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This study reviews scholarly papers and case studies on urban vacant land to gain a stronger understanding of its public value in terms of the ecological and social benefits it can bring. This literature review offers a conceptual overview of the potential benefits of vacant land with the goal of addressing gaps in knowledge about vacant land and to provide suggestions to planners and designers on how vacant properties can be integrated with other green infrastructure in cities. There are many opportunities to redevelop vacant land to enhance its ecological and social value, and many design professionals and scholars are becoming interested in finding new ways to exploit this potential, especially with regard to planning and design. A better appreciation of the public value of urban vacant land is vital for any effort to identify alternative strategies to optimize the way these spaces are utilized for both short-term and long-term uses to support urban regeneration and renewal. This study will help planners and designers to understand and plan for urban vacant land, leading to better utilization of these spaces and opening up alternative creative approaches to envisioning space and landscape design in our urban environments.
ContributorsKim, Gunwoo (Author) / Herberger Institute for Design and the Arts (Contributor)
Created2016-05-17
Description
Breast cancer is the leading cause of cancer-related deaths of women in the united states. Traditionally, Breast cancer is predominantly treated by a combination of surgery, chemotherapy, and radiation therapy. However, due to the significant negative side effects associated with these traditional treatments, there has been substantial efforts to develop alternative therapies to treat cancer. One such alternative therapy is a peptide-based therapeutic cancer vaccine. Therapeutic cancer vaccines enhance an individual's immune response to a specific tumor. They are capable of doing this through artificial activation of tumor specific CTLs (Cytotoxic T Lymphocytes). However, in order to artificially activate tumor specific CTLs, a patient must be treated with immunogenic epitopes derived from their specific cancer type. We have identified that the tumor associated antigen, TPD52, is an ideal target for a therapeutic cancer vaccine. This designation was due to the overexpression of TPD52 in a variety of different cancer types. In order to start the development of a therapeutic cancer vaccine for TPD52-related cancers, we have devised a two-step strategy. First, we plan to create a list of potential TPD52 epitopes by using epitope binding and processing prediction tools. Second, we plan to attempt to experimentally identify MHC class I TPD52 epitopes in vitro. We identified 942 potential 9 and 10 amino acid epitopes for the HLAs A1, A2, A3, A11, A24, B07, B27, B35, B44. These epitopes were predicted by using a combination of 3 binding prediction tools and 2 processing prediction tools. From these 942 potential epitopes, we selected the top 50 epitopes ranked by a combination of binding and processing scores. Due to the promiscuity of some predicted epitopes for multiple HLAs, we ordered 38 synthetic epitopes from the list of the top 50 epitope. We also performed a frequency analysis of the TPD52 protein sequence and identified 3 high volume regions of high epitope production. After the epitope predictions were completed, we proceeded to attempt to experimentally detected presented TPD52 epitopes. First, we successful transduced parental K562 cells with TPD52. After transduction, we started the optimization process for the immunoprecipitation protocol. The optimization of the immunoprecipitation protocol proved to be more difficult than originally believed and was the main reason that we were unable to progress past the transduction of the parental cells. However, we believe that we have identified the issues and will be able to complete the experiment in the coming months.
ContributorsWilson, Eric Andrew (Author) / Anderson, Karen (Thesis director) / Borges, Chad (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
In early 2026, the NASA Discovery Program will fall into orbit with a metal asteroid named Psyche. Through discovery and interaction, this exploration will give us insight into an asteroid that we cannot see or interpret. From a certain view, you can look at how this mission mimics that discovery with experimentation of our own senses. As a part of a team of eight seniors, we were tasked to help develop a mobile application that reflects the Psyche mission and shows the future of the project ten years from now. Since this is also a government funded project, it is pertinent to adhere to the ADA compliance guidelines required to make digital applications accessible to the larger public. As a designer, I wanted to push this concept further to showcase that accessibility is not something that should be stereotyped or discouraged from a design perspective. Each person that interacts with the application will have a different experience but it is this collaboration between the object and it's audience that creates this sense of discovery. Taking the mission's core values one step further, this application was designed and explored to uphold the foundations of what Universal Design is about. It is about connecting interested parties to the material they are looking for without unrealistic access that is dependent on ability.
ContributorsSchaecher, Lauren Allison (Author) / Sanft, Alfred (Thesis director) / Heywood, William (Committee member) / The Design School (Contributor) / Herberger Institute for Design and the Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Capstone project, I began developing an animated series called Legends of Gaia. The show follows a small group of people of mixed ages and backgrounds, as they travel across the world trying to stop the Galliean Empire, a technologically booming western power that has begun fighting a war for world domination. The purpose of this paper is to better explain the origins and inspirations of the mythology of my series, as well as the major two supernatural characters of my series, and the general geography (both physical and metaphysical) of the series. When first developing this series, I looked into the works of Joseph Campbell, as he wrote the book(s) on mythology in many ways. His most famous writings are probably the Hero's Journey and the Monomyth, the basic outline of the journey that most heroes go through, from the call ordinary world, to the call of the adventure, all the way to the hero returning (Campbell 211). Many classic examples of story telling follow the pattern Campbell outlined, and my work is no exception. However, I did not want my series to be a beat for beat retread of the Hero's Journey, and so some parts, such as the Refusal of the Call, when the hero rejects the adventure and befalls a tragedy, were skipped, while others, such as the resurrection, were realized in different ways. Using the Resurrection as an example, in my series the main female character, Diana is reborn twice throughout the series. Once in the final battle with the main villain into her true, goddess form, and the other when her battles are over, and she is reborn in her mortal form permanently.
ContributorsLopez, Richard (Author) / Collis, Adam (Thesis director) / Valenti, F. Miguel (Committee member) / Barzso, Tain (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
De Oriendo is a project devoted to a better understanding of the word "original" as it pertains to musical composition. It began as a way for me to try to tackle a twofold fascination that has been with me for the duration of my time at ASU, though I have not always been aware of it. The first half of this fascination is an enduring interest in tracing borrowed material used by composers and other artists throughout history. It seems that almost every research project I have undertaken in the last four years has had something to do with this concept. Scholars like Winton Dean, J. Peter Burkholder, and Sigmund Spaeth have spent parts of their careers charting out the genealogy of historical compositions, uncovering reused melodies and harmonic progressions in the process; the cases of it are countless, even among the most identifiable composers and songwriters. Since there is scholarship clearly demonstrating secondhand ideas in music, it becomes problematic to assume that the word "original" simply describes something completely new, that is, something that does not use material heard or seen before. The second half is more of a personal ambition: I thought that if I truly knew what composers and critics meant when they labeled a piece or an artist as original, then I could somehow find a way to achieve this distinction in my own attempts at composition and avoid that uninteresting, derivative sound I have always feared.
ContributorsLang, Jonathan (Author) / Levy, Benjamin (Thesis director) / Mook, Richard (Committee member) / Rockmaker, Jody (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor)
Created2012-12
ContributorsBingham, Tucker (Author) / Setlow, Jennifer (Thesis director) / Melo, Carla (Committee member) / Danowski, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor)
Created2012-12