Matching Items (14)
Description
Alzheimer's Disease (AD) is the sixth leading cause of death in the United States and the most common form of dementia. Its cause remains unknown, but it is known to involve two hallmark pathologies: Amyloid Beta plaques and neurofibrillary tangles (NFTs). Several proteins have been implicated in the formation of neurofibrillary tangles, including Tau and S100B. S100B is a dimeric protein that is typically found bound to Ca(II) or Zn(II). These experiments relate to the involvement of S100B in Alzheimer's Disease-related processes and the results suggest that future research of S100B is warranted. Zn(II)-S100B was found to increase the rate at which tau assembled into paired helical filaments, as well as affect the rate at which tubulin polymerized into microtubules and the morphology of SH-SY5Y neuroblastoma cells after 72 hours of incubation. Zn(II)-S100B also increased the firing rate of hippocampal neurons after 36 hours of incubation. Together, these results suggest several possibilities: Zn(II)-S100B may be a key part of the formation of paired helical filaments (PHFs) that subsequently form NFTs. Zn(II)-S100B may also be competing with tau to bind tubulin, which could lead to an instability of microtubules and subsequent cell death. This finding aligns with the neurodegeneration that is commonly seen in AD and which could be a result of this microtubule instability. Ultimately, these results suggest that S100B is likely involved in several AD-related processes, and if the goal is to find an efficient and effective therapeutic target for AD, the relationship between S100B, particularly Zn(II)-S100B, and tau needs to be further studied.
ContributorsNaegele, Hayley (Author) / Mcgregor, Wade C (Thesis advisor) / Baluch, Debra (Committee member) / Francisco, Wilson (Committee member) / Arizona State University (Publisher)
Created2013
Description
This creative project documents the changes to the Lopiano Habitat just north of Tempe Town Lake. Over the course of the project, the once restored wetland and desert habitat became overrun with debris and the plants and animals of the area were directly affected. Upon researching the city's choice to renovate the space, it was discovered that it was due to the increasing number of homeless and underserved individuals using the space for housing. Using photographs, the project displays the changed environment from lush habitat to trash-filled dirt patches. With the help of Julie Anand and Heather Green, I was able to select the best images to display as large scale prints, as well as small scale books that I constructed for my committee. Bioimagery was utilized to show what does not always meet the eye, and in some cases showed the effects that the demolition was having on the plant life, including what one of my committee members described as "an infection." They also acted as a metaphorical level to the photos in some cases, such as the hooks present on the regrown bamboo shoots that were slowly reclaiming the space. It was with the help of Dr. Page Baluch and her bioimagery lab that I was able to capture the smallest of details present on the samples I collected. The project serves as a potential starting point for other artists and community members to have a voice in the conversation and to hold the city accountable for their actions, especially when it comes to the underserved population. If they can spend so much time and funds into destroying what was once a beautiful habitat, why not put that effort into resources for the population they are trying to remove?
ContributorsGalbarski, Sydney (Author) / Anand, Julie (Thesis director) / Baluch, Debra (Committee member) / Green, Heather (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Phosphoinositol-Dependent Kinase 1 (PDK1) acts in conjunction with phosphorylated lipids such as Phosphoinositol-3,4,5-triphosphate (PIP3) to activate a variety of proteins that regulate mechanisms ranging from cell growth and survival to cytoskeletal rearrangement. In this investigation PDK1 was examined in the context of cellular division. The techniques of immunocytochemistry and live cell imaging were used to visualize the effects of the inhibition of PDK1 on division in HeLa cells. Division was impaired at metaphase of mitosis. The inhibited cells were unable to initiate anaphase cell-elongation ultimately leading to the flattening of spherical, metaphase cells. Preliminary studies with imunocytochemistry and live cell imaging suggested that insulin treatment reversed PDK1 inhibition, but the results were not statistically significant. Therefore, the recovery of PDK1 inhibition by insulin treatment could not be confirmed. Based on these observations a possible reason for the inability of the treated cells to complete cytokinesis could be the role of PDK1 in the Rho-kinase pathway that is required for the processes cell-elongation necessary for anaphase of mitosis.
ContributorsMasserano, Benjamin Max (Author) / Capco, David (Thesis director) / Baluch, Debra (Committee member) / Chandler, Douglas (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
With cities expanding and human development rapidly increasing, areas of dark sky are decreasing, resulting in beautiful stars and constellations appearing to disappear. The purpose of this project is to photograph the night sky and capture the natural beauty of the Milky Way and constellations All of the images captured for this project were taken at various locations around Arizona. Influences from cities and other human development are visible throughout the various photographs.
ContributorsMiller, Jack Robert (Author) / Anand, Julie (Thesis director) / Klett, Mark (Committee member) / Mechanical and Aerospace Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
With Each Passing Day is a thesis exhibition presented in Northlight Archive in Tempe, AZ, accompanied by a photographic book. This work investigates me and my changing relationship with my mother as I grow into a young woman and slowly finding more of her qualities within myself as each day passes. This thesis project explores the process of growth, finding independence, and understanding acceptance and control.
ContributorsDahlstrom, Tyler (Author) / Anand, Julie (Thesis director) / Klett, Mark (Committee member) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Shirin Neshat is recognized as the most prominent artist of the Iranian diaspora. Her two photographic series, Women of Allah (1993-97) and The Book of Kings (2012), are both reactions to the socio-political events and the change of female identity in Iran. The search for Iranian identity has a long tradition in Iranian photography. Neshat's figures, with their penetrating gazes, heavy draperies, and body postures, make reference to nineteenth-century Qajar photography. Through various cultural elements in her artworks, Neshat critiques oppression in Iranian society. Neshat employs and inscribes Persian poetry to communicate contradiction within Iranian culture.
To read Neshat’s photography, it is crucial to register her use of Persian language and historical poetry. Although the reading and understanding of the Persian texts Neshat inscribes on her photographs plays a fundamental role in the interpretation of her work, Neshat’s artworks are not entirely conceptual. The lack of translation of these included texts in Neshat’s exhibitions indicates a decorative use of Persian calligraphy. The Western eye can aesthetically explore this exotic Eastern decorative calligraphy. The formal qualities of Neshat’s photographs remain, even if the viewer is unable to read or understand the Persian texts.
To read Neshat’s photography, it is crucial to register her use of Persian language and historical poetry. Although the reading and understanding of the Persian texts Neshat inscribes on her photographs plays a fundamental role in the interpretation of her work, Neshat’s artworks are not entirely conceptual. The lack of translation of these included texts in Neshat’s exhibitions indicates a decorative use of Persian calligraphy. The Western eye can aesthetically explore this exotic Eastern decorative calligraphy. The formal qualities of Neshat’s photographs remain, even if the viewer is unable to read or understand the Persian texts.
ContributorsBokharachi, Elnaz (Author) / Mesch, Claudia (Thesis advisor) / Hoy, Meredith (Committee member) / Anand, Julie (Committee member) / Ghanem, Carla (Committee member) / Arizona State University (Publisher)
Created2015
Description
Whitney Nicoson’s Honors thesis exhibition, Tripoli Shores, is a collection of photographs that stems from an initial interest in portraiture—a desire to observe and render the change of identity shown by the artist and her mother during a particularly difficult period in their lives. While experiencing paralleling hardships, the two spent time together living at her grandfather’s cottages along the St Lawrence River in Upstate NY. The traditional notion of portraiture gradually grew beyond the representation of self to the documentation of the space. This space was once the epitome of structure, stability, and strength. Over the years, neglect and disrepair caused an inevitable breakdown in the structure. Nicoson seeks to create a permanent documentation of a home that is changing. With an interest in how the photographs of space relates to the change seen in the artist and her mother, the exhibition pursues the idea of forming identity in a place that is also forming its own.
ContributorsNicoson, Whitney Rae (Author) / Jenkins, William (Thesis director) / Anand, Julie (Committee member) / Shipley, Rosalind (Committee member) / Barrett, The Honors College (Contributor) / School of Art (Contributor)
Created2013-05
Description
This thesis is an exploration into somatic movement methods to help ease chronic pain. The study follows my personal experience as a researcher and a dancer with fibromyalgia and other chronic pain conditions. I carry forward a body-centered autoethnographic frame, as the prevailing ethos of this work revolves around considering bodily experience as an authority in personal well-being. My research follows the spirit of the Intuitive Inquiry research methodology developed by Dr. Rosemarie Anderson and evolved as I progressed through my own research and organizing processes. This thesis document is organized according to eight physical cycles of intuitive inquiry that emerged from my movement and research processes. The cycles address my conditions of chronic pain and disability, my history with dance competition in the United States, my experience with conceptualizations of the body, and the successes I experience with somatic practices, particularly Tensegrity as it applies to the body. My intuitive physical cycles conclude with a proposal for methods of movement and inner-body communication that promote ease in the body and sustainable movement.
ContributorsSmith, Holly (Author) / Roses-Thema, Cynthia (Thesis advisor) / Olarte, David (Committee member) / Anand, Julie (Committee member) / Tang, Yi-Yuan (Committee member) / Arizona State University (Publisher)
Created2023
Description
Male reproductive dysfunction accounts for almost half of male infertility cases, yet the signaling mechanisms involved in the male reproductive system remain unclear. Although the exact cause of male reproductive dysfunction varies, obtaining a better understanding of the modulators of smooth muscle contractions may provide new targets for the treatment of male reproductive conditions. The male reproductive tract, consisting of the testes, epididymis, vas deferens, and penis, is lined with innervated smooth muscle fibers that transport spermatozoa through the system. Contractions of these smooth muscle fibers can be modulated by neurotransmitters and hormones, like dopamine and norepinephrine, as well as biogenic amines. The focus of this study is on the biogenic amine tyramine, which is produced by the breakdown of tyrosine via decarboxylation. Tyramine has been shown to modulate vasoconstriction and increase blood pressure due to its effect on smooth muscle contractions. This study has found that tyramine localizes in male reproductive tissues and modulates smooth muscle contractions. Age and environment were also found to play a significant role in the expression of tyramine and its associated receptor, TAAR1.
ContributorsSteadman, Solange (Author) / Baluch, Debra (Thesis advisor) / Roberson, Robert (Committee member) / Sweazea, Karen (Committee member) / Arizona State University (Publisher)
Created2023
Description
The intracellular motility seen in the cytoplasm of angiosperm plant pollen tubes is known as reverse fountain cytoplasmic streaming (i.e., cyclosis). This effect occurs when organelles move anterograde along the cortex of the cell and retrograde down the center of the cell. The result is a displacement of cytoplasmic volume causing a cyclic motion of organelles and bulk liquid. Visually, the organelles appear to be traveling in a backwards fountain hence the name. The use of light microscopy bioimaging in this study has documented reverse fountain cytoplasmic streaming for the first time in fungal hyphae of Rhizopus oryzae and other members in the order Mucorales (Mucoromycota). This is a unique characteristic of the mucoralean fungi, with other fungal phyla (e.g., Ascomycota, Basidiomycota) exhibiting unidirectional cytoplasmic behavior that lacks rhythmic streaming (i.e., sleeve-like streaming). The mechanism of reverse fountain cytoplasmic streaming in filamentous fungi is currently unknown. However, in angiosperm plant pollen tubes it’s correlated with the arrangement and activity of the actin cytoskeleton. Thus, the current work assumes that filamentous actin and associated proteins are directly involved with the cytoplasmic behavior in Mucorales hyphae. From an evolutionary perspective, fungi in the Mucorales may have developed reverse fountain cytoplasmic streaming as a method to transport various organelles over long and short distances. In addition, the mechanism is likely to facilitate driving of polarized hyphal growth.
ContributorsShange, Phakade Mdima (Author) / Roberson, Robert W. (Thesis advisor) / Gile, Gillian (Committee member) / Baluch, Debra (Committee member) / Arizona State University (Publisher)
Created2020