Matching Items (5)
Description
The ASU COVID-19 testing lab process was developed to operate as the primary testing site for all ASU staff, students, and specified external individuals. Tests are collected at various collection sites, including a walk-in site at the SDFC and various drive-up sites on campus; analysis is conducted on ASU campus and results are distributed virtually to all patients via the Health Services patient portal. The following is a literature review on past implementations of various process improvement techniques and how they can be applied to the ABCTL testing process to achieve laboratory goals. (abstract)
ContributorsKrell, Abby Elizabeth (Co-author) / Bruner, Ashley (Co-author) / Ramesh, Frankincense (Co-author) / Lewis, Gabriel (Co-author) / Barwey, Ishna (Co-author) / Myers, Jack (Co-author) / Hymer, William (Co-author) / Reagan, Sage (Co-author) / Compton, Carolyn (Thesis director) / McCarville, Daniel R. (Committee member) / Industrial, Systems & Operations Engineering Prgm (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Malignant brain tumors are devastating despite aggressive treatments such as surgical resection, chemotherapy and radiation therapy. The average life expectancy of patients with newly diagnosed glioblastoma is approximately 15 months. One novel therapeutic strategy involves using a ketogenic diet (KD) which increases circulating ketones and reduces circulating glucose. While the preclinical work has shown that the KD increases survival, enhances radiation and alters several pathways in malignant gliomas, its impact on the anti-tumor immune response has yet to be examined. This dissertation demonstrates that mice fed the KD had increased tumor-reactive innate and adaptive immune responses, including increased cytokine production and cytolysis via tumor-reactive CD8+ T cells. Additionally, we saw that mice maintained on the KD had increased CD4 infiltration, while T regulatory cell numbers stayed consistent. Lastly, mice fed the KD had a significant reduction in immune inhibitory receptor expression as well as decreased inhibitory ligand expression on glioma cells, namely programmed death receptor -1 (PD-1) and its ligand programmed death receptor ligand -1 (PD-L1). Further, it is demonstrated that the ketone body beta-hydroxybutyrate (BHB) reduces expression of PD-L1 on glioma cells in vitro suggesting it may be responsible in part for immune-related changes elicited by the KD. Finally this dissertation also shows that the KD increases the expression of microRNAs predicted to target PD-L1 suggesting a potential mechanism to explain the ability of the KD to modulate immune inhibitory checkpoint pathways. Taken together these studies shed important light on the mechanisms underlying the KD and provide additional support for its use an adjuvant therapy for malignant glioma.
ContributorsWoolf, Eric Christopher (Author) / Compton, Carolyn C. (Thesis advisor) / Scheck, Adrienne C (Committee member) / Preul, Mark C (Committee member) / Blattman, Joseph N (Committee member) / Mehta, Shwetal (Committee member) / Arizona State University (Publisher)
Created2018
Description
Despite significant growth in research about supply chain integration, many questions remain unanswered regarding the path to integration and the benefits that can be accrued. This dissertation examines three aspects of supply chain integration in the health sector, leveraging the healthcare context to extend the theoretical boundaries, as well as applying supply chain knowledge to an industry known to be immature in terms of its supply chain practices.
In the first chapter, a supply chain operating model that breaks away from the traditional healthcare supply chain structures is examined. Consolidated Service Centers (CSCs) embody a shared services strategy, consolidating supply chain functions across multiple hospitals (i.e. horizontal integration) and disintermediating several key roles in healthcare supply chains such as the group purchasing organizations and national distributors. Through case studies, key characteristics of CSCs that enable them to reduce the level of supply chain complexity are examined.
The second chapter investigates buyer-supplier relationships in healthcare (i.e. supplier integration), where a high level of distrust exists between hospitals and their suppliers. This context is leveraged to study both enablers and barriers to buyer-supplier trust. The results suggest that contracting counteracts the negative effects of dependence on trust. Furthermore, the study reveals that hospital buyers may, in some situations, perceive dedicated resource investments made by suppliers as trust barriers, associating such investments with supplier upselling and entrenchment tactics. This runs contrary to how dedicated investments are perceived in most other industries.
In the third chapter, the triadic relationship between the hospital, supplier, and physician is taken into consideration. Given their professional autonomy and power, physicians commonly undermine hospital efforts in supply base rationalization and standardization. This study examines whether physician-hospital integration (i.e. customer integration) can drive physicians towards supply selection practices that align with the hospital’s sourcing strategies and ultimately result in better supply chain performance. This study utilizes theory on agency triads and professionalism and tests hypotheses through a random effects regression model applied to data about hospital financial performance and physician-hospital arrangements.
In the first chapter, a supply chain operating model that breaks away from the traditional healthcare supply chain structures is examined. Consolidated Service Centers (CSCs) embody a shared services strategy, consolidating supply chain functions across multiple hospitals (i.e. horizontal integration) and disintermediating several key roles in healthcare supply chains such as the group purchasing organizations and national distributors. Through case studies, key characteristics of CSCs that enable them to reduce the level of supply chain complexity are examined.
The second chapter investigates buyer-supplier relationships in healthcare (i.e. supplier integration), where a high level of distrust exists between hospitals and their suppliers. This context is leveraged to study both enablers and barriers to buyer-supplier trust. The results suggest that contracting counteracts the negative effects of dependence on trust. Furthermore, the study reveals that hospital buyers may, in some situations, perceive dedicated resource investments made by suppliers as trust barriers, associating such investments with supplier upselling and entrenchment tactics. This runs contrary to how dedicated investments are perceived in most other industries.
In the third chapter, the triadic relationship between the hospital, supplier, and physician is taken into consideration. Given their professional autonomy and power, physicians commonly undermine hospital efforts in supply base rationalization and standardization. This study examines whether physician-hospital integration (i.e. customer integration) can drive physicians towards supply selection practices that align with the hospital’s sourcing strategies and ultimately result in better supply chain performance. This study utilizes theory on agency triads and professionalism and tests hypotheses through a random effects regression model applied to data about hospital financial performance and physician-hospital arrangements.
ContributorsAbdulsalam, Yousef J (Author) / Schneller, Eugene S (Thesis advisor) / Gopalakrishnan, Mohan (Committee member) / Maltz, Arnold (Committee member) / Dooley, Kevin (Committee member) / Arizona State University (Publisher)
Created2016
Description
This Project Report documents the accomplishments of an extraordinary group of students, faculty, and staff at the Arizona state University, who participated in a year-long, multidisciplinary, first-of-its-kind academic endeavor entitled “The Making of a COVID Lab.” The lab that is the focus of this project is the ASU Biodesign Clinical Testing Laboratory, known simply as the ABCTL.
ContributorsCompton, Carolyn C. (Project director) / Christianson, Serena L. (Project director) / Floyd, Christopher (Project director) / Schneller, Eugene S (Research team head) / Rigoni, Adam (Research team head) / Stanford, Michael (Research team head) / Cheong, Pauline (Research team head) / McCarville, Daniel R. (Research team head) / Dudley, Sean (Research team head) / Blum, Nita (Research team head) / Magee, Mitch (Research team head) / Agee, Claire (Research team member) / Cosgrove, Samuel (Research team member) / English, Corinne (Research team member) / Mattson, Kyle (Research team member) / Qian, Michael (Research team member) / Espinoza, Hale Anna (Research team member) / Filipek, Marina (Research team member) / Jenkins, Landon James (Research team member) / Ross, Nathaniel (Research team member) / Salvatierra, Madeline (Research team member) / Serrano, Osvin (Research team member) / Wakefield, Alex (Research team member) / Calo, Van Dexter (Research team member) / Nofi, Matthew (Research team member) / Raymond, Courtney (Research team member) / Barwey, Ishna (Research team member) / Bruner, Ashley (Research team member) / Hymer, William (Research team member) / Krell, Abby Elizabeth (Research team member) / Lewis, Gabriel (Research team member) / Myers, Jack (Research team member) / Ramesh, Frankincense (Research team member) / Reagan, Sage (Research team member) / Kandan, Mani (Research team member) / Knox, Garrett (Research team member) / Leung, Michael (Research team member) / Schmit, Jacob (Research team member) / Woo, Sabrina (Research team member) / Anderson, Laura (Research team member) / Breshears, Scott (Research team member) / Majhail, Kajol (Research team member) / Ruan, Ellen (Research team member) / Smetanick, Jennifer (Research team member) / Bardfeld, Sierra (Research team member) / Cura, Joriel (Research team member) / Dholaria, Nikhil (Research team member) / Foote, Hannah (Research team member) / Liu, Tara (Research team member) / Raymond, Julia (Research team member) / Varghese, Mahima (Research team member)
Created2021
Description
Under the direction of Dr. Carolyn Compton, a group of seven Barrett honors students have embarked on a truly unique team thesis project to create a documentary on the process of creating a COVID-19 testing laboratory. This documentary tells the story of the ASU Biodesign Clinical Testing Laboratory (ABCTL), the first lab in the western United States to offer public saliva testing to identify the presence of COVID-19.
ContributorsCura, Joriel (Director, Photographer) / Foote, Hannah (Producer, Sound designer) / Raymond, Julia (Production personnel) / Bardfeld, Sierra (Narrator, Editor) / Dholaria, Nikhil (Writer of added commentary) / Liu, Tara (Writer of added commentary) / Varghese, Mahima (Writer of added commentary) / Compton, Carolyn C. (Interviewee, Project director) / Harris, Valerie (Interviewee) / LaBaer, Joshua (Interviewee) / Miceli, Joseph (Interviewee) / Nelson, Megan (Interviewee) / Ungaro, Brianna (Interviewee)
Created2021