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- Member of: Theses and Dissertations
Description
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality in the USA and throughout the world. Two phenotypes that promote this deadly outcome are the invasive potential of NSCLC and the emergence of therapeutic resistance in this disease. There is an unmet clinical need to understand the mechanisms that govern NSCLC cell invasion and therapeutic resistance, and to target these phenotypes towards abating the dismal five-year survival of NSCLC. The expression of the tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A; Fn14) correlates with poor patient survival and invasiveness in many tumor types including NSCLC. We hypothesize that suppression of Fn14 will inhibit NSCLC cell motility and reduce cell viability. Here we demonstrate that atorvastatin calcium treatment reduces Fn14 expression in NSCLC cell lines. Prior to Fn14 protein suppression, atorvastatin calcium modulated the expression of the Fn14 modulators P-ERK1/2 and P-NF-κβ. Atorvastatin calcium treatment inhibited the migratory capacity in H1975, H2030 and H1993 cells by at least 55%. When chemotactic migration in H2030 cells was induced by the Fn14 ligand TNF-like weak inducer of apoptosis (TWEAK) treatment, atorvastatin calcium successfully negated any stimulatory effects. Inversely, treatment of NSCLC cells with cholesterol resulted in a statistically significant increase in migration. Depletion of Fn14 expression via siRNA suppressed the migratory effect of cholesterol. Finally, atorvastatin calcium treatment sensitized cells to radiation treatment, reducing cell survival. These data suggest that atorvastatin calcium may inhibit NSCLC invasiveness through a mechanism involving Fn14, and may be a novel therapeutic target in NSCLC tumors expressing Fn14.
ContributorsCornes, Victoria Elisabeth (Author) / Stout, Valerie (Thesis director) / Whitsett, Timothy (Committee member) / Carson, Vashti (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
Across the world, nations manage their borders in various ways. Brazil and Uruguay share a non-militarized dry border, which creates a range of unique challenges and assets for that region. Through historical, linguistic, and cultural context as well as ethnography-inspired mixed method research, this paper demonstrates that the border region serves as an area of cultural blending. While elements of national affiliation are still present, at times, semiotic and linguistic elements are neither Brazilian nor Uruguayan, but have taken on their own identity.
ContributorsAraiza, Ulises (Co-author) / Desper, Tate (Co-author) / Escobar, Edward (Thesis director) / O'Connor, Brendan (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Transborder Studies (Contributor)
Created2015-05
Description
In 2012, President Obama presented an executive order, Deferred Action for Childhood Arrivals (DACA), which primarily defers the deportation of unauthorized immigrants who are under the age of 31 and who arrived to the US before the age 16, among other things. This study examines the impact DACA has had on the identity formation, interfamilial relationships, and future plans of 15 Mexican-origin adults (18-27 years old, 47% female) who were approved for DACA in Arizona. Participants were recruited using flyers and the snowball sampling method. Interviews were conducted using a semi-structured interview guide by a bilingual, culturally competent interviewer. The interviews were recorded and then a transcript-based pragmatic, thematic analysis of the interviews was conducted. Findings show that participants who arrive to the U.S. at a younger age (under 5) identify as American, while those who arrive at an older age (over 8) do not feel like they can identify as an American because they spent more time in Mexico and are more attached to their home culture. Physical characteristics also played a factor in whether or not participants felt like they could identify as American. Participants describe their financial responsibility in their families increasing since receiving DACA. They also describe how they are now seen as role models to other undocumented youth in their families. Despite the uncertain future of DACA, these participants continued to have ambitious goals such as becoming lawyers and working at robotics companies. Future studies should include larger sample sizes and formally test theories of identity.
ContributorsLopez, Alejandra (Author) / Diaz McConnell, Eileen (Thesis director) / Martinez, Airin (Committee member) / School of Social Transformation (Contributor) / School of Transborder Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Changes in Latino neighborhoods in Tucson, Arizona that occurred between 1990 and 2010 were studied. The overall Latino population increased substantially within the larger metropolitan area during the target time period. Neighborhoods were selected that had changed to become predominantly Latino during the target time period based on maps measuring ethnic clusters. Research was designed to characterize Latino neighborhoods in Tucson in terms of transformation. Methodology for comparison between changed and unchanged neighborhoods was developed. Observations were made in the three new neighborhoods, as well as in three historically Latino neighborhoods that experienced little change during the same time period. Interviews were conducted with residents from each neighborhood. Exploratory findings were made regarding the transformation of the neighborhoods with increased Latino populations. Findings showed that two areas of transformation increased largely because of the rise of higher density rental housing while one area transformed because two new affordable subdivisions were created within the studied time period. One new neighborhood's physical domain changed from an undeveloped land to a neighborhood with tract style houses. The historical areas have transformed in different ways including a decrease in crime and an increase in the younger population. The historical areas have experienced little change in the physical domain. All neighborhoods studied had evidences of a Spanish speaking population, and have businesses that cater to the surrounding Hispanic population.
ContributorsLeavitt, Isabella Maish (Author) / Lara-Valencia, Francisco (Thesis director) / Velez-Ibanez, Carlos (Committee member) / Barrett, The Honors College (Contributor) / School of Transborder Studies (Contributor) / School of Politics and Global Studies (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2014-05
Description
The fight for climate justice has been ongoing for decades. However, in a recent effort to address climate change, U.S. congressional leaders Alexandria Ocasio-Cortez of New York and Edward J. Markey of Massachusetts proposed a resolution known as the Green New Deal (GND). Though congress defeated the proposal, the policy changes envisioned within it have gained political momentum from states and municipalities. So much so, municipalities in the United States have decided to implement their own versions of the GND proposal. Throughout this paper, I analyze the components of three nationally recognized climate proposals that offer a unique approach to actualize the federal GND objectives: New York City's Climate Mobilization Act, Los Angeles's Green New Deal – Sustainable City pLAn, and Seattle's Green New Deal. From these proposals, I draw comparisons to Tempe's Climate Action plan to evaluate their efforts. Though this paper is primarily focused on analyzing the components of municipal GNDs across the nation, this paper also contends that municipalities' are a necessary complement to national efforts in mitigating climate change.
ContributorsMazariegos, Ashley (Author) / Fong, Benjamin Y. (Thesis director) / Calhoun, Craig (Committee member) / Economics Program in CLAS (Contributor) / School of Public Affairs (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
DescriptionThis thesis reviews the successes and failures of the New Deal Federal Public Art Projects. Considering these, it makes recommendations for a socially engaged public arts program under a Green New Deal to engage and inspire people across party lines behind a shared vision of a Green New Future.
ContributorsWhiteman, Elizabeth Anne (Author) / Fong, Benjamin (Thesis director) / Calhoun, Craig (Committee member) / Dean, Herberger Institute for Design and the Arts (Contributor) / School of Sustainability (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
Migration is natural, a human right, and to some extent, it is seen, allowed, and digested but by what bodies? Whose bodies? Who is given the privilege of range of motion, and who is chained to a ground, underground, buried?
Through a questioning of migration, a mechanism of movement, and its criminalization from the states through the establishment of citizenry, I aim to declare autonomy, and seek a dissection of what it means to criminalize, to establish, render a community as other.
Hasta mañana is a prayer to my parents’ bodies,
to bodies crossing the border,
to bodies displaced,
to bodies that never made it,
to bodies dug up,
buried,
Chained,
Hurting,
Aging,
to bodies I feel and see.
Through a questioning of migration, a mechanism of movement, and its criminalization from the states through the establishment of citizenry, I aim to declare autonomy, and seek a dissection of what it means to criminalize, to establish, render a community as other.
Hasta mañana is a prayer to my parents’ bodies,
to bodies crossing the border,
to bodies displaced,
to bodies that never made it,
to bodies dug up,
buried,
Chained,
Hurting,
Aging,
to bodies I feel and see.
ContributorsFlores Bustos, Yaritza Dayana (Author) / Danielson, Marivel (Thesis director) / Aranibar - Fernandez, Carolina (Committee member) / Chung, Samuel (Committee member) / School of Transborder Studies (Contributor) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The American Farm Bureau Federation (AFBF) is an organization promoting itself as "The National Voice of American Agriculture." However, small independent family farmers are losing their livlihoods, having their rural communities destroyed, and are suffering from mental illness due to the covert actions of the AFBF. In reality, the AFBF is a national advocate for agricultural conglomerates and industrial agriculture practice. The AFBF drives the American agribusiness sector and demobilizes small farmer mobilization for any iteration of a modern and sustainable agricultural revolution. This thesis seeks to evaluate the ways in which the Farm Bureau demobilizes farmers in their ideology, education, and activism and seeks to recommend effective ways challenge the American Farm Bureau in pursuit of an agriculturally just Green New Deal (GND). A GND for agriculture emphasizes the need for independent family farmers and ensuing components of sustainability, regenerative practice, and an integrated, healthy food system.
ContributorsRaderstorf, Alia Mcpherson (Author) / Fong, Benjamin (Thesis director) / Calhoun, Craig (Committee member) / School of Sustainable Engineering & Built Envirnmt (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
In the 1960s, prominent Civil Rights leaders proposed a Freedom Budget For All Americans, a policy proposal pamphlet with ambitious goals such as the abolition of poverty, universal healthcare and housing, fair wages for workers, a progressive tax, and more. These economic goals were meant to alleviate racial inequality by attacking the deep roots of inequality in the United States. While the Freedom Budget did not pass, the movement for the goals was incredibly remarkable and modern progressive movements like that for the Green New Deal can learn much from the successes and failures of the Freedom Budget. This thesis aims to identify strengths and weaknesses, analyze the causes behind them, and synthesize these factors into the modern context of the Green New Deal's fight.
ContributorsKhan, Myra Amir (Author) / Fong, Benjamin (Thesis director) / Calhoun, Craig (Committee member) / School of Transborder Studies (Contributor) / School of Sustainability (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
The identity of Latinx womxn is multidimensional and widely misrepresented in media. To address this problem, I plan on presenting the multifaceted nature of this intersection by documenting micro perspectives via photography. I articulate my individual perspectives of Latinx womxnhood by using lived experiences, testimonio, through a metanarrative, painting, poetry, and mixed-media art. My micro perspective/metanarrative, as well as the testimonio/art pieces, along with the photography will speak to the macro which is surrounding and engaging us. Testimonio and art are intertwined for me and this project is a proclamation of how these two flow into one another to the point where they are essentially the same. Nosotrxs is a project that focuses on reconciling the stereotypical, media representations of Latinx womxnhood with reality. How I approach this issue varies, I looked both inside and outside of myself to articulate what I see going on in the Latinx community. I photographed Latinx womxn of different nationalities, races, and gender expressions to humanize them to an audience. I painted two canvases, one with the phrase "What justifies a border between you and I?" and one with an impressionist/surrealist focus on Central America. My fourth piece is a sculptural minimalist desert with a video of U.S. border patrol agents destroying water jugs intended for migrants in the Sonoran desert along the U.S.-Mexico border. My fifth piece is a collection of poetry I wrote over the past year that reflect on my identity as a Latina woman based in Phoenix and born in California. All of these pieces together are a small representation of Latinx womxnhood in Phoenix, Arizona.
ContributorsMartinez, Claudia Belen (Author) / Fonseca, Vanessa (Thesis director) / Danielson, Marivel (Committee member) / Barrett, The Honors College (Contributor) / CISA - Interdisciplinary Humanities and Communication (Contributor) / School of Transborder Studies (Contributor)
Created2018-05