Matching Items (155)
Description
Glioblastoma multiforme (GBMs) is the most prevalent brain tumor type and causes approximately 40% of all non-metastic primary tumors in adult patients [1]. GBMs are malignant, grade-4 brain tumors, the most aggressive classication as established by the World Health Organization and are marked by their low survival rate; the median survival time is only twelve months from initial diagnosis: Patients who live more than three years are considered long-term survivors [2]. GBMs are highly invasive and their diffusive growth pattern makes it impossible to remove the tumors by surgery alone [3]. The purpose of this paper is to use individual patient data to parameterize a model of GBMs that allows for data on tumor growth and development to be captured on a clinically relevant time scale. Such an endeavor is the rst step to a clinically applicable predictions of GBMs. Previous research has yielded models that adequately represent the development of GBMs, but they have not attempted to follow specic patient cases through the entire tumor process. Using the model utilized by Kostelich et al. [4], I will attempt to redress this deciency. In doing so, I will improve upon a family of models that can be used to approximate the time of development and/or structure evolution in GBMs. The eventual goal is to incorporate Magnetic Resonance Imaging (MRI) data into a parameterized model of GBMs in such a way that it can be used clinically to predict tumor growth and behavior. Furthermore, I hope to come to a denitive conclusion as to the accuracy of the Koteslich et al. model throughout the development of GBMs tumors.
ContributorsManning, Miles (Author) / Kostelich, Eric (Thesis director) / Kuang, Yang (Committee member) / Preul, Mark (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Capstone project, I began developing an animated series called Legends of Gaia. The show follows a small group of people of mixed ages and backgrounds, as they travel across the world trying to stop the Galliean Empire, a technologically booming western power that has begun fighting a war for world domination. The purpose of this paper is to better explain the origins and inspirations of the mythology of my series, as well as the major two supernatural characters of my series, and the general geography (both physical and metaphysical) of the series. When first developing this series, I looked into the works of Joseph Campbell, as he wrote the book(s) on mythology in many ways. His most famous writings are probably the Hero's Journey and the Monomyth, the basic outline of the journey that most heroes go through, from the call ordinary world, to the call of the adventure, all the way to the hero returning (Campbell 211). Many classic examples of story telling follow the pattern Campbell outlined, and my work is no exception. However, I did not want my series to be a beat for beat retread of the Hero's Journey, and so some parts, such as the Refusal of the Call, when the hero rejects the adventure and befalls a tragedy, were skipped, while others, such as the resurrection, were realized in different ways. Using the Resurrection as an example, in my series the main female character, Diana is reborn twice throughout the series. Once in the final battle with the main villain into her true, goddess form, and the other when her battles are over, and she is reborn in her mortal form permanently.
ContributorsLopez, Richard (Author) / Collis, Adam (Thesis director) / Valenti, F. Miguel (Committee member) / Barzso, Tain (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
De Oriendo is a project devoted to a better understanding of the word "original" as it pertains to musical composition. It began as a way for me to try to tackle a twofold fascination that has been with me for the duration of my time at ASU, though I have not always been aware of it. The first half of this fascination is an enduring interest in tracing borrowed material used by composers and other artists throughout history. It seems that almost every research project I have undertaken in the last four years has had something to do with this concept. Scholars like Winton Dean, J. Peter Burkholder, and Sigmund Spaeth have spent parts of their careers charting out the genealogy of historical compositions, uncovering reused melodies and harmonic progressions in the process; the cases of it are countless, even among the most identifiable composers and songwriters. Since there is scholarship clearly demonstrating secondhand ideas in music, it becomes problematic to assume that the word "original" simply describes something completely new, that is, something that does not use material heard or seen before. The second half is more of a personal ambition: I thought that if I truly knew what composers and critics meant when they labeled a piece or an artist as original, then I could somehow find a way to achieve this distinction in my own attempts at composition and avoid that uninteresting, derivative sound I have always feared.
ContributorsLang, Jonathan (Author) / Levy, Benjamin (Thesis director) / Mook, Richard (Committee member) / Rockmaker, Jody (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor)
Created2012-12
ContributorsBingham, Tucker (Author) / Setlow, Jennifer (Thesis director) / Melo, Carla (Committee member) / Danowski, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor)
Created2012-12
Description
As obesity rates continue to rise in adolescents and young children, the concern for poor future health of the younger population grows. Physical activity and improving nutrition are two ways to combat obesity rates, and the Sustainability via Active Gardening Education (SAGE) project addresses this in underserved and low-income communities in Maricopa County. This project employs a curriculum designed to promote physical activity and healthy eating for Early Care and Education (ECE) sites, most of which are daycares. Further, utilizing indicators of future health can also allow for us to understand and lower obesity rates. One indicator of future health is grip strength: greater grip strength is associated with healthier outcomes such as lower triglycerides, blood pressure, and body mass index. Grip strength has been observed in the older population; however, there are few studies looking at grip strength in younger children, namely preschoolers. As grip strength is a predictor of health, it follows that it should be observed in preschoolers, and improved, if possible, by factors such as physical activity, which would ultimately improve obesity rates. This study aimed to see if there was any relationship between physical activity and grip strength in preschoolers aged 3-5 years old. To do so, grip strength, hand length, height, weight, and information regarding physical activity of preschoolers enrolled in the SAGE project were collected.
Physical activity and grip strength were not found to be significantly associated in this study; however, hand length and hand strength were associated. Among secondary outcomes, it was observed that males of ages 3 to 5-years-old may have greater hand grip strength than females of the same age group. Although this was not statistically significant, there was a trend toward statistical significance. Small sample size hampered observation of expected relationships between hand grip strength and dominant hand of the participants, and hand grip strength was not significantly related with BMI. Future directions would consist of collecting longitudinal data, as well as calling back previous years’ participants for additional data, so that there is a larger sample size for data analysis.
ContributorsAtluri, Haarika (Author) / Lee, Rebecca (Thesis director) / Tucker, Derek (Committee member) / Cantu Garcia, Lisbeth (Committee member) / De Mello, Gabrielli (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05