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Continuous advancements in biomedical research have resulted in the production of vast amounts of scientific data and literature discussing them. The ultimate goal of computational biology is to translate these large amounts of data into actual knowledge of the complex biological processes and accurate life science models. The ability to

Continuous advancements in biomedical research have resulted in the production of vast amounts of scientific data and literature discussing them. The ultimate goal of computational biology is to translate these large amounts of data into actual knowledge of the complex biological processes and accurate life science models. The ability to rapidly and effectively survey the literature is necessary for the creation of large scale models of the relationships among biomedical entities as well as hypothesis generation to guide biomedical research. To reduce the effort and time spent in performing these activities, an intelligent search system is required. Even though many systems aid in navigating through this wide collection of documents, the vastness and depth of this information overload can be overwhelming. An automated extraction system coupled with a cognitive search and navigation service over these document collections would not only save time and effort, but also facilitate discovery of the unknown information implicitly conveyed in the texts. This thesis presents the different approaches used for large scale biomedical named entity recognition, and the challenges faced in each. It also proposes BioEve: an integrative framework to fuse a faceted search with information extraction to provide a search service that addresses the user's desire for "completeness" of the query results, not just the top-ranked ones. This information extraction system enables discovery of important semantic relationships between entities such as genes, diseases, drugs, and cell lines and events from biomedical text on MEDLINE, which is the largest publicly available database of the world's biomedical journal literature. It is an innovative search and discovery service that makes it easier to search
avigate and discover knowledge hidden in life sciences literature. To demonstrate the utility of this system, this thesis also details a prototype enterprise quality search and discovery service that helps researchers with a guided step-by-step query refinement, by suggesting concepts enriched in intermediate results, and thereby facilitating the "discover more as you search" paradigm.
ContributorsKanwar, Pradeep (Author) / Davulcu, Hasan (Thesis advisor) / Dinu, Valentin (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2010
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Description

Vaccines are modern medicine’s best way of combating the majority of viral and bacterial illnesses and contagions to date. Thanks to the introduction of vaccines since the first uses of them in 1796 (Jenner’s smallpox vaccine), they have drastically reduced figures of disease worldwide, turning once lethal and life changing

Vaccines are modern medicine’s best way of combating the majority of viral and bacterial illnesses and contagions to date. Thanks to the introduction of vaccines since the first uses of them in 1796 (Jenner’s smallpox vaccine), they have drastically reduced figures of disease worldwide, turning once lethal and life changing conditions into minor annoyances; Some of these afflictions have even become nonexistent or even extinct in certain parts of the world outside of a controlled laboratory setting. With many advancements and overwhelming evidence proving their efficiency, it is clear that vaccines have become nothing less than a necessity for everyday healthcare in today’s world. <br/>The greatest contributor to the creation and evolution of vaccines throughout the years is by far the progress and work done in the field of molecular and cellular biology. These advancements have become the bedrock of modern vaccination, as shown by the differing types of vaccines and their methodology. The most common varieties of vaccines are include ‘dead’ or inactivated vaccines, one such example being the pertussis strain of vaccines, which have either dead or torn apart cells for the body to easily fight off, allowing the immune system to easily and quickly counter the illness; Additionally, there are also live attenuated vaccines (LAVs) in which a weaker version of the pathogen is introduced to the body to stimulate an immune response, or a recombinant mRNA vaccine where mRNA containing the coding for an antigen is presented for immunological response, the latter being what the current COVID-19 vaccines are based on. This is in part aided by the presence of immunological adjuvants, antigens and substances that the immune system can recognize, target, and remember for future infections. However, for more serious illnesses the body needs a bigger threat to analyze, which leads to live vaccines- instead of dead or individual components of a potential pathogen, a weakened version is created in the lab to allow the body to combat it. The idea behind this is the same, but to a larger degree so a more serious illness such as measles, mumps, and rubella (MMR) do not infect us.<br/>However, for the past couple of decades the public’s views on vaccination has greatly varied, with the rise of fear and disinformation leading those to believe that modern medicine is a threat in disguise. The largest of these arguments began in the late 90’s, when Dr. Andrew Wakefield published an article under the Lancet with false information connecting vaccinations to the occurrence of autism in younger children- a theory which has since then been proven incorrect numerous times over. Unfortunately, the rise of hysteria and paranoia in people, along with more misinformation from misleading sources, have strengthened the anti-vaccination cause and has made it into a serious threat to the health of those world-wide.<br/>The aim of this thesis is to provide an accurate and thorough analysis on these three themes- the history of vaccines, their inner workings and machinations in providing immune defenses for the body, and the current controversy of the anti-vaccination movement. Additionally, there will be two other sections going in-depth on two specific areas where vaccination is highly important; The spread and fear of the Human Immunodeficiency Virus (HIV) has been around for nearly four decades, so it begs the question: what makes this such a difficult virus, and how can a vaccine be created to combat it? Additionally, in the last year the world has encountered a new virus that has evolved into a global pandemic, SARS-COV 2. This new strain of coronavirus has shown itself to be highly contagious and rapidly mutating, and the race to quickly develop a vaccine to counteract it has been on-going since its first major infections in Wuhan, China. Overall, this thesis will go in-depth in providing the most accurate, up-to-date, and critical information regarding vaccinations today.

ContributorsKolb Celaya, Connor Emilio (Author) / Topal, Emel (Thesis director) / Huffman, Holly (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Working with chocolate is a difficult endeavor. However, through the use of additive manufacturing technologies, the labor involved can be reduced. One difficulty is the pumping of the melted chocolate through the system onto the print bed of the printer. In this paper, three systems of transferring chocolate are investigated:

Working with chocolate is a difficult endeavor. However, through the use of additive manufacturing technologies, the labor involved can be reduced. One difficulty is the pumping of the melted chocolate through the system onto the print bed of the printer. In this paper, three systems of transferring chocolate are investigated: A syringe system, a gear pump system, and an auger system. Each system is explained with a model of the proposed system and the pros and cons are discussed. Lastly, a system composed of parts of the syringe and auger system is proposed. The positive and negative aspects of this design are discussed, and a 3D model of the system is given as well. This system is suggested as a better option, and future research can be done to investigate and rate these systems in greater detail. In commercial food applications, these technologies can change the way chocolate is manipulated, and difficult practices can be simplified for home chefs.

ContributorsMester, Daniel (Author) / Chen, Xiangfan (Thesis director) / Gintz, Jerry (Committee member) / College of Integrative Sciences and Arts (Contributor, Contributor) / Engineering Programs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The mental health of ASU students has been negatively affected by the pandemic. Our research looks to prove that COVID-19 has caused an increase in stress levels while uncovering other relationships to stress. We obtained our data by conducting a survey through Google Forms that was exclusively accessible to ASU

The mental health of ASU students has been negatively affected by the pandemic. Our research looks to prove that COVID-19 has caused an increase in stress levels while uncovering other relationships to stress. We obtained our data by conducting a survey through Google Forms that was exclusively accessible to ASU students. Stress levels were measured with the use of the Perceived Stress Scale (PSS). We find that the stress of ASU students from before the pandemic to during rises from 15 to 22 points, a 50% increase (n = 228). We discovered that women are more stressed than men before and during the pandemic. We also discovered that there is no difference between stresses among different races. We notice that there is a parabolic relationship between enrollment time and stress levels with the peak occurring during semesters 2-6. We also conclude that students who attended more than 5 events during the pandemic had lower stress scores, and those who had their videos on for at least 3 events had lower stress scores. Furthermore, students who utilized campus resources to manage their stress had higher stress levels than those who did not.

ContributorsRana, Mannat (Co-author) / Levine, Benjamin (Co-author) / Martin, Thomas (Thesis director) / Rendell, Dawn (Committee member) / College of Integrative Sciences and Arts (Contributor) / Engineering Programs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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During the global COVID-19 pandemic in 2020, many universities shifted their focus to hosting classes and events online for their student population in order to keep them engaged. The present study investigated whether an association exists between student engagement (an individual’s engagement with class and campus) and resilience. A single-shot

During the global COVID-19 pandemic in 2020, many universities shifted their focus to hosting classes and events online for their student population in order to keep them engaged. The present study investigated whether an association exists between student engagement (an individual’s engagement with class and campus) and resilience. A single-shot survey was administered to 200 participants currently enrolled as undergraduate students at Arizona State University. A multiple regression analysis and Pearson correlations were calculated. A moderate, significant correlation was found between student engagement (total score) and resilience. A significant correlation was found between cognitive engagement (student’s approach and understanding of his learning) and resilience and between valuing and resilience. Contrary to expectations, participation was not associated with resilience. Potential explanations for these results were explored and practical applications for the university were discussed.

ContributorsEmmanuelli, Michelle (Author) / Jimenez Arista, Laura (Thesis director) / Sever, Amy (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The mental health of ASU students has been negatively affected by the pandemic. Our research looks to prove that COVID-19 has caused an increase in stress levels while uncovering other relationships to stress. We obtained our data by conducting a survey through Google Forms that was exclusively accessible to ASU

The mental health of ASU students has been negatively affected by the pandemic. Our research looks to prove that COVID-19 has caused an increase in stress levels while uncovering other relationships to stress. We obtained our data by conducting a survey through Google Forms that was exclusively accessible to ASU students. Stress levels were measured with the use of the Perceived Stress Scale (PSS). We find that the stress of ASU students from before the pandemic to during rises from 15 to 22 points, a 50% increase (n = 228). We discovered that women are more stressed than men before and during the pandemic. We also discovered that there is no difference between stresses among different races. We notice that there is a parabolic relationship between enrollment time and stress levels with the peak occurring during semesters 2-6. We also conclude that students who attended more than 5 events during the pandemic had lower stress scores, and those who had their videos on for at least 3 events had lower stress scores. Furthermore, students who utilized campus resources to manage their stress had higher stress levels than those who did not.

ContributorsRana, Mannat (Co-author) / Levine, Benjamin (Co-author) / Martin, Thomas (Thesis director) / Rendell, Dawn (Committee member) / College of Integrative Sciences and Arts (Contributor) / Engineering Programs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The mental health of ASU students has been negatively affected by the pandemic. Our research looks to prove that COVID-19 has caused an increase in stress levels while uncovering other relationships to stress. We obtained our data by conducting a survey through Google Forms that was exclusively accessible to ASU

The mental health of ASU students has been negatively affected by the pandemic. Our research looks to prove that COVID-19 has caused an increase in stress levels while uncovering other relationships to stress. We obtained our data by conducting a survey through Google Forms that was exclusively accessible to ASU students. Stress levels were measured with the use of the Perceived Stress Scale (PSS). We find that the stress of ASU students from before the pandemic to during rises from 15 to 22 points, a 50% increase (n = 228). We discovered that women are more stressed than men before and during the pandemic. We also discovered that there is no difference between stresses among different races. We notice that there is a parabolic relationship between enrollment time and stress levels with the peak occurring during semesters 2-6. We also conclude that students who attended more than 5 events during the pandemic had lower stress scores, and those who had their videos on for at least 3 events had lower stress scores. Furthermore, students who utilized campus resources to manage their stress had higher stress levels than those who did not.

ContributorsLevine, Benjamin (Co-author) / Rana, Mannat (Co-author) / Martin, Thomas (Thesis director) / Rendell, Dawn (Committee member) / College of Integrative Sciences and Arts (Contributor) / Engineering Programs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The current study examines the effects that college students' personal characteristics, such as age, sex, gender, or race/ethnicity, have on students’ perceptions of perceived victim blameworthiness. This study also examines how college students’ perceptions of blameworthiness change after being exposed to real life sexual assault vignettes that tap into issues

The current study examines the effects that college students' personal characteristics, such as age, sex, gender, or race/ethnicity, have on students’ perceptions of perceived victim blameworthiness. This study also examines how college students’ perceptions of blameworthiness change after being exposed to real life sexual assault vignettes that tap into issues surrounding rape myths. Specifically, I assess blameworthiness perceptions surrounding rape myths regarding clothing, drinking, and various situational characteristics. Blameworthiness perceptions were examined through a survey with pre-test and post-test questions that occurred before and after the student reviewed different sexual assault vignettes. Descriptive statistics show that the majority of college students, after being introduced to the vignettes, reduced their blameworthiness beliefs. Results from the regression analysis show that few individual characteristics are associated with changes in blameworthiness beliefs. Overall, these findings suggest that exposure to sexual assault vignettes have an effect on how individuals perceive victim blameworthiness.

ContributorsJones, Teairstayn K (Author) / Wallace, Danielle (Thesis director) / Fox-Talbot, Kate (Committee member) / School of Criminology and Criminal Justice (Contributor, Contributor) / Sanford School of Social and Family Dynamics (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

As the world’s population exponentially grows, more food production is required. This increasing food production currently has led to the un-sustainable production of chemical fertilizers and resultant overuse. A more sustainable option to enhance food production could be the use of fertilizer derived from food waste. To address this, we

As the world’s population exponentially grows, more food production is required. This increasing food production currently has led to the un-sustainable production of chemical fertilizers and resultant overuse. A more sustainable option to enhance food production could be the use of fertilizer derived from food waste. To address this, we investigated the possibility of utilizing a fertilizer derived from food waste to grow hydroponic vegetables. Arugula (Eruca sativa) ‘Slow Bolt’ and lettuce (Lactuca sativa) ‘Cherokee’ and ‘Rex’ were cultivated using indoor deep-flow hydroponic systems at 23 ºC under a photosynthetic photon flux density of 170 µmol∙m−2∙s−1 with an 18-hour photoperiod. Plant nutrient solutions were provided by food waste fertilizer or commercial 15:5:20 NPK fertilizer at the identical electrical conductivity (EC) of 2.3 mS·cm–1. At the EC of 2.3 mS·cm–1, chemical fertilizer contained 150 ppm N, 50 ppm P, and 200 ppm K, while food waste fertilizer had 60 ppm N, 26 ppm P, and 119 ppm K. Four weeks after the nutrient treatments were implemented, compared to plants grown with chemical fertilizer, lettuce ‘Rex’ grown with food waste fertilizer had four less leaves, 27.1% shorter leaves, 68.2% and 23.1% less shoot and root fresh weight, respectively. Lettuce ‘Cherokee’ and arugula grown with food waste fertilizer followed a similar trend with fresh shoot weights that were 80.1% and 95.6% less compared to the chemical fertilizer, respectively. In general, the magnitude of reduction in the plant growth was greatest in arugula. These results suggest that both fertilizers were able to successfully grow lettuce and arugula, although the reduced plant growth with the food waste fertilizer in our study is likely from a lower concentration of nutrients when we considered EC as an indicator of nutrient concentration equivalency of the two fertilizer types.

ContributorsCherry, Hannah Nichole (Author) / Park, Yujin (Thesis director) / Penton, Ryan (Committee member) / Chen, Zhihao (Committee member) / Environmental and Resource Management (Contributor, Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

In a COVID-19 world, student engagement has suffered drastically as organizations and universities shifted to an online format. Yet, there is still an opportunity and a space for digital content creation to bridge the gap in a virtual and hybrid university lifestyle. This project looks at how student groups can

In a COVID-19 world, student engagement has suffered drastically as organizations and universities shifted to an online format. Yet, there is still an opportunity and a space for digital content creation to bridge the gap in a virtual and hybrid university lifestyle. This project looks at how student groups can still engage students at ASU Tempe through digital content creation and which tools to use to enter the space.

ContributorsJavangula, Rahul (Author) / O'Flaherty, Katherine (Thesis director) / Shipley, Austen (Committee member) / Watts College of Public Service & Community Solut (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05