The Supply Chain of a company is the most critical component of a business as it directly impacts a company’s ability to deliver products/services to customers is a timely, cost effective method. With this amount of importance, a resilient supply chain is pivotal for positive future earnings in each successive quarter. Two pivotal metrics to gauge a Supply Chain include Production Delays and Excess Inventory. Through in-depth analysis, it was found that these metrics had caused abnormal amounts of price volatility with a stock’s performance. Understanding these metrics, the impact and lesson that COVID had taught, and analyzing earnings transcripts of publicly traded company’s demonstrates the use of Supply Chain health in comparison to company performance. This thesis aims to examine how a company's supply chain affects its performance, by analyzing different metrics and disruptions that have caused significant volatility in the stock market. The objective is to help investors maximize their profitability or reduce their risk by identifying the key factors that impact a company's supply chain.

Located directly south of Pima County, Arizona, there is a culturally rich community known as Santa Cruz County, Arizona. Santa Cruz County is a smaller community being home to an estimated 47,000 people. Santa Cruz County has a rich history given its proximity to the United States-Mexico border. One example of this rich history can be found at the Tumacacori National Historical Park (NHP) with the attractive and unique ruins. The Tumacacori NHP was once an active Spanish mission that oversaw the religious expansion and communal resources. While the Tumacacori NHP no longer operates in this manner, it does serve an important role in providing visitors with a diverse and immersive look into the history of the region and the Tumacacori mission. While the Tumacacori NHP is meant to be a place for all people to visit, most visitors are not from the local community. The reason for this stems from a lack of educational and engagement opportunities between the Tumacacori NHP and the community youth, mainly due to community members being unaware of the park’s existence or the programs that are offered. This project analyzes and uncovers this disconnect as well as the barriers between the Tumacacori NHP and the Santa Cruz County youth through a research study and the use of children’s literature.

In response to the Bosnian and Rwandan genocides of the 1990’s, the United Nations created the Responsibility to Protect (R2P) doctrine as part of its 2005 World Summit Outcome document. The goal of R2P is to promote the idea that the international community should act to protect populations from mass atrocity crimes (genocide, crimes against humanity, war crimes, and ethnic cleansing) in the case a State fails to meet their responsibility. This report seeks to examine the Responsibility to Protect principle and see how its concepts are perceived and implemented in the private sector, given the sector’s significant influence in the world today. Using R2P as a frame of reference, I explored the concept that private sector organizations, through their actions and operations, have a responsibility to not profit from or enable systems that perpetuate mass atrocity crimes against populations. This was done through an analysis of private sector firms, regulatory frameworks, industry norms, organization initiatives, and perspectives of actors engaging with the subject matter, in addition to a modern case study regarding the experience of Uighurs and Turkic Muslims in Xinjiang, China. The scope of this project was focused on select American companies that are multinational publicly traded companies with a market capitalization of over $200 billion. This report is meant to serve as a guide for into the concepts of R2P in the private sector and provides access to resources for further exploration.

Influenza virus A (IVA) poses a serious threat to human health, killing over 25,000 Americans in the 2022 flu season alone. In the past 10 years, vaccine efficacy has varied significantly, ranging from 20-60% each season. Because IVA is subject to high antigenic shift and strain cocirculation, more effective IVA vaccines are needed to reduce the incidence of disease. Herein we report the production of a recombinant immune complex (RIC) vaccine “4xM2e” in Nicotiana benthamiana plants using agroinfiltration for use as a potential universal IVA vaccine candidate. RICs fuse antigen to the C-terminus of an immunoglobulin heavy chain with an epitope tag cognate to the antibody, promoting immune complex formation to increase immunogenicity. IVA matrix protein 2 ectodomain (M2e) is selected to serve as vaccine antigen for its high sequence conservation, as only a small number of minor mutations have occurred since its discovery in 1981 in the human sequence. However, there is some divergence in zoonotic IVA strains, and to account for this, we designed a combination of human consensus, swine, and avian M2e variants, 4xM2e. This was fused to the C terminus of the RIC platform to improve M2e immunogenicity and IVA strain coverage. The 4xM2e RIC was produced in N. benthamiana and verified with SDS-PAGE and Western blot assays, along with an analysis of complex formation and the potential for complement activation via complement C1q ELISA. With this work, we demonstrate the potential of RICs and plant-expression systems to generate universal IVA vaccine candidates.

The purpose of this thesis was to understand the importance of supply chain visibility (SCV) and to provide an analysis of the technology available for achieving SCV. Historical events where companies lacked efficient SCV were assessed to understand how errors in the supply chain can have detrimental effects on a company and their reputation. Environmental, social, and governance standards within the supply chain were defined along with the importance of meeting the legal and consumer expectations of a supply chain. There are many different organizations dedicated to helping companies meet ESG standards to achieve ethical, sustainable supply chains. Examples such as the Responsible Business Association and the Organization for Economic Co-Operation and Development were considered. A government solution to SCV, called the Freight Logistics Optimization Works Initiative, considered the importance of data sharing for large companies with complex supply chains, and this solution was assessed for understanding. Current companies and technologies available to achieve SCV were examined for understanding as to how the issue of SCV is currently addressed in the industry. A case study on the company Moses Lake Industries looked at how their complicated chemical manufacturing supply chain has adapted to achieve SCV. This included understanding supplier location, manufacturing processes, and risks. Future technologies that are currently being developed which could further benefit the supply chain industry were considered. Other future considerations, such as the movement of manufacturing out of high risk areas and the need for centralization of SCV solution, were also discussed.