Matching Items (764)
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In the 1970s James Watson recognized the inability of conventional DNA replication machinery to replicate the extreme termini of chromosomes known as telomeres. This inability is due to the requirement of a building block primer and was termed the end replication problem. Telomerase is nature's answer to the

In the 1970s James Watson recognized the inability of conventional DNA replication machinery to replicate the extreme termini of chromosomes known as telomeres. This inability is due to the requirement of a building block primer and was termed the end replication problem. Telomerase is nature's answer to the end replication problem. Telomerase is a ribonucleoprotein which extends telomeres through reverse transcriptase activity by reiteratively copying a short intrinsic RNA sequence to generate 3' telomeric extensions. Telomeres protect chromosomes from erosion of coding genes during replication, as well as differentiate native chromosome ends from double stranded breaks. However, controlled erosion of telomeres functions as a naturally occurring molecular clock limiting the replicative capacity of cells. Telomerase is over activated in many cancers, while inactivation leads to multiple lifespan limiting human diseases. In order to further study the interaction between telomerase RNA (TR) and telomerase reverse transcriptase protein (TERT), vertebrate TERT fragments were screened for solubility and purity following bacterial expression. Soluble fragments of medaka TERT including the RNA binding domain (TRBD) were identified. Recombinant medaka TRBD binds specifically to telomerase RNA CR4/CR5 region. Ribonucleotide and amino acid pairs in close proximity within the medaka telomerase RNA-protein complex were identified using photo-activated cross-linking in conjunction with mass spectrometry. The identified cross-linking amino acids were mapped on known crystal structures of TERTs to reveal the RNA interaction interface of TRBD. The identification of this RNA TERT interaction interface furthers the understanding of the telomerase complex at a molecular level and could be used for the targeted interruption of the telomerase complex as a potential cancer treatment.
ContributorsBley, Christopher James (Author) / Chen, Julian (Thesis advisor) / Allen, James (Committee member) / Ghirlanda, Giovanna (Committee member) / Arizona State University (Publisher)
Created2011
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This 15-week long course is designed to introduce students, specifically in Arizona, to basic sustainability and conservation principles in the context of local reptile wildlife. Throughout the course, the students work on identifying the problem, creating visions for the desired future, and finally developing a strategy to help with reptile

This 15-week long course is designed to introduce students, specifically in Arizona, to basic sustainability and conservation principles in the context of local reptile wildlife. Throughout the course, the students work on identifying the problem, creating visions for the desired future, and finally developing a strategy to help with reptile species survival in the valley. Research shows that animals in the classroom have led to improved academic success for students. Thus, through creating this course I was able to combine conservation and sustainability curriculum with real-life animals whose survival is directly being affected in the valley. My hope is that this course will help students identify a newfound passion and call to action to protect native wildlife. The more awareness and actionable knowledge which can be brought to students in Arizona about challenges to species survival the more likely we are to see a change in the future and a stronger sense of urgency for protecting wildlife. In order to accomplish these goals, the curriculum was developed to begin with basic concepts of species needs such as food and shelter and basic principles of sustainability. As the course progresses the students analyze current challenges reptile wildlife faces, like urban sprawl, and explore options to address these challenges. The course concludes with a pilot pitch where students present their solution projects to the school.

ContributorsGoethe, Emma Rae (Author) / Brundiers, Katja (Thesis director) / Bouges, Olivia (Committee member) / School of Sustainability (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The Constitution is a document that was made over 200 years ago by a population that could have never imagined the type of technology or social advances made in the 21st century. This creates a natural rift between governing ideals between then and now, that needs to be addressed. Rather

The Constitution is a document that was made over 200 years ago by a population that could have never imagined the type of technology or social advances made in the 21st century. This creates a natural rift between governing ideals between then and now, that needs to be addressed. Rather than holding the values of the nation to a time when people were not considered citizens because of the color of their skin, there need to be updates made to the Constitution itself. The need for change and the mechanisms were both established by the Framers while creating and advancing the Constitution. The ideal process to go about these changes is split between the formal Article V amendment process and judicial activism. The amendment process has infinite scope for changes that can be done, but due to the challenge involved in trying to pass any form of the amendment through both State and Federal Congresses, that process should be reserved for only fundamental or structural changes. Judicial activism, by way of Supreme Court decisions, is a method best applied to the protection of people’s rights.

Created2021-05
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Universal Basic Income is a proposed policy where the government would regularly pay all citizens in cash. The idea of a Universal Basic Income (UBI) has had a resurgence in recent years because of popular figures like Andrew Yang and Elon Musk, but its history and potential implications go dee

Universal Basic Income is a proposed policy where the government would regularly pay all citizens in cash. The idea of a Universal Basic Income (UBI) has had a resurgence in recent years because of popular figures like Andrew Yang and Elon Musk, but its history and potential implications go deep into the structure of human society. This thesis delves into how a basic income would transform social concepts of work and disrupt the personal economic model. With the bargaining power and freedom granted by a basic income, workers would find themselves in a position of work freedom and choice that has never existed in human history. With new freedom to do as they wish, the place of work in people’s lives needs to be reimagined as a source of fulfillment instead of an unlikeable but necessary part of everyday life. Workers will be given the choice to leave unfair or unfulfilling work and decide for themselves how they want to contribute within society. From increasing mental and economic well-being for most Americans to serving as a response to unemployment trends in the automated future, to encouraging greater business innovation, there are myriad ways in which basic incomes have the potential to benefit society. Framed by Martin Luther King Jr. and Franklin Delano Roosevelt as the only policy capable of abolishing poverty forever, Universal Basic income will be an important feature of transformative innovative policy advocacy until it is adopted by a major world government at which point the effects in practice will become clear.

ContributorsSimm, Michael Anthony (Author) / Soares, Rebecca (Thesis director) / Voorhees, Matthew (Committee member) / School of Sustainability (Contributor) / School of Politics and Global Studies (Contributor) / School for the Future of Innovation in Society (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Sex, Love, & Dating During the COVID-19 Pandemic is a creative thesis project that addresses two main issues: 1) the overall lack of resources and information available to the public about how to proceed with respect to sex, love, and dating during a global pandemic; and 2) my inability as

Sex, Love, & Dating During the COVID-19 Pandemic is a creative thesis project that addresses two main issues: 1) the overall lack of resources and information available to the public about how to proceed with respect to sex, love, and dating during a global pandemic; and 2) my inability as director of Devils in the Bedroom (an on-campus sexual health club at ASU) to get condoms and other sexual health materials into the hands of students while in quarantine. A resource was developed, an informational pamphlet on the three main topics (sex, love, and dating), as well as a program to distribute the materials by mail, the sexual health care packages.

ContributorsAnaya, Kiana Martina (Author) / SturtzSreetharan, Cindi (Thesis director) / Le, Tuong-Vi (Committee member) / School of Social Transformation (Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Globally, the incidental capture of non-target species in fisheries (bycatch) has been linked to declines of ecologically, economically, and culturally important marine species. Gillnet fisheries have especially high bycatch due to their non-selective nature, necessitating the development of new bycatch reduction technologies (BRTs). Net illumination is an emerging BRT that

Globally, the incidental capture of non-target species in fisheries (bycatch) has been linked to declines of ecologically, economically, and culturally important marine species. Gillnet fisheries have especially high bycatch due to their non-selective nature, necessitating the development of new bycatch reduction technologies (BRTs). Net illumination is an emerging BRT that has shown promise in reducing bycatch of marine megafauna, including sea turtles, cetaceans, and seabirds. However, little research has been conducted to understand the effects of net illumination on fish assemblages, including bony fish and elasmobranchs (i.e. sharks, rays, and skates). Here, I assessed a 7-year dataset of paired net illumination trials using four different types of light (green LEDs, green chemical glowsticks, ultraviolet (UV) lights, and orange lights) to examine the effects of net illumination on fish catch and bycatch in a gillnet fishery at Baja California Sur, Mexico. Analysis revealed no significant effect on bony fish target catch or bycatch for any light type. There was a significant decrease in elasmobranch bycatch using UV and orange lights, with orange lights showing the most promise for decreasing elasmobranch bycatch, resulting in a 50% reduction in bycatch rates. Analysis of the effects of net illumination on elasmobranch target catch was limited due to insufficient data. These results indicate that the illumination of gillnets may offer a practical solution for reducing fish bycatch while maintaining target catch. More research should be conducted to understand the effects of net illumination in different fisheries, how net illumination affects fisher profit and efficiency, and how net illumination affects fish behavior. Further optimization of net illumination is also necessary before the technology can be recommended on a broader scale.

ContributorsBurgher, Kayla Marie (Author) / Senko, Jesse (Thesis director) / Throop, Heather (Committee member) / School of Life Sciences (Contributor) / School of Sustainability (Contributor) / School of Geographical Sciences and Urban Planning (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Managing a work-home balance is a daunting task for any parent. It is often difficult to take leave from work to care for one’s family due to financial barriers, which simultaneously poses a threat to family development. Although many countries have parental leave policies in place to account for this,

Managing a work-home balance is a daunting task for any parent. It is often difficult to take leave from work to care for one’s family due to financial barriers, which simultaneously poses a threat to family development. Although many countries have parental leave policies in place to account for this, effectiveness of these policies vary by country. This study aims to find to what extent parental leave has an impact on the quality of life. In this study, quality of life was investigated by the rank of the country on the Happiness Index and through the lens of achieving sustainable family development, which was subsequently described to be reflected by a country’s governmental resources provided during parental leave, as well as the country’s Gender Inequality Index. Through a cross-cultural review of literature, it was found that there seems to be an indirect, complex correlation of parental leave to the quality of life, and external factors such as sociocultural ideals, gender inequality, and varying workplace practices have greater significance on quality of life.

ContributorsAlam, Ramisa Fariha (Co-author) / Mota, Urmi (Co-author) / SturtzSreetharan, Cindi (Thesis director) / Ruth, Alissa (Committee member) / School of Life Sciences (Contributor) / School of Social Transformation (Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Research has shown that being a female athlete in a male-dominated sports world is an oppressive burden, yet the experiences of being a black female athlete have been largely ignored. To combat this lack of attention, this paper invokes communication and feminist theorist Bell Hook's concept of moving black women

Research has shown that being a female athlete in a male-dominated sports world is an oppressive burden, yet the experiences of being a black female athlete have been largely ignored. To combat this lack of attention, this paper invokes communication and feminist theorist Bell Hook's concept of moving black women from margin to center to reveal the intersectional oppression of gender and racial narratives that they face in sports. By outlining the difference between white and black femininity and studying media portrayals of popular black female athletes such as Venus and Serena Williams and others, it becomes obvious how black women are typecast into certain social and athletic roles. This research also includes an auto-ethnographic component of my own experience as a black female lacrosse player at the NCAA Division I level. This component functions as a point of comparison and contrast of the ideas and concepts I discuss. Lastly, I offer recommendations and suggestions as to how to empower young black female athletes and retain them in a variety of sports. The goal of my thesis is to place special attention onto black women in an area which there is an extreme lack of representation. My own empirical research has led me to the conclusion that not only is such a discussion important, but it is absolutely necessary. If we are to fight back against hegemonic social structures such as racism and gender roles in the sports world, we must first understand what we are up against. My thesis gives us a glimpse into our imposing opponents, and I hope that future research continues this trend so that black female athletes like myself may one day be considered an athlete in the same sense that our white peers are.

ContributorsWright, Daniela Casselle (Author) / Edson, Belle (Thesis director) / Zanin, Alaina (Committee member) / Hugh Downs School of Human Communication (Contributor) / School of Social Transformation (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Thesis project on improving the socioeconomic conditions of waste pickers abroad for The Founders Lab

ContributorsUrbina-Bernal, Alejandro (Co-author) / Kidd, Isabella (Co-author) / Kapps, Jack (Co-author) / Byrne, Jared (Thesis director) / Marseille, Alicia (Committee member) / Jordan, Amanda (Committee member) / School of Politics and Global Studies (Contributor) / School of Social Transformation (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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This project analyzes the diversity of the various Chinese languages present in the Phoenix metropolitan area. The diversity and presence of these languages can be used to make inferences about different aspects of the Chinese American community in the Phoenix area, and therefore the dialects and compared to other aspects

This project analyzes the diversity of the various Chinese languages present in the Phoenix metropolitan area. The diversity and presence of these languages can be used to make inferences about different aspects of the Chinese American community in the Phoenix area, and therefore the dialects and compared to other aspects of the Chinese American immigration experience, such as where immigrants are from, what areas of Phoenix they reside, and the Chinese language skills of both the participants and their children. The data is then presented with historical context of the Phoenix Chinese community as well as a brief discussion on the current Chinese community in Phoenix as well as the acculturation of Chinese American children.

ContributorsMartin, Adam (Author) / Li, Wei (Thesis director) / Xie, Siqiao (Committee member) / Chemical Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05