Filtering by
- Resource Type: Text
![137748-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137748-Thumbnail%20Image.png?versionId=yCFq4_xR.quxWL0uzou9C7jYNLz_N5Tc&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T175329Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=fb967278cd98c25773b24f13fe46f494a360337687eaa0fbfc2e8b3a88f8df38&itok=imTkko24)
![137749-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137749-Thumbnail%20Image.png?versionId=uOVF.8FdzMf7cIqb.OQjOyy1CFl41HbN&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T005322Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=35ff8cdd77ec5e264a34a2cc57e718e0541f2627a21fe4d732c5a36b01e9ff78&itok=6w5p8s1J)
![137278-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137278-Thumbnail%20Image.png?versionId=1KKPkTxWlvuLe5GXLA5vpc9_v92jxsMJ&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T132616Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=3677f682e959d0c4caedaf1e4edf1ce7be5abfb18909b51a1805acc4a0b98d20&itok=3AnvZvph)
![137282-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137282-Thumbnail%20Image.png?versionId=JdSoyy6pFeEfyIfYOAVeX9HwS8V0q6UC&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T213917Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=608a99b73d85d05dbec655381320530992ce6796049d9f6445d9610fb4e4b9bf&itok=TYzTGMqM)
The purpose of this study is to know whether the primary motor cortex (M1) plays a role in the sensorimotor memory. It was hypothesized that temporary disruption of the M1 following the learning to minimize a tilt using a ‘L’ shaped object would negatively affect the retention of sensorimotor memory and thus reduce interference between the memory acquired in one context and the visual cues to perform the same task in a different context.
Significant findings were shown in blocks 1, 2, and 4. In block 3, subjects displayed insignificant amount of learning. However, it cannot be concluded that there is full interference in block 3. Therefore, looked into 3 effects in statistical analysis: the main effects of the blocks, the main effects of the trials, and the effects of the blocks and trials combined. From the block effects, there is a p-value of 0.001, and from the trial effects, the p-value is less than 0.001. Both of these effects indicate that there is learning occurring. However, when looking at the blocks * trials effects, we see a p-value of 0.002 < 0.05 indicating significant interaction between sensorimotor memories. Based on the results that were found, there is a presence of interference in all the blocks but not enough to justify the use of TMS in order to reduce interference because there is a partial reduction of interference from the control experiment. It is evident that the time delay might be the issue between context switches. By reducing the time delay between block 2 and 3 from 10 minutes to 5 minutes, I will hope to see significant learning to occur from the first trial to the second trial.
![137409-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137409-Thumbnail%20Image.png?versionId=swW.AIUCcC0wLleM.4GSmsbmxWbagt9F&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T005322Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=b6de0e1fd6979707d7d9d9d303f3c5213fc90ecff1353b223e090bb6b59e5592&itok=3nYGPm9x)
![136663-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/136663-Thumbnail%20Image.png?versionId=fhJ09sI6sDm21l8z2orQk86z.g6B5ek4&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T043510Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=1a1a07a8ebc32f87c933580e79a5f36a3041b54c8022e7c40ac54b59434a6869&itok=EyMcBJhE)
![141463-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-06/141463-Thumbnail%20Image.png?versionId=ENeUABe2Oyxa57Ihl_PyS6yF4grzWvE3&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240530/us-west-2/s3/aws4_request&X-Amz-Date=20240530T154456Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=25e0b8adb35752d781eb5d677152ca29b3318012766c800a6e41c2bfe78fafe6&itok=goj-kO6R)
Five immunocompetent C57BL/6-cBrd/cBrd/Cr (albino C57BL/6) mice were injected with GL261-luc2 cells, a cell line sharing characteristics of human glioblastoma multiforme (GBM). The mice were imaged using magnetic resonance (MR) at five separate time points to characterize growth and development of the tumor. After 25 days, the final tumor volumes of the mice varied from 12 mm3 to 62 mm3, even though mice were inoculated from the same tumor cell line under carefully controlled conditions. We generated hypotheses to explore large variances in final tumor size and tested them with our simple reaction-diffusion model in both a 3-dimensional (3D) finite difference method and a 2-dimensional (2D) level set method. The parameters obtained from a best-fit procedure, designed to yield simulated tumors as close as possible to the observed ones, vary by an order of magnitude between the three mice analyzed in detail. These differences may reflect morphological and biological variability in tumor growth, as well as errors in the mathematical model, perhaps from an oversimplification of the tumor dynamics or nonidentifiability of parameters. Our results generate parameters that match other experimental in vitro and in vivo measurements. Additionally, we calculate wave speed, which matches with other rat and human measurements.
![130891-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-07/130891-Thumbnail%20Image.png?versionId=zxynUMY65UuWf8ppYOrG6sJIYCz8cJYE&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T005322Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=82fac978eeb94c2eada803e1e76dac7f974fd95ffbdfdc1132269d9118335b8f&itok=cU9oq2cB)
![131364-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-07/131364-Thumbnail%20Image.png?versionId=IgLqIlFk.zGvQPs3XFm2HGcZ5NYXKxEd&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T204514Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=e5a4521d7d10b27963c63b07bd52649588aa9295de71f811802865c2604e3297&itok=v5Okd7RJ)
![132103-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-07/132103-Thumbnail%20Image.png?versionId=QznWzMO.4PNTfsETir.A415zBF_FNJ_T&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T074953Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=dea12306050f42704c8c61820648269481ccc0df88942319f606838f90eba661&itok=0KRjtQmp)
According to the National Institute on Deafness and other Communication Disorders (NIDCD), approximately 37 million Americans suffer from some degree of hearing loss, which impacts their ability to communicate fluently with the hearing world. This number includes up to 17% of the adult population, many who have experienced post-lingual or late-deafness. While hearing loss is known to be one of the most prevalent chronically disabling sensory conditions, little is known about the impact it has on individuals’ cultural identity and sense of well-being. There is somewhat of a deficit in the research literature addressing these issues of cultural identity, especially as it relates to post-lingually deaf adults. Improved knowledge of these dimensions of hearing loss is needed—a knowledge which could lead to more effective resources for late-deafened people. Though hearing loss can be disabling, access to American Sign Language and the Deaf culture may compensate for social and cultural loss and potentially improve well-being within late-deafened individuals. Using the framework of Social Identity Theory and Neil Glickman’s Deaf Identity Development model, this study sought to identify late-deafened adults who fall into the marginal category, placing them at greater risk of becoming socially marginalized and experiencing diminished well-being. Subjective well-being was then measured by the Flourishing Scale to determine how being socially marginal may impact one’s sense of self, personal prosperity, social efficacy, and sense of social competency. Results showed that marginal individuals do experience diminished subjective well-being, a fact which should be further explored by researchers, especially in the context of developing more effective interventions and services for late-deafened individuals.