Matching Items (110)
Description
Diseases have been part of human life for generations and evolve within the population, sometimes dying out while other times becoming endemic or the cause of recurrent outbreaks. The long term influence of a disease stems from different dynamics within or between pathogen-host, that have been analyzed and studied by many researchers using mathematical models. Co-infection with different pathogens is common, yet little is known about how infection with one pathogen affects the host's immunological response to another. Moreover, no work has been found in the literature that considers the variability of the host immune health or that examines a disease at the population level and its corresponding interconnectedness with the host immune system. Knowing that the spread of the disease in the population starts at the individual level, this thesis explores how variability in immune system response within an endemic environment affects an individual's vulnerability, and how prone it is to co-infections. Immunology-based models of Malaria and Tuberculosis (TB) are constructed by extending and modifying existing mathematical models in the literature. The two are then combined to give a single nine-variable model of co-infection with Malaria and TB. Because these models are difficult to gain any insight analytically due to the large number of parameters, a phenomenological model of co-infection is proposed with subsystems corresponding to the individual immunology-based model of a single infection. Within this phenomenological model, the variability of the host immune health is also incorporated through three different pathogen response curves using nonlinear bounded Michaelis-Menten functions that describe the level or state of immune system (healthy, moderate and severely compromised). The immunology-based models of Malaria and TB give numerical results that agree with the biological observations. The Malaria--TB co-infection model gives reasonable results and these suggest that the order in which the two diseases are introduced have an impact on the behavior of both. The subsystems of the phenomenological models that correspond to a single infection (either of Malaria or TB) mimic much of the observed behavior of the immunology-based counterpart and can demonstrate different behavior depending on the chosen pathogen response curve. In addition, varying some of the parameters and initial conditions in the phenomenological model yields a range of topologically different mathematical behaviors, which suggests that this behavior may be able to be observed in the immunology-based models as well. The phenomenological models clearly replicate the qualitative behavior of primary and secondary infection as well as co-infection. The mathematical solutions of the models correspond to the fundamental states described by immunologists: virgin state, immune state and tolerance state. The phenomenological model of co-infection also demonstrates a range of parameter values and initial conditions in which the introduction of a second disease causes both diseases to grow without bound even though those same parameters and initial conditions did not yield unbounded growth in the corresponding subsystems. This results applies to all three states of the host immune system. In terms of the immunology-based system, this would suggest the following: there may be parameter values and initial conditions in which a person can clear Malaria or TB (separately) from their system but in which the presence of both can result in the person dying of one of the diseases. Finally, this thesis studies links between epidemiology (population level) and immunology in an effort to assess the impact of pathogen's spread within the population on the immune response of individuals. Models of Malaria and TB are proposed that incorporate the immune system of the host into a mathematical model of an epidemic at the population level.
ContributorsSoho, Edmé L (Author) / Wirkus, Stephen (Thesis advisor) / Castillo-Chavez, Carlos (Thesis advisor) / Chowell-Puente, Gerardo (Committee member) / Arizona State University (Publisher)
Created2011
Description
Ten regional climate models (RCMs) and atmosphere-ocean generalized model parings from the North America Regional Climate Change Assessment Program were used to estimate the shift of extreme precipitation due to climate change using present-day and future-day climate scenarios. RCMs emulate winter storms and one-day duration events at the sub-regional level. Annual maximum series were derived for each model pairing, each modeling period; and for annual and winter seasons. The reliability ensemble average (REA) method was used to qualify each RCM annual maximum series to reproduce historical records and approximate average predictions, because there are no future records. These series determined (a) shifts in extreme precipitation frequencies and magnitudes, and (b) shifts in parameters during modeling periods. The REA method demonstrated that the winter season had lower REA factors than the annual season. For the winter season the RCM pairing of the Hadley regional Model 3 and the Geophysical Fluid-Dynamics Laboratory atmospheric-land generalized model had the lowest REA factors. However, in replicating present-day climate, the pairing of the Abdus Salam International Center for Theoretical Physics' Regional Climate Model Version 3 with the Geophysical Fluid-Dynamics Laboratory atmospheric-land generalized model was superior. Shifts of extreme precipitation in the 24-hour event were measured using precipitation magnitude for each frequency in the annual maximum series, and the difference frequency curve in the generalized extreme-value-function parameters. The average trend of all RCM pairings implied no significant shift in the winter annual maximum series, however the REA-selected models showed an increase in annual-season precipitation extremes: 0.37 inches for the 100-year return period and for the winter season suggested approximately 0.57 inches for the same return period. Shifts of extreme precipitation were estimated using predictions 70 years into the future based on RCMs. Although these models do not provide climate information for the intervening 70 year period, the models provide an assertion on the behavior of future climate. The shift in extreme precipitation may be significant in the frequency distribution function, and will vary depending on each model-pairing condition. The proposed methodology addresses the many uncertainties associated with the current methodologies dealing with extreme precipitation.
ContributorsRiaño, Alejandro (Author) / Mays, Larry W. (Thesis advisor) / Vivoni, Enrique (Committee member) / Huang, Huei-Ping (Committee member) / Arizona State University (Publisher)
Created2013
Description
Woody plant encroachment is a worldwide phenomenon linked to water availability in semiarid systems. Nevertheless, the implications of woody plant encroachment on the hydrologic cycle are poorly understood, especially at the catchment scale. This study takes place in a pair of small semiarid rangeland undergoing the encroachment of Prosopis velutina Woot., or velvet mesquite tree. The similarly-sized basins are in close proximity, leading to equivalent meteorological and soil conditions. One basin was treated for mesquite in 1974, while the other represents the encroachment process. A sensor network was installed to measure ecohydrological states and fluxes, including precipitation, runoff, soil moisture and evapotranspiration. Observations from June 1, 2011 through September 30, 2012 are presented to describe the seasonality and spatial variability of ecohydrological conditions during the North American Monsoon (NAM). Runoff observations are linked to historical changes in runoff production in each watershed. Observations indicate that the mesquite-treated basin generates more runoff pulses and greater runoff volume for small rainfall events, while the mesquite-encroached basin generates more runoff volume for large rainfall events. A distributed hydrologic model is applied to both basins to investigate the runoff threshold processes experienced during the NAM. Vegetation in the two basins is classified into grass, mesquite, or bare soil using high-resolution imagery. Model predictions are used to investigate the vegetation controls on soil moisture, evapotranspiration, and runoff generation. The distributed model shows that grass and mesquite sites retain the highest levels of soil moisture. The model also captures the runoff generation differences between the two watersheds that have been observed over the past decade. Generally, grass sites in the mesquite-treated basin have less plant interception and evapotranspiration, leading to higher soil moisture that supports greater runoff for small rainfall events. For large rainfall events, the mesquite-encroached basin produces greater runoff due to its higher fraction of bare soil. The results of this study show that a distributed hydrologic model can be used to explain runoff threshold processes linked to woody plant encroachment at the catchment-scale and provides useful interpretations for rangeland management in semiarid areas.
ContributorsPierini, Nicole A (Author) / Vivoni, Enrique R (Thesis advisor) / Wang, Zhi-Hua (Committee member) / Mays, Larry W. (Committee member) / Arizona State University (Publisher)
Created2013
Description
Solution methods for certain linear and nonlinear evolution equations are presented in this dissertation. Emphasis is placed mainly on the analytical treatment of nonautonomous differential equations, which are challenging to solve despite the existent numerical and symbolic computational software programs available. Ideas from the transformation theory are adopted allowing one to solve the problems under consideration from a non-traditional perspective. First, the Cauchy initial value problem is considered for a class of nonautonomous and inhomogeneous linear diffusion-type equation on the entire real line. Explicit transformations are used to reduce the equations under study to their corresponding standard forms emphasizing on natural relations with certain Riccati(and/or Ermakov)-type systems. These relations give solvability results for the Cauchy problem of the parabolic equation considered. The superposition principle allows to solve formally this problem from an unconventional point of view. An eigenfunction expansion approach is also considered for this general evolution equation. Examples considered to corroborate the efficacy of the proposed solution methods include the Fokker-Planck equation, the Black-Scholes model and the one-factor Gaussian Hull-White model. The results obtained in the first part are used to solve the Cauchy initial value problem for certain inhomogeneous Burgers-type equation. The connection between linear (the Diffusion-type) and nonlinear (Burgers-type) parabolic equations is stress in order to establish a strong commutative relation. Traveling wave solutions of a nonautonomous Burgers equation are also investigated. Finally, it is constructed explicitly the minimum-uncertainty squeezed states for quantum harmonic oscillators. They are derived by the action of corresponding maximal kinematical invariance group on the standard ground state solution. It is shown that the product of the variances attains the required minimum value only at the instances that one variance is a minimum and the other is a maximum, when the squeezing of one of the variances occurs. Such explicit construction is possible due to the relation between the diffusion-type equation studied in the first part and the time-dependent Schrodinger equation. A modication of the radiation field operators for squeezed photons in a perfect cavity is also suggested with the help of a nonstandard solution of Heisenberg's equation of motion.
ContributorsVega-Guzmán, José Manuel, 1982- (Author) / Sulov, Sergei K (Thesis advisor) / Castillo-Chavez, Carlos (Thesis advisor) / Platte, Rodrigo (Committee member) / Chowell-Puente, Gerardo (Committee member) / Arizona State University (Publisher)
Created2013
Description
Land-atmosphere interactions of semiarid shrublands have garnered significant scientific interest. One of the main tools used for this research is the eddy covariance (EC) method, which measures fluxes of energy, water vapor, and carbon dioxide. EC fluxes can be difficult to interpret due to complexities within the EC footprint (i.e. the surface conditions that contribute to the flux measurements). Most EC studies use a small number of soil probes to estimate the land surface states underlying the measured fluxes, which likely undersamples the footprint-scale conditions, especially in semiarid shrublands which are characterized by high spatial and temporal variability. In this study, I installed a dense network of soil moisture and temperature probe profiles in the footprint region of an EC tower at two semiarid sites: a woody savanna in southern Arizona and a mixed shrubland in southern New Mexico. For data from May to September 2013, I link land surface states to EC fluxes through daily footprints estimated using an analytical model. Novel approaches are utilized to partition evapotranspiration, estimate EC footprint soil states, connect differences in fluxes to footprint composition, and assess key drivers behind soil state variability. I verify the hypothesis that a small number of soil probes poorly estimates the footprint conditions for soil moisture, due to its high spatial variability. Soil temperature, however, behaves more consistently in time and space. As such, distributed surface measurements within the EC footprint allow for stronger ties between evapotranspiration and moisture, but demonstrate no significant improvement in connecting sensible heat flux and temperature. I also find that in these systems vegetation cover appears to have stronger controls on soil moisture and temperature than does soil texture. Further, I explore the influence of footprint vegetation composition on the measured fluxes, which reveals that during the monsoon season evaporative fraction tends to increase with footprint bare soil coverage for the New Mexico site and that the ratio of daily transpiration to evapotranspiration increases with grass coverage at the Arizona site. The thesis results are useful for understanding the land-atmosphere interactions of these ecosystems and for guiding future EC studies in heterogeneous landscapes.
ContributorsAnderson, Cody Alan (Author) / Vivoni, Enrique R (Thesis advisor) / Wang, Zhihua (Committee member) / Mays, Larry W. (Committee member) / Arizona State University (Publisher)
Created2013
Description
The North American Monsoon (NAM) is characterized by high inter- and intra-seasonal variability, and potential climate change effects have been forecasted to increase this variability. The potential effects of climate change to the hydrology of the southwestern U.S. is of interest as they could have consequences to water resources, floods, and land management. I applied a distributed watershed model, the Triangulated Irregular Network (TIN)-based Real-time Integrated Basin Simulator (tRIBS), to the Beaver Creek basin in Arizona. This sub-basin of the Verde River is representative of the regional topography, land cover, and soils distribution. As such, it can serve to illustrate the utility of distributed models for change assessment studies. Model calibration was performed utilizing radar-based NEXRAD data, and comparisons were done to two additional sources of precipitation data: ground-based stations and the North American Land Data Assimilation System (NLDAS). Comparisons focus on the spatiotemporal distributions of precipitation and stream discharge. Utilizing the calibrated model, I applied scenarios from the HadCM3 General Circulation Model (GCM) which was dynamically downscaled by the Weather Research and Forecast (WRF) model, to refine the representation of Arizona's regional climate. Two time periods were examined, a historical 1990-2000 and a future 2031-2040, to evaluate the hydrologic consequence in the form of differences and similarities between the decadal averages for temperature, precipitation, stream discharge and evapotranspiration. Results indicate an increase in mean air temperature over the basin by 1.2 ºC. The average decadal precipitation amounts increased between the two time periods by 2.4 times that of the historical period and had an increase in variability that was 3 times the historical period. For the future period, modeled streamflow discharge in the summer increased by a factor of 3. There was no significant change in the average evapotranspiration (ET). Overall trends of increase precipitation and variability for future climate scenarios have a more significant effect on the hydrologic response than temperature increases in the system during NAM in this study basin. The results from this study suggest that water management in the Beaver Creek will need to adapt to higher summer streamflow amounts.
ContributorsHawkins, Gretchen (Author) / Vivoni, Enrique R. (Thesis advisor) / Semken, Steven (Committee member) / Mays, Larry W. (Committee member) / Arizona State University (Publisher)
Created2012
Description
This doctoral thesis investigates the predictability characteristics of floods and flash floods by coupling high resolution precipitation products to a distributed hydrologic model. The research hypotheses are tested at multiple watersheds in the Colorado Front Range (CFR) undergoing warm-season precipitation. Rainfall error structures are expected to propagate into hydrologic simulations with added uncertainties by model parameters and initial conditions. Specifically, the following science questions are addressed: (1) What is the utility of Quantitative Precipitation Estimates (QPE) for high resolution hydrologic forecasts in mountain watersheds of the CFR?, (2) How does the rainfall-reflectivity relation determine the magnitude of errors when radar observations are used for flood forecasts?, and (3) What are the spatiotemporal limits of flood forecasting in mountain basins when radar nowcasts are used into a distributed hydrological model?. The methodology consists of QPE evaluations at the site (i.e., rain gauge location), basin-average and regional scales, and Quantitative Precipitation Forecasts (QPF) assessment through regional grid-to-grid verification techniques and ensemble basin-averaged time series. The corresponding hydrologic responses that include outlet discharges, distributed runoff maps, and streamflow time series at internal channel locations, are used in light of observed and/or reference data to diagnose the suitability of fusing precipitation forecasts into a distributed model operating at multiple catchments. Results reveal that radar and multisensor QPEs lead to an improved hydrologic performance compared to simulations driven with rain gauge data only. In addition, hydrologic performances attained by satellite products preserve the fundamental properties of basin responses, including a simple scaling relation between the relative spatial variability of runoff and its magnitude. Overall, the spatial variations contained in gridded QPEs add value for warm-season flood forecasting in mountain basins, with sparse data even if those products contain some biases. These results are encouraging and open new avenues for forecasting in regions with limited access and sparse observations. Regional comparisons of different reflectivity -rainfall (Z-R) relations during three summer seasons, illustrated significant rainfall variability across the region. Consistently, hydrologic errors introduced by the distinct Z-R relations, are significant and proportional (in the log-log space) to errors in precipitation estimations and stream flow magnitude. The use of operational Z-R relations without prior calibration may lead to wrong estimation of precipitation, runoff magnitude and increased flood forecasting errors. This suggests that site-specific Z-R relations, prior to forecasting procedures, are desirable in complex terrain regions. Nowcasting experiments show the limits of flood forecasting and its dependence functions of lead time and basin scale. Across the majority of the basins, flood forecasting skill decays with lead time, but the functional relation depends on the interactions between watershed properties and rainfall characteristics. Both precipitation and flood forecasting skills are noticeably reduced for lead times greater than 30 minutes. Scale dependence of hydrologic forecasting errors demonstrates reduced predictability at intermediate-size basins, the typical scale of convective storm systems. Overall, the fusion of high resolution radar nowcasts and the convenient parallel capabilities of the distributed hydrologic model provide an efficient framework for generating accurate real-time flood forecasts suitable for operational environments.
ContributorsMoreno Ramirez, Hernan (Author) / Vivoni, Enrique R. (Thesis advisor) / Ruddell, Benjamin L. (Committee member) / Gochis, David J. (Committee member) / Mays, Larry W. (Committee member) / Huang, Huei-Ping (Committee member) / Arizona State University (Publisher)
Created2012
Description
The purpose of this study is to first investigate the role of political socialization on young men and women and what motivates them to become politically active and make the ultimate decision to run for elected office. These effects include parental attitudes, exposure to political shows and news sources, participation in voluntary organizations, and overall community involvement. After understanding these direct and indirect effects of political socialization, I can attempt to explain the causes for the gender gap in political ambition \u2014 meaning that significantly more men are running for elected office compared to women.
ContributorsOsgood, Shannon Marie (Author) / Woodall, Gina (Thesis director) / Herrera, Richard (Committee member) / Barrett, The Honors College (Contributor) / College of Public Service and Community Solutions (Contributor) / School of Public Affairs (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05
Description
Mortality of 1918 influenza virus was high, partly due to bacteria coinfections. We characterize pandemic mortality in Arizona, which had high prevalence of tuberculosis. We applied regressions to over 35,000 data points to estimate the basic reproduction number and excess mortality. Age-specific mortality curves show elevated mortality for all age groups, especially the young, and senior sparing effects. The low value for reproduction number indicates that transmissibility was moderately low.
ContributorsJenner, Melinda Eva (Author) / Chowell-Puente, Gerardo (Thesis director) / Kostelich, Eric (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
The Undoing Project is an ongoing educational feminist YouTube channel that serves as an introduction to feminism and feminist theory. The objective for this project is to present feminist theory and feminist ideology in an accessible and entertaining way. Through this project I sought to accomplish three goals: to challenge the negative image of feminism, bridge the gap between the language of academia and the public, and to acknowledge and unlearn ingrained prejudices. The videos focus on theory, history, legislation, current events, and pop culture. The initial project consists of ten videos addressing the feminist wave models, a brief history of the feminist movement, and discussions of concepts like hegemony, intersectionality, masculinity, femininity, and race.
ContributorsBuchholtz, Kaylee Marie (Author) / Brian, Jennifer (Thesis director) / Grzanka, Patrick (Committee member) / Brouwer, Dan (Committee member) / Barrett, The Honors College (Contributor) / College of Public Service and Community Solutions (Contributor) / School of Social Transformation (Contributor) / Department of English (Contributor)
Created2015-05