This thesis discusses why there is so much employee turnover in the Sports Programs department, which is a working department of the Sun Devil Fitness Complex on Arizona State’s Tempe Campus. The analysis discusses the problems that have been noticed from personal experience, and the problems that have been explained by employees that left about why they decided to leave. The analysis is done based on the concepts of the four frames, based on research documented by Bolman and Deal in their book. There is an overview of all of the departments and specifically the Sports Programs department, and a deep dive into what that department does. There is a discussion of what problems may be present, and some solutions such as debriefings, trainings, and more objective evaluations that can be implemented into the department to try to fix the problems that have been noticed.

This project explorers the potential reasons for the discrepancies between state responses to the COVID-19 pandemic, with a particular focus on the possibility of a correlation between political ideology and a state’s nonpharmacological intervention policy timing. In addition to outlining the current literature on the preferences of conservative and liberal ideology, examples of both past and present scientific based pandemic responses are described as well. Given the current understanding of the social and economic dimension of conservative and liberal political ideology, it was hypothesized that there may be a positive correlation between conservative ideology and premature action by a state. Data was collected on the current ideological landscape and the daily COVID-19 cases numbers of each state in addition to tracking each state’s policy changes. Two correlation tests were performed to find that there was no significant positive or negative correlation between the two variables.

Vocal emotion production is important for social interactions in daily life. Previous studies found that pre-lingually deafened cochlear implant (CI) children without residual acoustic hearing had significant deficits in producing pitch cues for vocal emotions as compared to post-lingually deafened CI adults, normal-hearing (NH) children, and NH adults. In light of the importance of residual acoustic hearing for the development of vocal emotion production, this study tested whether pre-lingually deafened CI children with residual acoustic hearing may produce similar pitch cues for vocal emotions as the other participant groups. Sixteen pre-lingually deafened CI children with residual acoustic hearing, nine post-lingually deafened CI adults with residual acoustic hearing, twelve NH children, and eleven NH adults were asked to produce ten semantically neutral sentences in happy or sad emotion. The results showed that there was no significant group effect for the ratio of mean fundamental frequency (F0) and the ratio of F0 standard deviation between emotions. Instead, CI children showed significantly greater intensity difference between emotions than CI adults, NH children, and NH adults. In CI children, aided pure-tone average hearing threshold of acoustic ear was correlated with the ratio of mean F0 and the ratio of duration between emotions. These results suggest that residual acoustic hearing with low-frequency pitch cues may facilitate the development of vocal emotion production in pre-lingually deafened CI children.

Obesity rates among adults have steadily grown in recent decades all the way up to 42.4% in 2018. This is a 12% increase from the turn of the century (Center for Disease Control and Prevention, 2021). A major reason for this rise is increased consumption of processed, high-calorie foods. People eat these foods at a young age and develop bad eating habits that can last for the rest of their lives. It is essential to intervene early and help adolescents form balanced, healthy eating habits before bad habits are already formed. Our solution to this problem is Green Gamers. Green Gamers combines adolescent’s passion for gaming with healthy eating via in-game rewards for healthy eating. People will be able to purchase healthy food items, such as a bag of carrots, and on the packaging there will be a QR code. They will then be able to scan the code on our website, and earn points which will unlock in-game items and other rewards. Video game rewards act as effective motivators for you people to eat more healthy foods. After the solution was formulated, a preliminary survey was conducted to confirm that video game related rewards would inspire children to eat more healthy foods. Based on those results, we are currently in the process of running a secondary market research campaign to learn if gift card rewards are a stronger motivator. Our end goal for Green Gamers would be to partner with large gaming studios and food producers. This would allow us access to many gaming franchises, so that rewards are available from a wide variety of games: making the platform appealing to a diverse audience of gamers. Similarly, a relationship with large food producers would give us the ability to place QR codes on a greater assortment of healthy food items. Although no relationships with large companies have been forged yet, we plan to utilize funding to test our concept on small focus groups in schools.

Patent protection creates an encouraging environment for innovation, but it can be a hindrance to the availability of new medications. There are many countries that still harbor this competition while ensuring that all citizens have access to these medications. There are downsides to certain patent systems, but with a few modifications they can be remedied to achieve the highest level of access, quality of care, and best cost for the insured. In most of the countries reviewed, the patent system is thoroughly regulated with the consumers in mind. There are opportunities for manufacturers to create generic and cost effective medications within the typical patent protection timeline to ensure access to new medications. The systems that are in place encourage innovation with medical devices and medication by providing incentives for the researchers.

Antibiotic resistance is a growing crisis across the globe. With the use of antibiotics in heathcare settings in an ever-growing population, the growth of antibiotic resistance has been named a top 10 global public health threat by the World Health Organization. Through an analysis of 6 countries; Mexico, China, the United States, India, Saudi Arabia, and Ethiopia, I look at the current implementation of policy and contributing factors to the use and abuse of antibiotics within the country. Through my research, I was able to find knowledge, behaviors, and a lack of enforcement to be the main contributors to the growing antibiotic crisis. Based on the evidence, I suggested three policies that focused on treatment, prevention, or economic assistance in an effort to combat the antibiotic crisis on a global scale. With socio-economic factors in mind as well as sustainability of policy, the evidence pointed in the direction of a three-pronged approach on prevention with education, policy enforcement, and a global database to minimize the growth of antibiotic resistance as well as improve public health at a global level.

As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.

Developing a vaccine during the midst of a pandemic requires a careful balance between <br/>speed, safety, and efficacy. For the COVID-19 pandemic, the U.S. implemented Operation Warp Speed to accelerate the timeline for vaccine development. The FDA also imposed specific guidelines for granting Emergency Use Authorization (EUA). As of April 1st, 2021, Operation Warp Speed resulted in three different vaccines receiving EUA, all of which are currently being administered to the public. However, the rapid production and changes in the approval process intensified public scrutiny on the safety and efficacy of the vaccine. This thesis analyzes the differences in fast-tracking a vaccine, which consolidated the authorization process into months rather than years, and delineates the main concerns of the public regarding the COVID-19 vaccine through a media analysis. Although the EUA raised questions about the safety of the vaccine, polls indicate that most Americans would still be willing to receive the vaccine.

Recent studies suggest a role for the microbiota in autism spectrum disorders (ASD), potentially arising from their role in modulating the immune system and gastrointestinal (GI) function or from gut–brain interactions dependent or independent from the immune system. GI problems such as chronic constipation and/or diarrhea are common in children with ASD, and significantly worsen their behavior and their quality of life. Here we first summarize previously published data supporting that GI dysfunction is common in individuals with ASD and the role of the microbiota in ASD. Second, by comparing with other publically available microbiome datasets, we provide some evidence that the shifted microbiota can be a result of westernization and that this shift could also be framing an altered immune system. Third, we explore the possibility that gut–brain interactions could also be a direct result of microbially produced metabolites.

There is a growing body of scientific evidence that the health of the microbiome (the trillions of microbes that inhabit the human host) plays an important role in maintaining the health of the host and that disruptions in the microbiome may play a role in certain disease processes. An increasing number of research studies have provided evidence that the composition of the gut (enteric) microbiome (GM) in at least a subset of individuals with autism spectrum disorder (ASD) deviates from what is usually observed in typically developing individuals. There are several lines of research that suggest that specific changes in the GM could be causative or highly associated with driving core and associated ASD symptoms, pathology, and comorbidities which include gastrointestinal symptoms, although it is also a possibility that these changes, in whole or in part, could be a consequence of underlying pathophysiological features associated with ASD. However, if the GM truly plays a causative role in ASD, then the manipulation of the GM could potentially be leveraged as a therapeutic approach to improve ASD symptoms and/or comorbidities, including gastrointestinal symptoms.

One approach to investigating this possibility in greater detail includes a highly controlled clinical trial in which the GM is systematically manipulated to determine its significance in individuals with ASD. To outline the important issues that would be required to design such a study, a group of clinicians, research scientists, and parents of children with ASD participated in an interdisciplinary daylong workshop as an extension of the 1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism (www.microbiome-autism.com). The group considered several aspects of designing clinical studies, including clinical trial design, treatments that could potentially be used in a clinical trial, appropriate ASD participants for the clinical trial, behavioral and cognitive assessments, important biomarkers, safety concerns, and ethical considerations. Overall, the group not only felt that this was a promising area of research for the ASD population and a promising avenue for potential treatment but also felt that further basic and translational research was needed to clarify the clinical utility of such treatments and to elucidate possible mechanisms responsible for a clinical response, so that new treatments and approaches may be discovered and/or fostered in the future.