Matching Items (353)
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ContributorsChandler, N. Kayla (Author) / Neisewander, Janet (Thesis director) / Sanabria, Federico (Committee member) / Olive, M. Foster (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2013-05
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Description
Environmental and genetic factors contribute to schizophrenia etiology, yet few studies have demonstrated how environmental stimuli impact genes associated with the disorder. Immediate early genes (IEGs) are of great interest to schizophrenia research because they are activated in response to physiological stress from the environment, and subsequently regulate the expression

Environmental and genetic factors contribute to schizophrenia etiology, yet few studies have demonstrated how environmental stimuli impact genes associated with the disorder. Immediate early genes (IEGs) are of great interest to schizophrenia research because they are activated in response to physiological stress from the environment, and subsequently regulate the expression of downstream genes that are essential to neuropsychiatric function. An IEG, early growth response 3 (EGR3) has been identified as a main gene involved in a network of transcription factors implicated in schizophrenia susceptibility. The serotonin 2A receptor (5-HT2AR) seems to play an important role in schizophrenia and the dysfunction of the 5-HT2AR encoding gene, HTR2A, within the prefrontal cortex (PFC) contributes to multiple psychiatric illnesses including schizophrenia. EGR3's role as a transcription factor that is activated by environmental stimuli suggests it may regulate Htr2a transcription in response to physiological stress, thus affecting 5-HT2AR function in the prefrontal cortex (PFC). The aim of this study was to examine the relationship between Egr3 activation and Htr2a expression after an environmental stimulus. Sleep deprivation is an acute physiological stressor that activates Egr3. Therefore to examine the relationship between Egr3 and Htr2a expression after an acute stress, wild type and Egr3 knockout mice that express EGFP under the control of the Htr2a promoter were sleep deprived for 8 hours. We used immunohistochemistry to determine the location and density of Htr2a-EGFP expression after sleep deprivation and found that Htr2a-EGFP expression was not affected by sex or subregions of the PFC. Additionally, Htr2a-EGFP expression was not affected by the loss of Egr3 or sleep deprivation within the PFC. The LPFC subregions, layers V and VI showed significantly more Htr2a-EGFP expression than layers I-III in all animals for both sleep deprivation and control conditions. Possible explanations for the lack of significant effects in this study may be the limited sample size or possible biological abnormalities in the Htr2a-EGFP mice. Nonetheless, we did successfully visualize the anatomical distribution of Htr2a in the prefrontal cortex via immunohistochemical staining. This study and future studies will provide insight into how Egr3 activation affects Htr2a expression in the PFC and how physiological stress from the environment can alter candidate schizophrenia gene function.
ContributorsSabatino, Alissa Marie (Author) / Gallitano, Amelia (Thesis director) / Hruschka, Daniel (Thesis director) / Maple, Amanda (Committee member) / Barrett, The Honors College (Contributor)
Created2014-05
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Description
Some scholars have suggested that individuals are inclined to believe that they have souls because they are also inclined to believe that they have a core, immutable self. The present study will explore this question in several parts. First, what is the extent to which individuals report having a core

Some scholars have suggested that individuals are inclined to believe that they have souls because they are also inclined to believe that they have a core, immutable self. The present study will explore this question in several parts. First, what is the extent to which individuals report having a core self? Next, how do beliefs about a core self relate to belief or non-belief in an eternal soul? The final question looks at location as an extension of the core self and soul relationship. Where is the self perceived to reside within a dualistic framework, the body or the soul? This study assessed the stated beliefs of 200 respondents using Amazon Mechanical Turk as a recruiting platform. Greater belief in a core self was moderately associated with greater belief in an eternal soul (r= 0.30, p<.01), and with belief in the self as a reflection of the soul (r=0.31, p<.01) and as a reflection of the brain (r=0.21, p<.01). This suggests that belief in a core self does hold association with belief in an eternal soul. However, its perceived location seems to show little preference as residing withing the soul versus the body.
ContributorsLy, Destiny (Author) / Hruschka, Daniel (Thesis director) / Parker, John (Contributor) / Barrett, The Honors College (Contributor)
Created2014-12
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Description
The Affordable Care Act, or Obamacare, was signed into law with the goals of providing quality and affordable health care to every American, but there is concern that not enough young adults are gaining health insurance. Some believe it is because of the "young invincible" mentality of being healthy enough

The Affordable Care Act, or Obamacare, was signed into law with the goals of providing quality and affordable health care to every American, but there is concern that not enough young adults are gaining health insurance. Some believe it is because of the "young invincible" mentality of being healthy enough to not need health insurance, and others claim that the cost of health care is the main reason behind low enrollment rates in young adults. However, young adults may not be obtaining insurance because of a lack of understanding and awareness concerning the ACA. Do young adults understand how the ACA functions, and does this understanding (or lack thereof) determine their opinions towards it? In order to research this question, students at Arizona State University were given the opportunity to complete a survey and interview detailing their knowledge of Obamacare and how they felt about the health care law. Results indicated that though many respondents supported the law, respondents did not feel like they had enough information to understand the health care law, affecting their knowledge of it. These findings imply that in order for the ACA to be considered successful among young adults, awareness and education of the law must increase in order for young people to feel like they have an adequate understanding of it.
Created2015-05
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The United States’ War on Drugs declared in 1971 by President Richard Nixon and revamped by President Reagan in the 1980s has been an objectively failed initiative with origins based in racism and oppression. After exploring the repercussions of this endeavor for societies and individuals around the world, global researchers

The United States’ War on Drugs declared in 1971 by President Richard Nixon and revamped by President Reagan in the 1980s has been an objectively failed initiative with origins based in racism and oppression. After exploring the repercussions of this endeavor for societies and individuals around the world, global researchers and policymakers have declared that the policies and institutions created to fight the battle have left devastation in their wake. Despite high economic and social costs, missed opportunities in public health and criminal justice sectors, and increasing limits on our personal freedoms, all the measures taken to eradicate drug abuse and trafficking have been unsuccessful. Not only that, but militarized police tactics, mass incarceration, and harsh penalties that stifle opportunities for rehabilitation, growth, and change disproportionately harm poor and minority communities. <br/>Because reform in U.S. drug policy is badly needed, the goals of America’s longest war need to be reevaluated, implications of the initiative reexamined, and alternative strategies reconsidered. Solutions must be propagated from a diverse spectrum of contributors and holistic understanding through scientific research, empirical evidence, innovation, public health, social wellbeing, and measurable outcomes. But before we can know where we should be headed, we need to appreciate how we got to where we are. This preliminary expository investigation will explore and outline the history of drug use and prohibition in the United States before the War on Drugs was officially declared. Through an examination of the different patterns of substance use, evolving civil tolerance of users, racially-charged anti-drug misinformation/propaganda campaigns, and increasingly restrictive drug control policies, a foundation for developing solutions and strengths-based strategies for drug reform will emerge.

ContributorsSherman, Brooke (Author) / Jimenez-Arista, Laura (Thesis director) / Mitchell, Ojmarrh (Committee member) / College of Integrative Sciences and Arts (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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I conducted a literature review of articles pertaining to the history and treatment of rats. After outlining all of the relevant connections, I argue that as a result of people's conceptions about rats, rats do not receive the same respect and protections afforded other animals, such as cats and dogs,

I conducted a literature review of articles pertaining to the history and treatment of rats. After outlining all of the relevant connections, I argue that as a result of people's conceptions about rats, rats do not receive the same respect and protections afforded other animals, such as cats and dogs, in the laboratory and beyond. I present both negative and positive conceptions about rats and the realities of these conceptions. Finally, I talk about the changes that need to take place in laboratory research, why animals are still used in research today, and the alternatives that exist to animal models.

Created2021-05
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This white paper serves as an accumulation of research to guide needle exchange program (NEP) policies in the state of Arizona to decrease the transmission of infectious diseases such as HIV and HCV.

ContributorsLeaver, Jillian (Author) / Hruschka, Daniel (Thesis director) / Doran, Chris (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Urban encroachment into traditional snake territories has long been underway; likely increasing snake sightings in urban neighborhoods. With increasing overlap, I ask if the perceptions of snakes are actually influencing urban residents to say that snakes are a significant problem in their neighborhood today? I was interested in finding out

Urban encroachment into traditional snake territories has long been underway; likely increasing snake sightings in urban neighborhoods. With increasing overlap, I ask if the perceptions of snakes are actually influencing urban residents to say that snakes are a significant problem in their neighborhood today? I was interested in finding out whether or not there would be a positive correlation between the perception of snakes being a problem within a neighborhood and the actual number of sightings recorded. To address this, I used survey responses from 2017 regarding the risk perception of snakes from twelve neighborhoods within Maricopa County. These responses were then compared to the number of snake sightings within those same neighborhoods over a span of ten years using community science data from iNaturalist. The average results of the people who took the survey perceived that snakes were not a problem in their neighborhood. It was also found that in the outlying areas closer to natural snake habitat (desert preserves), a positive correlation between a higher survey response and a higher number of snake sightings could be seen. Overall, the conclusion of the data revealed that the perceptions of residents did not align with the actual number of snake sightings.

ContributorsMiranda, Caroline (Author) / Bateman, Heather (Thesis director) / Brown, Jeffrey (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The following is a review of the literature on Equine Assisted Psychotherapy (EAP) as a potential treatment for US service members with Post-Traumatic Stress Disorder(PTSD). EAP is a relatively new and undeclared psychotherapeutic technique that presents limitless opportunities for holistic growth in patients who have Post-Traumatic Stress Disorder (PTSD)

The following is a review of the literature on Equine Assisted Psychotherapy (EAP) as a potential treatment for US service members with Post-Traumatic Stress Disorder(PTSD). EAP is a relatively new and undeclared psychotherapeutic technique that presents limitless opportunities for holistic growth in patients who have Post-Traumatic Stress Disorder (PTSD) who have not achieved an improvement in their quality of life as a result of other conventional treatments. Due to its heterogenous nature, PTSD directly dismantles the brain’s reward circuitry pathway, altering the individual’s capacity for emotional resolution. For US veterans suffering from PTSD who have not received palpable improvements through traditional talk therapies, EAP is a treatment for emotional vulnerability and communal reintegration when used in conjunction with techniques of attachment theory and cognitive-behavioral theory. Previous studies show an uptick in interpersonal trust and an alleviation of maladaptive defensive mechanisms set in place by the individual to protect the psyche. Research is indicative of an alleviation in overall symptomatology with an emphasis in the rehearsal of therapeutic strategies within interpersonal relationships to rehabilitate social engagement and cognition. Due to the lack of foundational acceptance of EAP thus far as a treatment for PTSD, it is challenging to ascertain a marginalized understanding of the holistic effects of EAP on PTSD as a stand alone psychotherapeutic treatment.

ContributorsThompson, Kylee Shae (Author) / Jimenez, Laura (Thesis director) / Murphree, Julie (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Many women are subject to role conflict. Between participating in their jobs and social expectations about duties as a mother, they might experience considerable stress trying to fulfill both those demanding roles. Data was analyzed from 182,617 women in 38 low- and middle-income countries from MICS surveys, using linear regression

Many women are subject to role conflict. Between participating in their jobs and social expectations about duties as a mother, they might experience considerable stress trying to fulfill both those demanding roles. Data was analyzed from 182,617 women in 38 low- and middle-income countries from MICS surveys, using linear regression to examine how a number of children and working status interact to predict life satisfaction and happiness. Having more children was almost always associated with lower life satisfaction and happiness. The only exception was that among women who worked, more children to a point was associated with greater life satisfaction. Notably, work had different associations with emotional well-being depending on how it was measured. Having a job was generally associated with lower happiness, but greater life satisfaction. There is little evidence of an interaction between work and children indicating role conflict. Indeed, for life satisfaction, working seems to counteract the negative effect of having more children. Determining how large the effect of having both children and jobs are in women's lives can help determine the burden placed on women today and how that burden can be alleviated.

ContributorsKhan, Arisha (Author) / Hruschka, Daniel (Thesis director) / Pedram, Christina (Committee member) / School of Life Sciences (Contributor) / School of Human Evolution & Social Change (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05