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One of the major challenges that were yet to be solved for solid phase peptide synthesis was the lack of an efficient peptide sequencing technique that was less hazardous, easier to perform , and was more cost-effective. Sequencing peptides were held important in the field of Chemistry and Biochemistry because

One of the major challenges that were yet to be solved for solid phase peptide synthesis was the lack of an efficient peptide sequencing technique that was less hazardous, easier to perform , and was more cost-effective. Sequencing peptides were held important in the field of Chemistry and Biochemistry because it aided in drug discovery, finding ligands that bind to a specific target protein and finding alternative agents in transporting molecules to its desired location. Therefore, the overall purpose of this experiment was to develop a method of solid phase sequencing technique that was more environmental friendly, sequences at a faster rate, and was more cost-effective.
ContributorsCordovez, Lalaine Anne Ordiz (Author) / Woodbury, Neal (Thesis director) / Zhao, Zhan-Gong (Committee member) / Legutki, Joseph Barten (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-05
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While there is extensive information available about organizations that receive donated organs for transplant, much less is known about those that accept tissue and whole bodies for medical education and research. Throughout the United States, nontransplant anatomical donation organizations exist within an ambiguous sector of the donation industry, unencumbered by

While there is extensive information available about organizations that receive donated organs for transplant, much less is known about those that accept tissue and whole bodies for medical education and research. Throughout the United States, nontransplant anatomical donation organizations exist within an ambiguous sector of the donation industry, unencumbered by federal regulations. Although these companies adhere to the Uniform Anatomical Gift Act, the lack of a single entity responsible for overseeing their operations has led to public skepticism and animosity among competing businesses. Legislation has the potential to legitimize the industry. For it to be successful, however, the intricacies of a complex market that deals directly with the movement of human remains and intangible issues of human integrity and morality, must be thoroughly understood.
ContributorsGlynn, Emily Sanders (Author) / Brian, Jennifer (Thesis director) / Fisher, Rebecca (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor) / Department of English (Contributor)
Created2015-05
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Methicillin-Resistant Staphylococcus aureus (MRSA) infections are a major challenge to healthcare professionals. Treatment of MRSA is expensive, and otherwise avoidable deaths occur every year in the United States due to MRSA infections. Additionally, such infections lengthen patients’ stays in hospitals, keeping them out of work and adversely affecting the economy.

Methicillin-Resistant Staphylococcus aureus (MRSA) infections are a major challenge to healthcare professionals. Treatment of MRSA is expensive, and otherwise avoidable deaths occur every year in the United States due to MRSA infections. Additionally, such infections lengthen patients’ stays in hospitals, keeping them out of work and adversely affecting the economy. Beta lactam antibiotics used to be highly effective against S. aureus infections, but resistance mechanisms have rendered methicillin, oxacillin, and other beta lactam antibiotics ineffective against these infections. A promising avenue for MRSA treatment lies in the use of synthetic antibodies—molecules that bind with specificity to a given compound. Synbody 14 is an example of such a synbody, and has been designed with MRSA treatment in mind. Mouse model studies have even associated Syn14 treatment with reduced weight loss and morbidity in MRSA-infected mice. In this experiment, in vitro activity of Syn 14 and oxacillin was assessed. Early experiments measured Syn 14 and oxacillin’s effectiveness in inhibiting colony growth in growth media, mouse serum, and mouse blood. Syn14 and oxacillin had limited efficacy against USA300 strain MRSA, though interestingly it was noted that Syn14 outperformed oxacillin in mouse serum and whole mouse blood, indicating the benefits of its binding properties. A second experiment measured the impact that a mix of oxacillin and Syn 14 had on colony growth, as well as the effect of adding them simultaneously or one after the other. While use of either bactericidal alone did not show a major inhibitory effect on USA300 MRSA colony growth, their use in combination showed major decreases in colony growth. Moreover, it was found that unlike other combination therapies, Syn14 and oxacillin did not require simultaneous addition to MRSA cells to achieve inhibition of cell growth. They merely required that Syn14 be added first. This result suggests Syn14’s possible utility in therapeutic settings, as the time insensitivity of synergy removes a major hurdle to clinical use—the difficulty in ensuring that two drugs reach an affected area at the same time. Syn14 remains a promising antimicrobial agent, and further study should focus on its precise mechanism of action and suitability in clinical treatment of MRSA infections.
ContributorsMichael, Alexander (Author) / Diehnelt, Chris (Thesis director) / Stafford, Phillip (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2015-05
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With advances in biotechnology, personalized medicine has become an ever-expanding field. Even with so much growth, the critics equally match the proponents of personalized medicine. The source of their disagreement is rooted in the concept of empowerment. This analysis utilizes the personal genomics company 23andMe and their relationship with the

With advances in biotechnology, personalized medicine has become an ever-expanding field. Even with so much growth, the critics equally match the proponents of personalized medicine. The source of their disagreement is rooted in the concept of empowerment. This analysis utilizes the personal genomics company 23andMe and their relationship with the Federal Food and Drug Administration to illustrate varying views of empowerment. Specifically, the case study focuses on the ability to provide direct-to-consumer health reports to patients independent of physicians. In doing this, larger issues of what is at stake in personalized medicine are uncovered. These include but are not limited to: who determines what individuals get empowered and what information is determined good versus bad.
ContributorsSilverman, Adam Mattern (Author) / Brian, Jennifer (Thesis director) / Hurlbut, Ben (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor)
Created2015-05
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Brundtland’s definition of sustainability is the ability to “meet the needs of the present without compromising the ability of future generations to meet their needs” (IISD, 2021). But what if there are no future generations? Social sustainability, the sector of sustainability that foregrounds the well-being and livelihoods of people (and

Brundtland’s definition of sustainability is the ability to “meet the needs of the present without compromising the ability of future generations to meet their needs” (IISD, 2021). But what if there are no future generations? Social sustainability, the sector of sustainability that foregrounds the well-being and livelihoods of people (and thereby continuation of humanity), is included in definitions within the sustainability field, but less developed in sustainability practice. In an effort to bridge this gap of knowledge, 14 U.S. cities and over 100 sustainability policies were analyzed for their social sustainability performance. An eight-item analytical framework that deals with differing areas of social equity guided the analysis. Results found that most cities’ sustainability departments fell short of truly addressing social sustainability concerns. Out of the eight items, the most frequently addressed were housing security and racial and gender equality whereas few, if any, cities addressed the more specific social concerns of immigration, technology and media, or arts/cultural preservation. Future research is recommended to gain a better understanding of the ways existing cities can improve in this area.

ContributorsTam, Joey (Co-author) / Weekes, Daniel (Co-author) / Brian, Jennifer (Thesis director) / Keeler, Lauren (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Ankle monitors are not the bright, kind alternative to incarceration that they are made to be. Advocates propose them as a solution to overcrowded carceral sites and excessive federal expenditure on public corrections agencies. Their logic being we can release certain incarcerated people to reduce prison, jail, and detention center

Ankle monitors are not the bright, kind alternative to incarceration that they are made to be. Advocates propose them as a solution to overcrowded carceral sites and excessive federal expenditure on public corrections agencies. Their logic being we can release certain incarcerated people to reduce prison, jail, and detention center populations and require them to pay for their monitoring to reduce prison expenditures. While there is potential for ankle monitors to achieve these aspirations, it is necessary to recognize how and where they can produce harm. Rather than being an alternative to incarceration, ankle monitors are a method of incarceration. They serve the same functions and hold the same power as prisons and jails with a more elusive form. In the current implementation of ankle monitors, we see individual bodies being transformed into sources of data to be capitalized upon by the government and private companies. Along with this, there is a shift of the financial burden of incarceration from prisons to the person being punished. This acts to further perpetuate the cycles of poverty and financial oppression that are seen within traditional forms of incarceration. Ankle monitor advocates also claim ankle monitors allow incarcerated people to enjoy freedom beyond prison walls and reintegrate into society. In reality, this is an oversimplification of freedom. Individuals with ankle monitors find themselves to be limited in their freedoms by restricted movement and stigmatization. They are unable to live a “normal” life because their ankle monitors prevent them from doing so. These people cannot move as they please, they cannot find and hold employment, and they cannot interact with people like they normally would. Ankle monitor usage must be critically examined and altered if it is to be considered a meaningful, gentle alternative to incarceration.

ContributorsNg, Alexa (Author) / Brian, Jennifer (Thesis director) / Stevens, Nikki (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a congenital disease that affects the female reproductive organs, causing them to be either malformed or completely absent. Much of the research regarding MRKH primarily focuses on the biological aspects of the disease and ignores the social impacts of the disease. I have conducted research to

Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a congenital disease that affects the female reproductive organs, causing them to be either malformed or completely absent. Much of the research regarding MRKH primarily focuses on the biological aspects of the disease and ignores the social impacts of the disease. I have conducted research to assess three of the underlying factors affecting women with the disease and gained a better understanding of how this disease affects these individuals and creates new obstacles for them throughout their lives. I found that for many women with MRKH, the decision to pursue treatment is greatly influenced by their environments and communities. Treatments range from something minor like vaginal dilation to much more controversial and riskier experimental treatments like uterine transplant surgery to experience pregnancy. Patients often experience “gender role insecurity” based on the cultural norms of their society. Gender role insecurity is the concern that gender norms may go unfulfilled, and even affects the relationships between women with MRKH and those who do not have the disease. This is a concern that women feel due to social pressures and standards. Gender role insecurity is important because it lets us understand what women with MRKH feel they lack in terms of their femininity and why medical intervention is so highly prioritized. Some societies and cultures with a more traditional background have a greater influence regarding the treatment options that MRKH women pursue. By analyzing support groups and online message boards, it seems that these support groups give women with MRKH the support and freedom to explore a range of treatment options, away from significant social pressures.

ContributorsCondado, Julianna (Author) / Brian, Jennifer (Thesis director) / Dietz, Elizabeth (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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This study looked at student’s perceptions of COVID-19 and differences in how universities handled COVID-19. It aimed to assess what measures made students feel safe and were the most effective in lessening spread. A risk-perception survey scored feelings of safety/risk, and semi-structured interviews provided context. Descriptive statistics and thematic analysis

This study looked at student’s perceptions of COVID-19 and differences in how universities handled COVID-19. It aimed to assess what measures made students feel safe and were the most effective in lessening spread. A risk-perception survey scored feelings of safety/risk, and semi-structured interviews provided context. Descriptive statistics and thematic analysis showed mixed opinions on university measures, and interviews identified wearing masks, social distancing, isolating, and limiting social contacts as measures that were effective in curbing spread.

ContributorsHart, Alyssa Nicole (Author) / Brian, Jennifer (Thesis director) / Ivanova, Julia (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Developing a vaccine during the midst of a pandemic requires a careful balance between <br/>speed, safety, and efficacy. For the COVID-19 pandemic, the U.S. implemented Operation Warp Speed to accelerate the timeline for vaccine development. The FDA also imposed specific guidelines for granting Emergency Use Authorization (EUA). As of April

Developing a vaccine during the midst of a pandemic requires a careful balance between <br/>speed, safety, and efficacy. For the COVID-19 pandemic, the U.S. implemented Operation Warp Speed to accelerate the timeline for vaccine development. The FDA also imposed specific guidelines for granting Emergency Use Authorization (EUA). As of April 1st, 2021, Operation Warp Speed resulted in three different vaccines receiving EUA, all of which are currently being administered to the public. However, the rapid production and changes in the approval process intensified public scrutiny on the safety and efficacy of the vaccine. This thesis analyzes the differences in fast-tracking a vaccine, which consolidated the authorization process into months rather than years, and delineates the main concerns of the public regarding the COVID-19 vaccine through a media analysis. Although the EUA raised questions about the safety of the vaccine, polls indicate that most Americans would still be willing to receive the vaccine.

ContributorsDykstra, Tatum Nicole (Author) / Brian, Jennifer (Thesis director) / Koskan, Alexis (Committee member) / School of Life Sciences (Contributor) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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This podcast highlights the voices of organizers and activists across the nation. Representatives from various organizations and individual activists provide their experiences in working within reproductive health activist spaces. By listening to their stories and expertise, the hope is for listeners to center Reproductive Justice as a point of view.

This podcast highlights the voices of organizers and activists across the nation. Representatives from various organizations and individual activists provide their experiences in working within reproductive health activist spaces. By listening to their stories and expertise, the hope is for listeners to center Reproductive Justice as a point of view. The goal is to encourage the audience to join an organization, support their local organizations, or at the very least, learn about resources provided to them by local and national organizations.

ContributorsPerez, Maya Isabella (Co-author) / Adversario, Kim Alexis (Co-author) / Quan, H.L.T. (Thesis director) / Brian, Jennifer (Committee member) / School of Politics and Global Studies (Contributor, Contributor, Contributor, Contributor) / School of Public Affairs (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05