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- Creators: Dean, W.P. Carey School of Business
- Resource Type: Text
- Status: Published
Description
Alzheimer’s disease (AD) is characterized by the aberrant accumulation and aggregation of proteins that in turn contribute to learning and memory deficits. The mammalian target of rapamycin (mTOR) plays an essential role in regulating the synthesis and degradation of proteins that contribute to cell growth and learning and memory. Hyperactivity of mTOR can cause detrimental effects to protein homeostasis and has been linked to AD. The proline-rich Akt-substrate 40 kDa (PRAS40) is a negative regulator of mTOR, as it binds to mTOR directly, reducing its activity. Upon phosphorylation, PRAS40 detaches from mTOR thereby releasing its inhibitory effects. Increased phosphorylation of PRAS40, and a subsequent increase in mTOR activity has been linked to diabetes, cancer, and other conditions; however, PRAS40’s direct role in the pathogenesis of AD is still unclear. To investigate the role of PRAS40 in AD pathology, we generated a PRAS40 conditional knockout mouse model and, using a neuronal-specific Cre recombinase, selectively removed PRAS40 from APP/PS1 mice. Removing neuronal PRAS40 exacerbated Abeta levels and plaque load but paradoxically had no significant effects on mTOR signaling. Mechanistically, the increase in Abeta pathology was linked to a decrease in autophagy function. Our data highlight a primary role of PRAS40 in the pathogenesis of AD.
ContributorsSurendra, Likith (Author) / Oddo, Salvatore (Thesis director) / Velazquez, Ramon (Committee member) / Pratico, Domenico (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The purpose of this research is to discuss and analyze the arguments found in animal-dependent research debates that are formed from the use of speciesism and liberationism. Speciesism is often used to draw distinctions between humans and nonhuman animals in an attempt to lessen or eliminate nonhuman animals from their inclusion in the human moral scope. On the other hand, liberationism is commonly used to argue that nonhuman animals should be included in the human moral scope by claiming that certain characteristics of nonhuman animals are morally important. Although it is not possible to include every viewpoint and style of argument created through the use of these two ideologies, I believe that the two chosen texts accurately represent the arguments made by the majority of those that endorse either one. With that said, both ideologies seek to either justify or condemn certain types of human action that affect nonhuman animals. Through the analysis of the speciesist and liberationist arguments, it has become evident that both speciesism and liberationism are ultimately lacking in their ability to justify or condemn human action that affects nonhuman animals. This discovery led to the creation of a speciesist/liberationist hybrid ideology that seeks to combine the most convincing features of each while avoiding most of the issues associated with either one. The result is a new theory that is able to produce more convincing justifications in regards to how humans ought to treat nonhuman animals.
ContributorsFuller, Stephen (Author) / Creath, Richard (Thesis director) / Minteer, Ben (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
In the Film and Media industries, it seems like it is completely male dominated both on and off the screen. With movements like Me Too and See Her it is important now, more than ever to make a change in the film industry. These movements have been great sparks to create changes in the field which lead to having more representation of women both on and off the screen and in film, tv and media. In my personal experience, when you are a woman on a film set it feels like you can get incredibly overshadowed or if you try to stand up for an idea you could be called bossy. A female mindset on a set, in major positions, seems like it can only be a good thing. Whether that is true or not there have been so few experiences and records of how an all-female set is ran. There is lot of fear that goes into running a set. Many women feel like they cannot handle the environment of a film set because of a certain stigma and stereotype of women in powerful positions. Women, while not always true, can be more understanding when difficult circumstances arise. The gender bias for larger film crews is almost 75 % male, this is a statistic that needs to change soon. It is important to teach the new generation that women in powerful creative roles in film is a normal occurrence and the only way we can get there is being more conscious about who is on our sets.
ContributorsSmith, Mallory Keller (Author) / Scott, Jason (Thesis director) / Lunde, Julia (Committee member) / School of Film, Dance and Theatre (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Department of Marketing (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Individuals with Down syndrome (DS) display significantly earlier symptoms of Alzheimer's disease (AD) beginning around age 35. Because AD-like symptoms tend to be ever present in those with DS, it is difficult to accurately evaluate those with DS for earlier onset of AD. It has been suggested that physical activity and sleep are potential measures to monitor for manifestations of early AD-like symptoms in people with DS. Our lab has previously shown remarkable improvements in physical activity, cognition, and motor control while using Assisted Cycle Therapy (ACT) for adolescents with DS, Parkinson's disease (PD), and stroke populations. This novel exercise intervention is suggested to mediate improvements in cerebral activation through upregulated neurogenesis, angiogenesis, and neuro-plastic mechanisms. Despite prior research, there remains to be limited studies behind these concepts in adults with DS and sleep, which is suspected to be an accurate metric for AD-like manifestations. Fifteen older adult participants with DS were assigned to one of two cycling interventions: ACT or VC. All participants were provided Fitbit HR devices for sleep and physical activity tracking. Only five adults had viable continuous collection of data for both sleep and physical activity. While none of our results reached conventional levels of significance, there were trends towards significance in the VC group for total steps taken and in the ACT group for sleep-onset latency (SOL). Individual cases of improvement were noted but it globally can be supported that Fitbit devices are not optimistic for adults with DS due to poor long-term compliance. It comes to no surprise to those involved with these groups that cooperativity tends to be low with long term interventions in research design. In spite of this significant barrier, Fitbit devices offer to be a reliable and inexpensive record keeper of physical activity and sleep. Future research should lean to investigate the viability of Fitbit devices within younger populations, the role of heart rate variability on sleep efficiency and sleep onset latency in DS, and utilize more extensive compliance reinforcement to obtain volume of data collection needed to establish significant measurements of physical activity and sleep in populations with DS.
ContributorsDietz, Matthew David (Author) / Ringenbach, Shannon (Thesis director) / Holzapfel, Simon (Committee member) / School of Nutrition and Health Promotion (Contributor) / School of Molecular Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Our lives are documented and facilitated by the internet. Given that an increasing proportion of time is being spent online, search and browsing history offers a unique frame of reference to conduct a qualitative study since it contains individual goals, day-to-day experiences, illicit thoughts, and questions, all while capturing sentiments rather than statistics. Seeing this recorded daily activity mapped out over the course of several years would hopefully provide a startling reminder of how life can be accurately and simply described as a series of constantly evolving interests and intentions, as well as give a sense of how exhaustively massive internet companies collect private information online. The search engine giant Google offers its users the transparency and freedom to export and download an archive of their web activity through a service known as Google Takeout. We propose using this service to empower ordinary individuals with Google accounts by developing a comprehensive and qualitative approach to understanding and gaining insights about their personal behavior online. In this paper, we first define and analyze the need for such a product. Then we conduct a variety of intent and interest-sensitive computational analysis methods on a sample browser history to explore and contextualize emergent trends, as a proof of concept. Finally, we create a blueprint for building an interactive application which uses our approach to generate dynamic dashboards and unique user profiles from search and browsing data.
ContributorsLi, Jason (Author) / Sopha, Matthew (Thesis director) / Shutters, Shade (Committee member) / Department of Information Systems (Contributor, Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
In this world of fading trends, a fear of missing out, and the next best thing, people crave lasting connection and authenticity. Music festivals are multi day musical and social events that have to power to bring people together for a ritualistic experience providing a meaningful awakening for each individual attendee. Peoples identity can be validated in the affirmative social negotiation and a safe environment - just so at a music festival. The ritual that exists at festivals through the actions attendees make all combine into an incomparable experience aiding them in their own personal growth and their connection to others and their surroundings. With the support of survey data on music festivals, the best changes to festival production would be the implementation of more purposeful activities to contribute to the ritual and meaning for attendees, as well as marketing content which showcases the elements of community, art and music, rather than the regular sales pitch. This shift of marketing content would set a positive tone for the given music festival, which is crucial in ensuring attendees arrive with good intentions and have that transformative experience to expand themselves and feel connected.
ContributorsPatterson-Gonzales, Ariel Christine (Author) / Gray, Nancy (Thesis director) / Nowak, Timothy (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This study aims to identify the potential irrationality in the personal investment decision-making habits of university students, as influenced by the framing effect, loss aversion, and related heuristics. Researchers conducted a cross-sectional study of 114 students (n = 102). Participants responded to a survey regarding their willingness to invest in certain hypothetical investment scenarios. Outcome was measured primarily using Likert scales and yes
o binomial options regarding the participant’s willingness to participate in a specific deal. The study was broken into three blocks, the first of which dealt with the framing effect and the subsequent two considered loss aversion. Of the data collected, there were multiple significant results found to support the framing effect and loss aversion. There was a significant difference between responses that were positively and negatively framed, and between varying upside potential in equivalent-risk scenarios. For block one, those participants who received the positive framing condition were more likely to invest in the master’s program than those who received the negative framing condition. For blocks two and three, the majority of participants exhibited loss averse behavior more extreme than the predicted amounts; closer to 4x the upside was required (rather than the predicted 2x) for the participants to participate in the deal. Although the results did replicate the framing effect and loss aversion, college students were more loss averse than was predicted.
o binomial options regarding the participant’s willingness to participate in a specific deal. The study was broken into three blocks, the first of which dealt with the framing effect and the subsequent two considered loss aversion. Of the data collected, there were multiple significant results found to support the framing effect and loss aversion. There was a significant difference between responses that were positively and negatively framed, and between varying upside potential in equivalent-risk scenarios. For block one, those participants who received the positive framing condition were more likely to invest in the master’s program than those who received the negative framing condition. For blocks two and three, the majority of participants exhibited loss averse behavior more extreme than the predicted amounts; closer to 4x the upside was required (rather than the predicted 2x) for the participants to participate in the deal. Although the results did replicate the framing effect and loss aversion, college students were more loss averse than was predicted.
ContributorsKlemish, Colby (Author) / Radway, Debra (Thesis director) / Arrfelt, Mathias (Committee member) / Goldinger, Stephen (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Psychology (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This thesis explores European identity through the European Union and the Eurovision Song Contest using Michael Walzer’s hyphenated American identity by expanding his argument to the EU, culture, and broadening the definition of diversity. Walzer had three main points about the American identity that makes it unique. First, a hyphen with a many side and a one side exist with no expectation of assimilation. Second, the should be a hyphen and can be emphasized. Third, there are unsuccessful patriotic fevers. On the political level, the EU has a hyphenated identity but fails with expectations of assimilation and successful patriotic fevers like Brexit. Walzer does not examine the cultural aspect of identity, this is where this thesis goes beyond his idea in examining European identity in the cultural institution of Eurovision. The literature and winning songs confirm that a hyphenated identity exists in Eurovision. I sorted the winning songs into three categories of diversity, national identity, and neutral. I did not reject two of my hypotheses, there were more neutral songs, and songs in diversity and national identity became common after 1992. The hypothesis I rejected was that national identity songs would be more common than diversity songs, this was not the case. I used Ukraine 2004 for diversity and Greece 2005 for national identity case studies. Overall, when there is a United States of Europe its identity will be the same as Walzer’s American identity. It is just not there yet, but with further European integration, it will.
ContributorsHubby, Turner Wilbanks (Author) / Kirkpatrick, Jennet (Thesis director) / Voorhees, Matthew (Committee member) / Watts College of Public Service & Community Solut (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Predictive analytics have been used in a wide variety of settings, including healthcare,
sports, banking, and other disciplines. We use predictive analytics and modeling to
determine the impact of certain factors that increase the probability of a successful
fourth down conversion in the Power 5 conferences. The logistic regression models
predict the likelihood of going for fourth down with a 64% or more probability based on
2015-17 data obtained from ESPN’s college football API. Offense type though important
but non-measurable was incorporated as a random effect. We found that distance to go,
play type, field position, and week of the season were key leading covariates in
predictability. On average, our model performed as much as 14% better than coaches
in 2018.
sports, banking, and other disciplines. We use predictive analytics and modeling to
determine the impact of certain factors that increase the probability of a successful
fourth down conversion in the Power 5 conferences. The logistic regression models
predict the likelihood of going for fourth down with a 64% or more probability based on
2015-17 data obtained from ESPN’s college football API. Offense type though important
but non-measurable was incorporated as a random effect. We found that distance to go,
play type, field position, and week of the season were key leading covariates in
predictability. On average, our model performed as much as 14% better than coaches
in 2018.
ContributorsBlinkoff, Joshua Ian (Co-author) / Voeller, Michael (Co-author) / Wilson, Jeffrey (Thesis director) / Graham, Scottie (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Information Systems (Contributor) / Department of Management and Entrepreneurship (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Since 1979, Phoenix has been organized into 15 theoretically self-contained urban villages in order to manage rapid growth. The major objective of the village plan was to decrease demand for personal vehicle use by internalizing travel to the closest village core, or an adjacent village core, instead of expanding travel to one metropolitan core. Phoenix’s transition from a monocentric urban structure to a more polycentric structure has yet to be studied for its efficacy on this goal of turning personal vehicle travel inward. This paper pairs more conventional measures of automobile dependence, such as, use of alternative modes of transportation in place of private vehicle use and commute times, with more nuanced measures of internal travel between work and home, job housing ratio, and job industry breakdowns to describe Phoenix’s reliance on automobiles. Phoenix’s internal travel ratios were higher when compared to adjacent cities and either on-par or lower when compared to non-adjacent cities that were comparable to Phoenix in population density and size.
ContributorsCuiffo, Kathryn Victoria (Author) / King, David (Thesis director) / Salon, Deborah (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Psychology (Contributor) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05