Filtering by
![135593-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/135593-Thumbnail%20Image.png?versionId=XA705hQN2E2Ow5lZk2j1xNNi3xUETmFC&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T005321Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=260127b1e4b01d0df6177e0d7147a3730ab2c7e1905975cac4feb81f663f1aa3&itok=JNOagfnl)
![137769-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137769-Thumbnail%20Image.png?versionId=IkZugY0PlnEEVYLtWGXqdMqhpNpMVSbq&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T005321Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=1fbfbf9107c968d44663911c2f439e55dad83a802b0eb97fb622733e2cd60211&itok=-3dUpwGT)
![137772-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137772-Thumbnail%20Image.png?versionId=J3jqWq8Gg7SsEDx4eFgnE2rav7z9X4v1&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T024731Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=146f41bfbc6e554c80459630deb18b37cff54067427990e7a1879233956ea395&itok=-TtIW1rY)
![137739-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137739-Thumbnail%20Image.png?versionId=vteSaXOl90kr9ih4VdglopMaOrpp8SuD&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T232639Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=fdcbd9f849c2ffe170c52e2a2c5c6a59280b64271ab254d602f90b856bcae795&itok=8xLC7YO1)
![137748-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137748-Thumbnail%20Image.png?versionId=yCFq4_xR.quxWL0uzou9C7jYNLz_N5Tc&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T175329Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=fb967278cd98c25773b24f13fe46f494a360337687eaa0fbfc2e8b3a88f8df38&itok=imTkko24)
![137749-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137749-Thumbnail%20Image.png?versionId=uOVF.8FdzMf7cIqb.OQjOyy1CFl41HbN&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T005322Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=35ff8cdd77ec5e264a34a2cc57e718e0541f2627a21fe4d732c5a36b01e9ff78&itok=6w5p8s1J)
![137282-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137282-Thumbnail%20Image.png?versionId=JdSoyy6pFeEfyIfYOAVeX9HwS8V0q6UC&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T213917Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=608a99b73d85d05dbec655381320530992ce6796049d9f6445d9610fb4e4b9bf&itok=TYzTGMqM)
The purpose of this study is to know whether the primary motor cortex (M1) plays a role in the sensorimotor memory. It was hypothesized that temporary disruption of the M1 following the learning to minimize a tilt using a ‘L’ shaped object would negatively affect the retention of sensorimotor memory and thus reduce interference between the memory acquired in one context and the visual cues to perform the same task in a different context.
Significant findings were shown in blocks 1, 2, and 4. In block 3, subjects displayed insignificant amount of learning. However, it cannot be concluded that there is full interference in block 3. Therefore, looked into 3 effects in statistical analysis: the main effects of the blocks, the main effects of the trials, and the effects of the blocks and trials combined. From the block effects, there is a p-value of 0.001, and from the trial effects, the p-value is less than 0.001. Both of these effects indicate that there is learning occurring. However, when looking at the blocks * trials effects, we see a p-value of 0.002 < 0.05 indicating significant interaction between sensorimotor memories. Based on the results that were found, there is a presence of interference in all the blocks but not enough to justify the use of TMS in order to reduce interference because there is a partial reduction of interference from the control experiment. It is evident that the time delay might be the issue between context switches. By reducing the time delay between block 2 and 3 from 10 minutes to 5 minutes, I will hope to see significant learning to occur from the first trial to the second trial.
![137409-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-05/137409-Thumbnail%20Image.png?versionId=swW.AIUCcC0wLleM.4GSmsbmxWbagt9F&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T005322Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=b6de0e1fd6979707d7d9d9d303f3c5213fc90ecff1353b223e090bb6b59e5592&itok=3nYGPm9x)
![148500-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-07/148500-Thumbnail%20Image.png?versionId=125A9Rnxu_gA2DecgxX1e2XCzJ1IsdWR&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240615/us-west-2/s3/aws4_request&X-Amz-Date=20240615T065555Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=9a54e65f3e0b0435d5c5e4bc91d53da83380c984232565fd3cc866888027fabb&itok=DVCXRfhn)
As life expectancy increases worldwide, age related diseases are becoming greater health concerns. One of the most prevalent age-related diseases in the United States is dementia, with Alzheimer’s disease (AD) being the most common form, accounting for 60-80% of cases. Genetics plays a large role in a person’s risk of developing AD. Familial AD, which makes up less than 1% of all AD cases, is caused by autosomal dominant gene mutations and has almost 100% penetrance. Genetic risk factors are believed to make up about 49%-79% of the risk in sporadic cases. Many different genetic risk factors for both familial and sporadic AD have been identified, but there is still much work to be done in the field of AD, especially in non-Caucasian populations. This review summarizes the three major genes responsible for familial AD, namely APP, PSEN1 and PSEN2. Also discussed are seven identified genetic risk factors for sporadic AD, single nucleotide polymorphisms in the APOE, ABCA7, NEDD9, CASS4, PTK2B, CLU, and PICALM genes. An overview of the main function of the proteins associated with the genes is given, along with the supposed connection to AD pathology.
![130891-Thumbnail Image.png](https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/styles/width_400/public/2021-07/130891-Thumbnail%20Image.png?versionId=zxynUMY65UuWf8ppYOrG6sJIYCz8cJYE&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ42ZLA5CUJ/20240616/us-west-2/s3/aws4_request&X-Amz-Date=20240616T005322Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=82fac978eeb94c2eada803e1e76dac7f974fd95ffbdfdc1132269d9118335b8f&itok=cU9oq2cB)