Matching Items (111)
Description
Analytic research on basketball games is growing quickly, specifically in the National Basketball Association. This paper explored the development of this analytic research and discovered that there has been a focus on individual player metrics and a dearth of quantitative team characterizations and evaluations. Consequently, this paper continued the exploratory research of Fewell and Armbruster's "Basketball teams as strategic networks" (2012), which modeled basketball teams as networks and used metrics to characterize team strategy in the NBA's 2010 playoffs. Individual players and outcomes were nodes and passes and actions were the links. This paper used data that was recorded from playoff games of the two 2012 NBA finalists: the Miami Heat and the Oklahoma City Thunder. The same metrics that Fewell and Armbruster used were explained, then calculated using this data. The offensive networks of these two teams during the playoffs were analyzed and interpreted by using other data and qualitative characterization of the teams' strategies; the paper found that the calculated metrics largely matched with our qualitative characterizations of the teams. The validity of the metrics in this paper and Fewell and Armbruster's paper was then discussed, and modeling basketball teams as multiple-order Markov chains rather than as networks was explored.
ContributorsMohanraj, Hariharan (Co-author) / Choi, David (Co-author) / Armbruster, Dieter (Thesis director) / Fewell, Jennifer (Committee member) / Brooks, Daniel (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2013-05
DescriptionThis paper provides an analysis of the differences in impacts made by companies that promote their sustainability efforts. A comparison of companies reveals that the ones with greater supply chain influence and larger consumer bases can make more concrete progress in terms of accomplishment for the sustainability realm.
ContributorsBeaubien, Courtney Lynn (Author) / Anderies, John (Thesis director) / Allenby, Brad (Committee member) / Janssen, Marco (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
The evolution of cooperation is a fundamental problem in biology, especially for non-relatives, where indirect fitness benefits cannot counter within-group inequalities. Multilevel selection models show how cooperation can evolve if it generates a group-level advantage, even when cooperators are disadvantaged within their group. This allows the possibility of group selection, but few examples have been described in nature. Here we show that group selection can explain the evolution of cooperative nest founding in the harvester ant Pogonomyrmex californicus. Through most of this species’ range, colonies are founded by single queens, but in some populations nests are instead founded by cooperative groups of unrelated queens. In mixed groups of cooperative and single-founding queens, we found that aggressive individuals had a survival advantage within their nest, but foundress groups with such non-cooperators died out more often than those with only cooperative members. An agent-based model shows that the between-group advantage of the cooperative phenotype drives it to fixation, despite its within-group disadvantage, but only when population density is high enough to make between-group competition intense. Field data show higher nest density in a population where cooperative founding is common, consistent with greater density driving the evolution of cooperative foundation through group selection.
ContributorsShaffer, Zachary (Author) / Sasaki, Takao (Author) / Haney, Brian (Author) / Janssen, Marco (Author) / Pratt, Stephen (Author) / Fewell, Jennifer (Author) / College of Liberal Arts and Sciences (Contributor)
Created2016-07-28
Description
Climate change presents the urgent need for effective sustainable water management that is capable of preserving natural resources while maintaining economical stability. States like California rely heavily on groundwater pumping for agricultural use, contributing to land subsidence and insufficient returns to water resources. The recent California drought has impacted agricultural production of certain crops. In this thesis, we present an agent-based model of farmers adapting to drought conditions by making crop choice decisions, much like the decisions Californian farmers have made. We use the Netlogo platform to capture the 2D spatial view of an agricultural system with changes in annual rainfall due to drought conditions. The goal of this model is to understand some of the simple rules farmers may follow to self-govern their consumption of a water resource. Farmer agents make their crop decisions based on deficit irrigation crop production function and a net present value discount rate. The farmers choose between a thirsty crop with a high production cost and a dry crop with a low production cost. Simulations results show that farmers switch crops in accordance with limited water and land resources. Farmers can maintain profit and yield by following simple rules of crop switching based on future yields and optimal irrigation. In drought conditions, individual agents expecting lower annual rainfall were able to increase their total profits. The maintenance of crop yield and profit is evidence of successful adaptation when farmers switch to crops that require less water.
ContributorsGokool, Rachael Shanta (Author) / Janssen, Marco (Thesis director) / Eakin, Hallie (Committee member) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Background
Grading schemes for breast cancer diagnosis are predominantly based on pathologists' qualitative assessment of altered nuclear structure from 2D brightfield microscopy images. However, cells are three-dimensional (3D) objects with features that are inherently 3D and thus poorly characterized in 2D. Our goal is to quantitatively characterize nuclear structure in 3D, assess its variation with malignancy, and investigate whether such variation correlates with standard nuclear grading criteria.
Methodology
We applied micro-optical computed tomographic imaging and automated 3D nuclear morphometry to quantify and compare morphological variations between human cell lines derived from normal, benign fibrocystic or malignant breast epithelium. To reproduce the appearance and contrast in clinical cytopathology images, we stained cells with hematoxylin and eosin and obtained 3D images of 150 individual stained cells of each cell type at sub-micron, isotropic resolution. Applying volumetric image analyses, we computed 42 3D morphological and textural descriptors of cellular and nuclear structure.
Principal Findings
We observed four distinct nuclear shape categories, the predominant being a mushroom cap shape. Cell and nuclear volumes increased from normal to fibrocystic to metastatic type, but there was little difference in the volume ratio of nucleus to cytoplasm (N/C ratio) between the lines. Abnormal cell nuclei had more nucleoli, markedly higher density and clumpier chromatin organization compared to normal. Nuclei of non-tumorigenic, fibrocystic cells exhibited larger textural variations than metastatic cell nuclei. At p<0.0025 by ANOVA and Kruskal-Wallis tests, 90% of our computed descriptors statistically differentiated control from abnormal cell populations, but only 69% of these features statistically differentiated the fibrocystic from the metastatic cell populations.
Conclusions
Our results provide a new perspective on nuclear structure variations associated with malignancy and point to the value of automated quantitative 3D nuclear morphometry as an objective tool to enable development of sensitive and specific nuclear grade classification in breast cancer diagnosis.
Grading schemes for breast cancer diagnosis are predominantly based on pathologists' qualitative assessment of altered nuclear structure from 2D brightfield microscopy images. However, cells are three-dimensional (3D) objects with features that are inherently 3D and thus poorly characterized in 2D. Our goal is to quantitatively characterize nuclear structure in 3D, assess its variation with malignancy, and investigate whether such variation correlates with standard nuclear grading criteria.
Methodology
We applied micro-optical computed tomographic imaging and automated 3D nuclear morphometry to quantify and compare morphological variations between human cell lines derived from normal, benign fibrocystic or malignant breast epithelium. To reproduce the appearance and contrast in clinical cytopathology images, we stained cells with hematoxylin and eosin and obtained 3D images of 150 individual stained cells of each cell type at sub-micron, isotropic resolution. Applying volumetric image analyses, we computed 42 3D morphological and textural descriptors of cellular and nuclear structure.
Principal Findings
We observed four distinct nuclear shape categories, the predominant being a mushroom cap shape. Cell and nuclear volumes increased from normal to fibrocystic to metastatic type, but there was little difference in the volume ratio of nucleus to cytoplasm (N/C ratio) between the lines. Abnormal cell nuclei had more nucleoli, markedly higher density and clumpier chromatin organization compared to normal. Nuclei of non-tumorigenic, fibrocystic cells exhibited larger textural variations than metastatic cell nuclei. At p<0.0025 by ANOVA and Kruskal-Wallis tests, 90% of our computed descriptors statistically differentiated control from abnormal cell populations, but only 69% of these features statistically differentiated the fibrocystic from the metastatic cell populations.
Conclusions
Our results provide a new perspective on nuclear structure variations associated with malignancy and point to the value of automated quantitative 3D nuclear morphometry as an objective tool to enable development of sensitive and specific nuclear grade classification in breast cancer diagnosis.
ContributorsNandakumar, Vivek (Author) / Kelbauskas, Laimonas (Author) / Hernandez, Kathryn (Author) / Lintecum, Kelly (Author) / Senechal, Patti (Author) / Bussey, Kimberly (Author) / Davies, Paul (Author) / Johnson, Roger (Author) / Meldrum, Deirdre (Author) / Ira A. Fulton Schools of Engineering (Contributor) / School of Electrical, Computer and Energy Engineering (Contributor) / Biodesign Institute (Contributor) / Center for Biosignatures Discovery Automation (Contributor) / College of Liberal Arts and Sciences (Contributor) / School of Life Sciences (Contributor) / Department of Physics (Contributor)
Created2012-01-05
Description
In our exponentially expanding world, the knowledge of a group versus that of an individual is more relevant than ever. Social insects have evolved to rely on the information from the collective, and in the case of harvester ants, their choice revolves around the best seeds to collect.
The objective of this experiment is to study a colony’s seed preference following previous exposure to a seed type in the seed harvester ant Pogonomyrmex californicus. It was hypothesized that foragers would demonstrate a measurable preference for the seed type they had previously experienced over the novel seed type. The cuticular hydrocarbon profile is suspected to be an influence in the foragers’ seed selection. Following an incubation period with the designated seed type, a series of preference trials were conducted over the course of two days for two experiments in which each colony fragment was given a seed pile with a 1:1 ratio of niger and sesame, after which any seeds moved off the seed pile were determined to be chosen, as well as if the workers were observed moving the seeds off the pile from the video recordings. Using video recordings, the seed selections of individual foragers were also tracked. The results partially support the hypothesis, however, in some cases, the ants did not collect enough seeds for the preference to be significant, and not all colony fragments had preferences that lined up with what they had previously experienced according to their treatment. Familiarity with the hydrocarbon profile of the seed type the colony had experienced is a possible proximal explanation for why colonies had seed preferences that aligned with their treatment, the seed they were designated to experience. Due to the low quantity of seeds collected during preference trials, seed preference amongst individual foragers remains unclear due to many different foragers selecting a seed during only one trial, with very few foragers returning to forage for seeds over the course of the experiment.
The objective of this experiment is to study a colony’s seed preference following previous exposure to a seed type in the seed harvester ant Pogonomyrmex californicus. It was hypothesized that foragers would demonstrate a measurable preference for the seed type they had previously experienced over the novel seed type. The cuticular hydrocarbon profile is suspected to be an influence in the foragers’ seed selection. Following an incubation period with the designated seed type, a series of preference trials were conducted over the course of two days for two experiments in which each colony fragment was given a seed pile with a 1:1 ratio of niger and sesame, after which any seeds moved off the seed pile were determined to be chosen, as well as if the workers were observed moving the seeds off the pile from the video recordings. Using video recordings, the seed selections of individual foragers were also tracked. The results partially support the hypothesis, however, in some cases, the ants did not collect enough seeds for the preference to be significant, and not all colony fragments had preferences that lined up with what they had previously experienced according to their treatment. Familiarity with the hydrocarbon profile of the seed type the colony had experienced is a possible proximal explanation for why colonies had seed preferences that aligned with their treatment, the seed they were designated to experience. Due to the low quantity of seeds collected during preference trials, seed preference amongst individual foragers remains unclear due to many different foragers selecting a seed during only one trial, with very few foragers returning to forage for seeds over the course of the experiment.
ContributorsNewton, Natalie Nicole (Author) / Fewell, Jennifer (Thesis director) / Steven, Pratt (Committee member) / Ioulia, Bespalova (Committee member) / School of Art (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Coffee is an important link between the United States and Latin America and an important part of Latin America’s culture and economy. This paper looks at the similarities and differences between coffee organizations in Colombia, Ecuador, Peru, and Guatemala. Colombia has the strongest coffee organizations with the most political power. Guatemala and Peru, to a lesser extent, have well organized and powerful organizations that make up their industry. However, Ecuador has a significantly less organized organization. At their core, each country has a similar structure. There is one organization on the national level that watches out for the industry as a whole. Underneath that, there are smaller, often regional organizations made up of cooperatives pooling their resources for export. They function in similar ways as the national organizations, but have less reach. At the bottom, there are individual cooperatives and independent farmers. These cooperatives do not have much reach or connection to international markets.
ContributorsChabin, James Edward (Author) / Janssen, Marco (Thesis director) / Taylor, Keith (Committee member) / School of Sustainability (Contributor) / School of International Letters and Cultures (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Dielectrophoresis has been shown in the recent past to successfully separate bioparticles of very subtle differences at high resolutions using biophysical forces. In this study, we test the biophysical differences of methicillin resistant and susceptible Staph. aureus that are known to have very similar genomes by using a modified gradient insulator-based dielectrophoresis device (g-iDEP). MRSA is commonly seen in hospitals and is the leading killer of infectious bacteria, claiming the lives of around 10,000 people annually. G-iDEP improves many capabilities within the DEP field including sample size, cost, ease of use and analysis time. This is a promising foundation to creating a more clinically optimized diagnostic tool for both separation and detection of bacteria in the healthcare field. The capture on-set potential for fluorescently tagged MRSA (801 ± 34V) is higher than fluorescently tagged MSSA (610 ± 32V), resulting in a higher electrokinetic to dielectrophoretic mobility ratio for MRSA. Since the strains have proven to be genomically similar through sequencing, it is reasonable to attribute this significant biophysical difference to the added PBP2a enzyme in MRSA. These results are consistent with other bacterial studied within in this device and have proven to be reproducible.
ContributorsSmithers, Jared (Author) / Hayes, Mark (Thesis director) / Woodbury, Neal (Committee member) / School of Criminology and Criminal Justice (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Diabesity is a global epidemic affecting millions worldwide. Diabesity is the term given to the link between obesity and Type II diabetes. It is estimated that ~90% of patients diagnosed with Type II diabetes are overweight or have struggled with excess body fat in the past. Type II diabetes is characterized by insulin resistance which is an impaired response of the body to insulin that leads to high blood glucose levels. Adipose tissue, previously thought of as an inert tissue, is now recognized as a major endocrine organ with an important role in the body's immune response and the development of chronic inflammation. It is speculated that adipose tissue inflammation is a major contributor to insulin resistance particular to Type II diabetes. This literature review explores the popular therapeutic targets and marketed drugs for the treatment of Type II diabetes and their role in decreasing adipose tissue inflammation. rAGE is currently in pre-clinical studies as a possible target to combat adipose tissue inflammation due to its relation to insulin resistance. Metformin and Pioglitazone are two drugs already being marketed that use unique chemical pathways to increase the production of insulin and/or decrease blood glucose levels. Sulfonylureas is one of the first FDA approved drugs used in the treatment of Type II diabetes, however, it has been discredited due to its life-threatening side effects. Bariatric surgery is a form of invasive surgery to rid the body of excess fat and has shown to normalize blood glucose levels. These treatments are all secondary to lifestyle changes, such as diet and exercise which can help halt the progression of Type II diabetes patients.
ContributorsRobles, Alondra Maria (Author) / Woodbury, Neal (Thesis director) / Redding, Kevin (Committee member) / Allen, James (Committee member) / Hendrickson, Kirstin (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Studies of cooperation remain an important aspect in understanding the evolution of social cues and interactions. One example of cooperation is pleometrosis, an associative behavior of forming a colony with two unrelated, fertile queens. However, most ant species display haplometrosis, the founding of a colony by a single queen. In these associations, the queen typically rejects cooperation. In populations of Pogonomyrmex californicus, both pleometrosis and haplometrosis exists. It is not clear how associative -metrosis became a practiced behavior since haplometrotic queens tend to fight. However, as fighting in pleometrotic queens became less frequent, this induces benefit, in terms of cost savings, in having associative behaviors. The hypothesis tested was nest excavation of pleometrotic queens show sociality, while haplometrotic queens show association independence. Isolated pleometrotic queens (P) showed low excavation rate at 2.72cm2/day, compared to the rate when the task was shared in (PP) nests, 4.57cm2/day. Nest area of the (P) queens were also affected during days 3 and 4 of the experiment, where there was presence of nest area decrease. Furthermore, the excavation session of (P) was the only one determined as significant between all other nests. Although the (P) queens have low values, they eventually reach a similar point as the other nests by day 6. However, the lack of haste in excavation leads to longer exposure to the elements, substituting the risk of losing cuticles in excavation for the risk of predation. For the haplometrotic queens, nests of (H) and (HH) displayed no significant difference in excavation values, leading to having social effect in their association.
ContributorsGabriel, Ian Paulo Villalobos (Author) / Fewell, Jennifer (Thesis director) / Pratt, Stephen (Committee member) / Bespalova, Ioulia (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05