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Does school participatory budgeting (SPB) increase students’ political efficacy? SPB, which is implemented in thousands of schools around the world, is a democratic process of deliberation and decision-making in which students determine how to spend a portion of the school’s budget. We examined the impact of SPB on political efficacy in one middle school in Arizona. Our participants’ (n = 28) responses on survey items designed to measure self-perceived growth in political efficacy indicated a large effect size (Cohen’s d = 1.46), suggesting that SPB is an effective approach to civic pedagogy, with promising prospects for developing students’ political efficacy.
ContributorsGibbs, Norman P. (Author) / Bartlett, Tara Lynn (Author) / Schugurensky, Daniel, 1958- (Author)
Created2021-05-01
Description
Pathogenic Gram-negative bacteria employ a variety of molecular mechanisms to combat host defenses. Two-component regulatory systems (TCR systems) are the most ubiquitous signal transduction systems which regulate many genes required for virulence and survival of bacteria. In this study, I analyzed different TCR systems in two clinically-relevant Gram-negative bacteria, i.e., oral pathogen Porphyromonas gingivalis and enterobacterial Escherichia coli. P. gingivalis is a major causative agent of periodontal disease as well as systemic illnesses, like cardiovascular disease. A microarray study found that the putative PorY-PorX TCR system controls the secretion and maturation of virulence factors, as well as loci involved in the PorSS secretion system, which secretes proteinases, i.e., gingipains, responsible for periodontal disease. Proteomic analysis (SILAC) was used to improve the microarray data, reverse-transcription PCR to verify the proteomic data, and primer extension assay to determine the promoter regions of specific PorX regulated loci. I was able to characterize multiple genetic loci regulated by this TCR system, many of which play an essential role in hemagglutination and host-cell adhesion, and likely contribute to virulence in this bacterium. Enteric Gram-negative bacteria must withstand many host defenses such as digestive enzymes, low pH, and antimicrobial peptides (AMPs). The CpxR-CpxA TCR system of E. coli has been extensively characterized and shown to be required for protection against AMPs. Most recently, this TCR system has been shown to up-regulate the rfe-rff operon which encodes genes involved in the production of enterobacterial common antigen (ECA), and confers protection against a variety of AMPs. In this study, I utilized primer extension and DNase I footprinting to determine how CpxR regulates the ECA operon. My findings suggest that CpxR modulates transcription by directly binding to the rfe promoter. Multiple genetic and biochemical approaches were used to demonstrate that specific TCR systems contribute to regulation of virulence factors and resistance to host defenses in P. gingivalis and E. coli, respectively. Understanding these genetic circuits provides insight into strategies for pathogenesis and resistance to host defenses in Gram negative bacterial pathogens. Finally, these data provide compelling potential molecular targets for therapeutics to treat P. gingivalis and E. coli infections.
ContributorsLeonetti, Cori (Author) / Shi, Yixin (Thesis advisor) / Stout, Valerie (Committee member) / Nickerson, Cheryl (Committee member) / Sandrin, Todd (Committee member) / Arizona State University (Publisher)
Created2013
Description
The study of bacterial resistance to antimicrobial peptides (AMPs) is a significant area of interest as these peptides have the potential to be developed into alternative drug therapies to combat microbial pathogens. AMPs represent a class of host-mediated factors that function to prevent microbial infection of their host and serve as a first line of defense. To date, over 1,000 AMPs of various natures have been predicted or experimentally characterized. Their potent bactericidal activities and broad-based target repertoire make them a promising next-generation pharmaceutical therapy to combat bacterial pathogens. It is important to understand the molecular mechanisms, both genetic and physiological, that bacteria employ to circumvent the bactericidal activities of AMPs. These understandings will allow researchers to overcome challenges posed with the development of new drug therapies; as well as identify, at a fundamental level, how bacteria are able to adapt and survive within varied host environments. Here, results are presented from the first reported large scale, systematic screen in which the Keio collection of ~4,000 Escherichia coli deletion mutants were challenged against physiologically significant AMPs to identify genes required for resistance. Less than 3% of the total number of genes on the E. coli chromosome was determined to contribute to bacterial resistance to at least one AMP analyzed in the screen. Further, the screen implicated a single cellular component (enterobacterial common antigen, ECA) and a single transporter system (twin-arginine transporter, Tat) as being required for resistance to each AMP class. Using antimicrobial resistance as a tool to identify novel genetic mechanisms, subsequent analyses were able to identify a two-component system, CpxR/CpxA, as a global regulator in bacterial resistance to AMPs. Multiple previously characterized CpxR/A members, as well as members found in this study, were identified in the screen. Notably, CpxR/A was found to transcriptionally regulate the gene cluster responsible for the biosynthesis of the ECA. Thus, a novel genetic mechanism was uncovered that directly correlates with a physiologically significant cellular component that appears to globally contribute to bacterial resistance to AMPs.
ContributorsWeatherspoon-Griffin, Natasha (Author) / Shi, Yixin (Thesis advisor) / Clark-Curtiss, Josephine (Committee member) / Misra, Rajeev (Committee member) / Nickerson, Cheryl (Committee member) / Stout, Valerie (Committee member) / Arizona State University (Publisher)
Created2013
Description
Since the introduction of the common school in the United States (US), education has constantly been in a state of reform. Given the importance of student learning to the future state of our nation, it is important to understand how positive educational reform can be achieved. This ethnographic case study aims to try to understand how a reform effort works as an educational and a sociocultural process, and what the important contributing factors to actualizing school reform are, as well as the challenges of effective implementation. Specifically, this study focuses on a school-wide reform effort based upon Stephen Covey's Seven Habits (1989). Qualitative research methods were used to address the research questions in this study. The researcher drew upon interviews, observations, and artifact and field note collection to tell the story of an elementary school engaged in year three of a school-wide reform initiative from the viewpoint of 10 teachers involved. Three recurring themes emerged from the data. First, data indicate that school reform is most effective when a school culture is created that supports the activation of teacher voice, efficacy, and coparticipation. Second, time and support are factors impacting implementation. Third, teachers reported that the common language from the reform has impacted the culture of the school. The evolution of a school culture is not simple and is demonstrated in the different ways the teachers experience the reform. Questions of authenticity arise when the reform effort changes from a grassroots, bottom-up initiative to a more top-down, bureaucratized business model.
ContributorsLamp, Michelle (Author) / Mccarty, Teresa (Thesis advisor) / Schugurensky, Daniel, 1958- (Committee member) / Powers, Jeanne (Committee member) / Arizona State University (Publisher)
Created2013
Description
Providing nutrition information at point of sale at restaurants has gained in popularity in recent years and will soon become a legal requirement. Consumers are using this opportunity to become more informed on the nutritional quality of the foods they consume in an effort to maintain healthfulness. Prior research has confirmed the utility of this information in adult populations. However, research on adolescents in school environments has resulted in mixed findings. This study investigated the effect of exposure to calorie and fat information on student purchases at lunchtime in a high school cafeteria. Additionally, it explored other factors that may contribute to students' food selections during school lunches. The research methods included analysis of changes in cafeteria food sales in one school, surveys, and focus groups. Analysis of cafeteria food sales during lunch did not show any significant change in the average number of calories and fat purchased per student between pre and post intervention. However, information gathered from focus group questioning demonstrated how students used the nutrition information to change their behavior after they have purchased their food.
ContributorsFresques, Audrey Delfina (Author) / Schugurensky, Daniel, 1958- (Thesis advisor) / Barnett, Joshua (Committee member) / Cruz, Heather (Committee member) / Arizona State University (Publisher)
Created2013
Description
The purpose of this study is to examine the influence of neoliberalism on the occurrence and intervention of genocide, particularly the ability to create othered groups through a process of dehumanization that desensitizes those in power to the human condition. I propose Social Externalization Theory as paradigm that explains how neoliberalism can be used as a means social control to create subjects vulnerable to political and collective violence that is justified as the externalized cost of economic growth, development, and national security. Finally, the conflict in Darfur (2003 - 2010) serves as a case study to analyze the influence of neoliberal policies on the resistance of the International community to recognize the violence as genocide. Analysis of the case study found that some tenets of neoliberalism produce results that fit within the ideologies of genocide and that some aspects of neoliberalism assume a genocidal mentality. In this case, those in positions power engage in daily activities that justify some suffering as acceptable, thus desensitizing them to the harm that their decisions generate.
ContributorsCalleja, Robert J (Author) / Romero, Mary (Thesis advisor) / Swadener, Beth Blue (Committee member) / Schugurensky, Daniel, 1958- (Committee member) / Arizona State University (Publisher)
Created2013
Description
This dissertation explores the unique role schools play in contributing toward a sustainable future for their communities. This was undertaken by first conducting a thorough review and analysis of the literature on the current utilization of schools as agents of sustainable development, along with an evaluation of schools engaging in this model around the United States. Following this, a framework was developed to aid in the assessment of school-community engagements from the perspective of social change. Sustainability problem solving tools were synthesized for use by schools and community stakeholders, and were tested in the case study of this dissertation. This case study combined methods from the fields of sustainable development, transition management, and social change to guide two schools in their attempts to increase community sustainability through addressing a shared sustainability problem: childhood obesity. The case study facilitated the creation of a sustainable vision for the Phoenix Metropolitan Area without childhood obesity, as well as strategic actions plans for each school to utilize as they move forward on addressing this challenge.
ContributorsLawless, Tamara Hope (Author) / Golub, Aaron (Thesis advisor) / Redman, Charles (Committee member) / Schugurensky, Daniel, 1958- (Committee member) / Arizona State University (Publisher)
Created2013
Description
Sustainability challenges with severe local to global impacts require fundamental shifts in what industrial societies aspire to, generate, consume, and represent, as well as how they function. Transition governance is a promising framework to support these transformational efforts. A key component of transition governance is the construction of transition strategies, i.e., action schemes for how to transition from the current state to a sustainable one. Despite accomplishments in building theory and methodology for transition governance, the concepts of what transition strategies entail and how they relate to specific interventions are still underdeveloped. This dissertation further develops the concept of transition strategies, and explores how different stakeholder groups and allies can develop and test transition strategies across different scales, in the specific context of urban sustainability challenges. The overarching research question is: How can cities build and implement comprehensive transition strategies across different urban scales, from the city to the organizational level? The dissertation comprises four studies that explore the dynamic between transition strategies and experiments at the city, neighborhood, and organizational levels with empirical examples from Phoenix, Arizona. The first study reviews and compares paradigms of intentional change, namely transition governance, backcasting, intervention research, change management, integrated planning, and adaptive management in order to offer a rich set of converging ideas on what strategies for intentional change towards sustainability entail. The second study proposes a comprehensive concept of transition strategies and illustrates the concept with the example of sustainability strategies created through a research partnership with the City of Phoenix. The third study explores the role of experiments in transition processes through the lens of the neighborhood-level initiative of The Valley of the Sunflowers. The fourth study examines the role organizations can play in initiating urban sustainability transitions using exemplary strategies and experiments implemented at a local high school. The studies combined contribute to the further development of transition theory and sustainable urban development concepts. While this research field is at a nascent stage, the thesis provides a framework and empirical examples for how to build evidence-based transition strategies in support of urban sustainability.
ContributorsKay, Braden Ryan (Author) / Wiek, Arnim (Thesis advisor) / Loorbach, Derk (Committee member) / Schugurensky, Daniel, 1958- (Committee member) / Tiger, Fern (Committee member) / Arizona State University (Publisher)
Created2012
Description
The Empowerment Zones were created in 1993 under Clinton's administration, demonstrating a commitment to solving tough socio-economic problems in distressed communities. The main objective associated with this program was economic recovery of distressed communities by creating jobs and providing various services to the indigenous populations. The designation of the Empowerment Zones went in three rounds (1994, 1998, and 2001), and although the types and amounts of federal incentives varied across rounds, the four principles around which the program originated remain unchanged: strategic vision for change, community based partnerships, economic opportunity, and sustainable community development. Since its inception, the Empowerment Zones program has been implemented in 30 urban and 10 rural communities in 27 states across the U.S. Two central questions lead the research of this dissertation project: 1) What have been the main accomplishments of the round three federal Empowerment Zones program in Tucson? 2) What have been the main challenges of the round three federal Empowerment Zones program in Tucson? By using a case study research design and various techniques for data collection and analysis (including the program package Atlas.ti), this study examined the accomplishments and the challenges associated with the round three designated Empowerment Zone in Tucson. Evidence was collected from multiple sources, including 24 interviews, over 60 local newspaper articles, relevant documentation, annual performance reports, and other sources. The analysis reveals that the program's implementation in Tucson was strong in the beginning, but after two years, the earlier success started to fade quickly. The shortcomings of program design became evident during the implementation phase and further in the inability of the administration to collect relevant data to demonstrate the program's success. The consequences of the inability to provide data for program evaluation influenced the enthusiasm of the administrators and program partners, and weakened the political support. The reduction in the grant component contributed to overemphasis of the business development component thereby ignoring most community development aspects essential for the success of the program in Tucson. This study did not find evidence for the claim that round three of the empowerment zones program based on federal tax incentives contributes to the creation of new jobs and the attraction of new business in economically deprived communities in Tucson.
ContributorsAndonoska, Ljubinka (Author) / Schugurensky, Daniel, 1958- (Thesis advisor) / Miller, Gerald J. (Committee member) / Svara, James H. (Committee member) / Arizona State University (Publisher)
Created2013
Description
The passing of anti-immigrant legislation in the state of Arizona over the last decade has exacerbated an already oppressive system perpetuated by globalization and its byproducts, neoliberalism and neoconservativism. The social justice activist educators who live and work with the children and families most affected by these laws and policies must learn to navigate these controls if they hope to sustain their work. I have drawn from Freire's work surrounding the theories of praxis and conscientization to explain the motivation of these teachers, and the sociological theory of Communities of Practice (Lave & Wenger, 1991; Wenger, 1998; & Wenger, McDermott, & Snyder, 2002), to explain how the group, Arizona Teachers for Justice serves as a space of learning and support for these educators. This dissertation is a multiple case study and has employed semi-structured interviews with four social justice activist educators to understand how social justice activist educators in Arizona cope and sustain their teaching and activism, particularly through their membership in groups such as Arizona Teachers for Justice. The teachers in this study are each at different stages in their careers and each teaches in a different setting and/or grade level. This cross section provides multiple perspectives and varied lenses through which to view the struggles and triumphs of social justice activist educators in the state of Arizona. The teachers in this study share their experiences of being singled out for their activism and explain the ways they cope with such attacks. They explain how they manage to fulfill their dedication to equity by integrating critical materials while adhering to common core standards. They express the anger that keeps them fighting in the streets and the fears that keep them from openly rejecting unjust policies. The findings of this study contribute to the discussion of how to not only prepare social justice activist educators, but ways of supporting and sustaining their very crucial work. Neoliberal and neoconservative attacks on education are pervasive and it is critical that we prepare teachers to face these structural pressures if we hope to ever change the dehumanizing agenda of these global powers.
ContributorsEversman, Kimberly A (Author) / Swadener, Elizabeth (Thesis advisor) / Sandlin, Jennifer (Committee member) / Schugurensky, Daniel, 1958- (Committee member) / Arizona State University (Publisher)
Created2013