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Alzheimer's Disease (AD) is the most common form of dementia observed in elderly patients and has significant social-economic impact. There are many initiatives which aim to capture leading causes of AD. Several genetic, imaging, and biochemical markers are being explored to monitor progression of AD and explore treatment and detection

Alzheimer's Disease (AD) is the most common form of dementia observed in elderly patients and has significant social-economic impact. There are many initiatives which aim to capture leading causes of AD. Several genetic, imaging, and biochemical markers are being explored to monitor progression of AD and explore treatment and detection options. The primary focus of this thesis is to identify key biomarkers to understand the pathogenesis and prognosis of Alzheimer's Disease. Feature selection is the process of finding a subset of relevant features to develop efficient and robust learning models. It is an active research topic in diverse areas such as computer vision, bioinformatics, information retrieval, chemical informatics, and computational finance. In this work, state of the art feature selection algorithms, such as Student's t-test, Relief-F, Information Gain, Gini Index, Chi-Square, Fisher Kernel Score, Kruskal-Wallis, Minimum Redundancy Maximum Relevance, and Sparse Logistic regression with Stability Selection have been extensively exploited to identify informative features for AD using data from Alzheimer's Disease Neuroimaging Initiative (ADNI). An integrative approach which uses blood plasma protein, Magnetic Resonance Imaging, and psychometric assessment scores biomarkers has been explored. This work also analyzes the techniques to handle unbalanced data and evaluate the efficacy of sampling techniques. Performance of feature selection algorithm is evaluated using the relevance of derived features and the predictive power of the algorithm using Random Forest and Support Vector Machine classifiers. Performance metrics such as Accuracy, Sensitivity and Specificity, and area under the Receiver Operating Characteristic curve (AUC) have been used for evaluation. The feature selection algorithms best suited to analyze AD proteomics data have been proposed. The key biomarkers distinguishing healthy and AD patients, Mild Cognitive Impairment (MCI) converters and non-converters, and healthy and MCI patients have been identified.
ContributorsDubey, Rashmi (Author) / Ye, Jieping (Thesis advisor) / Wang, Yalin (Committee member) / Wu, Tong (Committee member) / Arizona State University (Publisher)
Created2012
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Sanctuary jurisdictions are jurisdictions that do not enforce one or more aspects of federal immigration policy in regards to unauthorized immigrants. Some states maintain state-wide sanctuary policies while others are adamantly against them. Estimates of taxes that unauthorized immigrants pay and estimates of the amount of state funding that unauthorized

Sanctuary jurisdictions are jurisdictions that do not enforce one or more aspects of federal immigration policy in regards to unauthorized immigrants. Some states maintain state-wide sanctuary policies while others are adamantly against them. Estimates of taxes that unauthorized immigrants pay and estimates of the amount of state funding that unauthorized immigrants can access (education, financial aid, corrections, and welfare) reveal that regardless of sanctuary status, unauthorized immigrants may “pay in” more than they “take out” from the system. The status of “sanctuary jurisdiction” does not appear to have much if any effect on the net state budget. However, unauthorized immigrants are able to access more welfare programs in sanctuary states.

ContributorsLattus, Anna Olivia (Author) / Herrendorf, Berthold (Thesis director) / Hobijn, Bart (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Economics Program in CLAS (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The present study explored the relationship between desired purchasing behavior and individual differences using two nationally-representative, longitudinal samples of the U.S. population early in the COVID-19 pandemic. Past research has shown that individual differences provide information about how one might respond to threat. Therefore, we predicted changes in desired purchasing

The present study explored the relationship between desired purchasing behavior and individual differences using two nationally-representative, longitudinal samples of the U.S. population early in the COVID-19 pandemic. Past research has shown that individual differences provide information about how one might respond to threat. Therefore, we predicted changes in desired purchasing behavior across different sociodemographic variables that might reflect those differences. Specifically, we investigated hypotheses related to political orientation, age, sexual orientation, socioeconomic status, and whether or not the participant had children. We measured participants’ reported desired purchasing behavior across eleven categories of goods and investigated the connection between specific demographic variables and desired purchasing behavior. We found that conservatives desired to purchase more basic protection goods (guns/ammunition, cash, gas) and that older people desired to purchase more cleaning supplies and toiletries. These findings illustrate possible explanations for purchasing behavior during the COVID-19 pandemic and reveal directions for marketing designed to influence purchasing behavior.

ContributorsZeider, Justyn (Author) / Varnum, Michael (Thesis director) / Neuberg, Steven (Committee member) / Department of Psychology (Contributor) / School of International Letters and Cultures (Contributor) / School of Social Transformation (Contributor) / Sandra Day O'Connor College of Law (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Telehealth is the use of information and communications technology by healthcare professionals to provide care to patients. When this technology is being used specifically for genetic services, it is called telegenetics. Previous studies that examine the small-scale use of telegenetics for the field of genetic counseling have shown that the

Telehealth is the use of information and communications technology by healthcare professionals to provide care to patients. When this technology is being used specifically for genetic services, it is called telegenetics. Previous studies that examine the small-scale use of telegenetics for the field of genetic counseling have shown that the technology may provide a way to address the problem of patient access to genetic counseling services, assuming its efficacy. Patients are satisfied with telegenetics, but genetic counselors hold more reservations. Because of this and the many regulatory barriers in its way, telegenetics was only slowly being adopted when the coronavirus was declared a pandemic in March 2020. The pandemic forced a switch to telegenetics at a scale never seen before. This study begins with a literature review to assess the situation of telegenetics before and during the pandemic. It then surveys practicing genetic counselors in Arizona in order to reveal what they think about telegenetics when it is the encouraged, and sometimes only, modality. Since the literature review revealed that genetic counselors, not patients, are the ones with concerns, it is important to hear their points of view. This study reveals that genetic counselors want telegenetics as an option but not as a replacement for in-person appointments. All respondents agreed that increased patient access is the main benefit of telegenetics. There are reported challenges that must be overcome, but genetic counselors in Arizona overwhelming believe that telegenetics use will be continued in the future.

ContributorsThornton, Gillian Frances (Author) / Hunt Brendish, Katherine (Thesis director) / Frow, Emma (Committee member) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

For the Love of the Game is a 15-minute documentary highlighting what the culture of soccer is like in Spain. Filmed completely in Valencia, Spain, this short film shows the actual atmosphere of everyday soccer. People of all ages and backgrounds give depth into what it's like to grow u

For the Love of the Game is a 15-minute documentary highlighting what the culture of soccer is like in Spain. Filmed completely in Valencia, Spain, this short film shows the actual atmosphere of everyday soccer. People of all ages and backgrounds give depth into what it's like to grow up in Spain with and fall in love with the game.

ContributorsRaboin, Sarandon Grace (Author) / Jacoby, Jim (Thesis director) / Kassing, Jeffrey (Committee member) / School of International Letters and Cultures (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Language has a critical role as a social determinant of health and a source of healthcare disparities. Rhetorical devices are ubiquitous in medicine and are often used to persuade or inform care team members. Rhetorical devices help a healthcare team acknowledge and interpret narratives. For example, metaphors are frequently used

Language has a critical role as a social determinant of health and a source of healthcare disparities. Rhetorical devices are ubiquitous in medicine and are often used to persuade or inform care team members. Rhetorical devices help a healthcare team acknowledge and interpret narratives. For example, metaphors are frequently used as rhetorical devices by patients to describe cancer, including winning or losing a battle, surviving a fight, war, potentially implying that the patient feels helpless like a pawn fighting in a struggle directed by the physician, thus reducing patient autonomy and agency. However, this occidental approach is flawed because it excessively focuses on the individual's agency and marginalizes external factors, such as cultural beliefs and social support (Sontag, 1989). Although there is a large body of research about how the rhetoric of medicine affects patients in the United States, there is a lack of such research about how patient experiences' rhetoric can help increase the understanding of Latino populations' unique social determinants. This creative project aims to analyze the rhetorical differences in the description of disease amongst Latino and American communities, translating to creating an educational module for a Spanish for biomedical sciences class. The objective is to increase future healthcare professionals' ability to understand how the composition of descriptions and medical rhetoric in different mediums of humanities can serve as critical tools to analyze social determinants in Latino healthcare delivery.

ContributorsKottapalli, Sai Bhuvana (Author) / Estevez, Dulce (Thesis director) / Oberstein, Bruce (Committee member) / School of Molecular Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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This thesis is a supplement textbook designed with ASU’s MAT 370, or more generally, a course in introductory real analysis (IRA). With research in the realms of mathematics textbook creation and IRA pedagogy, this supplement aims to provide students or interested readers an additional presentation of the materials. Topics discussed

This thesis is a supplement textbook designed with ASU’s MAT 370, or more generally, a course in introductory real analysis (IRA). With research in the realms of mathematics textbook creation and IRA pedagogy, this supplement aims to provide students or interested readers an additional presentation of the materials. Topics discussed include the real number system, some topology of the real line, sequences of real numbers, continuity, differentiation, integration, and the Fundamental Theorem of Calculus. Special emphasis was placed on worked examples of proven results and exercises with hints at the end of every chapter. In this respect, this supplement aims to be both versatile and self-contained for the different mathematics skill levels of readers.

ContributorsCarpenter, Jackson Robinett (Author) / Jones, Don (Thesis director) / Quigg, John (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Melanoma is one of the most severe forms of skin cancer and can be life-threatening due to metastasis if not caught early on in its development. Over the past decade, the U.S. Government added a Healthy People 2020 objective to reduce the melanoma skin cancer rate in the U.S. population.

Melanoma is one of the most severe forms of skin cancer and can be life-threatening due to metastasis if not caught early on in its development. Over the past decade, the U.S. Government added a Healthy People 2020 objective to reduce the melanoma skin cancer rate in the U.S. population. Now that the decade has come to a close, this research investigates possible large-scale risk factors that could lead to incidence of melanoma in the population using logistic regression and propensity score matching. Logistic regression results showed that Caucasians are 14.765 times more likely to get melanoma compared to non-Caucasians; however, after adjustment using propensity scoring, this value was adjusted to 11.605 times more likely for Caucasians than non-Caucasians. Cholesterol, Chronic Obstructive Pulmonary Disease, and Hypertension predictors also showed significance in the initial logistic regression. By using the results found in this experiment, the door has been opened for further analysis of larger-scale predictors and gives public health programs the initial information needed to create successful skin safety advocacy plans.

ContributorsFalls, Nicole Elizabeth (Author) / Wilson, Jeffrey (Thesis director) / Dornelles, Adriana (Committee member) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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This paper will explore how suppliers are being evaluated. It will focus on the automotive industry and the state of supplier relations in two major automotive manufacturers in the United States. A literature review will reveal common supplier metrics across industries and what they attempt to measure. Further exploration into

This paper will explore how suppliers are being evaluated. It will focus on the automotive industry and the state of supplier relations in two major automotive manufacturers in the United States. A literature review will reveal common supplier metrics across industries and what they attempt to measure. Further exploration into the structure and problems at one automotive manufacturer will reveal areas of improvement. Finally, a new balanced scorecard system will be proposed to better measure supplier performance.
ContributorsChan, Catherine Ngar-See (Author) / Pfund, Michele (Thesis director) / Fowler, John (Committee member) / Johnson, Eleni (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Supply Chain Management (Contributor) / Department of Marketing (Contributor)
Created2015-05
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As Arizona enters its fifteenth year of drought and Lake Mead hits historic lows, water management and policy planning will become increasingly important to ensure future water security in the Southwestern region of the United States. This thesis compares water demand trends and policies at the municipal level in Phoenix

As Arizona enters its fifteenth year of drought and Lake Mead hits historic lows, water management and policy planning will become increasingly important to ensure future water security in the Southwestern region of the United States. This thesis compares water demand trends and policies at the municipal level in Phoenix and Tucson, Arizona over the time period from 1980-2010. By analyzing gallons per capita per day (GPCD) trends for each city in the context of population growth, drought, and major state and local policies over the twenty year period, reasons for declines in per capita water demand were explored. Despite differences in their available water sources and political cultures, both the City of Phoenix and the City of Tucson have successfully reduced their per capita water consumption levels between 1980 and 2010. However, this study suggests that each city's measured success at reducing GPCD has been more a result of external events (supply augmentation, drought, and differing development trends) rather than conservation and demand reduction regulations adopted under the auspices of the Groundwater Management Act.
ContributorsSnyder, Rachel Claire (Author) / Larson, Kelli (Thesis director) / Hirt, Paul (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Sustainability (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05