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Description
Restraint stress is the most commonly used laboratory stressor. It is difficult to characterize as psychological or physical, because past studies show psychological features, but the nature of confinement adds a physical dimension. This was the first study to investigate how experience with restraint stress affects brain response to the next stress without a physical burden. Pair-housed adult male rats were transported to a novel context and restrained or left undisturbed (6hr). The next day, rats were returned to the same context and were either restrained or left undisturbed in the context (n=8/group). After 90min, rats were euthanized to determine functional activation in limbic structures using Fos immunohistochemistry and to measure HPA axis reactivity through blood serum corticosterone levels. Regardless of day 1 experience, context exposure on day 2 enhanced Fos expression in CA1 and CA3 of the hippocampus, basolateral amygdala, and central amygdala. Conversely, other regions and corticosterone levels demonstrated modulation from the previous day's experience. Specifically, rats that were placed back into the restraint context but not restrained on day 2 showed enhanced Fos expression in the dentate gyrus suprapyramidal blade (DGSup), and infralimbic cortex (IL). Also Fos expression was attenuated in rats that received two restraint exposures in the IL and medial amygdala (MEA), suggesting habituation. Only the DG infrapyramidal blade (DGInf) showed enhanced Fos expression to restraint on day 2 without influence of the previous day. While context predominately directed Fos activation, prior experience with restraint influenced Fos expression in the DGSup, IL, MEA and corticosterone levels to support restraint having psychological components.
ContributorsAnouti, P. Danya (Author) / Conrad, D. Cheryl (Thesis director) / Hammer, Ronald (Committee member) / Hoffman, N. Ann (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Lyme disease is a common tick-borne illness caused by the Gram-negative bacterium Borrelia burgdorferi. An outer membrane protein of Borrelia burgdorferi, P66, has been suggested as a possible target for Lyme disease treatments. However, a lack of structural information available for P66 has hindered attempts to design medications to target the protein. Therefore, this study attempted to find methods for expressing and purifying P66 in quantities that can be used for structural studies. It was found that by using the PelB signal sequence, His-tagged P66 could be directed to the outer membrane of Escherichia coli, as confirmed by an anti-His Western blot. Further attempts to optimize P66 expression in the outer membrane were made, pending verification via Western blotting. The ability to direct P66 to the outer membrane using the PelB signal sequence is a promising first step in determining the overall structure of P66, but further work is needed before P66 is ready for large-scale purification for structural studies.
ContributorsRamirez, Christopher Nicholas (Author) / Fromme, Petra (Thesis director) / Hansen, Debra (Committee member) / Department of Physics (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
This thesis project focuses on algorithms that generate good sampling points for function approximation. In one dimension, polynomial interpolation using equispaced points is unstable, with high Oscillations near the endpoints of the interpolated interval. On the other hand, Chebyshev nodes provide both stable and highly accurate points for polynomial interpolation. In higher dimensions, optimal sampling points are unknown. This project addresses this problem by finding algorithms that are robust in various domains for polynomial interpolation and least-squares. To measure the quality of the nodes produced by said algorithms, the Lebesgue constant will be used. In the algorithms, a number of numerical techniques will be used, such as the Gram-Schmidt process and the pivoted-QR process. In addition, concepts such as node density and greedy algorithms will be explored.
ContributorsGuo, Maosheng (Author) / Platte, Rodrigo (Thesis director) / Welfert, Bruno (Committee member) / School of Mathematical and Statistical Sciences (Contributor, Contributor) / Department of Physics (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Preliminary feasibility studies for two possible experiments with the GlueX detector, installed in Hall D of Jefferson Laboratory, are presented. First, a general study of the feasibility of detecting the ηC at the current hadronic rate is discussed, without regard for detector or reconstruction efficiency. Second, a study of the use of statistical methods in studying exotic meson candidates is outlined, describing methods and providing preliminary data on their efficacy.
ContributorsPrather, Benjamin Scott (Author) / Ritchie, Barry G. (Thesis director) / Dugger, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Physics (Contributor)
Created2015-05
Description
The OMFIT (One Modeling Framework for Integrated Tasks) modeling environment and the BRAINFUSE module have been deployed on the PPPL (Princeton Plasma Physics Laboratory) computing cluster with modifications that have rendered the application of artificial neural networks (NNs) to the TRANSP databases for the JET (Joint European Torus), TFTR (Tokamak Fusion Test Reactor), and NSTX (National Spherical Torus Experiment) devices possible through their use. This development has facilitated the investigation of NNs for predicting heat transport profiles in JET, TFTR, and NSTX, and has promoted additional investigations to discover how else NNs may be of use to scientists at PPPL. In applying NNs to the aforementioned devices for predicting heat transport, the primary goal of this endeavor is to reproduce the success shown in Meneghini et al. in using NNs for heat transport prediction in DIII-D. Being able to reproduce the results from is important because this in turn would provide scientists at PPPL with a quick and efficient toolset for reliably predicting heat transport profiles much faster than any existing computational methods allow; the progress towards this goal is outlined in this report, and potential additional applications of the NN framework are presented.
ContributorsLuna, Christopher Joseph (Author) / Tang, Wenbo (Thesis director) / Treacy, Michael (Committee member) / Orso, Meneghini (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Physics (Contributor)
Created2015-05
Description
Almost commuting matrices, i.e. matrices with a sufficiently small commutator, may be nearly commuting, i.e. there may exist matrices close by which do commute. By referencing current literature, this condition is studied for fixed dimension, unitary, self-adjoint, and orthogonal matrices. These proofs are made more accessible and compared to each other, providing insight to possible future progress in the field.
ContributorsMolloy, Riley Phillip (Author) / Spielberg, Jack (Thesis director) / Quigg, John (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Physics (Contributor)
Created2015-05
Description
Recently, electric and magnetic field sensing has come of interest to the military for a variety of applications, including imaging circuitry and detecting explosive devices. This thesis describes research at the ASU's Flexible Electronics and Display Center (FEDC) towards the development of a flexible electric and magnetic field imaging blanket. D-dot sensors, which detect changes in electric flux, were chosen for electric field sensing, and a single D-dot sensor in combination with a lock-in amplifier was used to detect individuals passing through an oscillating electric field. This was then developed into a 1 x 16 array of D-dot sensors used to image the field generated by two parallel wires. After the fabrication of a two-dimensional array, it was discovered that commercial field effect transistors did not have a high enough off-resistance to isolate the sensor form the column line. Three alternative solutions were proposed. The first was a one-dimensional array combined with a mechanical stepper to move the array across the E-field pattern. The second was a 1 x 16 strip detector combined with the techniques of computed tomography to reconstruct the image of the field. Such techniques include filtered back projection and algebraic iterative reconstruction (AIR). Lastly, an array of D-dot sensors was fabricated on a flexible substrate, enabled by the high off-resistance of the thin film transistors produced by the FEDC. The research on magnetic field imaging began with a feasibility study of three different types of magnetic field sensors: planar spiral inductors, Hall effect sensors, and giant magnetoresistance (GMR). An experimental array of these sensors was designed and fabricated, and the sensors were used to image the fringe fields of a Helmholtz coil. Furthermore, combining the inductors with the other two types of sensors resulted in three-dimensional sensors. From these measurements, it was determined that planar spiral inductors and Hall effect sensors are best suited for future imaging arrays.
ContributorsLarsen, Brett William (Author) / Allee, David (Thesis director) / Papandreou-Suppappola, Antonia (Committee member) / Barrett, The Honors College (Contributor) / Department of Physics (Contributor) / Electrical Engineering Program (Contributor)
Created2015-05
Description
In a pure spin current, electrons of opposite spins flow in opposite directions, thus information is conveyed by spin current without any charge current. This process almost causes no power consumption, which has the potential to realize ultra-low-power-consumption electronics. Recently, thermal effects in magnetic materials have attracted a great deal of attention because of its potential to generate pure spin currents using a thermal gradient (∇T), such as the spin Seebeck effect. However, unlike electric potential, the exact thermal gradient direction is experimentally difficult to control, which has already caused misinterpretation of the thermal effects in Py and Py/Pt films. In this work, we show that a well-defined ∇T can be created by two thermoelectric coolers (TECs) based on Peltier effect. The ∇T as well as its sign can be accurately controlled by the driven voltage on the TECs. Using a square-wave driven potential, thermal effects of a few μV can be measured. Using this technique, we have measured the anomalous Nernst effect in magnetic Co/Py and Py/Pt layers and determined their angular dependence. The angular dependence shows the same symmetry as the anomalous Hall effect in these films.
This work has been carried out under the guidance of the author’s thesis advisor, Professor Tingyong Chen.
This work has been carried out under the guidance of the author’s thesis advisor, Professor Tingyong Chen.
ContributorsSimaie, Salar (Author) / Chen, Tingyon (Thesis director) / Alizadeh, Iman (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor) / Department of Physics (Contributor)
Created2015-05
Description
Agent based models allow for complex results from simple parameters. The mobile agents in my model, the firms, are allocated an amount of capital, while the static agents, the workers, are allocated a range of wages. The firms are then allowed to move around and compete until they match with a worker that maximizes their production. It was found from the simulation that as competition increases so do wages. It was also found that when firms stay in the environment for longer that a higher wage is possible as a result of a larger window for drawn out competition. The different parameters result in a range of equilibriums that take variable amounts of time to reach. These results are interesting because they demonstrate that the mean wage is strongly dependent upon the window of time that firms are able to compete within. This type of model was useful because it demonstrated that there is a variation in the time dependence of the equilibrium. It also demonstrated that when there is very little entry and exiting of the market, that wage levels out at an equilibrium that is the same, regardless of the ratio between the number of firms and the number of workers. Further work to be done on this model includes the addition of a Matching Function so that firms and workers have a more fair agreement. I will also be adding parameters that allow for firms to see the workers around them so that firms are able to interact with multiple workers at the same time. Both of these alteration should improve the overall accuracy of the model.
ContributorsElledge, Jacob Morris (Author) / Veramendi, Gregory (Thesis director) / Murphy, Alvin (Committee member) / Department of Economics (Contributor) / Department of Physics (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
Integration of dielectrics with graphene is essential to the fulfillment of graphene based electronic applications. While many dielectric deposition techniques exist, plasma enhanced atomic layer deposition (PEALD) is emerging as a technique to deposit ultrathin dielectric films with superior densities and interfaces. However, the degree to which PEALD on graphene can be achieved without plasma-induced graphene deterioration is not well understood. In this work, we investigate a range of plasma conditions across a single sample, characterizing both oxide growth and graphene deterioration using spectroscopic analysis and atomic force microscopy. Investigation of graphene and film quality produced by these conditions yields insight into plasma effects. Using a specially designed sample configuration, we achieve ultrathin (< 1 nm) aluminum oxide films atop graphene.
ContributorsTrimble, Christie Jordan (Author) / Nemanich, Robert (Thesis director) / Zaniewski, Anna (Committee member) / Department of Physics (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05