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Heart disease is the leading cause of death in the developed world and often occurs following myocardial infarction. Apelin is an endogenous prepropeptide that has been studied for its role in improving cardiac contractility and vasodilation but suffers from a short half-life in the body. By encasing apelin in a nanoparticle patch, we were able to slowly release apelin to cardiac tissue and observe its effects for one month following induced myocardial infarction surgery in mice. This study demonstrates that the apelin nanoparticles can protect the heart from myocardial-induced heart failure, observing overall improved cardiac function and reduction of fibrotic scarring associated with post-myocardial infarction compared to a nontreated group.
Platelet Rich Plasma (PRP) is an emerging procedure in regenerative medicine that offers a non-surgical minimally invasive way for tissue repair and regeneration. PRP has many different bioactive molecules that are able to influence and help achieve greater recovery and regenerative outcomes. Diet has many effects on platelets and looking at the mechanism in which platelet function and aggregation are affected with different diets shows how they are able to affect PRP therapy. Looking at these mechanisms allows for better physician recommendations for preprocedural diets to optimize efficacy. This paper conducts a systematic review to investigate the influence that diet can have on PRP outcomes. It was shown that high fat diets lower the efficacy of treatment while the Mediterranean diet helps promote platelet function and help efficacy. The future is to look at more diets while also integrating lifestyle choice before treatment for optimal outcomes.
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With the increase in the severity of drought conditions in the Southwest region of the U.S. paired with rising temperatures, it is becoming increasingly important to look at the systems used to keep people cool in hot-arid cities like Tempe, Arizona. Outdoor misting systems are often deployed by businesses. These systems rely on the evaporative cooling effect of water. This study examines the relationship between misting droplet size, water usage, and thermal comfort using low-pressure misting systems, tested within hot and dry conditions representative of the arid U.S. southwest. A model misting system using three nozzle orifice sizes was set up in a controlled heat chamber environment (starting baseline conditions of 40°C air temperature and 15 % relative humidity). Droplet size was measured using water-reactive paper, while water use was determined based on weight-change measurements. These measurements were paired with temperature and humidity measurements observed in several locations around the chamber to allow for a spatial analysis. Thermal comfort is determined based on psychrometric changes (temperature and absolute humidity) within the room. On average, air temperatures decreased between 2 to 4°C depending on nozzle size and sensor location. The 0.4 mm nozzle had a decent spread across the heat chamber and balanced water usage and effectiveness well. Limitations within the study showed ventilation is important for an effective system, corroborating other studies findings and suggesting that adding air circulation could improve evaporation and comfort and thus effectiveness. Finally, visual cues, such as wetted surfaces, can signal businesses to change nozzle sizes and/or make additional modifications to the system area.
Maternal morbidity and mortality rates in the United States continues to rise, with a wide range of contributing factors such as mental illness, cardiovascular disease and systemic inequality. This metastudy provides a holistic view of the research that has been published on the issue of U.S. maternal healthcare from 2000-2022. The patterns of publications on specific topics over time can tell us what is perceived as a current major cause by physicians, public leaders, researchers, and the public. A deeper dive into systemic inequality as a cause of maternal morbidity and mortality highlights it as a major contributor to these high rates, but that progress is slowly being made through the implementation of detection and prevention tactics, as well as accessible prenatal programs and care.