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How are perceptions of morality and disgust regarding meat consumption related to each other? Which factor is more salient in determining one's willingness to eat the meat of a specific animal? How do these answers vary across religious groups? This study investigates the ways that concepts like morality and disgust are related to food preferences and hopes to shed light on the mechanisms that enforce culturally sanctioned food taboos. The study compares 4 groups of people in the U.S.: Christians (n = 39), Hindus (n = 29), Jews (n = 23), and non-religious people (n = 63). A total of 154 participants were given surveys in which they rated their feelings about eating various animals. Data from Christian and non-religious groups exhibited similar patterns such as a high likelihood of eating a given animal when starving, while results from Jews and Hindus were consistent with their religion's respective food taboos. Despite these differences, morality and disgust are strongly correlated with one another in almost all instances. Moreover, morality and disgust are almost equally important considerations when determining willingness to eat when starving.
ContributorsParekh, Shaili Rajul (Author) / Hruschka, Daniel (Thesis director) / Jacobs, Mark (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor) / School of Human Evolution and Social Change (Contributor) / Hugh Downs School of Human Communication (Contributor)
Created2014-12
Description
The evolution of blindness in cave animals has been heavily studied; however, little research has been done on the interaction of migration and drift on the development of blindness in these populations. In this study, a model is used to compare the effect that genetic drift has on the fixation of a blindness allele for varying amounts of migration and selection. For populations where the initial frequency is quite low, genetic drift plays a much larger role in the fixation of blindness than populations where the initial frequency is high. In populations where the initial frequency is high, genetic drift plays almost no role in fixation. Our results suggest that migration plays a greater role in the fate of the blindness allele than selection.
ContributorsMerry, Alexandra Leigh (Author) / Cartwright, Reed (Thesis director) / Rosenberg, Michael (Committee member) / Schwartz, Rachel (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
The United States is experiencing an increase in the prevalence and influence of complementary and alternative medicine (CAM) in patient healthcare, reflecting the increasingly positive public and professional attitudes on the use of CAM therapies. Despite the growing presence of CAM in U.S. healthcare, there are still many barriers to integration. This study aims to reveal the attitudes of conventional, integrative and CAM practitioners concerning the major challenges of CAM's integration, explore their proposed solutions, and reveal any discrepancies in these attitudes among different types of practitioners. Twenty-eight practitioners were interviewed on the challenges in the five facets of CAM's integration: integration into hospitals, integration into medical schools, insurance coverage for CAM, licensing & regulation of CAM practitioners, and clinical research in CAM. The overall positive attitudes on the benefits of CAM's integration support previous research on the subject; however, the conventional practitioners were unable to extend these benefits to real-world application, and they were unaware of many of the challenges facing CAM's integration. The CAM practitioners attributed many of the problems facing integration to the inability of CAM's philosophy to comply with the current ideology of medical academia, health insurance model, and laws that govern the licensing and regulation of medical practitioners. The CAM and integrative practitioners perceived there to be a large resistance from conventional practitioners, specifically concerning the integration of CAM into education, providing insurance coverage for CAM, and the licensing and regulation of CAM practitioners. They attributed this to a perceived lack of research on safe and effective treatments in CAM. The conventional practitioner responses reflected this weariness of treatment effectiveness in their responses. However, the CAM and integrative practitioners believed these claims to be largely inaccurate, and constructed by the influence and manipulation of large-scale medical corporations and organizations. The participants believed that more evidence-based research in CAM, and increased public awareness in CAM therapies will force conventional practitioners to increase their knowledge in CAM, helping to alleviate their fears and skepticism of CAM therapies. By easing these concerns, dialogue can occur among practitioners of different modalities that will help to ensure a smooth integration of CAM and will raise the quality of patient healthcare by providing safe and effective resources for alternate forms of treatment.
ContributorsJohnston, Shantele Hanna Lee (Author) / Hruschka, Daniel (Thesis director) / Hurlbut, Ben (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2014-05
Description
Fat-stigma has become a popular topic of research in recent years as obesity and Western ideals have made their way around the globe. Previous studies have found that the internalization and expression of body norms can vary dramatically depending on location, gender, and many other cultural factors. Differing levels of body satisfaction have been linked to the internalization of these norms, and the development of low body esteem can result in many physical and emotional problems. Although there is an abundance of research on the topic of fat-stigma, few studies have investigated the related, but seemingly independent, topic of the ideal thin body. Furthermore, limited research has looked directly at body size stereotypes in Guatemala, and those that have, focused solely on Guatemala City. Furthermore, no previous cross-cultural analyses were found comparing body norms among US and rural Guatemalan adolescents. By surveying 9-10 year old students in Acatenango, Guatemala and Phoenix, Arizona, this study compared the preferences as well as stereotypes for average, thin, and fat body sizes in these two contexts. The results of this study illustrate a contrast between a fat-negative and a thin-negative culture, and highlight the complexity of the emergence of body norms around the world. We find that, in contrast to previous studies, neither the western ideal thin body nor obesity stereotypes have been internalized in Acatenango. Furthermore, negative evaluations of fat bodies and positive evaluations of thin bodies seem to be made independently of each other. Americans had a much higher prejudice against fat children and were more likely to be thin-positive (OR=1.997), while Guatemalans were more likely to be thin-negative. On average, the American students were much more polarized in their judgments on different body sizes, and experienced greater levels of body dissatisfaction. Finally, American students favored an ideal figure over one size smaller than Guatemalan students. Results suggest that there are still rural communities that have not been entirely affected by the spread of western body norms.
ContributorsCole, Dawn Michelle (Author) / Maupin, Jonathan (Thesis director) / Hruschka, Daniel (Committee member) / Barrett, The Honors College (Contributor) / School of Geographical Sciences and Urban Planning (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2013-12
Description
Africa is the area of the largest economic water scarcity on earth, with multiple countries, political systems, and geographies involved. Additionally, water scarcity affects more countries in sub-Saharan African than anywhere else on earth, with consequences like waterborne diseases, loss of agricultural development, educational setbacks, and security threats. This thesis synthesizes data on the diverse geographies and politics involved in building a sustainable African water system. It presents historical and present technologies, costs, and problems implementing sustainable potable water solutions, and suggests regional differences and individualized solutions, pointing out advantages and disadvantages of damming, boreholes, open wells, open-source water, and sewer systems. It goes on to discuss grant programs for water and wastewater solutions and technologies. Finally it addresses two divergent, yet equally important data models for African water planning, combining their contributions in order to gain insight into the problem that neither alone can. The research overlaps aquifer and demographic data to see where water should be a priority in Africa. The author finds that hydrology as well as demographic data, when combined, point to the greatest water need in the Sahel. However, many growing cities are situated in areas with high aquifer levels making borehole technology some of the most economical as well as sustainable water sourcing. Recommendations include cultural humility, attention to political and environmental consequences of solutions, and cost-effective ways of addressing the lack of access to clean drinking water in Africa.
ContributorsBarbur, Denisa Teodora (Author) / Gaughan, Monica (Thesis director) / Hruschka, Daniel (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2014-05
Description
Protein AMPylation is a recently discovered and relatively unstudied post-translational modification (PTM). AMPylation has previously been shown to play an important role in metabolic regulation and host pathogenesis in bacteria, but the recent identification of potential AMPylators across many species in every domain of life has supported the possibility that AMPylation could be a more fundamental and physiologically significant regulatory PTM. For the first time, we characterized the auto-AMPylation capability of the human protein SOS1 through in vitro AMPylation experiments using full-length protein and whole-domain truncation mutants. We found that SOS1 can become AMPylated at a tyrosine residue possibly within the Cdc25 domain of the protein, the Dbl homology domain is vital for efficient auto-AMPylation activity, and the C-terminal proline-rich domain exhibits a complex regulatory function. The proline-rich domain alone also appears to be capable of catalyzing a separate, unidentified covalent self-modification using a fluorescent ATP analogue. Finally, SOS1 was shown to be capable of catalyzing the AMPylation of two endogenous human protein substrates: a ubiquitous, unidentified protein of ~49kDa and another breast-cancer specific, unidentified protein of ~28kDa.
ContributorsOber-Reynolds, Benjamin John (Author) / LaBaer, Joshua (Thesis director) / Borges, Chad (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
The purpose of this study was to investigate how the human-animal relationship affects one's willingness to seek veterinary care for a pet. It is important to understand this topic because past research has shown that companion animals play a very large role in the lives of many people. However, there has been a decline in the frequency of veterinary visits despite an increase in the number of pets. The variables of the human-animal relationship that were tested were one's views on the intelligence of a pet and its ability to feel emotions, and the closeness one feels to a pet. Demographic factors were also considered. The dependent variable of one's willingness to seek veterinary care was measured by the amount one would spend on veterinary treatment for a healthy pet, the amount one would spend on an older pet, and the responsibility one feels for the health and well-being of one's pet. The study revealed that the closeness one feels to a pet and one's views on a pet's ability to feel emotion both have a positive correlation with one's willingness to seek veterinary care for a pet. However, there was no correlation between one's views on the intelligence of a pet and one's willingness to seek veterinary care, and there was only a very slight correlation between income and one's willingness to seek veterinary care. Understanding these factors could be important in ensuring that companion animals receive the necessary care to promote their health and well-being.
ContributorsMagnussen, Hailey Eve (Author) / Hruschka, Daniel (Thesis director) / Risley-Curtiss, Christina (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
Curanderos are Hispanic traditional healers who attend to their clients through spiritual, natural, and physical techniques. Recent studies have shown that a subset of the Hispanic population refer to these healers for HIV and STD treatment and believe they are important in a collaborative targeted HIV intervention. Thus, curanderos were interviewed and the lay population of Phoenix was sampled in order to get a better idea of the utility of these healers in an HIV prevention effort targeted at the Hispanic community. Due to the limitations of this study there was not sufficient enough data to make significant conclusions; however the interviews with the curanderos were surprising in the they had significant roles as healers in the Phoenix area, patients have referred to them for HIV and STD treatment, and a couple of the healers have integrated western medical knowledge into their practice.
ContributorsMartinez, Justin Anthony (Author) / Maupin, Jonathan (Thesis director) / Hruschka, Daniel (Committee member) / Aguilera, Miguel (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
In this thesis, glycan nodes, the basic subunits of complex biological sugars, were studied to determine the reproducibility of gas chromatography-mass spectrometry (GC/MS) based methylation analysis of whole blood plasma by normalization using an internal standard of heavy permethylated glycans. Glycans are complex biological sugars that have a variety of applications in the human body and will display aberrant compositions when produced by cancerous cells. Thus an assay to determine their composition can be used as a diagnostic tool. It was shown that the assay may have potential use, but needs further refinement to become an improvement over current methods by analyzing the results of ratio-determination and replicate experiments.
ContributorsMiyasaki, Tyler Takeo (Author) / Borges, Chad (Thesis director) / Van Horn, Wade (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Chemical Engineering Program (Contributor)
Created2015-05
Description
Western diets, high in dietary fat and red meat, are associated with hyperglycemia and weight gain, symptoms that promote insulin resistance and diabetes. Previous studies have shown that elevated glucose promotes glycation of circulating proteins such as albumin, which is thought to lead to hyperglycemia complications. It was hypothesized that diets with no meat consumption (pesco-vegetarian and lacto-vegetarian) would reduce protein glycation, in comparison to a diet with meat. Forty six healthy adult omnivorous subjects were randomized into one of three groups and instructed to either consume red meat (i.e. meat) or poultry twice per day (control), eliminate meat and increase fish consumption (pesco-vegetarian), or adopt a vegetarian diet devoid of fish, meat or poultry (lacto-vegetarian) for four weeks. Fasting plasma samples were collected from participants at baseline and after 4 weeks of the dietary intervention. Plasma glucose concentrations were measured using a commercially available kit. Percent glycated albumin was measured on a separate aliquot of plasma by mass spectrometry. Plasma glucose concentrations were significantly increased following 4-weeks of pesco-vegetarian diet (P=0.002, paired t-test). Neither the lacto-vegetarian (P=0.898) or the control diet (P=0.233) affected plasma glucose concentrations. Despite the significant increase in plasma glucose following a pesco-vegetarian diet, no change in percent glycated albumin was observed (P>0.50, ANOVA). These findings may indicate a protective effect of the pesco-vegetarian diet on protein glycation in the presence of elevated plasma glucose and suggest the need for additional studies to examine the link between increased fish consumption and glucose regulation.
ContributorsRaad, Noor (Author) / Sweazea, Karen (Thesis director, Committee member) / Borges, Chad (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2015-05