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- Creators: School of Life Sciences
- Creators: Department of Finance
- Resource Type: Text
Description
This thesis discusses the complex situation involved in a person’s choice or means to vaccinate
themselves as well as their children. Included is a brief history on vaccines, a section describing
their mechanism of action, as well as information on how the vaccines work within our bodies.
The focus will then turn to the patient’s choice on whether or not to vaccinate themselves or their
child, including factors such as socioeconomic status, education level and their location. Within
this paper are the views of anti-vaccinators, as well as the views of pro-vaccinators and
suggestions on how to reeducate the public. I conclude that the AFIX model is of particular value
in public education: This involves Assessment of immunization coverage, Feedback in
informing providers of their performance, Incentives to help keep them motivated, and eXchange
of information which can be combined with incentives. While the AFIX model has focused on
doctors and nurses in the past, I conclude this model would be most effectively employed with
pharmacists, who see patients more routinely and often have higher levels of trust among the
general public.
themselves as well as their children. Included is a brief history on vaccines, a section describing
their mechanism of action, as well as information on how the vaccines work within our bodies.
The focus will then turn to the patient’s choice on whether or not to vaccinate themselves or their
child, including factors such as socioeconomic status, education level and their location. Within
this paper are the views of anti-vaccinators, as well as the views of pro-vaccinators and
suggestions on how to reeducate the public. I conclude that the AFIX model is of particular value
in public education: This involves Assessment of immunization coverage, Feedback in
informing providers of their performance, Incentives to help keep them motivated, and eXchange
of information which can be combined with incentives. While the AFIX model has focused on
doctors and nurses in the past, I conclude this model would be most effectively employed with
pharmacists, who see patients more routinely and often have higher levels of trust among the
general public.
ContributorsBernal-Fung, Yasmin (Author) / Martin, Thomas (Thesis director) / Morgan, Lawrence (Committee member) / School of Life Sciences (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The National Basketball Association is a star driven league, more so than any other sports league in the world. Basketball is played with five players on the court at a time, with rotations of eight or nine players being commonplace for most teams. Compared to a sport such as football where there are eleven starters on defense and eleven starters on offense, it makes sense that a single player in basketball will have more impact on the game than a single player in football. Players such as James Harden and LeBron James create top teams in the league that would otherwise be mediocre because of the presence that they bring to the basketball court.
Every owner and general manager of every team in the National Basketball Association desires a superstar that can vault a franchise to the next level. This is easier said than done. There are only a limited number of franchises that can attract stars through free agency, and teams do not often give up their best players through trades. Even when a star does become available through trade, the price to acquire that star is often so steep that the team trading for him fails to improve in the process. While one player can have a huge impact in basketball, it is still necessary to surround that player with players that have a proper skillset. For James Harden and LeBron James to have the most impact on the court, it is best to surround them with good three-point shooters that can give them space to drive to the rim and provide them with the option to pass the ball out to the perimeter.
Every owner and general manager of every team in the National Basketball Association desires a superstar that can vault a franchise to the next level. This is easier said than done. There are only a limited number of franchises that can attract stars through free agency, and teams do not often give up their best players through trades. Even when a star does become available through trade, the price to acquire that star is often so steep that the team trading for him fails to improve in the process. While one player can have a huge impact in basketball, it is still necessary to surround that player with players that have a proper skillset. For James Harden and LeBron James to have the most impact on the court, it is best to surround them with good three-point shooters that can give them space to drive to the rim and provide them with the option to pass the ball out to the perimeter.
ContributorsKnowlton, Bradley Edward (Author) / Simonson, Mark (Thesis director) / Hoffmeister, J (Committee member) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
DescriptionSulforaphane(SFN)isanisothiocyanate(ITC)derivedfromcruciferousvegetables,suchas
broccoli,thatisgrowinginpopularityforitsantioxidantandanti-inflammatorycapabilities.
Furthermore,SFNhasbeendemonstratedtoimproverenalcancercarcinoma(RCC)treatment
outcomesinconjunctionwithmultipleotherformsoftherapy,whichisespeciallyimportant
consideringRCC’spoortherapeuticoutcomeswithchemotherapy.Theaimofthisstudywasto
determinetheeffectsofSFNonRCC invitro utilizingcellviabilityanalysisandLC/MS-MS
targetedmetabolicprofilingtorevealpathwaysresponsibleforSFN’spossibleenhancementof
chemotherapytreatmentinRCC.CCK-8resultsshowthat15 μMofSFNcausedasignificant(p
<0.05)increaseinRCCproliferation.Kruskal-Wallistestsrevealed16metabolitesinourcell,
and28inthemediumtobesignificant(p<0.05).Anorthogonalpartialleastsquares-discriminant
analysis,OPLS-DA,ofsignificantmetaboliteswasusedtocomparedtreatedandnon-treated
samplesforbothdatasetsandshoweda100%predictiveaccuracy(AUC=1).Enrichment
analysisdeterminedthatatotalof7metabolicpathwaysweresignificantlyenriched(VLCFA
β-oxidation,glutamatemetabolism,theureacycle,ammoniarecycling,glycine/serine,alanine,
andglucose-alaninecycle).Pathwayanalysisshowedhistidinemetabolismtobetheonly
significantlyaffectedpathwaybetweenbothdatasets.SFN-inducedmetaboliccharacteristics
foundinRCCwereconsistentwithknownantioxidantandanti-inflammatorypathways.Ourdata
suggeststhatthetherapeuticmechanismsofSFNarelikelyduetointeractionswithTandNKT
cellsthatprotectthemfromoxidativestress.Futureexperimentsregardingantioxidantresearch
incancershouldbecompletely invivo,asopposedto invitro, inordertomaintainthenatural
physiology of cancer cells in the presence of host immune cells.
broccoli,thatisgrowinginpopularityforitsantioxidantandanti-inflammatorycapabilities.
Furthermore,SFNhasbeendemonstratedtoimproverenalcancercarcinoma(RCC)treatment
outcomesinconjunctionwithmultipleotherformsoftherapy,whichisespeciallyimportant
consideringRCC’spoortherapeuticoutcomeswithchemotherapy.Theaimofthisstudywasto
determinetheeffectsofSFNonRCC invitro utilizingcellviabilityanalysisandLC/MS-MS
targetedmetabolicprofilingtorevealpathwaysresponsibleforSFN’spossibleenhancementof
chemotherapytreatmentinRCC.CCK-8resultsshowthat15 μMofSFNcausedasignificant(p
<0.05)increaseinRCCproliferation.Kruskal-Wallistestsrevealed16metabolitesinourcell,
and28inthemediumtobesignificant(p<0.05).Anorthogonalpartialleastsquares-discriminant
analysis,OPLS-DA,ofsignificantmetaboliteswasusedtocomparedtreatedandnon-treated
samplesforbothdatasetsandshoweda100%predictiveaccuracy(AUC=1).Enrichment
analysisdeterminedthatatotalof7metabolicpathwaysweresignificantlyenriched(VLCFA
β-oxidation,glutamatemetabolism,theureacycle,ammoniarecycling,glycine/serine,alanine,
andglucose-alaninecycle).Pathwayanalysisshowedhistidinemetabolismtobetheonly
significantlyaffectedpathwaybetweenbothdatasets.SFN-inducedmetaboliccharacteristics
foundinRCCwereconsistentwithknownantioxidantandanti-inflammatorypathways.Ourdata
suggeststhatthetherapeuticmechanismsofSFNarelikelyduetointeractionswithTandNKT
cellsthatprotectthemfromoxidativestress.Futureexperimentsregardingantioxidantresearch
incancershouldbecompletely invivo,asopposedto invitro, inordertomaintainthenatural
physiology of cancer cells in the presence of host immune cells.
ContributorsHrovat, Jonathan Matthew (Co-author) / Bresette, William (Co-author) / Gu, Haiwei (Thesis director) / Jasbi, Paniz (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
REACT is a student-led venture which strives to address the healthcare disparities from geographic, linguistic and cultural isolation of the refugee community in Arizona/Phoenix. We will achieve this by Understanding the needs of the community, Engaging the community directly, Educating through the use of culturally appropriate materials, and providing access to supplemental Patient Care.
This venture is unique in that it is an interdisciplinary fusion between students, health professionals, and non-profit organizations empowering underserved refugees. A refugee is an individual forced to leave their country because of persecution, war, or violence. Once they arrive in the United States, they are forced to restart their lives, often with little to no financial assets, minimal English literacy, and a lack of transferable skills from their previous occupations in their home countries. In addition to these socioeconomic disparities, it is common for refugees to face health disparities. Consequently, refugees are one of the most vulnerable populations in our society.
Our organization provides value to the refugee community through our three key services. These are made up of supplemental resources, educational workshops, and clinical services. Our supplemental materials include resources that our clients will use after they have left our care to further improve their health and quality of life. These items include personal hygiene kits, informational pamphlets, and nutritional foods.
The educational workshops we provide specifically address identified knowledge gaps that impede the autonomy of our clients’ health and wellbeing. Several of the topics that we cover (but are not limited to) are diabetes, postpartum depression, nutrition, dental hygiene, AHCCCS, and nutrition. The clinical services that the clinic will provide will be supplementary primary care services that will encompass basic physical exams, A1C blood pressure checks, and vaccinations. These services all are aimed at alleviating the barriers to health that refugees face and ultimately improve their quality of life.
Our venture seeks to maintain positive and sustained relationships with our client segments through continuous community engagement. In conjunction with providing educational workshops and clinical care in the future, REACT continually engages the community by planning formal and informal programming with the refugees based on the needs and wishes of individual communities.
REACT generates these services through the work of medical students from Mayo Clinic Alix School of Medicine and undergraduates from Arizona State University. Our team brings together the experience from hundreds of hours of work in the community, collaborations with refugee community leaders, and the insight of professionals in the healthcare/social-work industry.
Further, our members have had extensive experience working with refugees, training in culturally sensitive practices, and delivering care to those that need it most. With the cost of healthcare exponentially rising, there is little hope for refugees to find adequate culturally competent healthcare. This leads to an increase in chronic diseases, preventable health issues, and increased hospitalization costs. Supporting REACT is not only an investment in the health of the refugees but the health of our entire healthcare system.
This venture is unique in that it is an interdisciplinary fusion between students, health professionals, and non-profit organizations empowering underserved refugees. A refugee is an individual forced to leave their country because of persecution, war, or violence. Once they arrive in the United States, they are forced to restart their lives, often with little to no financial assets, minimal English literacy, and a lack of transferable skills from their previous occupations in their home countries. In addition to these socioeconomic disparities, it is common for refugees to face health disparities. Consequently, refugees are one of the most vulnerable populations in our society.
Our organization provides value to the refugee community through our three key services. These are made up of supplemental resources, educational workshops, and clinical services. Our supplemental materials include resources that our clients will use after they have left our care to further improve their health and quality of life. These items include personal hygiene kits, informational pamphlets, and nutritional foods.
The educational workshops we provide specifically address identified knowledge gaps that impede the autonomy of our clients’ health and wellbeing. Several of the topics that we cover (but are not limited to) are diabetes, postpartum depression, nutrition, dental hygiene, AHCCCS, and nutrition. The clinical services that the clinic will provide will be supplementary primary care services that will encompass basic physical exams, A1C blood pressure checks, and vaccinations. These services all are aimed at alleviating the barriers to health that refugees face and ultimately improve their quality of life.
Our venture seeks to maintain positive and sustained relationships with our client segments through continuous community engagement. In conjunction with providing educational workshops and clinical care in the future, REACT continually engages the community by planning formal and informal programming with the refugees based on the needs and wishes of individual communities.
REACT generates these services through the work of medical students from Mayo Clinic Alix School of Medicine and undergraduates from Arizona State University. Our team brings together the experience from hundreds of hours of work in the community, collaborations with refugee community leaders, and the insight of professionals in the healthcare/social-work industry.
Further, our members have had extensive experience working with refugees, training in culturally sensitive practices, and delivering care to those that need it most. With the cost of healthcare exponentially rising, there is little hope for refugees to find adequate culturally competent healthcare. This leads to an increase in chronic diseases, preventable health issues, and increased hospitalization costs. Supporting REACT is not only an investment in the health of the refugees but the health of our entire healthcare system.
ContributorsMarostica, Chance William (Author) / Ferry, Lara (Thesis director) / Smith, Diana (Committee member) / Economics Program in CLAS (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Whistleblowing in Biomedical Research and Medicine: An Analysis of Ethical Expectations and Dilemmas
Description
In biomedical research institutions and medical institutions alike, whistleblowing, or the reporting of misconduct, has been severely retaliated against. Whistleblowers report misconduct by adhering to institutional whistleblowing policies, and do so in order to maintain ethical practice within their institution; it is important to note that by taking this ethical action, whistleblowers are aiming to protect the future of biomedical research and medicine. Despite these intentions, whistleblowing has developed a negative stigma due to the misconception that whistleblowers have self-proclaimed authority and are unable to function as part of a team. The retaliation against whistleblowers has been connected to psychological and professional fallout for the whistleblower, and it has been found that many whistleblowers suffer as a direct result of a lack of institutional support. The problems with whistleblowing culture demonstrate issues surrounding how ethics are maintained in institutions, who ethics policies apply to, and who has authority. The retaliation seen against whistleblowers outlines inherent institutional failures, and highlights the need for institutional change in order to both promote ethical practice and protect the whistleblowers who adhere to ethics policies. This thesis discusses such failures in detail, and outlines several broad solutions in order to combat this issue.
ContributorsTaylor, Kylee Anne (Author) / Robert, Jason (Thesis director) / Ellison, Karin (Committee member) / Johnson, Nate (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The Innovation Space program is a joint venture among the Herberger Institute for Design and the Arts, Ira A. Fulton Schools of Engineering and W.P. Carey School of Business in order for transdisciplinary students to develop a product that creates social change. LG was the sponsor for 2018-2019 class with the goal of creating comfortable cooling that is better for the environment. Throughout seven phases, the Sumo team developed three product ideas, selected one product idea, developed a business plan and implementation plan. The Ciel vent system was picked and tested for any assumptions made in the initial business plan. After adjustments were made to the final phase seven business plan, a reflection was completed about the W. P. Carey School of Business and Innovation Space experience.
ContributorsHarris, Madison Nicole (Author) / Rhett, Trujillo (Thesis director) / Craig, Hedges (Committee member) / Department of Finance (Contributor) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
In our exponentially expanding world, the knowledge of a group versus that of an individual is more relevant than ever. Social insects have evolved to rely on the information from the collective, and in the case of harvester ants, their choice revolves around the best seeds to collect.
The objective of this experiment is to study a colony’s seed preference following previous exposure to a seed type in the seed harvester ant Pogonomyrmex californicus. It was hypothesized that foragers would demonstrate a measurable preference for the seed type they had previously experienced over the novel seed type. The cuticular hydrocarbon profile is suspected to be an influence in the foragers’ seed selection. Following an incubation period with the designated seed type, a series of preference trials were conducted over the course of two days for two experiments in which each colony fragment was given a seed pile with a 1:1 ratio of niger and sesame, after which any seeds moved off the seed pile were determined to be chosen, as well as if the workers were observed moving the seeds off the pile from the video recordings. Using video recordings, the seed selections of individual foragers were also tracked. The results partially support the hypothesis, however, in some cases, the ants did not collect enough seeds for the preference to be significant, and not all colony fragments had preferences that lined up with what they had previously experienced according to their treatment. Familiarity with the hydrocarbon profile of the seed type the colony had experienced is a possible proximal explanation for why colonies had seed preferences that aligned with their treatment, the seed they were designated to experience. Due to the low quantity of seeds collected during preference trials, seed preference amongst individual foragers remains unclear due to many different foragers selecting a seed during only one trial, with very few foragers returning to forage for seeds over the course of the experiment.
The objective of this experiment is to study a colony’s seed preference following previous exposure to a seed type in the seed harvester ant Pogonomyrmex californicus. It was hypothesized that foragers would demonstrate a measurable preference for the seed type they had previously experienced over the novel seed type. The cuticular hydrocarbon profile is suspected to be an influence in the foragers’ seed selection. Following an incubation period with the designated seed type, a series of preference trials were conducted over the course of two days for two experiments in which each colony fragment was given a seed pile with a 1:1 ratio of niger and sesame, after which any seeds moved off the seed pile were determined to be chosen, as well as if the workers were observed moving the seeds off the pile from the video recordings. Using video recordings, the seed selections of individual foragers were also tracked. The results partially support the hypothesis, however, in some cases, the ants did not collect enough seeds for the preference to be significant, and not all colony fragments had preferences that lined up with what they had previously experienced according to their treatment. Familiarity with the hydrocarbon profile of the seed type the colony had experienced is a possible proximal explanation for why colonies had seed preferences that aligned with their treatment, the seed they were designated to experience. Due to the low quantity of seeds collected during preference trials, seed preference amongst individual foragers remains unclear due to many different foragers selecting a seed during only one trial, with very few foragers returning to forage for seeds over the course of the experiment.
ContributorsNewton, Natalie Nicole (Author) / Fewell, Jennifer (Thesis director) / Steven, Pratt (Committee member) / Ioulia, Bespalova (Committee member) / School of Art (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Many young people from The Gambia have been migrating illegally by routes through the desert to get to Libya and across the Mediterranean Sea to get to Italy. This is called back-way migration. A fair number of articles have been written that focus on the migrants leaving; however, the story that is not being told as often is about the families they leave behind. This thesis seeks to explore the everyday problems that occur to the families left behind and the country at large, as a result of the mass exodus of young people.
ContributorsDaramy, Mohammed K (Author) / Bhattacharjya, Nilanjana (Thesis director) / Shaw-Smith, Lynette (Committee member) / School of Sustainability (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The number of cancer survivors in the United States is growing rapidly and it is expected to double by 2040. Arizona is nationally ranked with the 14th highest number of survivors, many of which experience a wide range of persisting medical complications that result from the cancer and associated treatment. Consequently, there is an increased need for services tailored to the health and wellness of survivors. Studies have shown that exercise rehabilitation is effective in improving the physical and mental health of this patient population. This project aimed to investigate the status of medically-based exercise rehabilitation for cancer survivors in Arizona. It focused on services offered by cancer treatment centers and cardiac rehabilitation clinics, with cardiac rehabilitation providing a possible delivery method for future cancer exercise rehabilitation. A directory of resources was compiled based on responses to structured telephone interviews with the cancer treatment centers (n=32) and cardiac rehabilitation clinics (n=34) within the state. The directory will serve as a resource for both patients and clinicians by identifying statewide related services that are available at the medical institutions and within the community. Results showed that 42.9% and 39.4% of the cancer treatment centers and cardiac rehabilitation clinics, respectively, offered exercise related services for cancer survivors. 78.6% of cancer centers stated that they refer cancer survivors to physical therapy, while only 35.7% refer survivors to community-based programs. Only 2 cardiac rehabilitation clinics, or 6%, offered preventative cardiology exercise consultations to cancer survivors. In conclusion, rehabilitative exercise resources for cancer survivors in Arizona were limited. Additional cancer rehabilitation efficacy studies are needed to further clarify evidence-based practice guidelines and provide direction for optimal methods of healthcare delivery. It is recommended that this directory remains current with routine updates in an effort to increase patient accessibility to care.
ContributorsHitt, Ellen (Author) / Scales, Robert (Thesis director) / Huberty, Jennifer (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
Description
Schools across the United States have been subject to a rise in violent incidents since 2013. Reading about school shootings, racist acts, and violent demonstrations in schools has unfortunately become commonplace, which is contributing to inequitable outcomes for some student populations. These equity gaps have triggered demands for more equitable solutions in schools, a responsibility that falls on the shoulders of stakeholders like school governing boards, principals, and parents.
Chandler Unified School District (CUSD), a large school system in Arizona that serves 45,000 students from preschool through high school, has been unable to escape similar structural and frictional inequities within its schools. One instance of a racially charged student performance at Santan Middle School motivated CUSD to take a more immediate look at equity in the district. It is during this response that our team of New Venture Group consultants engaged with Matt Strom, Assistant Superintendent of CUSD, in analyzing the important question of “how CUSD can take steps towards closing equity gaps within the district?”
CUSD defines an equity gap as any difference in student opportunity, achievement, discipline, attendance, etc. contributable to a student’s ethnicity, gender, or socioeconomic status. Currently, certain student populations in CUSD perform vastly different academically and receive different opportunities within schools, but as was our problem statement, CUSD is aiming to reduce (and eventually close) these gaps.
Our team approached this problem in three phases: (1) diagnosis, (2) solution creation, and (3) prevention. In phase one, we created a dashboard to help principals easily and visually identify gaps by toggling parameters on the dashboard. Phase two focused on the generation of recommendations for closing gaps. To achieve this goal, a knowledge of successful gap-closing strategies will be paired with the dashboard. In our final phase, the team of consultants created a principal scorecard to ensure equity remains a priority for principals.
Chandler Unified School District (CUSD), a large school system in Arizona that serves 45,000 students from preschool through high school, has been unable to escape similar structural and frictional inequities within its schools. One instance of a racially charged student performance at Santan Middle School motivated CUSD to take a more immediate look at equity in the district. It is during this response that our team of New Venture Group consultants engaged with Matt Strom, Assistant Superintendent of CUSD, in analyzing the important question of “how CUSD can take steps towards closing equity gaps within the district?”
CUSD defines an equity gap as any difference in student opportunity, achievement, discipline, attendance, etc. contributable to a student’s ethnicity, gender, or socioeconomic status. Currently, certain student populations in CUSD perform vastly different academically and receive different opportunities within schools, but as was our problem statement, CUSD is aiming to reduce (and eventually close) these gaps.
Our team approached this problem in three phases: (1) diagnosis, (2) solution creation, and (3) prevention. In phase one, we created a dashboard to help principals easily and visually identify gaps by toggling parameters on the dashboard. Phase two focused on the generation of recommendations for closing gaps. To achieve this goal, a knowledge of successful gap-closing strategies will be paired with the dashboard. In our final phase, the team of consultants created a principal scorecard to ensure equity remains a priority for principals.
ContributorsFerrara, Justin Christopher (Co-author) / Lee, Cynthia (Co-author) / Weston, Joshua (Co-author) / Licon, Wendell (Thesis director) / Strom, Matthew (Committee member) / Department of Economics (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Information Systems (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12