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- Creators: Arizona State University
- Creators: School of Molecular Sciences
- Creators: Department of Supply Chain Management
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Description
Panpsychism is the view that consciousness is an intrinsic state of the world. While early forms were advanced by Spinoza and Russell, only recently has panpsychism gained widespread academic consideration. In this paper, I will argue for panpsychism, based on a similarity of the nature of our consciousness with the nature of the parts of our consciousness. This argument will be motivated by an anti-strong emergentist viewpoint, while allowing for complex consciousness to arise from a form of weak emergence between fundamental parts. Ultimately, this argument demonstrates that an identity theorist would collapse to panpsychism or strong emergentism, the former being preferred. From this, I argue that panpsychists can gain some intuitive benefits of dualism and materialism, without inheriting their issues. This positions the panpsychist well to respond to issues like Jackson’s (1982) Mary-argument. I will then discuss possible objections to panpsychism, focusing primarily on the combination problem. I conclude that the co-consciousness strategy is the optimal solution to this problem and can account for the inverse issue of the decombination problem that cosmopsychism faces. Overall, panpsychism’s explanatory power and compatibility with other disciplines makes it a favorable theory within the philosophy of mind.
ContributorsKing, Liam (Author) / Watson, Jeffrey (Thesis director) / Botham, Thad (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2024-05
Description
Background: Eosinophilic esophagitis (EoE) is an increasingly prevalent allergic disease characterized by eosinophilic inflammation and symptoms of esophageal dysfunction. Diagnosis and monitoring require repeated, invasive endoscopic esophageal biopsies to assess levels of eosinophilic inflammation. Recently, the minimally invasive esophageal string test (EST) has been used collect protein in mucosal secretions as a surrogate for tissue biopsies in monitoring disease activity. From the string, assessment of the eosinophil-associated proteins major basic protein-1 (MBP-1) and eotaxin-3 (Eot3) is used to assess disease activity; however, this requires measurement in a reference laboratory, for which the turnaround time for results exceeds the time required for histopathologic assessment of endoscopic biopsies. In addition, MBP-1 and Eot3 are not markers unique to eosinophils. These obstacles can be overcome by targeting eosinophil peroxidase (EPX), an eosinophil-specific protein, using a rapid point-of-care test. Currently, EPX is measured by a labor-intensive enzyme-linked immunosorbent assay (ELISA), but we sought to optimize a rapid point-of-care test to measure EPX in EST segments.
Methods: We extracted protein from residual EST segments and measured EPX levels by ELISA and a lateral flow assay (LFA).
Results: EPX levels measured by LFA strongly correlated with those quantified by ELISA
(rs = 0.90 {95% CI: 0.8283, 0.9466}). The EPX LFA is comparable to ELISA for measuring EPX levels in ESTs.
Conclusions: The EPX LFA can provide a way to rapidly test EPX levels in ESTs in clinical settings and may serve as a valuable tool to facilitate diagnosis and monitoring of EoE.
ContributorsDao, Adelyn (Author) / Lake, Douglas (Thesis director) / Borges, Chad (Committee member) / Wright, Benjamin (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
This research examines supply chain performance and antecedents to better supply chain performance in manufacturing organizations, with a focus on manufacturing organizations following engineer-to-order and assemble-to-order production models. The variables of supply chain integration, internal communication, employee satisfaction, leader support, and the alignment of information and communication technology are empirically supported in affecting supply chain performance, and thus carry managerial and organizational implications in how they can be influenced, ideally for the benefit of manufacturing organizations. The data gathered for this study was obtained through interviews with sourcing professionals, as well as surveys distributed to corporate manufacturing employees. The findings on these variables fall in line with previous research explored in the report, adding credibility to previous studies, as well as their associated recommendations and implications. Organizational management and leadership, to improve supply chain performance, must strategically integrate information and communication technology, be clear and consistent in their messaging to employees, engage in effective conflict resolution, and provide support for necessary transparency and communication-enhancing initiatives.
ContributorsKoeppen, Matthew (Author) / Wiedmer, Robert (Thesis director) / Hogan, Michael (Committee member) / Barrett, The Honors College (Contributor) / Department of Management and Entrepreneurship (Contributor) / Department of Supply Chain Management (Contributor)
Created2024-05
Description
In the realm of supply chain management, student organizations play a crucial role in shaping the future leaders of the field. The Supply Chain Management Association at ASU (SCMA at ASU) stands as a testament to the impact such organizations can have. Recognized as a powerhouse within the highly competitive landscape of student-run organizations at the W.P. Carey School of Business, SCMA at ASU not only facilitates networking opportunities but also serves as a channel for industry insights, professional growth, and the development of an engaged student community.
The purpose of this guidebook is to distill the collective experience of SCMA at ASU into a comprehensive resource that can guide and inspire the establishment, maintenance, and growth of student-led supply chain organizations at universities nationwide.
To create the most informative guidebook possible, this resource will not only draw upon the rich experiences and achievements of SCMA at ASU but also incorporate insights and information from supply chain student organizations across various universities. This inclusion ensures a diverse range of successful strategies, innovative practices, and practical advice, reflecting what has worked best for these organizations in different academic and operational contexts. By pooling knowledge from a broad spectrum of successful SCM student organizations, this guidebook aims to serve as an essential tool for any university looking to enhance its supply chain program through student-led initiatives, fostering a new generation of supply chain professionals equipped to navigate and lead in an ever-changing global landscape.
ContributorsGe, Kara (Author) / Collins, Gregory (Thesis director) / Printezis, Antonios (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Supply Chain Management (Contributor)
Created2024-05
ContributorsGe, Kara (Author) / Collins, Gregory (Thesis director) / Printezis, Antonios (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Supply Chain Management (Contributor)
Created2024-05
ContributorsGe, Kara (Author) / Collins, Gregory (Thesis director) / Printezis, Antonios (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Supply Chain Management (Contributor)
Created2024-05
Description
This paper examines the multifaceted challenges surrounding college students' nutrition, with a specific focus on Arizona State University (ASU). Examining economic shifts, psychological influences, nutrition knowledge, and body image dynamics, it reveals the profound impact on students' food security and eating behaviors. Despite existing initiatives, persistent gaps in resources remain, necessitating comprehensive interventions to support students effectively. In response, "The Ultimate Health Resource for ASU Students," a website, was developed as an innovative solution. This platform aims to empower students by providing a centralized hub to access vital resources, connect with peers, and discover nutritious recipes. Proposed strategies encompass expanding food pantry offerings, developing mobile applications for nutritional guidance, and fostering partnerships with local organizations. By tackling these challenges head-on and fostering a culture of support, ASU can ensure that all students have equitable access to nutritious food options and the necessary resources to thrive academically and personally. The website serves as a place of empowerment, offering practical solutions and fostering a sense of community among ASU students striving for optimal health and well-being.
ContributorsLujan, Lexy (Author) / Buffington, Dillynn (Co-author) / O’Flaherty, Katherine (Thesis director) / Brand, Ashley (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution & Social Change (Contributor) / School of Molecular Sciences (Contributor) / College of Health Solutions (Contributor)
Created2024-05
Description
The aim of this thesis is to explore and understand how cultural, socio-economic, and political factors intersect to influence and affect societal happiness. We examine this by exploring the discrepancies that exist between the world’s happiest country, Finland, and the world’s 15th happiest nation, the United States. Through our explanation, we find that the cultural differences within nations is the implicit key to success in happiness. More specifically, the differences between femininity, experienced in the Nordic region, and masculinity, experienced in the United States. Social, economic, and political factors are in large part a result of the underlying culture. We see the nuanced ways in which cultural orientations shape social structures and policies which directly impact a society’s well-being. In analysis of the World Happiness Report, we acknowledge the multifaceted nature of happiness metrics, highlighting the importance of inclusive policy-making and responsive governance. Amidst its growing popularity the topic of societal happiness is growing in attention from both the public and policymakers. A collective pursuit of happiness emerges despite the cultural diversity prevalent throughout the world. By examining these complex relationships, we look to offer insight that helps create a deeper understanding of the complex relationship that exists between culture and societal happiness and well-being.
ContributorsEcherivel, Emerson (Author) / Silva, Matthew (Co-author) / Sturgess, Jessica (Thesis director) / Cloutier, Scott (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Molecular Sciences (Contributor)
Created2024-05
Description
Computational biophysics is a powerful tool for observing and understanding the microscopic machinery that underpins the biological world. Molecular modeling and simulations can help scientists understand a cell’s behavior and the mechanisms that drive it. Empirical evidence can provide information on the structure and organization of biomolecular machines, which serve as the backbone of biomolecular modeling. Experimental data from probing the cell’s inner workings can provide modelers with an initial structure from which they can hypothesize and independently verify function, complex formation, and response. Additionally, molecular data can be used to drive simulations toward less probable but equally interesting states. With the advent of machine learning, researchers now have an unprecedented opportunity to take advantage of the wealth of data collected in a biomolecular experiment. This dissertation presents a comprehensive review of atomistic modeling with cryo-electron microscopy and the development of new simulation strategies to maximize insights gained from experiments. The review covers the integration of cryo-EM and molecular dynamics, highlighting the evolution of their relationship and the recent history of MD innovations in cryo-EM modeling. It also covers the discoveries made possible by the integration of molecular modeling with cryo-EM. Next, this work presents a method for fitting small molecules into cryo-electron microscopy maps, which uses neural network potentials to parameterize a diverse set of ligands. The method obtained fitted structures commensurate with, if not better than, the structures submitted to the Protein Data Bank. Additionally, the work describes the data-guided Multi- Map methodology for ensemble refinement of molecular movies. The method shows that cryo-electron microscopy maps can be used to bias simulations along a specially constructed reaction coordinate and capture conformational transitions between known intermediates. The simulated pathways appear reversible with minimal hysteresis and require only low-resolution density information to guide the transition. Finally, the study analyzes the SARS-CoV-2 spike protein and the conformational heterogeneity of its receptor binding domain. The simulation was guided along an experimentally determined free energy landscape. The resulting motions from following a pathway of low-energy states show a degree of openness not observed in the static models. This sheds light on the mechanism by which the spike protein is utilized for host infection and provides a rational explanation for the effectiveness of certain therapeutics. This work contributes to the understanding of biomolecular modeling and the development of new strategies to provide valuable insights into the workings of cellular machinery.
ContributorsVant, John Wyatt (Author) / Singharoy, Abhishek (Thesis advisor) / Heyden, Matthias (Committee member) / Presse, Steve (Committee member) / Arizona State University (Publisher)
Created2024
Description
The focus of this study is on enhancing cultural competency and increasing an ethnorelative worldview perspective among instructional designers through an innovative approach that integrates global professionals and reciprocal learning. The study is grounded in the context of Arizona State University’s mission to create inclusive learning experiences, particularly in online education, confronting the challenge of effectively providing instructional design that supports a global learner. The dissertation builds upon the existing literature on instructional design, highlighting the need for cultural competency in a globalized educational context. It underscores the growing necessity for instructional designers to adapt their skills and approaches to meet the diverse needs of global learners. The research aims to achieve professional development experiences through a reciprocal learning framework involving international instructional professionals. The research questions explore the role of reciprocal learning in fostering ethnorelative worldviews and the perceived value of this learning for the professional development of instructional designers. The study addresses critical skills such as cultural empathy, active listening, self-awareness of biases, and a commitment to continual learning. The research highlights the gaps in current instructional design training, particularly in the context of global education and cultural competency, contributing to the field of instructional design by proposing a model that integrates global perspectives into the professional development of instructional designers.
ContributorsPate, Amy Loree (Author) / Basile, Carole (Thesis advisor) / Maynard, Andrew (Committee member) / Silova, Iveta (Committee member) / Arizona State University (Publisher)
Created2024