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Purpose: To investigate the predictive value of mobility during a hospital stay and patterns of mobility during the month following discharge on hospital readmission and 30-day changes in functional status in older heart failure patients.
Methods: This was a prospective observational study of 21 older (ages 60+) patients admitted with a primary diagnosis of heart failure. Patients wore two inclinometric accelerometers (rib area and thigh) to record posture and an accelerometer placed at the ankle to record ambulatory activity. Patients wore all sensors continuously during hospitalization and the ankle accelerometer for 30 days after hospital discharge. Function was assessed in all patients the day after hospital discharge and again at 30 days post-discharge.
Results: Five patients (23.8%) were readmitted within the 30 day post-discharge period. None of the hospital or post-discharge mobility measures were associated with readmission after adjustment for covariates. Higher percent lying time in the hospital was associated with slower Timed Up and Go (TUG) time (b = .08, p = .01) and poorer hand grip strength (b = -13.94, p = .02) at 30 days post-discharge. Higher daily stepping activity during the 30 day post-discharge period was marginally associated with improvements in SPPB scores at 30 days (b = <.001, p = .06).
Conclusion: For older heart failure patients, increased time lying while hospitalized is associated with slower walking time and poor hand grip strength 30 days after discharge. Higher daily stepping after discharge may be associated with improvements in physical function at 30 days.
Background: Although aerobic exercise has been shown to improve the glycemic control of individuals with type 2 diabetes, a simple and effective approach to manage post-meal glycemic control remains less clear.
Purpose: This study examined the effect of 15-minute of post-meal aerobic exercise on the glycemic control and anxiety scores as compared with control trials in participants with and without type 2 diabetes.
Methods: Six adults volunteered to participate in the study (3 adults with type 2 diabetes, age = 44.33 ± 7.71; and 3 adults without type 2 diabetes, age = 31.67 ± 15.76). All participants received aerobic exercise intervention and control treatments. The aerobic exercise treatment was listening to upbeat music and dancing for 15-minutes, whereas the control participants ingested 1 gram of vitamin C 30-minutes post-meal. Glucose levels were measured at baseline, and the 10, and 15-minute mark in both exercise intervention and control conditions 30-minutes post-meal.
Results: There was a significant interaction between treatment and time on the change in glucose levels (P<0.001). There was a significant mean difference in change in glucose levels between exercise intervention and control conditions (P = 0.002). Change in glucose levels in exercise intervention was significantly decreased at 10-minute (-18 ± 4.35 vs. 1.67 ± 4.34, P = 0.009) and 15-minute (-24 ± 4.88 vs. 5.67 ± 4.88, P = 0.001) compared with control condition. Although there were no statistical differences in state anxiety scores between pre- and post-exercise intervention (p=0.42), there was a significant trend in the reduction of state anxiety scores in diabetic participants, as compared with healthy participants, after 15-minute exercise intervention (-8 vs. -1).
Conclusion: Aerobic exercise for 15-minute by dancing to music after a meal is an effective approach to controlling the blood glucose levels in type 2 diabetic and healthy persons.
Vegetarian diets are typically more sustainable than omnivorous ones due to using less environmental resources in the production of food. An important consideration with plant protein and vegetarian diets, however, is whether this would affect athletic performance. To examine this, 70 male and female endurance athletes were compared for maximal oxygen uptake (VO2 max), peak torque when doing leg extensions, and body composition. Vegetarians had higher VO2 max, but peak torque was not significantly different by diet. Omnivores had higher total body mass, lean body mass, and there was a trend for peak torque to be higher.
To investigate whether plant-protein can comparably support development of lean body mass and strength development in conjunction with strength training, 61 healthy young males and females began a 12-week training and protein supplementation study. While previous training studies have shown no differences for lean body mass or strength development when consuming either soy (plant) or whey (animal) protein supplements in very large amounts (>48 grams), when consuming around 15-20 grams, whey has contributed to greater lean body mass accrual, although strength increases remain similar. The present study matched supplements by leucine content instead of by total protein amount since leucine has been shown to be a key stimulator of muscle protein synthesis and is more concentrated in animal protein. There were no significant differences between the whey or soy group for lean body mass or strength development, as assessed using isokinetic dynamometry doing leg extensions and flexions.
Urologic diseases interstitial cystitis (IC), overactive bladder (OAB), and urinary tract infection (UTI) affect tens of millions of people per year in the US alone. The human microbiome consists of a diverse community of bacteria (bacteriome) and viruses (virome) harbored in each individual that contributes to health and disease. Little is known about how the microbiome impacts urinary disorders. Using next-generation metagenomic sequencing, we characterized the urinary bacteriome and virome of patients with urinary disorders (IC, OAB, and UTI) and healthy controls. We show that the bacteriome was distinctly altered in patients by their respective urinary disorder. IC was characterized by a distinct prevalence of the genus Lactobacillus, while OAB was characterized by the genus Bacteroides, and UTI was characterized by Comamonas. IC, OAB, and UTI all also had significantly differed virome profiles from healthy individuals. In particular, we found that Lactobacillus phages were significantly associated with IC and Corynebacterium virus was associated with UTI samples, meanwhile no particular virus was correlated with OAB samples. Overall, we show that changes in the urinary microbiome are associated with incidence and spectrum of urinary diseases. These findings could lead to new microbiome modalities of treatment.