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- Creators: College of Liberal Arts and Sciences
Description
Glioblastoma multiforme is associated with a very low survival rate and is recognized as the most vicious form of intracranial cancer. The Akt gene pathway has three different isoforms, each of which has a different role in the tumors of GBM. Preliminary data suggests that Akt3 may work to decrease tumorigenicity. A produced image that visualizes the subcellular localization of Akt3 led the author to believe that Akt3 may reduce tumorigenicity by decreasing genomic instability caused by the cancer. To explore this, flow cytometry was performed on GBM cell lines with Akt3v1 over-expression, Akt3v2 over-expression, and a control glioma cell line.
ContributorsGhorayeb, Antoine (Author) / Neisewander, Janet (Thesis director) / Diehnelt, Chris (Committee member) / Moussallem, Suzan (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
The lonely, empty face panhandling on the street corner has a story to tell. At first glance, most people write the homeless off as less than worthy. However, there is a deeper connection and understanding of relationships and a sense of community unseen by the majority of passer-byers. Amidst the humdrum beat of every day life, there is toil to find basic necessities such as food, water, sanitation, and a place to rest. At the same time, there is laughter and friendship as they help one another through the hostilities of their circumstances. Combining the creative elements of photojournalism and qualitative interviewing, the basic daily needs and struggles of the homeless will be delved into to answer how friendship is pertinent to survival on the streets.
ContributorsFisher, Meghan (Author) / Hruschka, Daniel (Thesis director) / Hita, Liza (Committee member) / Newland, Judy (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
The purpose of my honors thesis project was to generate the tools needed for in vivo imaging by determining the optimal plasmid-fluorophore combination. To determine the optimal plasmid and fluorophore, asd plasmids were constructed with various promoters, origins of replications, and red fluorophores. The optimal asd plasmid for fluorescent in vivo imaging was determined by the plasmid stability, growth rate, and growth phase dependence on fluorescent intensity. The end goal is to be able to use the asd plasmid in vaccine strains for the purpose of in vivo imaging of the recombinant attenuated Salmonella vaccine (RASV).
ContributorsEudy, L. Adam (Author) / Curtiss, Roy (Thesis director) / Roland, Kenneth (Committee member) / Forbes, Stephen (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Microfinance is a term that refers to providing basic financial services to the poor; it has become a powerful tool for poverty alleviation. The idea is a relatively new one - modern microfinance began through experiments in the 1970's - but it has grown quickly and currently serves over 155 million clients worldwide. There are many studies that provide evidence of the positive impact of microfinance and the movement has an array of enthusiastic proponents. It is certainly not the only solution in the battle against poverty, however, and there are also studies that question the true depth of its impact. In looking at microfinance around the globe, one thing becomes clear: although it is an international phenomenon, microfinance has definitely found more success in some regions over others.
ContributorsEdgell, Bailey (Author) / Mendez, Jose (Thesis director) / Schoellman, Todd (Committee member) / Forbes, Stephen (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Prospective memory is defined as remembering to carry out specified actions in the future. Research has suggested that prospective memory retrieval is reliant on multiple cognitive processes to function, and the ways in which these different processes are used is dependent on a variety of variables relating to the prospective memory task at hand. The current study focuses on the strength of the association between the prospective
memory cue and the prospective memory intention. Based on literature suggesting that aspects of prospective memory are reliant on executive control functioning, the current study examined the possibility that executive control depletion would affect prospective memory ability on subsequent tasks. Results showed that depletion of executive control resources, measured objectively, did not impair prospective memory in either a low or
high cue-association condition. However, participants‟ subjective assessment of their own fatigue correlated significantly with their subsequent prospective memory performance, regardless of association condition. The results of the study indicate that depletion studies that fail to account for both objective and subjective measures suffer from an unclear interpretation of effects, and that recognition of perceived expectancies
of cognitive resource limitation can assist in improving prospective memory ability.
memory cue and the prospective memory intention. Based on literature suggesting that aspects of prospective memory are reliant on executive control functioning, the current study examined the possibility that executive control depletion would affect prospective memory ability on subsequent tasks. Results showed that depletion of executive control resources, measured objectively, did not impair prospective memory in either a low or
high cue-association condition. However, participants‟ subjective assessment of their own fatigue correlated significantly with their subsequent prospective memory performance, regardless of association condition. The results of the study indicate that depletion studies that fail to account for both objective and subjective measures suffer from an unclear interpretation of effects, and that recognition of perceived expectancies
of cognitive resource limitation can assist in improving prospective memory ability.
ContributorsCook, Carson (Author) / Brewer, Gene (Thesis director) / Presson, Clark (Committee member) / Homa, Donald (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Social proof and mismatch of self-preference have been assumed to play an important role in the inference of value. They can be influential factors when it comes to decision-making in a mate-selection environment. In this thesis study, participants took an online survey in the form of a dating website. They answered a series of questions about the traits they would like to see in a potential mate. They were then presented with four potential mates and asked to rank them by their preferences. The results show that participants most preferred the potential mate with a high social proof and a low mismatch of self-preference and least preferred the potential mate with a low social proof and a high mismatch of self-preference. When comparing just social proof and mismatch of self-preference, there was not an interaction effect between the two. I conclude that even though social proof is a powerful influencing factor by itself, it did not have the power to trump the mismatch of self-preference.
ContributorsAkhter, Sumbal (Author) / Kwan, Virginia (Thesis director) / Knight, George (Committee member) / Cohen, Adam (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Purpose: Advance care planning (ACP) allows an individual to discuss and document their personal preferences at end-of-life. ACP has been shown to improve communication and reduce discomfort for patients and their families. The literature supports utilizing formalized, multimodality training programs for healthcare providers in order to increase their confidence in initiating ACP discussions. These findings led to the initiation of an evidence-based practice project in a primary care setting with the purpose of increasing advance care planning discussions between providers and patients with the use of a standardized education tool.
Background and Significance: National regulations mandate that patients are provided information about advance directives in the healthcare setting, but completion rates are not monitored and continue to be low. ACP is now a billable service for healthcare providers, but it has not provided enough incentive to increase completion rates. Barriers for healthcare providers in the outpatient setting include lack of time, protocols, and lack of education on how to initiate and foster advance care planning discussions.
Methods: Healthcare providers in a primary care office attended a 15-minute structured educational session with and a toolkit was provided on the importance of ACP, how to initiate conversations with patients, and bill for the service. Participants completed a portion of the Knowledge, Attitudinal, and Experiential Survey on Advance Directives (KAESAD) survey assessing their confidence in ACP before and three months post intervention. Participant confidence (N = 6) in ACP was analyzed using the Wilcoxin test and descriptive statistics. The number of billed ACP services for the office was collected for four months post intervention and compared to the previous four months. Outcomes: A significant increase in provider confidence after participating in a multimodality education program was found in the results (Z = -2.21, p = .03). There was a 42.1% increase in the number of billed ACP discussions for the office in the four months post intervention.
Conclusion: The future desired state is that ACP discussions become standard practice in primary care leading to the completion of advance directives. This can be accomplished through formalized education sessions and resources for providers in order to increase their confidence in initiating ACP discussions with patients. The ultimate goal is to decrease unnecessary spending at end-of-life while improving patient and family satisfaction with the quality of care received at end-of-life.
Background and Significance: National regulations mandate that patients are provided information about advance directives in the healthcare setting, but completion rates are not monitored and continue to be low. ACP is now a billable service for healthcare providers, but it has not provided enough incentive to increase completion rates. Barriers for healthcare providers in the outpatient setting include lack of time, protocols, and lack of education on how to initiate and foster advance care planning discussions.
Methods: Healthcare providers in a primary care office attended a 15-minute structured educational session with and a toolkit was provided on the importance of ACP, how to initiate conversations with patients, and bill for the service. Participants completed a portion of the Knowledge, Attitudinal, and Experiential Survey on Advance Directives (KAESAD) survey assessing their confidence in ACP before and three months post intervention. Participant confidence (N = 6) in ACP was analyzed using the Wilcoxin test and descriptive statistics. The number of billed ACP services for the office was collected for four months post intervention and compared to the previous four months. Outcomes: A significant increase in provider confidence after participating in a multimodality education program was found in the results (Z = -2.21, p = .03). There was a 42.1% increase in the number of billed ACP discussions for the office in the four months post intervention.
Conclusion: The future desired state is that ACP discussions become standard practice in primary care leading to the completion of advance directives. This can be accomplished through formalized education sessions and resources for providers in order to increase their confidence in initiating ACP discussions with patients. The ultimate goal is to decrease unnecessary spending at end-of-life while improving patient and family satisfaction with the quality of care received at end-of-life.
ContributorsSmith, Arsena (Author) / Nunez, Diane (Thesis advisor)
Created2018-04-30
Description
Purpose: Improve chronic obstructive pulmonary disease (COPD) screening in primary care by implementing Global Initiative for Chronic Obstructive Lung Disease (GOLD) screening criteria.
Background and Significance: Evidence shows primary care providers (PCPs) are not adhering to the GOLD Guidelines for COPD screening.
Methods: Guideline education with pre/post-intervention survey and percent of eligible participants screened.
Results: Pre-intervention surveys (n=10) and post-intervention surveys (n=8) completed. Significant increase in knowledge regarding the CAT score (M score = 11.50, U = 24.000, p<.05). Part 2) 24% (n=6) of participants were screened with the CAT questionnaire.
Conclusions: PCPs are aware of the GOLD Guidelines, but do not always adhere to its recommendations. Future research should concentrate on effective ways to implement the GOLD Guidelines screening recommendations in primary care clinics.
Background and Significance: Evidence shows primary care providers (PCPs) are not adhering to the GOLD Guidelines for COPD screening.
Methods: Guideline education with pre/post-intervention survey and percent of eligible participants screened.
Results: Pre-intervention surveys (n=10) and post-intervention surveys (n=8) completed. Significant increase in knowledge regarding the CAT score (M score = 11.50, U = 24.000, p<.05). Part 2) 24% (n=6) of participants were screened with the CAT questionnaire.
Conclusions: PCPs are aware of the GOLD Guidelines, but do not always adhere to its recommendations. Future research should concentrate on effective ways to implement the GOLD Guidelines screening recommendations in primary care clinics.
ContributorsManng, Jillian (Author) / Nunez, Diane (Thesis advisor)
Created2017-04-30
Description
Background: There is a great need to provide people with Parkinson disease (PD) not only quality medical care, but social support and disease-related resources. Nurses have the training and interpersonal relationship skills to make a tremendous difference in the lives of people living with PD. Objective: This quality improvement project evaluated the effect of a nurse navigation program on self-efficacy among people living with PD.
Methods: Twenty-four members of a PD specific wellness center in the United States were recruited to participate in a nurse navigation program for a 12-week period. The intervention period included an initial needs assessment, ten individual 45-minute sessions focused on specific aspects of PD wellness, and a concluding visit. Results: There was a significant decline in quality of life based on average PDQ-39 scores for the participants in January 2019 (M =24.44, SD=16.66) compared to January 2018 (M=20.11, SD =12.78) where higher scores signify worse quality of life; t(23)-4.329 p=0.025. Average self-efficacy for managing chronic disease pre-intervention scores (M=6.58, SD=1.70) verses post-intervention scores (M=7.44, SD=1.48) showed a significant increase in self-efficacy with a medium effect size; t(23)-0.854 p=0.016, d=0.54. Additionally, unique satisfaction surveys showed high satisfaction with nurse navigation throughout the participant sample and wellness center staff members.
Conclusions: A nurse navigation program focusing on specific aspects of PD management can help improve participant’s confidence in self-management of PD despite disease progression. Additionally, nurse navigation for people with PD was associated with high satisfaction among participants and staff members of a PD wellness center.
Methods: Twenty-four members of a PD specific wellness center in the United States were recruited to participate in a nurse navigation program for a 12-week period. The intervention period included an initial needs assessment, ten individual 45-minute sessions focused on specific aspects of PD wellness, and a concluding visit. Results: There was a significant decline in quality of life based on average PDQ-39 scores for the participants in January 2019 (M =24.44, SD=16.66) compared to January 2018 (M=20.11, SD =12.78) where higher scores signify worse quality of life; t(23)-4.329 p=0.025. Average self-efficacy for managing chronic disease pre-intervention scores (M=6.58, SD=1.70) verses post-intervention scores (M=7.44, SD=1.48) showed a significant increase in self-efficacy with a medium effect size; t(23)-0.854 p=0.016, d=0.54. Additionally, unique satisfaction surveys showed high satisfaction with nurse navigation throughout the participant sample and wellness center staff members.
Conclusions: A nurse navigation program focusing on specific aspects of PD management can help improve participant’s confidence in self-management of PD despite disease progression. Additionally, nurse navigation for people with PD was associated with high satisfaction among participants and staff members of a PD wellness center.
ContributorsDe Santiago, Stephanie (Author) / Nunez, Diane (Author, Thesis advisor)
Created2019-04-15
Description
Nurse practitioners and physician assistants, collectively termed advanced practice providers (APPs), report a lack of onboarding and professional support which has been shown to lead to job dissatisfaction, high turnover rates, professional attrition, and gaps in patient care; wasting billions of healthcare dollars and falling short of the Quadruple Aim. A time-honored, integral means of support in many industries is mentorship. This is a dynamic, evolving relationship between an experienced professional and a novice professional that promotes knowledge application, systems navigation, organizational socialization and personal role integration.
Unfortunately, healthcare organizations have been slow to adopt mentorship, as evidenced by the paucity of studies on mentorship programs in health care, and APP turnover rates twice that of physicians. This evidenced-based project expands on the limited existing studies regarding the associations between mentorship and organizational commitment, as well as explores the desired characteristics of quality mentors and perceived barriers to APP mentorship.
A survey of multispecialty APPs at an oncology practice within a larger, multi-state integrated healthcare delivery system reveals access to mentors and time are the biggest barriers. The most desired mentorship characteristics are professional knowledge and motivational support. Career development through mentorship can increase job satisfaction and retention, as well as improve the quality of care provided by APPs. By strengthening the professional foundations, patients will benefit with continuity of care, improved quality measures, and efficient systems communication reaching the Quadruple Aim targets.
ContributorsWhite, Deb L. (Author) / Nunez, Diane (Thesis advisor)
Created2019-04-30