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- Creators: Department of Psychology
- Member of: Theses and Dissertations
- Resource Type: Text
In order to explore this assemblage, this project is organized around four foundational questions: How is mental illness produced, surveilled, and differentially regulated as a social formation within medicine and policy? How does media reproduce and renegotiate these medical and political mental health discourses? How do these mental health discourses intersect with gender, race, and sexuality? How does our assemblage of cultural, medical, and political discourse produce, observe, and regulate intersectional mentally ill subjects in relationship to shifting ideals of normative subjecthood?
This project answers these questions over the course of several case studies, each of which explores a set of thematically linked texts as a window into understanding how mental illness operates intersectionally and biopolitically in cultural discourses and social institutions. The first section establishes a broad theoretical framework for articulating how discourses of gender and sexuality are central to the production of mental illness in the United States today. The second section explores how this intersection of gender, sexuality, and mental illness is observed and regulated through social institutions like the workplace, the nation-state, and the carceral system. The final section explores emergent discourses of mental illness that move us away from centering individual mentally healthy subjects as idealized entities and toward understanding mental and emotional well-being as a collective social enterprise.
To determine if the disruption of the MMR pathway results in the reduced conservation of methylated adenines as well as an increased tolerance for mutations that result in the loss or gain of new GATC sites, we surveyed individual clones isolated from experimentally evolving wild-type and MMR-deficient (mutL- ;conferring an 150x increase in mutation rate) populations of E. coli with whole-genome sequencing. Initial analysis revealed a lack of mutations affecting methylation sites (GATC tetranucleotides) in wild-type clones. However, the inherent low mutation rates conferred by the wild-type background render this result inconclusive, due to a lack of statistical power, and reveal a need for a more direct measure of changes in methylation status. Thus as a first step to comparative methylomics, we benchmarked four different methylation-calling pipelines on three biological replicates of the wildtype progenitor strain for our evolved populations.
While it is understood that these methylated sites play a role in the MMR pathway, it is not fully understood the full extent of their effect on the genome. Thus the goal of this thesis was to better understand the forces which maintain the genome, specifically concerning m6A within the GATC motif.
Past studies have shown that exercise in the form of high intensity interval training (HIIT) is the "ideal form of exercise to improve health and performance without overstressing the immune system" (Fisher et. al, 2011, p. 5). Additionally, HIIT has been found to promote cardiovascular health and immunity (Fisher et. al, 2011). The proposed study will evaluate the neuropsychological effects of HIIT on breast cancer patients undergoing anthracycline-based chemotherapy. The intervention group (n = 17) will receive a HIIT protocol concurrent with chemotherapy treatment. There will also be a control group (n= 17) to compare the effects of the intervention. Breast cancer survivorship is often ridden with various health and mental problems, the implementation of HIIT procedures could help to reduce these issues. It is expected that knowledge from this study will be useful in the healthcare setting to benefit breast cancer patients. This study will uniquely add to the limited research base by introducing an intervention for neuropsychological declines in breast cancer patients.