary users, which is independent of the secondary users' transmission. The secondary user with high- est transmitted SNR which also satisfies the interference constraint is selected to communicate. The active number of secondary users is a binomial random variable. This is then followed by a derivation of the scaling law of the ergodic capacity with mean number of users and the closed form expression of average BER under this situation. The ergodic capacity under binomial user distribution is shown to outperform the Poisson case. Monte-Carlo simulations are used to supplement our analytical results and compare the performance of different user distributions.
ContributorsZeng, Ruochen (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Duman, Tolga (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2012
Description
In this thesis, an integrated waveform-agile multi-modal tracking-beforedetect sensing system is investigated and the performance is evaluated using an experimental platform. The sensing system of adapting asymmetric multi-modal sensing operation platforms using radio frequency (RF) radar and electro-optical (EO) sensors allows for integration of complementary information from different sensors. However, there are many challenges to overcome, including tracking low signal-to-noise ratio (SNR) targets, waveform configurations that can optimize tracking performance and statistically dependent measurements. Address some of these challenges, a particle filter (PF) based recursive waveformagile track-before-detect (TBD) algorithm is developed to avoid information loss caused by conventional detection under low SNR environments. Furthermore, a waveform-agile selection technique is integrated into the PF-TBD to allow for adaptive waveform configurations. The embedded exponential family (EEF) approach is used to approximate distributions of parameters of dependent RF and EO measurements and to further improve target detection rate and tracking performance. The performance of the integrated algorithm is evaluated using real data from three experimental scenarios.
ContributorsLiu, Shubo (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Duman, Tolga (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2012
Description
A new type of Ethernet switch based on the PCI Express switching fabric is being presented. The switch leverages PCI Express peer-to-peer communication protocol to implement high performance Ethernet packet switching. The advantages and challenges of using the PCI Express as the switching fabric are addressed. The PCI Express is a high-speed short-distance communication protocol largely used in motherboard-level interconnects. The total bandwidth of a PCI Express 3.0 link can reach as high as 256 gigabit per second (Gb/s) per 16 lanes. Concerns for PCI Express such as buffer speed, address mapping, Quality of Service and power consumption need to be considered. An overview of the proposed Ethernet switch architecture is presented. The switch consists of a PCI Express switching fabric and multiple adaptor cards. The thesis reviews the peer-to-peer (P2P) communication protocol used in the switching fabric. The thesis also discusses the packet routing procedure in P2P protocol in detail. The Ethernet switch utilizes a portion of the Quality of Service provided with PCI Express to ensure guaranteed transmission. The thesis presents a method of adapting Ethernet packets over the PCI Express transaction layer packets. The adaptor card is divided into the following two parts: receive path and transmit path. The commercial off-the-shelf Media Access Control (MAC) core and PCI Express endpoint core are used in the adaptor. The output address lookup logic block is responsible for converting Ethernet MAC addresses to PCI Express port addresses. Different methods of providing Quality of Service in the adaptor card include classification, flow control, and error detection with the cooperation of the PCI Express switch are discussed. The adaptor logic is implemented in Verilog hardware description language. Functional simulation is conducted in ModelSim. The simulation results show that the Ethernet packets are able to be converted to the corresponding PCI Express transaction layer packets based on their destination MAC addresses. The transaction layer packets are then converted back to Ethernet packets. A functionally correct FPGA logic of the adaptor card is ready for implementation on real FPGA development board.
ContributorsChen, Caiyi (Author) / Hui, Joseph (Thesis advisor) / Reisslein, Martin (Committee member) / Zhang, Yanchao (Committee member) / Arizona State University (Publisher)
Created2012
ContributorsPoulenc, Francis, 1899-1963 (Composer)
ContributorsPoulenc, Francis, 1899-1963 (Composer)