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Description
Electric vehicles (EVs) are at the forefront of revolutionizing the automotive industry as we know it. For the past century, transportation has relied on internal combustion engines (ICE); however, their source of power has been actively contributing to the dangerous buildup of greenhouse gasses. As we move towards a more sustainable future, interest in electric vehicles is growing rapidly. Predominantly powered by lithium-ion batteries, the automotive industry faces a new set of challenges in obtaining ethically sourced raw materials, meeting demand levels, and ensuring that their new supply chain is sustainable throughout the entire production lifecycle. Understanding the sourcing of key battery raw materials, the environmental implications of battery production, and the overall supply chain is crucial as this industry continues to grow. Is it possible to meet and sustain the demand for lithium-ion batteries? How can we ensure that these batteries do not do more harm than good to our environment in the long run? To answer these questions, this thesis will conduct a thorough analysis of present and future concerns and provide recommendations on how to ensure a sustainable and successful future with electric vehicles.
ContributorsGroth, Alianna (Author) / Printezis, Antonios (Thesis director) / Van Orden, Joseph (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2024-05
Our Own Heart, Beating Higher and Higher: On the Possibility of Genuine Encounter Among Human Beings
Description
Because of the necessarily interwoven nature of existence and the human person’s formation in the image and likeness of God, one inherently has enough in common with any other in order to behold him/her properly. Such an interaction increases the beholder's proximity to both the beheld and God simultaneously; it enables one to briefly glimpse these pieces of reality as God Himself does. Such a claim falls primarily under Saint Thomas Aquinas’s foundation of creation (especially his fusion of Plato’s idea of participation and Aristotle’s concept of act and potency, resulting in his own contribution of esse and essence) and Saint Augustine’s concept of the human person. This remains true even under the pressing weight of liberalistic divisiveness and such potent objects as those raised by Muriel Rukeyser’s “Effort at Speech Between Two People,” Victor Hugo’s The Hunchback of Notre Dame," and Mary Shelley’s "Frankenstein; or, The Modern Prometheus.”
ContributorsCartwright, Sophia (Author) / Kushner, Aaron (Thesis director) / Thurow, Aaron (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / School of International Letters and Cultures (Contributor)
Created2024-05
Description
Fumonisins are fungal metabolites found in corn and cereals. Fumonisins pose health risks, including suspected carcinogenicity, yet their mechanism of toxicity remains unclear. While modifications in the human gut microbiome can impact host health, the effects of fumonisins on the microbiome are not well understood. Thus, our study aimed to assess a possible dose-response relationship between fumonisin B1 (FB1) and the gut microbiome. We utilized in vitro anaerobic bioreactors with media simulating most of the nutrients in the human large intestine, inoculated them with fecal samples from 19 healthy adults and treated them with FB1 at concentrations of 0, 10, 100, and 1000 ppb. Analyses of bioreactor headspace revealed declining methane production over time, possibly influenced by the addition of dimethyl sulfoxide (DMSO). Significant differences in acetic acid production were observed in 10 ppb reactor (Day 2) and 100 ppb reactor (Day 8) when compared to 0 ppb control. Microbiome analysis showed minimal shifts in microbial relative abundances during FB1 treatment, except for Desulfovibrio desulfuricans C at Day 8 when compared between 0 ppb and 10 ppb as well as 10 ppb and 1000 ppb at Day 16. Alpha diversity analyses indicated significant differences in observed features within bioreactors of different treatments, with some variation in Faith’s Phylogenetic Diversity between the 0 ppb and 10 ppb bioreactors. Beta diversity analyses, however, revealed no significant differences between bioreactors. Overall, our findings suggest no clear dose-response relationship between FB1 treatment and gut microbiome composition/functions. The presence of DMSO may have obscured potential effects. This research will help contribute to our understanding of mycotoxicity influence on the human gut microbiome.
ContributorsSanchez Carreon, Aurely (Author) / Krajmalnik-Brown, Rosa (Thesis director) / Cheng, Qiwen (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor)
Created2024-05
Description
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by a wide range of symptoms and severities, affecting communication, behavior, and social interactions. With the prevalence of ASD rising to affect nearly 1 in 36 children in the United States, understanding and addressing the multifaceted needs of those with ASD is increasingly critical. This review explores the interplay between genetic, environmental, and immune factors in the onset of ASD, focusing on metabolic dysfunctions and the role of the gut-brain axis. Emerging research highlights the significance of abnormal metabolites and gut microbiota imbalances in contributing to the pathophysiology of ASD, suggesting that these factors may influence neurological function and behavior through modulating immune responses.
Recent analyses have uncovered metabolic disturbances in ASD, affecting amino acid metabolism, glutathione metabolism, glycolysis and the TCA cycle, homocysteine metabolism, ketone body synthesis, and lipid metabolism. These disturbances offer insights into how metabolic dysfunctions may contribute to the neurological and behavioral features of ASD. Furthermore, the gut microbiota's role in immune responses and the controversial impact of antibiotic use on gut flora composition is important to the complexity of ASD and the need for a nuanced understanding of treatment effects.
This review delves into the current understanding of metabolic dysfunctions in children with ASD, emphasizing the critical role of gut microbiota and the impact of antibiotic use. Specifically, this review discusses SCFAs, para-cresol, amino acid metabolites, and glutathione and their respective specific treatments. It also explores the potential of vitamin/mineral supplementation as a therapeutic strategy, highlighting significant improvements in metabolic markers and behavioral symptoms associated with ASD. The findings from key studies, including those by Adams et al., suggest that targeted nutritional interventions and careful management of gut health could offer promising avenues for improving the quality of life for individuals with ASD. The review also acknowledges the need for further research to confirm the long-term effects of these interventions and to develop personalized treatment approaches that consider the unique needs in individuals with ASD.
ContributorsNandakumar, Keshav (Author) / Adams, James (Thesis director) / Flynn, Christina (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
Mental health perceptions within the Somali community are shaped by cultural, educational, geographical, and religiosity factors. This study aimed to explore the mental health views of Somalis in Somalia and those in the United States, considering the influence of culture and religion. A comprehensive survey was conducted, and data from 44 participants were analyzed using paired t-tests and correlations. Results revealed diverse beliefs among participants, with some attributing distress to spiritual causes like possession by Jinn or punishment by Allah, while others viewed it as a result of loss of faith or biological factors. Despite limitations such as a small sample size and recruitment challenges, the study contributes to understanding the views of an understudied group. Future research should focus on longitudinal studies to address the changing mental health views as well as the needs within the Somali community.
ContributorsNur, Istarlin (Author) / Cohen, Adam (Thesis director) / Johnson, Kathryn (Committee member) / Aglozo, Eric (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
Alzheimer’s disease (AD) is characterized by memory decline and dementia, and conclusively diagnosed postmortem from tangles and plaques. Plaques come from β-amyloid protein (Aβ), which damages the brain, especially the hippocampus, a structure vital for memory formation. However, whether plaques and tangles cause or result from AD is unclear. Our goal was to use a preclinical AD model to identify the early stages of cognitive dysfunction before AD becomes severe to enhance targeted interventions. We used a transgenic mouse (APP/PS1) that slowly develops plaques, with minimal expression around 5-6 months (young adult) with more expression by 12 months (middle-age). Our aim was to determine whether young adult mice would show cognitive symptomatology that could be used as a future metric for targeted treatment before AD advances further. We had three independent variables: Sex (Male, Female), Age (5-6, 8-10 months) and Genotype (APP/PS1, wildtype, WT). We used behavioral assays to assess spatial memory (hippocampal function), working memory (prefrontal cortex function), and anxiety (amygdala function). For my honor’s thesis, I focused on using the Morris Water Maze (MWM) to assess hippocampal function and the Open Field (OF) to assess anxiety and locomotion. In MWM, all groups were given four trials/day for four days with a probe trial to assess strategy immediately after the last trial on day 4. All groups swam shorter distances across days to show they were learning and revealed sex differences. The APP/PS1 males (young and old) learned the task more slowly than their WT male counterparts, but were using spatial strategies as demonstrated by the probe trial. For the females, all groups learned the task similarly, but the probe trial revealed that the APP/PS1 females (young and old) were using non-spatial strategies. Moreover, the males significantly swam shorter distances than the females, learning faster. The use of the visible platform task confirmed that the mice were capable of performing the swim task. For the OF, mice were placed in a square arena and given 10 minutes to explore and found sex differences in anxiety profile. All the female mice expressed similar anxiety profiles, whereas the APP/PS1 males had higher anxiety profiles than their WT males counterparts. These results revealed that there were sex-specific differences in cognition and anxiety profiles in the APP/PS1 mouse model. This indicates that individual characteristics are important to consider when using tailored interventions. In summary, these findings emphasize the potential for early detection and targeted treatment strategies to help mitigate AD progression.
ContributorsMontero, Martina Anne (Author) / Conrad, Cheryl (Thesis director) / Gewirtz, Jonathan (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
Autosomal Dominant Polycystic Kidney Disease (ADPKD) accounts for 10% of patients on dialysis and leads to a complete life transformation, as patients suffer from pain, fatigue, and isolation. With 22% of ADPKD patients experiencing depression, this study hoped to unveil specific coping strategies that mediate the link between patients’ sources of social support and levels of depression (Simms et al., 2016). Online survey data was collected with a sample of ADPKD adults (N= 81, 67.9% female), administering measures that capture social support (SS), coping strategies (CS), and depression. Mediation analyses revealed that the relationship between three types of social support (e.g., family, friends, and significant others) and depression, were significantly mediated by two types of coping strategies: acceptance (p < 0.05 - 0.01) and planning (p < 0.001). More specifically, acceptance coping partially mediated the link between the social support of family and significant others and depression, whereas acceptance coping demonstrated a trend towards partial mediation in the link between friends’ social support and depression, with acceptance mitigating depression. Interestingly, utilizing planning coping masked the link between familial social support and depression, such that planning increased depression. Taken together, ADPKD patients who learn to accept their diagnosis are less depressed, while those who plan ahead experience greater depression.
ContributorsFusciello, Chiara (Author) / Taylor, Teri (Thesis director) / Flores, Valerie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
Caregiving for a disabled or ill relative can be an extremely stressful role, leading to increased acute physiological responses to stress and also chronic cardiovascular disease (CVD) outcomes. Furthermore, an important consideration for studying CVD and daily stress in caregivers is less is known about gender differences in the effects of caregiving. The aims of this study were to examine the associations between gender and daily stressors on cardiovascular health in caregivers. A sample of 1,841 respondents (ranging from 33-84 years) from the Midlife in the United States study answered a question about caregiving and participated in both a daily diary and biomarker subprojects. Within the sample, only 13.04% of respondents classified themselves as caregivers. Regression analysis was used to test 1. whether stressor exposure and stressor reactivity, which is the emotional response to stress, differ by caregiver status and gender, 2. cardiovascular health as indicated by the American Heart Association’s Life’s Simple Seven measure (on scale of poor, intermediate, or ideal) is predicted by caregiving status and gender, 3. whether daily stress is associated with Life’s Simple Seven, and 4. whether daily stress moderates the associations between caregiving and gender with cardiovascular health. Important findings of the study included that caregivers and women experienced more daily stressors, while caregivers and men had greater cardiovascular risk, but this was not related to experience of daily stressors. These results are discussed within the context of study limitations and opportunities for future research building upon daily stress and caregiving.
ContributorsBiernot, Kelsey (Author) / Koffer, Rachel (Thesis director) / Gómez-Morales, Abigail (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
Objective: Previous studies have expressed that individuals with dyslexia may be hypersensitive to stimuli when compared to typical individuals, creating the neural noise hypothesis. This study uses electroencephalogram (EEG) to look at participants' mismatch negativity (MMN) response to the distinctive English phoneme /æ/ and an allophone of the phoneme /æ/, measuring their reaction to the variation between these two sounds.
Methods: Twenty-two adults, fourteen with dyslexia and 8 controls partook in an auditory oddball EEG experiment measuring MMN with the amplitudes and latencies being collected.
Results: Five participants demonstrated a large MMN response, four of which were in the dyslexic group. These participants’ results indicate an increased sensitivity to phonetic differences.
Significance: Understanding how some individuals with dyslexia process phonetic differences may be key to comprehending how a dyslexic subtype takes in auditory information.
ContributorsOvaska, Madeline (Author) / Peter, Beate (Thesis director) / Daliri, Ayoub (Committee member) / Kim, Yookyung (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
Latinx youth experience increased risk of depressive symptoms (DS) due to cultural and universal risk factors. Acculturative family distancing (AFD) and mother-adolescent conflict (MAC) are significant in predicting depressive symptoms (DS) among Latinx adolescents. Guided by resilience frameworks, this study examined the effects of AFD and MAC on Latinx adolescent DS, and whether family cohesion (FC) moderated these relations. Self-reported survey data was gathered from 207 Latinx students and analyzed using regression analyses. Results indicated that MAC and AFD were significant and positively related to DS. However, family cohesion (FC) did not emerge as a significant moderator for these relations.
ContributorsTimmons, Isabella (Author) / Nair, Rajni (Thesis director) / Bauer, Richard (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2024-05