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patient recovery time. It is a surgical procedure done by using long reached tools and an
endoscopic camera to operate on the body though small incisions made near the point of
operation while viewing the live camera feed on a nearby display screen. Multiple camera
views are used in various industries such as surveillance and professional gaming to
allow users a spatial awareness advantage as to what is happening in the 3D space that is
presented to them on 2D displays. The concept has not effectively broken into the
medical industry yet. This thesis tests a multi-view camera system in which three cameras
are inserted into a laparoscopic surgical training box along with two surgical instruments,
to determine the system impact on spatial cognition, perceived cognitive workload, and
the overall time needed to complete the task, compared to one camera viewing the
traditional set up. The task is a non-medical task and is one of five typically used to train
surgeons’ motor skills when initially learning minimally invasive surgical procedures.
The task is a peg transfer and will be conducted by 30 people who are randomly assigned
to one of two conditions; one display and three displays. The results indicated that when
three displays were present the overall time initially using them to complete a task was
slower; the task was perceived to be completed more easily and with less strain; and
participants had a slightly higher performance rate.
The focus of my honors thesis is to find ways to use deep learning in tandem with tools in statistical mechanics to derive new ways to solve problems in biophysics. More specifically, I’ve been interested in finding transition pathways between two known states of a biomolecule. This is because understanding the mechanisms in which proteins fold and ligands bind is crucial to creating new medicines and understanding biological processes. In this thesis, I work with individuals in the Singharoy lab to develop a formulation to utilize reinforcement learning and sampling-based robotics planning to derive low free energy transition pathways between two known states. Our formulation uses Jarzynski’s equality and the stiff-spring approximation to obtain point estimates of energy, and construct an informed path search with atomistic resolution. At the core of this framework, is our first ever attempt we use a policy driven adaptive steered molecular dynamics (SMD) to control our molecular dynamics simulations. We show that both the reinforcement learning (RL) and robotics planning realization of the RL-guided framework can solve for pathways on toy analytical surfaces and alanine dipeptide.
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