Matching Items (568)
Description
SYSTEMA NERVOSUM is an interdisciplinary personal narrative on design, music, and identity. The project is composed of eleven parts, each addressing the themes of interconnection, the power of the human body, internal and external misunderstanding, and fear. The goal of SYSTEMA NERVOSUM was to create a body of work that reflected the very essence of creative and interdisciplinary thinking.
ContributorsSmall, Elizabeth Quincy (Author) / Bates, Denise (Thesis director) / Ach, Jada (Committee member) / School of Art (Contributor) / College of Integrative Sciences and Arts (Contributor) / The Design School (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
In a COVID-19 world, student engagement has suffered drastically as organizations and universities shifted to an online format. Yet, there is still an opportunity and a space for digital content creation to bridge the gap in a virtual and hybrid university lifestyle. This project looks at how student groups can still engage students at ASU Tempe through digital content creation and which tools to use to enter the space.
ContributorsJavangula, Rahul (Author) / O'Flaherty, Katherine (Thesis director) / Shipley, Austen (Committee member) / Watts College of Public Service & Community Solut (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
The modern web presents an opportunity for educators and researchers to create tools that are highly accessible. Because of the near-ubiquity of modern web browsers, developers who hope to create educational and analytical tools can reach a large au- dience by creating web applications. Using JavaScript, HTML, and other modern web development technologies, Genie was developed as a simulator to help educators in biology, genetics, and evolution classrooms teach their students about population genetics. Because Genie was designed for the modern web, it is highly accessible to both educators and students, who can access the web application using any modern web browser on virtually any device. Genie demonstrates the efficacy of web devel- opment technologies for demonstrating and simulating complex processes, and it will be a unique educational tool for educators who teach population genetics.
ContributorsRoos, Benjamin Hirsch (Author) / Cartwright, Reed (Thesis director) / Wilson Sayres, Melissa (Committee member) / Mayron, Liam (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2015-05
Description
The aim of this project was to conduct an investigation of the cosmetic industry, particularly the field encompassing Botox and dermal fillers. The research helped to identify the various types of fillers used in the market as well as to explore the potential advantages of mechanical injectors within the field. This research and an industry analysis was further used to investigate the necessary components that would best accommodate the patent for a mechanical hand-held injector for the injection of dermal fillers.
ContributorsJames, Merine (Author) / Martin, Thomas (Thesis director) / Devine, John (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Developments in commercial genetic testing have made it possible for people to find out a wealth of information that was previously difficult or impossible to obtain. Genetic testing is a novel solution to the adaptive problem of paternal uncertainty. We hypothesized that participants in the control condition would have greater interest in their paternal genetic information than their maternal genetic information and that participants who were cued to their dissimilarities with their father would seek out genetic information regarding their paternal side of the family above all other conditions. Neither of the two tested hypotheses were supported by the data. Analyses of several variables suggest that the manipulation did work to enhance perceptions of similarity and dissimilarity to parents, that participants were paying attention, and that the dependent variables were sensitive. Some incidental findings suggest that feelings of similarity, rather than dissimilarity, to father are related to interest in learning about paternal genealogy.
ContributorsSabree, Kaelyn Adele (Author) / Kenrick, Douglas (Thesis director) / Corbin, William (Committee member) / Neuberg, Steven (Committee member) / Ko, Ahra (Committee member) / Department of Psychology (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
The use of Artificial Intelligence in assistive systems is growing in application and efficiency. From self-driving cars, to medical and surgical robots and industrial tasked unsupervised co-robots; the use of AI and robotics to eliminate human error in high-stress environments and perform automated tasks is something that is advancing society’s status quo. Not only has the understanding of co-robotics exploded in the industrial world, but in research as well. The National Science Foundation (NSF) defines co-robots as the following: “...a robot whose main purpose is to work with people or other robots to accomplish a goal” (NSF, 1). The latest iteration of their National Robotics Initiative, NRI-2.0, focuses on efforts of creating co-robots optimized for ‘scalability, customizability, lowering barriers to entry, and societal impact’(NSF, 1). While many avenues have been explored for the implementation of co-robotics to create more efficient processes and sustainable lifestyles, this project’s focus was on societal impact co-robotics in the field of human safety and well-being. Introducing a co-robotics and computer vision AI solution for first responder assistance would help bring awareness and efficiency to public safety. The use of real-time identification techniques would create a greater range of awareness for first responders in high-stress situations. A combination of environmental features collected through sensors (camera and radar) could be used to identify people and objects within certain environments where visual impairments and obstructions are high (eg. burning buildings, smoke-filled rooms, ect.). Information about situational conditions (environmental readings, locations of other occupants, etc.) could be transmitted to first responders in emergency situations, maximizing situational awareness. This would not only aid first responders in the evaluation of emergency situations, but it would provide useful data for the first responder that would help materialize the most effective course of action for said situation.
ContributorsScott, Kylel D (Author) / Benjamin, Victor (Thesis director) / Liu, Xiao (Committee member) / Engineering Programs (Contributor) / College of Integrative Sciences and Arts (Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
Approximately 15,000 children die every day due to preventable illnesses (World Health Organization, 2016, 2017). Most of these deaths have been concentrated in developing countries and specifically in Sub-Saharan Africa, South Asia and to a lesser extent in Central Asia. Many studies have analyzed determinants of infant mortality rates across regions of South Asia. Despite neighboring South Asia, reasons for infant mortality in Central Asia do not seem to be as heavily researched. To investigate whether there are differences in the risk factors for infant mortality between South Asia and Central Asia, I analyzed data on 557,089 women and 1,272,916 children from Demographic Health Surveys and Multiple Indicator Cluster Surveys in 5 Central Asian (Azerbaijan, Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan) and 5 South Asian (Afghanistan, Bangladesh, India, Nepal, Pakistan) countries. Binary logistic regression predicted whether a child was alive based on a number of maternal and child characteristics, including maternal age, maternal education, maternal residence, place of delivery, wealth, open defecation, prenatal care, and vaccinations. There were similarities along with differences in child survival outcomes between Central Asia and South Asia. Maternal age, maternal education, and the DPT 3 vaccination appeared to have protective effects on child survival rates in both Central Asia and South Asia whereas delivery outside of the hospital and open defecation have negative effects on child survival outcomes. Tetanus, polio 1, and the BCG vaccinations appeared to have a more pronounced positive effect on child survival in Central Asia whereas measles and polio 3 appear to have a more pronounced positive effect in South Asia. Wealth also appeared to have a greater protective effect in South Asia as opposed to Central Asia. More research needs to be conducted to elaborate on reasons for why there are differences between Central Asia and South Asia.
ContributorsAlam, Mariam (Author) / Hrsuchka, Daniel (Thesis director) / Gaughan, Monica (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Background
Drosophila melanogaster has been established as a model organism for investigating the developmental gene interactions. The spatio-temporal gene expression patterns of Drosophila melanogaster can be visualized by in situ hybridization and documented as digital images. Automated and efficient tools for analyzing these expression images will provide biological insights into the gene functions, interactions, and networks. To facilitate pattern recognition and comparison, many web-based resources have been created to conduct comparative analysis based on the body part keywords and the associated images. With the fast accumulation of images from high-throughput techniques, manual inspection of images will impose a serious impediment on the pace of biological discovery. It is thus imperative to design an automated system for efficient image annotation and comparison.
Results
We present a computational framework to perform anatomical keywords annotation for Drosophila gene expression images. The spatial sparse coding approach is used to represent local patches of images in comparison with the well-known bag-of-words (BoW) method. Three pooling functions including max pooling, average pooling and Sqrt (square root of mean squared statistics) pooling are employed to transform the sparse codes to image features. Based on the constructed features, we develop both an image-level scheme and a group-level scheme to tackle the key challenges in annotating Drosophila gene expression pattern images automatically. To deal with the imbalanced data distribution inherent in image annotation tasks, the undersampling method is applied together with majority vote. Results on Drosophila embryonic expression pattern images verify the efficacy of our approach.
Conclusion
In our experiment, the three pooling functions perform comparably well in feature dimension reduction. The undersampling with majority vote is shown to be effective in tackling the problem of imbalanced data. Moreover, combining sparse coding and image-level scheme leads to consistent performance improvement in keywords annotation.
Drosophila melanogaster has been established as a model organism for investigating the developmental gene interactions. The spatio-temporal gene expression patterns of Drosophila melanogaster can be visualized by in situ hybridization and documented as digital images. Automated and efficient tools for analyzing these expression images will provide biological insights into the gene functions, interactions, and networks. To facilitate pattern recognition and comparison, many web-based resources have been created to conduct comparative analysis based on the body part keywords and the associated images. With the fast accumulation of images from high-throughput techniques, manual inspection of images will impose a serious impediment on the pace of biological discovery. It is thus imperative to design an automated system for efficient image annotation and comparison.
Results
We present a computational framework to perform anatomical keywords annotation for Drosophila gene expression images. The spatial sparse coding approach is used to represent local patches of images in comparison with the well-known bag-of-words (BoW) method. Three pooling functions including max pooling, average pooling and Sqrt (square root of mean squared statistics) pooling are employed to transform the sparse codes to image features. Based on the constructed features, we develop both an image-level scheme and a group-level scheme to tackle the key challenges in annotating Drosophila gene expression pattern images automatically. To deal with the imbalanced data distribution inherent in image annotation tasks, the undersampling method is applied together with majority vote. Results on Drosophila embryonic expression pattern images verify the efficacy of our approach.
Conclusion
In our experiment, the three pooling functions perform comparably well in feature dimension reduction. The undersampling with majority vote is shown to be effective in tackling the problem of imbalanced data. Moreover, combining sparse coding and image-level scheme leads to consistent performance improvement in keywords annotation.
ContributorsSun, Qian (Author) / Muckatira, Sherin (Author) / Yuan, Lei (Author) / Ji, Shuiwang (Author) / Newfeld, Stuart (Author) / Kumar, Sudhir (Author) / Ye, Jieping (Author) / Biodesign Institute (Contributor) / Center for Evolution and Medicine (Contributor) / College of Liberal Arts and Sciences (Contributor) / School of Life Sciences (Contributor) / Ira A. Fulton Schools of Engineering (Contributor)
Created2013-12-03
Description
Background
“Stoichioproteomics” relates the elemental composition of proteins and proteomes to variation in the physiological and ecological environment. To help harness and explore the wealth of hypotheses made possible under this framework, we introduce GRASP (http://www.graspdb.net), a public bioinformatic knowledgebase containing information on the frequencies of 20 amino acids and atomic composition of their side chains. GRASP integrates comparative protein composition data with annotation data from multiple public databases. Currently, GRASP includes information on proteins of 12 sequenced Drosophila (fruit fly) proteomes, which will be expanded to include increasingly diverse organisms over time. In this paper we illustrate the potential of GRASP for testing stoichioproteomic hypotheses by conducting an exploratory investigation into the composition of 12 Drosophila proteomes, testing the prediction that protein atomic content is associated with species ecology and with protein expression levels.
Results
Elements varied predictably along multivariate axes. Species were broadly similar, with the D. willistoni proteome a clear outlier. As expected, individual protein atomic content within proteomes was influenced by protein function and amino acid biochemistry. Evolution in elemental composition across the phylogeny followed less predictable patterns, but was associated with broad ecological variation in diet. Using expression data available for D. melanogaster, we found evidence consistent with selection for efficient usage of elements within the proteome: as expected, nitrogen content was reduced in highly expressed proteins in most tissues, most strongly in the gut, where nutrients are assimilated, and least strongly in the germline.
Conclusions
The patterns identified here using GRASP provide a foundation on which to base future research into the evolution of atomic composition in Drosophila and other taxa.
“Stoichioproteomics” relates the elemental composition of proteins and proteomes to variation in the physiological and ecological environment. To help harness and explore the wealth of hypotheses made possible under this framework, we introduce GRASP (http://www.graspdb.net), a public bioinformatic knowledgebase containing information on the frequencies of 20 amino acids and atomic composition of their side chains. GRASP integrates comparative protein composition data with annotation data from multiple public databases. Currently, GRASP includes information on proteins of 12 sequenced Drosophila (fruit fly) proteomes, which will be expanded to include increasingly diverse organisms over time. In this paper we illustrate the potential of GRASP for testing stoichioproteomic hypotheses by conducting an exploratory investigation into the composition of 12 Drosophila proteomes, testing the prediction that protein atomic content is associated with species ecology and with protein expression levels.
Results
Elements varied predictably along multivariate axes. Species were broadly similar, with the D. willistoni proteome a clear outlier. As expected, individual protein atomic content within proteomes was influenced by protein function and amino acid biochemistry. Evolution in elemental composition across the phylogeny followed less predictable patterns, but was associated with broad ecological variation in diet. Using expression data available for D. melanogaster, we found evidence consistent with selection for efficient usage of elements within the proteome: as expected, nitrogen content was reduced in highly expressed proteins in most tissues, most strongly in the gut, where nutrients are assimilated, and least strongly in the germline.
Conclusions
The patterns identified here using GRASP provide a foundation on which to base future research into the evolution of atomic composition in Drosophila and other taxa.
ContributorsGilbert, James D. J. (Author) / Acquisti, Claudia (Author) / Martinson, Holly M. (Author) / Elser, James (Author) / Kumar, Sudhir (Author) / Fagan, William F. (Author) / Biodesign Institute (Contributor) / Center for Evolution and Medicine (Contributor) / College of Liberal Arts and Sciences (Contributor) / School of Life Sciences (Contributor)
Created2013-09-04
Description
Background
Improvements in sequencing technology now allow easy acquisition of large datasets; however, analyzing these data for phylogenetics can be challenging. We have developed a novel method to rapidly obtain homologous genomic data for phylogenetics directly from next-generation sequencing reads without the use of a reference genome. This software, called SISRS, avoids the time consuming steps of de novo whole genome assembly, multiple genome alignment, and annotation.
Results
For simulations SISRS is able to identify large numbers of loci containing variable sites with phylogenetic signal. For genomic data from apes, SISRS identified thousands of variable sites, from which we produced an accurate phylogeny. Finally, we used SISRS to identify phylogenetic markers that we used to estimate the phylogeny of placental mammals. We recovered eight phylogenies that resolved the basal relationships among mammals using datasets with different levels of missing data. The three alternate resolutions of the basal relationships are consistent with the major hypotheses for the relationships among mammals, all of which have been supported previously by different molecular datasets.
Conclusions
SISRS has the potential to transform phylogenetic research. This method eliminates the need for expensive marker development in many studies by using whole genome shotgun sequence data directly. SISRS is open source and freely available at https://github.com/rachelss/SISRS/releases.
Improvements in sequencing technology now allow easy acquisition of large datasets; however, analyzing these data for phylogenetics can be challenging. We have developed a novel method to rapidly obtain homologous genomic data for phylogenetics directly from next-generation sequencing reads without the use of a reference genome. This software, called SISRS, avoids the time consuming steps of de novo whole genome assembly, multiple genome alignment, and annotation.
Results
For simulations SISRS is able to identify large numbers of loci containing variable sites with phylogenetic signal. For genomic data from apes, SISRS identified thousands of variable sites, from which we produced an accurate phylogeny. Finally, we used SISRS to identify phylogenetic markers that we used to estimate the phylogeny of placental mammals. We recovered eight phylogenies that resolved the basal relationships among mammals using datasets with different levels of missing data. The three alternate resolutions of the basal relationships are consistent with the major hypotheses for the relationships among mammals, all of which have been supported previously by different molecular datasets.
Conclusions
SISRS has the potential to transform phylogenetic research. This method eliminates the need for expensive marker development in many studies by using whole genome shotgun sequence data directly. SISRS is open source and freely available at https://github.com/rachelss/SISRS/releases.
ContributorsSchwartz, Rachel (Author) / Harkins, Kelly (Author) / Stone, Anne (Author) / Cartwright, Reed (Author) / Biodesign Institute (Contributor) / Center for Evolution and Medicine (Contributor) / College of Liberal Arts and Sciences (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2015-06-11