Matching Items (81)
Description
Nonalcoholic fatty liver disease is the most common form of chronic liver disease in the United States. Diets high in saturated fats are known to promote obesity and hepatic steatosis. The consumption of a high fat diet (HFD) can increase the risk factors associated with insulin resistance, which can lead to the onset of diabetes and obesity. A prior study of a soil-derived organometallic complex (OMC) showed that supplementation reduces glucose and body mass in diabetic mice. The goal of this study was to test the efficacy of a similar OMC compound on the mitigation of hepatic steatosis induced from a HFD. Six-week-old male Sprague-Dawley rats (n=42) were divided into the following diet groups: standard rodent chow or 60% kcal from fat high fat diet (mainly lard) for 10-weeks. Rats were further divided into OMC treatment groups with OMC added to their drinking water: 0 mg/ml, 0.6 mg/ml or 3.0mg/ml OMC. At 10 weeks, study animals were euthanized with sodium pentobarbital (200 mg/kg, i.p.) and cardiac plasma as well as liver samples were collected and stored at -80° C until further analyses. Plasma ALT and AST as well as liver triglyceride and free glycerol concentrations were measured using commercially available kits. To assess cellular injury, aspartate transaminase (AST; released mainly from injured cardiac and liver cells) and alanine transaminase (ALT; released mainly from injured liver cells) were examined. Rats fed HFD had elevated plasma ALT activity, which was prevented by treatment with the high dose of OMC (p<0.05). No changes in plasma AST activity were detected. Examination of liver triglyceride and free glycerol concentrations showed increased fat accumulation in the liver of rats consuming HFD (Two-Way ANOVA, p<0.001). OMC did not prevent this increase. These findings suggest that, although OMC does not prevent the accumulation of lipids in the liver of rats fed HFD, it does mitigate liver injury resulting from excess dietary intake of saturated fats.
ContributorsWood, Courtney Ann (Author) / Sweazea, Karen (Thesis director) / Shaibi, Gabriel (Committee member) / Johnston, Carol (Committee member) / School of Art (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
To determine whether a 3-month lifestyle intervention could increase social support (SS) and physical activity (PA) in Latino adolescents with obesity. Participants in the intervention will increase (SS) from family and friends and PA. Youth attended weekly nutritional and exercise sessions at the YMCA. Familial and Friend SS for PA is not significant; moderate to vigorous PA is significant. Culturally-grounded & community-based intervention leads to changes in SS for PA and PA in Latino adolescents.
ContributorsMartin, Dwayne Jeffery (Author) / Shaibi, Gabriel (Thesis director) / Williams, Allison (Committee member) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
My aims with this research project were to conduct a network analysis on collaborators in the ¡Viva Maryvale! project, a diabetes prevention program in Maryvale, AZ. The goals of the social network analysis were to measure the connections that collaborating organizations have to each other, the strength of these connections, and the activities that connected organizations collaborate on. I hypothesized that performing a network analysis would inform me of the strengths and weaknesses of the ¡Viva Maryvale! project in order to advise the next steps of a targeted approach to diabetes prevention among vulnerable populations, thus affecting public health outcomes in the greater Phoenix Valley.
ContributorsKellog, Anna (Author) / Shaibi, Gabriel (Thesis director) / Soltero, Erica (Committee member) / School of Public Affairs (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Background: The prevalence of childhood obesity has disproportionately affected Latino youth and can be seen with an increase incidence of Type 2 Diabetes. This increase in obesity can be attributed to physical inactivity. Increases in social support and self-efficacy are independently related to increases in physical activity. A lifestyle intervention can lead to increases in social support, self-efficacy and physical activity. Objective/Hypothesis: The objective of this study was to determine whether a 12-week lifestyle intervention could increase social support, self-efficacy and physical activity in obese Latino adolescents that participated in the intervention. It was hypothesized that adolescents that participated in the intervention would increase self-efficacy, social support from family and friends, and physical activity compared to their control counterparts. Study Design/Participants: In a randomized control trial, there were 125 Latino (n= 60 experimental group; n= 65 control group; mean age = 15.17 +- 1.65 Males n = 60; n = 65 females) participants included in this study. Participants were also required to have a BMI percentile >= 95th percentile for age and gender or BMI >= 30 kg/m2. Methods: The intervention, which was developed using the Social Cognitive Theory had components focusing on social support and self-efficacy and also consisted of nutrition education classes and physical activity sessions for 12 weeks. The psychosocial constructs of self-efficacy and social support were measured using the Adolescent Self-Efficacy for Diet and Activity Behaviors and Adolescent Social Support for Diet and Exercise Survey, respectively. Physical activity was assessed by the 3-day Physical Activity Recall. Results: We found significant increases in social support in family (p = 0.042) and vigorous physical activity (p = 0.001). There was also a significant difference between control and treatment group for moderate to vigorous physical activity after the intervention (p = 0.027). There were no changes in social support from friends or self-efficacy. Conclusion: We concluded that a 12-week lifestyle intervention did lead to changes in social support and physical activity behaviors. These changes could have been influenced by the intervention as they were measured these constructs pre/post intervention.
ContributorsRahman, Hanna (Author) / Shaibi, Gabriel (Thesis director) / Hoffner, Kristin (Committee member) / School of Nutrition and Health Promotion (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The purpose of this study was to examine the association between VLDL and diabetes risk factors, and the impact of a lifestyle intervention on VLDL levels in obese Latino youth. Participants (N=160) in this study were taken from a lager diabetes prevention program for Latino adolescents (Age=14.8±0.8 years, BMI=98.2±1.4). Youth participated in a 12-week lifestyle intervention that included physical activity (60 minutes, 3x/week) and nutrition education sessions (60 minutes, 1x/week) that were delivered to families at the downtown Phoenix YMCA. Primary outcomes included VLDL and diabetes risk factors including fasting and 2-hour glucose and insulin which were measured at baseline and 12-weeks post-intervention. Baseline VLDL levels were significantly correlated with fasting insulin (r =.270, P<0.01) and youth who were more insulin resistant displayed higher VLDL levels compared to youth who were less insulin resistant derived from fasting insulin levels (M=29.8±14.7 mg/dl vs. M=21.6±9.6 mg/dl, P<0.01). In total, 77 participants completed the lifestyle intervention. At post-intervention, VLDL levels were significantly reduced (M=26.0±13.3 mg/dl to M=23.3±11.6 mg/dl, P=0.02). Culturally-grounded, community-based, family-focused lifestyle interventions are a promising approach for reducing cardiovascular disease risk factors in high-risk youth at risk for diabetes.
ContributorsNavabi, Neeku Ariana (Author) / Shaibi, Gabriel (Thesis director) / Soltero, Erica (Committee member) / Ryder, Justin (Committee member) / School of Nutrition and Health Promotion (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Obesity and related health disparities including type 2 diabetes disproportionately impact Latino youth. These health disparities may be the result of gene-environment interactions, but limited research has examined these interactions in the pediatric age group. Lifestyle intervention is the cornerstone for preventing diabetes among high-risk populations and epigenetic and genetic factors may help explain the biological mechanisms underlying diabetes risk reduction following lifestyle changes. MicroRNAs (miRNAs) are small, non-coding RNA’s that regulate gene expression and have emerged as potential biomarkers for predicting type 2 diabetes risk in adults but have yet to be applied to youth. Therefore, the purpose of this study was to identify changes in miRNA expression among Latino youth with prediabetes (4 female/2 male, ages 14-16, BMI percentile 99 ±.2) who participated in a 12-week lifestyle intervention focused on increasing physical activity and improving nutrition-related behaviors.
ContributorsKarch, Jamie (Co-author) / Day, Samantha (Co-author) / Shaibi, Gabriel (Thesis director) / Coletta, Dawn (Committee member) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
This project aimed to identify barriers to participation and develop strategies to increase the accessibility of a diabetes prevention program in the Latino community. Surveys were administered to past participants of a randomized control trial at a community event where study results were shared. The top concerns expressed by respondents were related to the use of personal information. Primary barriers to participation included work/school commitments and transportation issues. Strategies to increase accessibility included providing flexible class times, having bilingual research staff, and using multiple forms of community outreach such as flyers, health events, phone calls, texts, and social media. Expanding community partners was also identified as a primary strategy for increasing program reach. Researchers should focus on addressing confidentiality concerns, providing financial compensation for attendance, flexible scheduling, and utilizing diverse outreach methods to enhance access to diabetes prevention programs in the Latino community
ContributorsHouck, Kassidy (Author) / Shaibi, Gabriel (Thesis director) / Williams, Allison (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2023-05
Description
Although evidence from previous studies suggests a correlation between Adverse
Childhood Experiences (ACEs) and the risk of Type 2 Diabetes (T2D), research efforts have yet
to fully explore this association among Latino young adults. The objective of this longitudinal study was to assess the potential influence of ACEs scores on the diabetes risk among Latino adults who previously engaged in a diabetes prevention lifestyle intervention program. Five years post intervention, 41 individuals out of the original cohort of 91 participants
returned for follow-up and answered a 10-question survey assessing ACEs. Diabetes risk (fasting glucose, 2-hour fasting glucose, HbA1c, and BMI) and quality of life were assessed at 5
timepoints (baseline, 3-months, 6-months, 12-months, and 60-months). Utilizing SPSS, T-tests were utilized to assess the relationship between ACEs and T2D risk. Among the 41 participants (age was 20.6 ±0.9), the mean reported ACE score was 1.5 ±1.9, ranging from 0 to 7. The most frequently reported ACEs was emotional abuse (n=12, 30.0%) and the least frequently reported ACEs was sexual abuse (n=3, 7.3%). Individuals who reported 0 ACEs had significantly lower fasting glucose at 12 months and had lower BMI at 60 months compared to those with 1-7 ACEs. In this study, there was a significant relationship between higher ACEs and
increased BMI and fasting glucose among Latinos. Implementing culturally-sensitive
interventions addressing family dynamics along with health behaviors could prove pivotal in
preventing and managing diabetes among Latino youth.
ContributorsChrostowski, Emilia (Author) / Shaibi, Gabriel (Thesis director) / Braxton, Morgan (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
Puberty is a critical stage in the human life course. Specifically, puberty is the physiological transitionary period that marks the beginning of human reproduction capability. These physiological changes are markedly different in boys and girls and accordingly typically occur on different timelines. Furthermore, these timelines are not a set guideline for every child as some may develop earlier and others later. This age of onset is a general range that has been observed and considered to be the normal age of onset. The normal age of onset of puberty is typically between ages 8 and 13 for girls or 9 and 14 for boys (Brito & Latronico, 2015, 93). Any development seen before these ages is typically defined as early onset and development seen after is late development. Professionals have further defined different stages of puberty in both boys and girls. In girls, this involves breast development, body hair growth, changes in height and weight, and menarche (Wheeler, 1991, pg. 2). In boys, pubertal development often involves genital growth, body hair growth, deepening of voice, and growth spurts (6). Puberty onset has been a popular topic of study in the health sciences as the age of onset can indicate the impact of biological and environmental factors. In particular, inequality in research of pubertal onset, the effects of early/delayed onset, and race/ethnicity is of special interest. For instance, there is a lack of existing literature on the role that culture plays on pubertal onset in Latino youth. This analysis intends to investigate the relationship between the integration of Hispanic culture in children’s lives and pubertal onset.
ContributorsGuerra, Santino (Author) / Sheehan, Connor (Thesis director) / Shaibi, Gabriel (Committee member) / Barrett, The Honors College (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Human Evolution & Social Change (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
Background: There is limited literature evaluating the impact of disseminating research results to past research study participants and their families. The purpose of the study was to evaluate whether disseminating results from a diabetes prevention program to past participants and their families facilitates motivation to engage in healthier behaviors. Methods: Previous youth participants from the “Every Little Step Counts” study were contacted and invited to a community dissemination event in November of 2022 at a local YMCA in the Phoenix Metropolitan area. All individuals in attendance at the event were invited to complete a 10-item questionnaire following a presentation about diabetes and the study results. 10 youth past participants, 9 adult past participants, and 13 community members completed the questionnaire to assess whether dissemination of past study results increases motivation to engage in healthier behaviors. Results: Aggregate responses revealed a 28.43% increase in motivation to eat healthier and a 33.45% increase in motivation to increase exercise. An increase in average response frequency was evident amongst all figures, indicating that overall, dissemination of research results was found to increase motivation to engage in healthier behaviors across community members, adult participants, and youth participants. Conclusions: This study supports the importance of disseminating research results from a diabetes prevention program to past participants in order to reinforce and maintain behavior change skills taught throughout the study, with the long-term goal of reducing type 2 diabetes risk in youth.
ContributorsDerkach, Katherine (Author) / Shaibi, Gabriel (Thesis director) / Williams, Allison (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2023-05