Matching Items (755)
Filtering by
- Creators: Department of Finance
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
- Resource Type: Text
Description
In this project, biochemical characteristics of peptide binding agents, synthetic antibodies or synbodies, were examined with respect to the capture efficiency and specific binding ability to norovirus. Norovirus, although generally not a deadly pathogen, is the most common cause of acute gastroenteritis and outbreaks present a large social and financial burden to the healthcare and food service industries. With Dr. Diehnelt's laboratory group, a platform has been developed that enables us to rapidly construct peptide-based affinity ligands that can be characterized for binding to norovirus. The design needed to display clear results, be simple to operate, and be inexpensive to produce and use. Four synbodies, originally engineered with a specificity to the GII.4 Minerva genotype were tested with different virus strains varying in similarity to the GII.4 Minerva between 43% and 95.4%. Initial assays utilized norovirus-like particles to qualitatively compare the capture efficiency of the different synbodies without utilizing limited resources. To quantify the amount of actual virus captured by the synbodies, western blots with RT-PCR and RT-qPCR were utilized. The results indicated the synbodies were able to enrich the dilute solutions of the different noroviruses utilizing a magnetic bead pull-down assay. The capture efficiencies of the synbodies were comparable to currently utilized binding agents such as aptamers and porcine gastric mucine magnetic beads. This thesis presents data collected over nearly two years of research at the Center for Innovations in Medicine at the Biodesign Institute located at Arizona State University.
ContributorsSlosky, Rachael Marie (Author) / Diehnelt, Chris (Thesis director) / Stafford, Phillip (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Within recent years, metal-organic frameworks, or MOF’s, have gained a lot of attention in the materials research community. These micro-porous materials are constructed of a metal oxide core and organic linkers, and have a wide-variety of applications due to their extensive material characteristic possibilities. The focus of this study is the MOF-5 material, specifically its chemical stability in air. The MOF-5 material has a large pore size of 8 Å, and aperture sizes of 15 and 12 Å. The pore size, pore functionality, and physically stable structure makes MOF-5 a desirable material. MOF-5 holds applications in gas/liquid separation, catalysis, and gas storage. The main problem with the MOF-5 material, however, is its instability in atmospheric air. This inherent instability is due to the water in air binding to the zinc-oxide core, effectively changing the material and its structure. Because of this material weakness, the MOF-5 material is difficult to be utilized in industrial applications. Through the research efforts proposed by this study, the stability of the MOF-5 powder and membrane were studied. MOF-5 powder and a MOF-5 membrane were synthesized and characterized using XRD analysis. In an attempt to improve the stability of MOF-5 in air, methyl groups were added to the organic linker in order to hinder the interaction of water with the Zn4O core. This was done by replacing the terepthalic acid organic linker with 2,5-dimethyl terephthalic acid in the powder and membrane synthesis steps. The methyl-modified MOF-5 powder was found to be stable after several days of exposure to air while the MOF-5 powder exhibited significant crystalline change. The methyl-modified membrane was found to be unstable when synthesized using the same procedure as the MOF-5 membrane.
ContributorsAnderson, Anthony David (Author) / Lin, Jerry Y.S. (Thesis director) / Ibrahim, Amr (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
As the IoT (Internet of Things) market continues to grow, Company X needs to find a way to penetrate the market and establish larger market share. The problem with Company X's current strategy and cost structure lies in the fact that the fastest growing portion of the IoT market is microcontrollers (MCUs). As Company X currently holds its focus in manufacturing microprocessors (MPUs), the current manufacturing strategy is not optimal for entering competitively into the MCU space. Within the MCU space, the companies that are competing the best do not utilize such high level manufacturing processes because these low cost products do not demand them. Given that the MCU market is largely untested by Company X and its products would need to be manufactured at increasingly lower costs, it runs the risk of over producing and holding obsolete inventory that is either scrapped or sold at or below cost. In order to eliminate that risk, we will explore alternative manufacturing strategies for Company X's MCU products specifically, which will allow for a more optimal cost structure and ultimately a more profitable Internet of Things Group (IoTG). The IoT MCU ecosystem does not require the high powered technology Company X is currently manufacturing and therefore, Company X loses large margins due to its unnecessary leading technology. Since cash is king, pursuing a fully external model for MCU design and manufacturing processes will generate the highest NPV for Company X. It also will increase Company X's market share, which is extremely important given that every tech company in the world is trying to get its hands into the IoT market. It is possible that in ten to thirty years down the road, Company X can manufacture enough units to keep its products in-house, but this is not feasible in the foreseeable future. For now, Company X should focus on the cost market of MCUs by driving its prices down while maintaining low costs due to the variables of COGS and R&D given in our fully external strategy.
ContributorsKadi, Bengimen (Co-author) / Peterson, Tyler (Co-author) / Langmack, Haley (Co-author) / Quintana, Vince (Co-author) / Simonson, Mark (Thesis director) / Hertzel, Michael (Committee member) / Department of Supply Chain Management (Contributor) / Department of Finance (Contributor) / Department of Information Systems (Contributor) / Department of Marketing (Contributor) / School of Accountancy (Contributor) / W. P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Industry is changing. Businesses are plagued with problems of inefficiency, ineffectiveness, and waste. Many of these issues arise from some common mistakes within established management structures; these issues include lack of expertise in leadership positions, lack of unity across the organization, and imbalance within the business. Using Information Measurement Theory, the Kashiwagi Solution Model, and leadership theories, this thesis presents a simple approach to creating a business structure through explaining the basic tenets of a successful modern business. It was determined that the first and most important task of a business is to set realistic long-term goals for the organization. This thesis proposes that the basic needs of a successful business also includes having the right individuals, team formation, positive leadership, and the proper alignment of resources. It was found that it is best to hire individuals that exhibit some Type A characteristics because those individuals are likely to effectively carry out the goals of the business. Forming these individuals into small teams increases their processing speeds and encourages a balance of accountability, innovative solutions, and a network of learning. Furthermore, consistent, positive leadership that lives the company culture is a key element to successfully maintaining the business vision and maximizing associate effectiveness. It was also determined that aligning the organization to work towards the business vision can be performed through implementing a flat structure, placing individuals in roles that maximize effectiveness, and establishing the right business goals so that there is a consistent business vision at all levels of the organization. This thesis also provides guidance on how to implement these tenets in a simple, dominant way. Ultimately, the four proposed tenets working in unison towards business goals can lead to a successful and adaptable modern business.
ContributorsMeade, Payton Drew (Author) / Kashiwagi, Dean (Thesis director) / Kashiwagi, Jacob (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Sex trafficking in the United States is an enormous illegal underground business economy that involves the sexual exploitation of many persons. Due to the large nature of the sex trafficking business and the many different types of sex trafficking, it is helpful for social workers, government agencies, and activists to understand the intricacies of the various types of sex trafficking. This research focused on determining the human resources business structures behind pimp businesses that relied on mental coercion of the victim. The data source used, Pimpfeet.com—an online pimp authored blog—provided data from actual pimps on their business practices that were analyzed to determine trends in recruitment and retention. These trends were compared to human resource management theories from business literature to determine to what extent, or if at all, a pimp’s business recruited and retained workers in a way that was similar to how a legal business would, according to human resources strategies. The data extracted from Pimpfeet.com and used in this study consisted of 69 pimp quotes that were put into three recruitment categories and five retention categories based on human resource management literature in order to see which categories were used for recruitment and retention by pimps. This study found that pimp recruitment and retention followed, to some extent, the same models described in the human resource management literature, with slight modifications. This study showed that job embeddedness theory (Holtom, Mitchel and Lee, 2009) was able to explain much of why sex trafficking victims are retained so well by pimps since they are so embedded in the prostitution lifestyle. These findings show the different business techniques that pimps use for recruitment and retention of sex workers and are useful for understanding how a social worker, government entity or an activist can combat these forces to help remove victims from a pimp’s control, or keep victims from getting recruited in the first place. Further areas of research related to this topic were suggested.
ContributorsRivera, Kameron (Co-author) / La Benz, Alexis (Co-author) / Roe-Sepowitz, Dominique (Thesis director) / Corley, Kevin (Committee member) / W. P. Carey School of Business (Contributor) / Chemical Engineering Program (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
In a dormant state, cancer cells survive chemotherapy leaving the opportunity for cancer cell relapse and metastasis ultimately leading to patient death. A novel aminoglycoside-based hydrogel ‘Amikagel’ developed in Dr. Rege’s lab serves as a platform for a 3D tumor microenvironment (3DTM) mimicking cancer cell dormancy and relapse. Six Amikagels of varying mechanical stiffness and adhesivities were synthesized and evaluated as platforms for 3DTM formation through cell viability and cell cycle arrest analyses. The impact of fetal bovine serum concentration and bovine serum albumin concentration in the media were studied for their impact on 3DTM formation. These experiments allow us to identify the best possible Amikagel formulation for 3DTM.
ContributorsGjertsen, Haley Nicole (Author) / Rege, Kaushal (Thesis director) / Grandhi, Taraka Sai Pavan (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Company X has developed RealSenseTM technology, a depth sensing camera that provides machines the ability to capture three-dimensional spaces along with motion within these spaces. The goal of RealSense was to give machines human-like senses, such as knowing how far away objects are and perceiving the surrounding environment. The key issue for Company X is how to commercialize RealSense's depth recognition capabilities. This thesis addresses the problem by examining which markets to address and how to monetize this technology. The first part of the analysis identified potential markets for RealSense. This was achieved by evaluating current markets that could benefit from the camera's gesture recognition, 3D scanning, and depth sensing abilities. After identifying seven industries where RealSense could add value, a model of the available, addressable, and obtainable market sizes was developed for each segment. Key competitors and market dynamics were used to estimate the portion of the market that Company X could capture. These models provided a forecast of the discounted gross profits that could be earned over the next five years. These forecasted gross profits, combined with an examination of the competitive landscape and synergistic opportunities, resulted in the selection of the three segments thought to be most profitable to Company X. These segments are smart home, consumer drones, and automotive. The final part of the analysis investigated entrance strategies. Company X's competitive advantages in each space were found by examining the competition, both for the RealSense camera in general and other technologies specific to each industry. Finally, ideas about ways to monetize RealSense were developed by exploring various revenue models and channels.
ContributorsDunn, Nicole (Co-author) / Boudreau, Thomas (Co-author) / Kinzy, Chris (Co-author) / Radigan, Thomas (Co-author) / Simonson, Mark (Thesis director) / Hertzel, Michael (Committee member) / WPC Graduate Programs (Contributor) / Department of Psychology (Contributor) / Department of Finance (Contributor) / School of Accountancy (Contributor) / Department of Economics (Contributor) / School of Mathematical and Statistical Science (Contributor) / W. P. Carey School of Business (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Based on theoretical calculations, a material that is highly transmissive below 3000 nm and opaque above 3000 nm is desired to replace glass covers for flat plate solar thermal systems. Additionally, a suitable replacement material needs to have a sufficiently high operating temperature in order to prevent the glazing from melting and warping in a solar system. Traditional solar thermal applications use conventional soda lime glass or low iron content glass to accomplish this; however, this project aims to investigate acrylic, polycarbonate, and FEP film as suitable alternatives for conventional solar glazings. While UV-Vis and FT-IR spectroscopy indicate that these polymer substitutes may not be ideal when used alone, when used in combination with coatings and additives, these materials may present an opportunity for a glazing replacement. A model representing a flat plate solar collector was developed to qualitatively analyze the various materials and their performance. Using gathered spectroscopy data, the model was developed for a multi-glazing system and it was found that polymer substitutes could perform better in certain system configurations. To complete the model, the model must be verified using empirical data and coatings and additives investigated for the purposes of achieving the desired materials optical specifications.
ContributorsBessant, Justin Zachary (Author) / Friesen, Cody (Thesis director) / Lorzel, Heath (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This paper intends to analyze the Phoenix Suns' shooting patterns in real NBA games, and compare them to the "NBA 2k16" Suns' shooting patterns. Data was collected from the first five Suns' games of the 2015-2016 season and the same games played in "NBA 2k16". The findings of this paper indicate that "NBA 2k16" utilizes statistical findings to model their gameplay. It was also determined that "NBA 2k16" modeled the shooting patterns of the Suns in the first five games of the 2015-2016 season very closely. Both, the real Suns' games and the "NBA 2k16" Suns' games, showed a higher probability of success for shots taken in the first eight seconds of the shot clock than the last eight seconds of the shot clock. Similarly, both game types illustrated a trend that the probability of success for a shot increases as a player holds onto a ball longer. This result was not expected for either game type, however, "NBA 2k16" modeled the findings consistent with real Suns' games. The video game modeled the Suns with significantly more passes per possession than the real Suns' games, while they also showed a trend that more passes per possession has a significant effect on the outcome of the shot. This trend was not present in the real Suns' games, however literature supports this finding. Also, "NBA 2k16" did not correctly model the allocation of team shots for each player, however, the differences were found only in bench players. Lastly, "NBA 2k16" did not correctly allocate shots across the seven regions for Eric Bledsoe, however, there was no evidence indicating that the game did not correctly model the allocation of shots for the other starters, as well as the probability of success across the regions.
ContributorsHarrington, John P. (Author) / Armbruster, Dieter (Thesis director) / Kamarianakis, Ioannis (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
A series of mitochondria targeting probes was synthesized for the purpose of exploring the feasibility of a mitochondria targeting fluorescent sensor. Of the probes, the probe with a two carbon spacer showed the best co-localization from staining with the established MitoTracker Red® FM, indicating a potential development of the probe into mitochondria targeting sensor. However, cytotoxicity was observed for the probe with a six carbon spacer. Three additional mitochondria targeting fluorescent probes of longer spacer groups were synthesized, but the cytotoxicity was not observed to be as high as that of the probe with a two carbon spacer. The cytotoxicity was characterized to be that of caspase dependent cell death. To screen for a possible effect on apoptosis due to the mitochondrial probe, three fluorescent fusion proteins binding the anti-apoptotic proteins were designed and expressed. Each purified fusion protein was then incubated with the cytotoxic mitochondrial probe, and the mixture was isolated by running an affinity column. The fluorescence analysis of eluted fractions showed preliminary data of possible interaction between the protein and the mitochondrial probe.
ContributorsLee, Fred (Author) / Meldrum, Deirdre R. (Thesis director) / Tian, Yanqing (Committee member) / Zhang, Liqiang (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-12