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- Creators: College of Health Solutions
Description
As patients sustain injuries that hinder their independence, occupational therapists help them regain their independence by improving overall health and happiness. However, it is common for patients to face issues throughout their rehabilitation experiences. In this thesis, I interviewed Caroline Jasper, a pediatric occupational therapist, and Colette Brogan, an adult occupational therapist. Questions included common patient barriers, potential solutions, and advice to provide insight into their respective populations.
ContributorsLowenthal, Rachel (Author) / Kingsbury, Jeffrey (Thesis director) / Miossi, Lindsey (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2024-05
Description
Chisholm’s contrary-to-duty paradox raises important questions for formulating instances of conditional obligation. Angelika Kratzer is one linguist whose theories offer some solutions to these questions; more generally, she provides theories for how we should represent modals, conditionals, and other features of language in terms of functions. Though her theories are incredibly useful, they do not adequately represent the Chisholm scenario as a whole. In this paper, I attempt to address this shortcoming in her theory. First, I present and explain some of Kratzer’s main ideas. Then, I explain how her theory offers a solution to Chisholm’s Paradox, and examine a shortcoming of her theory as presented– specifically, the fact that her theory does not account for the importance of different norms in relation to each other. Finally, with the Chisholm situation as a backdrop, I offer my own contribution to her theory. Namely, I propose assigning an importance “score” to each norm, and factoring that “score” into the machinery of Kratzer’s theory.
ContributorsBrooks, Elizabeth (Author) / nair, shyam (Thesis director) / Pinillos, Angel (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2024-05
Description
Immediate early genes (IEGs) are the first set of genes to be transcribed in a cell in response to stimuli; their expression is quick and is not protein synthesis dependent. Neurons are activated in response to external stimuli, causing a rapid increase in IEG expression in the brain. IEG proteins go on to affect fundamental neurobiological processes that are known to be dysfunctional in patients with psychiatric disorders, and therefore IEGs have been connected to the pathogenesis of schizophrenia. Early growth response (Egr) genes are immediate early gene transcription factors (IEG-TFs) that are expressed in response to an altered environment. The IEG-TFs, early growth response 1 (EGR1) and early growth response 3 (EGR3) are necessary for processes such as memory and synaptic plasticity; lack of function in these genes causes dysfunction or disruption of these processes. We wanted to observe if increasing the function of Egrs by overexpressing them will lead to improved memory. To help further understand how behavior is affected by the overexpression (O/E) of Egr1 in response to stimuli, the AAV-ESARE-Egr1 virus was developed to be injected in the hippocampus of mice. In the hippocampus of wild-type (WT) mice, cells that are active endogenously express Egr1. The virus was created using the synaptic activity-response element (SARE), an element discovered on the promoter of the IEG activity-regulated cytoskeleton-associated (Arc) gene by our collaborators in Japan. Using an “enhanced” form of SARE (ESARE), our newly created virus acts to overexpress Egr1 only in response to activity in the hippocampus; we can then observe if the behavioral processes associated with Egr1 will improve. First, this project aims to validate that the AAV-ESARE-Egr1 virus is increasing Egr1 expression in the active hippocampal dentate gyrus (DG) granule cells of WT mice, and only in response to activity. The activity is in the form of a physiological stimulus, environmental enrichment (EE) and a non-physiological stimulus, electroconvulsive seizures (ECS). After confirming these characteristics of AAV-ESARE-Egr1 we can then use it to observe if EGR1 O/E improves the memory of mice.
ContributorsWallace, Sophie (Author) / Lewis, Candace (Thesis director) / Gallitano, Amelia (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05
Description
Objective: Previous studies have expressed that individuals with dyslexia may be hypersensitive to stimuli when compared to typical individuals, creating the neural noise hypothesis. This study uses electroencephalogram (EEG) to look at participants' mismatch negativity (MMN) response to the distinctive English phoneme /æ/ and an allophone of the phoneme /æ/, measuring their reaction to the variation between these two sounds.
Methods: Twenty-two adults, fourteen with dyslexia and 8 controls partook in an auditory oddball EEG experiment measuring MMN with the amplitudes and latencies being collected.
Results: Five participants demonstrated a large MMN response, four of which were in the dyslexic group. These participants’ results indicate an increased sensitivity to phonetic differences.
Significance: Understanding how some individuals with dyslexia process phonetic differences may be key to comprehending how a dyslexic subtype takes in auditory information.
ContributorsOvaska, Madeline (Author) / Peter, Beate (Thesis director) / Daliri, Ayoub (Committee member) / Kim, Yookyung (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
This project is a policy analysis of Medical-Legal Partnerships (MLP). There is a serious lack of civil legal help for low income individuals in America. One way to address this issue is incorporating legal care into medical care through an MLP, which provides free legal help to address patients’ Social Determinants of Health. This thesis advocates for the incorporation of MLPs into healthcare, as well as more research into the health benefits if an MLP.
ContributorsBrock, Riley (Author) / Kizer, Elizabeth (Thesis director) / Helitzer, Deborah (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / School of Politics and Global Studies (Contributor)
Created2024-05
Description
In recent years, diversity and inclusion has become the focus of every company and business in the world due to the rising societal pressure of avoiding being “canceled”. In America, the unfortunate truth is that healthcare is a business, and it is not exempt from feeling these societal pressures, and although strides are being made in a positive direction, racism is a systemic issue that spans far beyond a change in company culture. Being that skin tone is a pertinent element of racism, one can see how the study of skin, known as dermatology, can easily be influenced by racial discrimination. Throughout this thesis paper, I want to discuss not only the racial disparities in healthcare, but I want to also explore how these disparities impact the patient and provider alike.
ContributorsShamsid-Deen, Reeasah (Author) / Barca, Lisa (Thesis director) / Medcalf, Rollin (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor) / School of Public Affairs (Contributor)
Created2024-05
Description
This duo thesis is an autoethnography of what it means to be Filipino-American in the United States. Being raised in varying backgrounds yet with the similarity of being Filipino, there are aspects of our lives that are simultaneously similar and different. The goal of this project is the exploration of one’s cultural, familial and personal identities and how they intersect with their individuality and sense of belonging. Through this project, we documented our experience as Filipinos in the United States and our travel back to the Philippines and showcased it through videos. It is a means to document our reflections on this project to share with the Filipino community and individuals who share the same sentiments.
ContributorsTamayo, Rianne Daisy (Author) / Onayan, Youla Tricia (Co-author) / O'Flaherty, Katherine (Thesis director) / Fedock, Rachel (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2024-05
Description
This duo thesis is an autoethnography of what it means to be Filipino-American in the United States. Being raised in varying backgrounds yet with the similarity of being Filipino, there are aspects of our lives that are simultaneously similar and different. The goal of this project is the exploration of one’s cultural, familial and personal identities and how they intersect with their individuality and sense of belonging. Through this project, we documented our experience as Filipinos in the United States and our travel back to the Philippines and showcased it through videos. It is a means to document our reflections on this project to share with the Filipino community and individuals who share the same sentiments.
ContributorsOnayan, Youla Tricia (Author) / Tamayo, Rianne Daisy (Co-author) / O'Flaherty, Katherine (Thesis director) / Fedock, Rachel (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2024-05
Description
Familiar size is a pictorial depth cue for which an object's known physical size and visual angle influence observations of apparent distance. There is controversy over the type of process that accounts for the reports of depth. According to Gogel (1976), a non-perceptual cognitive process occurs when the observer experiences a display larger or smaller than a familiar object, such as off-size. The viewer judges that the object is closer or farther away than its perceived distance. Gogel had his participants move their heads to test this notion to see if the apparent depth generated motion parallax. He found that the displays generated slight illusory motion parallax when observers moved laterally.
We created sets of novel objects that varied in size but were identical in shape and color. Twenty-two college students were familiarized with a smaller or larger version of three objects and asked to judge its apparent distance by moving a rod viewed with both eyes. After apparent depth was reported, the rod was placed at the same distance as the familiarized object, and the observer moved their head back and forth. Perception of the motion of the object toward and away from the rod that was concurrent with the motion of the head was found on trials in which a large depth illusion was reported. On trials with little depth effect observed, subjects reported no apparent motion. Thus, the motion supports the view that familiar size is a perceptual illusion, and when it is sufficiently compelling, it can create apparent motion.
ContributorsChengalasetty, Amoolya (Author) / Yonas, Albert (Thesis director) / Tang, YiYuan (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / College of Health Solutions (Contributor)
Created2024-05
Description
Background: Dyslexia is a neurodevelopmental impacting reading and writing ability present in around 5 to 9 percent of the population. The etiology of the condition is not currently well understood.
Purpose: To identify new genes of interest regarding the etiology of dyslexia, describe the interaction of those genes within known gene networks, and discuss potential relationships between their expression in the early developing brain and phenotypic outcomes.
Method: With informed consent, participants’ phenotypic and exome data were collected. Phenotypic data were collected using assessments measuring reading and spelling ability. Exome data were collected via saliva samples and processed at the UW-CRDR. Exome data were then filtering using Seqr and compared across participant families. Certain genes with identical variations were visually validated using the Integrated Genome Viewer, and then investigated using STRING Network Analysis and the Human Brain Transcriptome.
Results: Three genes were identified: BCL6, DNAH1, and DNAH12. Protein-protein interactions were confirmed between DNAH1 and DNAH12 via STRING Network Analysis. BLC6 and DNAH1 experience higher postnatal expression in the cerebellar cortex. DNAH12 experiences higher prenatal expression in the hippocampus.
Discussion: The findings appear to be consistent with a heterogenous and polygenic model of dyslexia. The correlation between the participants’ genotypes and phenotypes is not strong enough to draw significant conclusions regarding genotype/phenotype connections. A larger participant sample size and analysis of a large pool of shared genes may reveal a clearer relationship.
ContributorsBanta, Claire (Author) / Peter, Beate (Thesis director) / Liu, Li (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05